Keygraf 2 Capsule 10's
MRP ₹900
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About Keygraf 2 Capsule
Keygraf 2 Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. Organ rejection occurs when a patient’s immune system recognises the donor organ as foreign and tries to eliminate it.
Keygraf 2 Capsule contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.
Take Keygraf 2 Capsule as prescribed. You are advised to use Keygraf 2 Capsule for as long as your doctor has recommended it for you based on your medical condition. Some people may experience nausea, diarrhoea, headache, kidney problems, infection, fever, constipation or high blood pressure. Most of these side effects of Keygraf 2 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
If you are allergic to Tacrolimus or any other medicines, please tell your doctor. If you are pregnant or a breastfeeding mother, it is advised to consult a doctor before using Keygraf 2 Capsule . Avoid alcohol consumption with Keygraf 2 Capsule . Drive only if you are alert, as Keygraf 2 Capsule may cause some people vision problems or nervous disturbances. If you are about to get vaccinated, inform your doctor before taking Keygraf 2 Capsule . Keygraf 2 Capsule may increase the risk of infections or skin cancer as it lowers the body’s immune defence system.
Uses of Keygraf 2 Capsule
Keygraf 2 Capsule is used to treat various medical conditions. The detailed uses are as follows:
- Prevention of Organ Transplant Rejection: Keygraf 2 Capsule is used to stop the body from rejecting a transplanted kidney, liver, heart, or lung. It works by lowering the activity of certain immune cells that could attack the new organ. It is usually given along with other anti-rejection medicines.
- Other Off-Label Uses: In some cases, Keygraf 2 Capsule may be used for graft-versus-host disease (after bone marrow or stem cell transplant), autoimmune liver diseases (autoimmune hepatitis, lupus nephritis), autoimmune eye conditions (uveitis, scleritis), and other immune-related disorders such as rheumatoid arthritis, Crohn’s disease, or myasthenia gravis, particularly when standard treatments are not effective.
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Directions for Use
- Take Keygraf 2 Capsule at least 1 hour before or 2 to 3 hours after a meal or as advised by your doctor.
- Strictly follow your doctor's recommendation regarding the dosage and duration.
- Swallow it as a whole with water.
- Do not crush, break or chew it.
Medicinal Benefits
- Keygraf 2 Capsule belongs to the class of medicines called immunosuppressants, which reduce the activity of the body's immune system, and it contains Tacrolimus as the active ingredient.
- It works by lowering the activity of certain white blood cells (T-lymphocytes) that trigger immune reactions, helping to prevent the body from attacking transplanted organs and reducing harmful immune responses.
- It is used to prevent rejection of kidney, liver, heart, or lung transplants, usually along with other anti-rejection medicines.
- It may also be used for graft-versus-host disease, autoimmune liver conditions, autoimmune eye inflammation, and certain severe autoimmune diseases (such as rheumatoid arthritis, Crohn's disease, or myasthenia gravis) when other treatments are not effective.
- It provides several benefits, including protecting transplanted organs from rejection, improving long-term transplant survival, reducing the need for high-dose steroids, managing severe immune reactions in certain diseases, and improving quality of life for transplant patients.
How Keygraf 2 Capsule Works
Storage
- Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
- Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
- Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
- Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
- Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
- Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
- Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
- Talk to your doctor about oral potassium supplements.
- Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
- Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
- Get sufficient sleep and manage stress which helps in improving white blood cell count.
- Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
- Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
- Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
- Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
- Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
- Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
- Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
- Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
- Change positions or take a break from activity to relieve symptoms.
- Avoid postures that put a lot of pressure on just one area of the body.
- If you have vitamin deficiency, take supplements or change your diet.
- Exercise regularly like cycling, walking or swimming.
- Avoid sitting with your legs crossed.
- Clench and unclench your fists and wiggle your toes.
- Massage the affected area.
- Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
- Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
- Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
- Try relaxing techniques like deep breathing, mindfulness meditation and any others.
- Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
- Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
- Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
What if I have taken an overdose of Keygraf 2 Capsule
Drug Warnings
- Inform your doctor if you are allergic to Tacrolimus or any other medicines before starting Keygraf 2 Capsule .
- If you are pregnant or breastfeeding, consult your doctor before using Keygraf 2 Capsule to ensure it is safe for you and your baby.
- Avoid alcohol consumption while taking Keygraf 2 Capsule , as it may increase side effects.
- Drive or operate machinery only if you feel alert, since Keygraf 2 Capsule may occasionally cause vision problems, dizziness, or nervous system disturbances.
- Inform your doctor before receiving any vaccines, as Keygraf 2 Capsule suppresses the immune system and may reduce the effectiveness of certain vaccines.
- Keygraf 2 Capsule can increase the risk of infections and skin cancer due to lowered immune defence; use protective clothing and sunscreen while outdoors.
- When preparing the oral suspension, use glass or metal containers only, as the granules can stick to plastic (PVC) and result in an incomplete dose.
- Avoid inhaling the granules or letting them, or the prepared suspension, come into contact with your skin or eyes. If accidental contact occurs, wash the area thoroughly with soap and water or rinse eyes with plain water.
Drug-Drug Interactions
Drug-Drug Interactions
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Combining Keygraf 2 Capsule with Thioridazine can increase the risk of irregular heart rhythm.
How to manage the interaction:
Taking Keygraf 2 Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Taking Keygraf 2 Capsule with Ziprasidone can increase the risk of irregular heart rhythm.
How to manage the interaction:
Taking Keygraf 2 Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
Taking Keygraf 2 Capsule with dronedarone can increase the risk of irregular heart rhythm.
How to manage the interaction:
Taking Keygraf 2 Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Taking Keygraf 2 Capsule with saquinavir can increase the risk of irregular heart rhythm.
How to manage the interaction:
Taking Keygraf 2 Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
Taking Keygraf 2 Capsule with Mifepristone may significantly increase the blood levels of Keygraf 2 Capsule, which may increase the risk and/or severity of side effects.
How to manage the interaction:
Taking Keygraf 2 Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
Taking cidofovir with Keygraf 2 Capsule can increase the risk of kidney problems.
How to manage the interaction:
Taking Keygraf 2 Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.
Taking Keygraf 2 Capsule with primidone can increase the risk of kidney problems.
How to manage the interaction:
Although taking Keygraf 2 Capsule and primidone together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
Taking Keygraf 2 Capsule with ritonavir may significantly increase the blood levels of Keygraf 2 Capsule.
How to manage the interaction:
Although taking Keygraf 2 Capsule and ritonavir together can possibly result in an interaction, but it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Using cladribine together with Keygraf 2 Capsule may increase the risk of serious infections
How to manage the interaction:
Although taking Keygraf 2 Capsule and clozapine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
Taking Keygraf 2 Capsule with neomycin may increase risk of kidney problems.
How to manage the interaction:
Although taking Keygraf 2 Capsule and neomycin together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Drug-Food Interactions
Drug-Food Interactions
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Grapefruit Juice, Grapefruit
How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Keygraf 2 Capsule treatment may lead to increased Keygraf 2 Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Keygraf 2 Capsule.
Diet & Lifestyle Advise
- Eat a balanced diet rich in fruits, vegetables, whole grains, lean proteins, and healthy fats to support immune system balance and overall recovery after transplant.
- Limit salt intake to help manage blood pressure, which can be affected by Tacrolimus and other transplant medications.
- Avoid grapefruit and grapefruit juice, as they can increase Tacrolimus levels in the blood and raise the risk of side effects.
- Stay hydrated by drinking enough water daily to support kidney function and prevent dehydration.
- Limit alcohol consumption or avoid it entirely, as it can stress the liver and interfere with medication effectiveness.
- Avoid undercooked or raw meat, seafood, and unpasteurised dairy products to reduce the risk of infections that can compromise your immune system.
- Practice good hand hygiene and food safety to minimise exposure to harmful bacteria or viruses.
- Maintain a healthy weight through a balanced diet and light physical activity, as recommended by your doctor.
- Avoid herbal supplements or over-the-counter medicines without medical advice, as they can interact with Tacrolimus and other immunosuppressants.
- Manage stress and get adequate rest, as this supports immune health and overall well-being during long-term transplant recovery.
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Alcohol
Unsafe
Avoid alcohol consumption with Keygraf 2 Capsule as it may increase the risk of adverse effects. Please consult a doctor before consuming alcohol with Keygraf 2 Capsule .
Pregnancy
Caution
Using Tacrolimus during pregnancy may cause kidney dysfunction or neonatal hyperkalemia (high potassium levels in the blood). Therefore, please consult a doctor if you are pregnant before taking Keygraf 2 Capsule and if you are a woman of childbearing age, use effective contraceptive methods while using Keygraf 2 Capsule .
Breast Feeding
Consult your doctor
Keygraf 2 Capsule may be excreted in breast milk. Therefore, please inform your doctor if you are a breastfeeding mother before taking Keygraf 2 Capsule . You should avoid taking Keygraf 2 Capsule during breastfeeding or avoid breastfeeding while on treatment with Keygraf 2 Capsule .
Driving
Caution
Keygraf 2 Capsule may cause vision problems or nervous disturbances in a few people. Therefore, avoid driving if you experience any of these symptoms after taking Keygraf 2 Capsule .
Liver
Consult your doctor
Please consult a doctor if you have liver diseases/conditions before taking Keygraf 2 Capsule .
Kidney
Consult your doctor
Please consult a doctor if you have Kidney diseases/conditions before taking Keygraf 2 Capsule .
Children
Safe if prescribed
Keygraf 2 Capsule should be used in children in doses as advised by a doctor only.
Heart
Keygraf 2 Capsule can be used in heart patients, especially post-transplant, but it require close monitoring due to risks like arrhythmias, hypertension, and kidney strain. Always consult your cardiologist before starting, as dose adjustments and regular ECG and blood tests may be necessary.
Geriatrics
Caution
Keygraf 2 Capsule can be taken by geriatric patients, but they require careful monitoring due to increased sensitivity to side effects like kidney dysfunction and high blood pressure. Dose adjustments and regular blood tests are essential to ensure safety and effectiveness.
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Reference
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
- https://www.medsafe.govt.nz/consumers/cmi/t/tacrolimussandozcap.pdf
- https://www.astellas.com/us/system/files/prografwpi_3.pdf
- https://www.medicines.org.uk/emc/product/461/smpc
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210115s000,050708s047,050709s040lbl.pdf
- https://www.drugs.com/cdi/tacrolimus-granules-for-suspension.html
- https://www.astellas.com/us/system/files/prografinstructionstouse_2.pdf
