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More about the Product

Composition :

KETOCONAZOLE-0.5MG

Manufacturer/Marketer :

Leeford Healthcare Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ketofly Tablet

Ketofly Tablet is a prescription medication used to treat serious, systemic fungal infections that affect internal organs. It is prescribed when other alternative antifungal treatments are not suitable or cannot be tolerated by the patient. This medication works by stopping the growth of the fungus causing the infection.

It is crucial to take it exactly as prescribed by your doctor, usually once daily, and at the same time each day to maintain a steady level of the medicine in your body. For proper absorption, this tablet should be taken with food or an acidic beverage, as stomach acid is required for it to dissolve correctly. Making simple lifestyle adjustments, such as avoiding alcohol during treatment, will help support your body's recovery.

While taking this medicine, you may experience mild side effects such as nausea, mild stomach discomfort, or headaches. However, you must contact your doctor immediately if you notice serious signs of liver damage, such as yellowing of your skin or eyes, severe abdominal pain, or unusually dark urine.

Before starting this medication, talk to your doctor if you have a history of liver disease, heart rhythm conditions, or adrenal gland issues. Do not take this if you have active liver disease or if you are taking certain medications that can cause serious heart rhythm problems when combined with it.

This medicine can interact significantly with other drugs, including common cholesterol-lowering pills and certain sedatives, which can increase the risk of severe side effects. Avoid alcohol while taking this medicine because the combination increases the risk of liver damage.

If you are pregnant, breastfeeding, or an elderly patient, you must consult your doctor to discuss whether this medication is safe for you. The safety and effectiveness of Ketofly Tablet in children have not been well established. It should only be used in children if prescribed by a doctor after carefully considering the benefits and risks.

Uses of Ketofly Tablet

Your doctor may recommend this medicine to help manage the following conditions:

  • Systemic fungal infections: It helps treat deep-seated fungal infections inside the body, such as blastomycosis, coccidioidomycosis, and histoplasmosis, by stopping the spread of the fungus.
  • Severe fungal infections resistant to other therapies: It is used when alternative antifungal treatments are unavailable or cannot be tolerated, helping to clear stubborn infections from the body.
  • Cushing's syndrome: It may reduce the production of cortisol (a stress hormone). Use it only under specialist supervision. 

Key Benefits

When taken consistently as directed, this medicine may provide the following health benefits:

  • Treats serious fungal infections: It helps treat serious fungal infections that cannot be effectively treated with topical medicines.
  • Relieves infection symptoms: It may help reduce symptoms such as persistent fever, tiredness, and discomfort caused by the fungal infection as it clears the infection.
  • Alternative treatment option: It may be used when other systemic antifungal medicines are not suitable or cannot be tolerated, as advised by your doctor.

Directions for Use

  • Ketofly Tablet can be taken with or without food.
  • Your doctor will decide the dose and duration depending on your condition.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew, or break Ketofly Tablet as it may affect the way the medication is absorbed.

How Ketofly Tablet Works

This medicine contains Ketofly Tablet , which is an antifungal. It works by targeting the protective outer layer of the fungal cells, known as the cell membrane. It blocks the production of a key substance called ergosterol, which the fungus needs to keep its cell membrane strong and intact. Without this crucial substance, holes develop in the fungal cell membrane, causing the cell's contents to leak out. This action weakens the fungus, stops it from multiplying, and ultimately leads to the destruction of the infection-causing fungal cells.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Ketofly Tablet as it may increase the risk of liver damage and cause adverse effects.

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Pregnancy

Consult your doctor

Ketofly Tablet is a Category C pregnancy drug and is given to pregnant women only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Ketofly Tablet may be excreted in breast milk. Therefore, it is recommended to avoid breastfeeding while taking Ketofly Tablet .

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Driving

Caution

Ketofly Tablet may cause dizziness or drowsiness. Therefore, drive only if you alert after taking Ketofly Tablet .

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Liver

Unsafe

Ketofly Tablet is contraindicated in patients with chronic or acute liver disease. Therefore, inform your doctor if you have any Liver diseases/conditions.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Ketofly Tablet in patients with kiver diseases/conditions, consult a doctor.

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Children

Consult your doctor

Ketofly Tablet is not recommended for children below 2 years of age. For children above 2 years, it is recommended to use only if the doctor has determined that benefits outweigh risks.

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Heart

Caution

If you have any concerns regarding the use of Ketofly Tablet in patients with heart diseases/conditions, consult a doctor.

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Geriatrics

Caution

Ketofly Tablet should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Ketofly Tablet

If you accidentally take more than your prescribed dose, seek emergency medical attention. Symptoms of an overdose may include severe nausea, vomiting, or dizziness.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol during treatment, as it can increase the risk of serious liver damage.
  • Take with an acidic drink if advised: If you take medicines that reduce stomach acid (such as antacids or H2 blockers), ask your doctor or pharmacist whether you should take Ketofly Tablet with an acidic drink, such as cola, to help improve absorption.
  • Rest and stay hydrated: Get enough rest and drink plenty of fluids to support your recovery from the infection.
  • Maintain good hygiene: Wash towels, clothing, and other personal items regularly to help prevent the infection from spreading or coming back.
     
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How Soon It Starts Working

  • The time required for Ketofly Tablet to start to work: Ketofly Tablet ideally shows its action within 1 hour after administration.
  • The time for which the effects of Ketofly Tablet last: The effect of Ketofly Tablet lasts for 8 hours.

What if you forget to take Ketofly Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store the tablets at room temperature, ideally between 20°C and 25°C (68°F and 77°F).

Drug Warnings

  • Attend regular check-ups: Your doctor may perform liver function tests before and during treatment. If you have certain heart conditions or risk factors, your doctor may also recommend an electrocardiogram (ECG) before starting treatment.
  • Use only as prescribed: Do not use this medicine to treat mild fungal infections of the skin or nails unless your doctor specifically recommends it.
  • Check before taking other medicines: Talk to your doctor or pharmacist before starting any new prescription medicines, over-the-counter medicines, herbal products, or vitamin supplements, as Ketofly Tablet can interact with many medicines.
  • Important safety warning: It is associated with a risk of serious, potentially life-threatening liver damage. It is generally prescribed only when other suitable antifungal treatments are not appropriate or have not been effective. Your doctor will monitor your liver function before and during treatment.
  • Complete the full course: The duration of treatment depends on the type and severity of the fungal infection. Continue taking this medicine for the full course prescribed by your doctor, even if you start feeling better.

verifiedApollotooltip
  • Sedatives: Medicines such as alprazolam and oral midazolam may build up in the body when taken with Ketofly Tablet , increasing the risk of excessive drowsiness, slowed breathing, and other serious side effects.
  • Cholesterol-lowering medicines (statins): Taking Ketofly Tablet with simvastatin or lovastatin can greatly increase the risk of muscle damage (myopathy) and muscle breakdown (rhabdomyolysis). These medicines should generally not be used together.
  • Acid-reducing medicines: Medicines such as omeprazole, pantoprazole, ranitidine, or antacids can reduce the absorption of medicine, making it less effective. Your doctor may advise you on how to take these medicines safely.

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  • Alcohol: Drinking alcohol while taking this medicine increases the risk of severe liver damage. 

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Habit Forming

No

Therapeutic Class

[ANTIFUNGALS - ORAL]

FAQs

Ketofly Tablet belongs to a class of drugs called antifungals indicated to treat various systemic fungal infections such as blastomycosis (infection caused by Blastomyces fungus), chromomycosis (chronic infection of the skin and subcutaneous tissue), Coccidioidomycosis (infection caused by Coccidioides fungus), paracoccidioidomycosis (infection caused by Paracoccidioides fungus) and histoplasmosis (lung infection caused by Histoplasma fungus).
Ketofly Tablet works by destroying fungal cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thus, kills fungi and treats the fungal infection.
Ketofly Tablet is not recommended to treat fungal meningitis (fungal infection spreads to the brain and spinal cord) as it poorly penetrates into the cerebrospinal fluid. Therefore, inform your doctor if you have fungal meningitis so that appropriate medication may be prescribed.
You are recommended to avoid foods containing chocolate and caffeine such as cocoa beans, tea, coffee, cola and energy drinks while taking Ketofly Tablet as it may increase the adverse effects of caffeine such as drowsiness, nervousness or nausea.
You are not recommended to take Ketofly Tablet with simvastatin (lipid-lowering drug) as co-administration of these medicines may cause muscle problems. Therefore, please consult a doctor before taking Ketofly Tablet with other medicines.
No, you are not recommended to stop taking Ketofly Tablet without consulting your doctor as it may cause recurring infection. Therefore, take Ketofly Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Ketofly Tablet , please consult your doctor.
No, you should not take it with antacids. Antacids reduce stomach acid, which this medicine needs to dissolve and absorb. Take antacids at least two hours before or two hours after taking this medication, or talk to your doctor.
Your doctor will order regular blood tests to monitor your liver function, as this medication can cause serious liver damage. These tests help ensure the medicine is safe for your body to process.
No, you should avoid alcohol completely while taking this medication. Both alcohol and this medicine are processed by the liver, and combining them significantly increases the risk of severe liver damage.
No, it is generally not recommended during pregnancy unless your doctor decides the benefits outweigh the potential risks to the unborn baby. Talk to your doctor if you are pregnant or planning to become pregnant.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one and continue with your normal schedule. Do not double the dose to catch up.
No, oral tablets of Ketofly Tablet are not recommended for mild skin or nail infections due to the risk of serious side effects like liver damage. Your doctor will prescribe safer, alternative treatments for these conditions.
If you have low stomach acid or take acid-reducing medications, your doctor may advise you to take it with an acidic drink, such as a cola beverage, to help your body absorb the medicine.
Watch for symptoms such as unusual tiredness, loss of appetite, persistent nausea, dark urine, pale stools, or yellowing of the skin and eyes. If you notice any of these, contact your doctor right away.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 018533S040Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Ketoconazole Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Ketoconazole cream [Prescribing Information]. 2014. [Accessed on 10 Jun. 2025]Check here
  4. Ketoconazole [Summary of Product Characteristics]. 2023. [Accessed on 10 Jun. 2025]Check here
  5. Ketoconazole Ketoconazole. 2026. [Accessed on 01 Apr. 2026]Check here
  6. Ketoconazole 2% w/w Shampoo - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 31 Oct 2025]Check here
  7. Ketoconazole (Topical Route) Description and Brand Names - Mayo Clinic [Internet]. Mayoclinic.org. 2021 [Accessed on 31 Oct 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Leeford Healthcare Limited , Leo House, Shaheed Bhagat Singh Nagar, Dugri-Dhandra Road, Near Joseph School , Ludhiana-141116.
Other Info - KET0258
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