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compositionComposition:SULPHAMETHOXAZOLE-80MG+TRIMETHOPRIM-16MG
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Prescription Medicine
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Kolibitor Injection 5 ml is used to treat bacterial infections. It contains Sulfamethoxazole (sulfonamide) and Trimethoprim (antifolate). These antibiotics work together to prevent bacteria from producing folic acid, which is necessary for DNA production. Thus, it inhibits the growth and multiplication of bacteria and stops the spread of infection. Common side effects of Kolibitor Injection 5 ml may include abnormal heartbeats, headache, diarrhoea, skin rashes, nausea, thrush or candidiasis (a fungal infection that affects the mouth or vagina).

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

SULPHAMETHOXAZOLE-80MG+TRIMETHOPRIM-16MG

Manufacturer/Marketer :

Fusion Health Care Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Kolibitor Injection 5 ml

Kolibitor Injection 5 ml is a prescription antibiotic injection used to treat severe bacterial infections. It is commonly prescribed for serious chest infections like certain types of pneumonia, severe urinary tract infections, and deep gut infections. This medication is typically reserved for cases where oral medications are not suitable or when the infection requires direct, rapid entry into the bloodstream.

Kolibitor Injection 5 ml is given as a slow drip into a vein by a healthcare professional on a strict, consistent schedule. Maintaining a steady amount of the medicine in your body is critical to completely clearing the infection. Staying well-hydrated by drinking plenty of water during your course of treatment is a highly effective way to support your kidneys while using this medicine.

While this medication is highly effective, some people may experience mild side effects like nausea, vomiting, or a temporary skin rash. However, you must contact your doctor immediately if you notice serious symptoms such as a severe, peeling skin rash, yellowing of your skin or eyes, or persistent watery diarrhoea.

Talk to your doctor before starting this medicine if you have underlying health conditions, especially kidney problems, liver damage, asthma, or blood disorders. Do not use this medicine if you have a known allergy to sulfa medications, severe liver damage, or severe kidney disease.

This medicine can interact with other substances, such as certain blood thinners, blood pressure medications, or diabetes treatments, potentially changing how they affect your body. If you are pregnant, breastfeeding, or are an older adult, you should consult your doctor to discuss the risks and benefits before starting treatment.

Uses of Kolibitor Injection 5 ml

Kolibitor Injection 5 ml is prescribed to treat serious bacterial infections and prevent certain opportunistic infections in people at high risk. Its main uses include: 

  • Pneumocystis pneumonia (PCP): Kolibitor Injection 5 ml helps treat and prevent this severe lung infection, which primarily affects individuals with weakened immune systems.
  • Severe urinary tract infections: It targets and destroys bacteria causing deep or complicated infections in the bladder and kidneys.
  • Shigellosis: It stops the growth of bacteria in the gut, reducing severe diarrhoea, stomach cramps, and dehydration caused by the infection.
  • Nocardiosis: It acts against this rare, long-term bacterial infection that can damage the lungs, skin, or brain.

Key Benefits

Kolibitor Injection 5 ml offers several important benefits that help control severe bacterial infections and support a faster recovery, including:

  • Rapid delivery into the bloodstream: Because Kolibitor Injection 5 ml is injected directly into a vein, it bypasses the digestive tract and enters your bloodstream immediately. This rapid delivery allows the medication to begin fighting the infection right away, which is critical for treating severe or life-threatening conditions.
  • Faster infection control: By effectively stopping the spread of bacteria, the medicine helps lower high fevers, relieves body aches, and speeds up your overall recovery time.
  • Protection against serious complications: It helps protect your vital organs from the damage that untreated, severe infections can cause, helping you return to your normal routine faster.

Directions for Use

  • Your doctor will determine the dosage and frequency depending on your condition.
  • Kolibitor Injection 5 ml will be administered by a healthcare professional.
  • Do not self-administer.

How Kolibitor Injection 5 ml Works

Kolibitor Injection 5 ml contains two active medicines that work together to treat bacterial infections by preventing bacteria from growing and multiplying. Sulphamethoxazole is an antibiotic that blocks the first step in the production of folic acid, an essential nutrient that bacteria need to grow, multiply, and survive. Trimethoprim is an antibiotic that blocks the next step in the same folic acid production pathway. By stopping this process at a second point, it further prevents bacteria from producing the DNA and other essential components needed for their survival. Together, these medicines block folic acid production at two different stages, preventing bacteria from multiplying, helping eliminate the infection, and allowing the body's immune system to clear the remaining bacteria.
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Alcohol

Consult your doctor

The interaction of Kolibitor Injection 5 ml with alcohol is unknown. If you have any concerns, please discuss them with your doctor.

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Pregnancy

Consult your doctor

Kolibitor Injection 5 ml may harm the foetus. Therefore, if you are pregnant or planning pregnancy, inform your doctor before receiving Kolibitor Injection 5 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Avoid breastfeeding while on treatment with Kolibitor Injection 5 ml due to its potential risk of bilirubin displacement and kernicterus (brain damage). If you are a breastfeeding mother, please inform your doctor before receiving Kolibitor Injection 5 ml.

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Driving

Consult your doctor

Limited information is available on the effect of Kolibitor Injection 5 ml on driving. Please discuss with your doctor before driving or operating machinery after receiving Kolibitor Injection 5 ml.

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Liver

Consult your doctor

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Kolibitor Injection 5 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Kolibitor Injection 5 ml is contraindicated in patients with severe liver disease.

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Kidney

Consult your doctor

If you have a pre-existing or a history of kidney diseases, inform your doctor before receiving Kolibitor Injection 5 ml. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition. Kolibitor Injection 5 ml is contraindicated in patients with severe kidney disease.

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Children

Caution

Kolibitor Injection 5 ml is contraindicated in children less than two months of age (less than six weeks) due to the risk of bilirubin displacement and kernicterus (brain damage).

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Heart

Caution

Inform your doctor before receiving Kolibitor Injection 5 ml if you have a pre-existing or a history of heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Kolibitor Injection 5 ml should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Kolibitor Injection 5 ml

Because a trained healthcare provider gives this medication, an overdose is rare. However, if you suspect an overdose or experience severe nausea, dizziness, confusion, or breathing problems during or after your infusion, seek immediate medical attention.

Diet & Lifestyle Advise

  • Drink plenty of fluids: Drink at least 8 to 10 glasses of water daily while receiving this treatment. This helps flush the medicine through your kidneys and prevents the formation of crystals in your urine.
  • Protect your skin from the sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing, a wide-brimmed hat, and use a high-SPF sunscreen when going outdoors. Avoid tanning beds.
  • Support your gut health: Antibiotics can disrupt the natural balance of bacteria in your digestive system. Talk to your doctor about eating fermented foods like yoghurt or taking a probiotic after you finish your treatment.
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Have a query?

How Soon It Starts Working

The time required for Kolibitor Injection 5 ml to start to work: The time required for Kolibitor Injection 5 ml to show its action is not clinically established. The time for which the effects of Kolibitor Injection 5 ml last: The duration of action for Kolibitor Injection 5 ml is not clinically established.

What if you forget to take Kolibitor Injection 5 ml

Since this medicine is given by a medical professional in a clinical setting, missing a dose is unlikely. However, if you miss an appointment or suspect you missed a scheduled dose, contact your clinic or healthcare provider immediately to reschedule.

Storage

•Store Kolibitor Injection 5 ml at controlled room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Do not refrigerate or freeze the injection solution, as cold temperatures can cause crystals to form in the liquid.

Drug Warnings

  • Inspect the solution before use: Do not use the vial or infusion bag if the solution appears cloudy or contains visible particles.
  • Report infusion site reactions: Tell your doctor or nurse immediately if you experience pain, burning, redness, or swelling at the injection site during the infusion.
  • Avoid certain vaccines: Do not receive live bacterial vaccines, such as the typhoid vaccine, while receiving this medicine unless advised by your doctor, as the vaccine may be less effective.
  • Attend regular monitoring appointments: Complete all scheduled blood tests to monitor your kidney function, blood cell counts, and overall response to treatment, especially during prolonged therapy.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Kolibitor Injection 5 ml:

  • Blood thinners (such as warfarin): May increase the risk of bleeding and require closer monitoring.
    ACE inhibitors and other potassium-increasing medicines: May increase potassium levels in the blood, raising the risk of hyperkalaemia.
  • Oral diabetes medicines: May increase the risk of low blood sugar (hypoglycaemia).
    Anti-seizure medicines (such as phenytoin): May increase the levels of these medicines in the body, increasing the risk of side effects.
Trimethoprim + sulfamethoxazoleBCG vaccine
Critical
Trimethoprim + sulfamethoxazolePotassium acetate
Severe

Drug-Drug Interactions

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Trimethoprim + sulfamethoxazoleBCG vaccine
Critical
How does the drug interact with Kolibitor Injection 5 ml:
Using trimethoprim and sulfamethoxazole with BCG vaccine can reduce the effect of BCG vaccine

How to manage the interaction:
Taking Trimethoprim and sulfamethoxazole with BCG vaccine may lead to an interaction, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms consult a doctor. Do not stop using any medications without a doctor's advice.
Trimethoprim + sulfamethoxazolePotassium acetate
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Potassium acetate with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Potassium acetate with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazolePerindopril
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Perindopril with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Perindopril with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleRopivacaine
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Ropivacaine with Trimethoprim and sulfamethoxazole can lead to increased risk of side effects.

How to manage the interaction:
Although taking Ropivacaine with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience gray coloured skin, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, difficulty in breathing, increased heartrate, anxiety or confusion . Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleAmiloride
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Amiloride with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Amiloride with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleLisinopril
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Lisinopril with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Lisinopril with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazolePotassium gluconate
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Potassium gluconate with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Potassium gluconate with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleIrbesartan
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Irbesartan with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Irbesartan with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleAzilsartan medoxomil
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Azilsartan medoxomil with Trimethoprim and sulfamethoxazole can lead to increased potassium salt in blood.

How to manage the interaction:
Although taking Azilsartan medoxomil with sulfamethoxazole and trimethoprim may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in hands or feet, feeling of heaviness in the legs, or slow or rapid heartbeat. Do not stop using any medications without talking to a doctor.
Trimethoprim + sulfamethoxazoleProcaine
Severe
How does the drug interact with Kolibitor Injection 5 ml:
Taking Procaine with Trimethoprim and sulfamethoxazole can lead to increased risk of side effects.

How to manage the interaction:
Although taking Procaine with Trimethoprim and sulfamethoxazole may lead to an interaction, it can be taken if prescribed by a doctor. However, consult the doctor if you experience gray coloured skin, nausea, headache, dizziness, lightheadedness, tiredness, shortness of breath, difficulty in breathing, increased heartrate, anxiety or confusion . Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Kolibitor Injection 5 ml when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTIC COMBINATION]

FAQs

Kolibitor Injection 5 ml is used to treat Bacterial infections.
Kolibitor Injection 5 ml is a combination of two antibiotics, Trimethoprim and Sulfamethoxazole. These antibiotics work together to prevent bacteria from producing folic acid, which is necessary for DNA production. Thereby inhibiting the growth and multiplication of bacteria, it stops the spread of infection.
Kolibitor Injection 5 ml may cause diarrhoea as a common side effect. Drink plenty of fluids and eat fibre-rich food if you experience diarrhoea. However, if the condition persists or worsens, or if you notice blood or mucus in your stools, inform your doctor immediately.
Kolibitor Injection 5 ml is not used to treat viral infections. Kolibitor Injection 5 ml is a combination of antibiotics that is used to treat only bacterial infections. If you have a viral infection, please consult a doctor so that appropriate medication may be prescribed.
Yes, you can usually receive this medicine if you have a penicillin allergy, as it belongs to a completely different class of antibiotics. However, you must inform your doctor if you have an allergy to sulfa medicines. Talk to your doctor about your complete allergy history.
It is highly recommended to avoid alcohol while receiving this treatment. Alcohol can increase your risk of side effects like nausea, vomiting, or rapid heartbeat, and can dehydrate your body, putting extra stress on your kidneys. Talk to your doctor for more guidance.
Drinking plenty of water is essential because it helps your kidneys process and excrete the medicine safely. Adequate hydration prevents the active ingredients from forming crystals in your urine, which can cause kidney irritation. Talk to your doctor if you have fluid restrictions.
This medicine is generally not recommended during pregnancy, especially during the first and third trimesters, as it can interfere with folic acid levels and affect the developing baby. Talk to your doctor to discuss safer alternative treatments.
Let your doctor or nurse know immediately if you feel pain, burning, redness, or swelling at the injection site. They can check the infusion line or change the injection site to prevent skin damage. Talk to your doctor if the pain persists after the infusion.
No, you must complete the entire course of treatment prescribed by your doctor. Stopping the antibiotic early, even if you feel completely recovered, can allow the remaining bacteria to multiply and cause the infection to return, potentially making it resistant to treatment. Talk to your doctor if you experience intolerable side effects.

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Country of origin

India

Manufacturer/Marketer address

Fusion House, Plot No. 22, H.No 8-2-350/B, Road No. 3, Banjara Hills, Hyderabad, Telangana-500034
Other Info - KOL0091
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