Keygraf Capsule 10's

Keygraf Capsule is used to treat various medical conditions. The detailed uses are as follows:

• Prevention of Organ Transplant Rejection: Keygraf Capsule is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
• Other Off-Label Uses: In some cases, Keygraf Capsule may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.

• Keygraf Capsule belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
• It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
• It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
• It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
• It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.

• Take Keygraf Capsule at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
• Strictly follow your doctor's recommendation regarding the dosage and duration.
• Swallow it as a whole with water.
• Do not crush, break or chew it.

• Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
• Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
• Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
• Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
• Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
• Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
• Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
• Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
• Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
• Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.

• Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Keygraf Capsule .
• If you are pregnant or breastfeeding, consult your doctor before using Keygraf Capsule to ensure it is safe for you and your baby.
• Avoid alcohol consumption while taking Keygraf Capsule , as it may increase side effects.
• Drive or operate machinery only if you feel alert, since Keygraf Capsule may occasionally cause vision problems, dizziness, or nervous system disturbances.
• Inform your doctor before receiving any vaccines, as Keygraf Capsule suppresses the immune system and may reduce the effectiveness of certain vaccines.
• Keygraf Capsule can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
• When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
• Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.