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compositionComposition:METFORMIN-1000MG+SAXAGLIPTIN-5MG
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Kombiglyze XR 5 mg/1000 mg Tablet is used to treat type 2 diabetes. It contains Saxagliptin and Metformin which work by lowering the liver's glucose production, delaying glucose absorption from the intestines, and increasing the body's response to insulin. In some cases, this medicine may cause side effects such as low blood glucose levels, upper respiratory tract infection and headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METFORMIN-1000MG+SAXAGLIPTIN-5MG

Manufacturer/Marketer :

AstraZeneca Pharma India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Kombiglyze XR 5 mg/1000 mg Tablet

Kombiglyze XR 5 mg/1000 mg Tablet is a prescription oral medication used to manage high blood sugar levels in adults with type 2 diabetes. This medicine helps control glucose levels when diet and exercise alone are not enough to keep blood sugar within a safe range. It is not used for treating type 1 diabetes or diabetic ketoacidosis.

To get the best results, you must take Kombiglyze XR 5 mg/1000 mg Tablet consistently every day exactly as your healthcare provider prescribes. It is typically taken with meals to reduce the chance of getting an upset stomach. Combining this medication with healthy dietary choices and regular physical activity is essential to achieve long-term success.

While taking Kombiglyze XR 5 mg/1000 mg Tablet, some people may experience mild side effects, such as a stuffy nose or an upset stomach. However, you must seek medical care immediately if you experience severe symptoms, such as persistent, severe stomach pain that radiates to your back, as this can be a sign of a serious pancreas condition. Talk to your doctor if you notice any unusual symptoms that do not go away.

Before starting Kombiglyze XR 5 mg/1000 mg Tablet, talk to your doctor if you have a history of kidney disease, liver damage, or heart problems. Do not take this if you have severe kidney failure, acute metabolic acidosis, or if you are allergic to any of its components. Your doctor will evaluate your health history to ensure this treatment is safe for you.

This medicine can interact with alcohol, contrast dyes used in medical scans, and certain other medications, which may increase the risk of a rare but serious medical emergency called lactic acidosis. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss if this medication is safe for you.

Uses of Kombiglyze XR 5 mg/1000 mg Tablet

Kombiglyze XR 5 mg/1000 mg Tablet is used to treat Type 2 diabetes mellitus. The detailed uses of Kombiglyze XR 5 mg/1000 mg Tablet are as follows:

  • Type 2 Diabetes Mellitus: Kombiglyze XR 5 mg/1000 mg Tablet is prescribed to lower blood sugar levels in adults whose glucose levels are not adequately controlled by diet, exercise, or other single-agent diabetes medications.

Key Benefits

Kombiglyze XR 5 mg/1000 mg Tablet helps manage type 2 diabetes by combining two complementary blood sugar-lowering medicines in a single tablet. With regular use, it supports consistent blood sugar control, simplifies your treatment routine, and helps protect against long-term diabetes-related complications.

  • Convenient Dual-Action Blood Sugar Control: By combining two different blood sugar-lowering mechanisms into one daily tablet, this medicine helps maintain blood sugar levels within the target range while reducing the need for multiple medications.
  • Supports Consistent Diabetes Management: This medicine provides effective day-to-day blood sugar control, helping you maintain better overall health and an active lifestyle.
  • Protection Against Long-Term Diabetes Complications: By keeping blood sugar levels under control over time, this medicine helps reduce the risk of nerve damage, kidney impairment, vision loss, and cardiovascular complications.
Side effects of Kombiglyze Xr 5/1000mg Tab
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
  • Frequent flossing and brushing can help remove bacteria and debris that can give your teeth a metallic taste.
  • The metallic flavor may be caused by a zinc deficiency. Eat foods like meat, chicken, and oysters that are high in zinc.
  • Reducing the intake of foods with strong aromas, like onions and garlic, as they may intensify the taste of metallic substances.
  • Avoid smoking and tobacco products as they may intensify the metallic flavor.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Take Kombiglyze XR 5 mg/1000 mg Tablet with or without food as advised by your doctor.
  • It is advised to take Kombiglyze XR 5 mg/1000 mg Tablet once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Kombiglyze XR 5 mg/1000 mg Tablet Works

Kombiglyze XR 5 mg/1000 mg Tablet contains two active components that work in different, complementary ways to regulate your blood sugar levels. The first active component, saxagliptin, belongs to a class of medicines called DPP-4 inhibitors. It works by increasing the levels of natural hormones in your body called incretins. These hormones help your pancreas release more insulin when your blood sugar is high, especially after eating, and signal your liver to produce less sugar. The second active component, metformin, belongs to the biguanide class. It works primarily by reducing the amount of glucose that your liver makes and releases into your bloodstream. Additionally, it improves your body's sensitivity to insulin, allowing your cells to use sugar from your blood more effectively, and slows down the absorption of sugar from the food you eat.
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Alcohol

Unsafe

Kombiglyze XR 5 mg/1000 mg Tablet is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.

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Pregnancy

Caution

No harmful interaction has been reported in pregnant mothers, yet the patient is advised to consult a doctor before taking this drug during pregnancy.

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Breast Feeding

Caution

No harmful interaction has been reported in breastfeeding mothers, yet the patient is advised to consult a doctor before taking this drug.

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Driving

Caution

Caution is to be taken. If a patient feels dizzy while taking Kombiglyze XR 5 mg/1000 mg Tablet, do not drive or use any tools or machines. Hypoglycaemia may affect your ability to drive and use machines or work with a safe foothold, and there is a risk of hypoglycaemia after taking this medicine in combination with other medicines known to cause hypoglycaemia, such as insulin and sulphonylureas.

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Liver

Caution

It should be used with caution if you have liver conditions. Patients with severe liver problems are advised to take this drug with a doctor's consultation.

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Kidney

Caution

It should be used with caution if you have kidney problems. Patients with reduced kidney function are advised to consult with a doctor before taking Kombiglyze XR 5 mg/1000 mg Tablet as the doctor may decrease the dose as per his own judgment.

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Children

Caution

Kombiglyze XR 5 mg/1000 mg Tablet is not recommended for children and adolescents under 18 years. It is not known if this medicine is safe and effective when used in children and adolescents under 18 years of age. Consult your doctor for more information.

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Heart

Caution

Let your doctor know if you have any history of heart problems. Your doctor will weigh the benefits and potential risks before prescribing Kombiglyze XR 5 mg/1000 mg Tablet.

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Geriatrics

Caution

Kombiglyze XR 5 mg/1000 mg Tablet should be given to elderly patients only when prescribed by a doctor. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Kombiglyze XR 5 mg/1000 mg Tablet

In case of an accidental overdose, you may experience severe low blood sugar, severe nausea, vomiting, or rapid breathing. Seek emergency medical attention immediately.

Diet & Lifestyle Advise

  • Monitor your carbohydrate intake: Focus on complex carbohydrates like whole grains, vegetables, and legumes, which release glucose slowly and help prevent sudden blood sugar spikes.
  • Stay active regularly: Aim for at least 150 minutes of moderate-intensity exercise, such as brisk walking or swimming, every week to help your muscles use insulin more efficiently.
  • Keep a regular meal schedule: Eating your meals at consistent times each day helps stabilise blood sugar levels and works in harmony with your medication.
  • Track your blood sugar levels: Monitor and log your glucose readings as recommended by your doctor to see how your body responds to the treatment.

Health Queries

I have had diabetes for two years and am taking Kombiglyze XR 1000 mg along with a daily multivitamin, protein powder, and Salmon Omega-3 supplements. My fasting blood sugar is 90 and postprandial is 168; is this combination safe and should I continue taking these products?

Vikas Singh

Vikas Singh

M Pharmacy

Your blood sugar levels are well-controlled; a fasting level of 90 mg/dL and a postprandial level of 168 mg/dL are within the target range for diabetes management. The combination of Kombiglyze XR with multivitamins, protein powder, and Salmon Omega-3 is generally safe, as there are no known major interactions. However, make sure to check your protein powder label to ensure it contains no added sugars that could impact your glucose levels. Since your current regimen is highly effective, you can safely continue it. Always share your complete supplement list with your doctor to ensure regular monitoring of your kidney and liver function.

What is a cost-effective alternative to Kombiglyze XR 5 mg/1000 mg?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

A cost-effective alternative to Kombiglyze XR 5 mg/1000 mg is Riax-M XR 5 mg/1000 mg. Always check with your doctor or pharmacist before switching to make sure the strength and formulation match your prescription and are safe for you.

I recently had angioplasty and am a diabetic patient. I'm currently taking Amaryl, Pan 40, and Kombiglyze. I've been feeling dizzy and experiencing joint pain for the last three days.

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Since you recently had angioplasty and have diabetes, dizziness and joint pain should not be ignored. These symptoms can be due to low or fluctuating blood sugar, side effects of medicines like Amaryl, dehydration, or sometimes heart or BP-related issues after the procedure. Check your blood sugar and blood pressure, avoid skipping meals, and stay well hydrated. Please contact your doctor for review, especially if dizziness persists, worsens, or is associated with sweating, chest discomfort, or weakness.
health query

Have a query?

How Soon It Starts Working

The time required for Kombiglyze XR 5 mg/1000 mg Tablet to start to work: The time required for Kombiglyze XR 5 mg/1000 mg Tablet to show its action is unknown. The time for which the effects of Kombiglyze XR 5 mg/1000 mg Tablet last: The duration of action for Kombiglyze XR 5 mg/1000 mg Tablet is clinically unknown.

What if you forget to take Kombiglyze XR 5 mg/1000 mg Tablet

If you miss a dose of Kombiglyze XR 5 mg/1000 mg Tablet, take it as soon as you remember with food. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure what to do.

Storage

• Store Kombiglyze XR 5 mg/1000 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). • Keep the tablets in their original packaging to protect them from moisture and direct light.

Drug Warnings

  • Check tablet appearance: Always inspect your tablets before taking them; do not use them if the packaging is damaged or if the tablets look discoloured or broken.
  • Monitor for lactic acidosis: Be aware of signs of lactic acidosis, such as unexplained muscle pain, fast breathing, or a slow heartbeat, and contact your doctor immediately if they occur.
  • Avoid excessive alcohol: Limit or avoid drinking alcohol while taking this medicine, as alcohol can significantly increase your risk of lactic acidosis and low blood sugar.
  • Pause before medical procedures: Tell your surgeon or dentist you are taking Kombiglyze XR 5 mg/1000 mg Tablet before any scheduled surgery, or if you need an imaging test using contrast dye, as you may need to temporarily stop taking this medication.
  • Check kidney function regularly: Ensure you attend your scheduled blood tests so your doctor can monitor your kidney health while you are on this medicine.

Drug-Drug Interactions

verifiedApollotooltip

Insulin or sulfonylureas: Combining these with Kombiglyze XR 5 mg/1000 mg Tablet may increase the risk of low blood sugar.

  • Strong CYP3A4/5 inhibitors (such as ketoconazole): Can increase the levels of certain components of Kombiglyze XR 5 mg/1000 mg Tablet in your blood, raising the risk of side effects.
  • Carbonic anhydrase inhibitors (such as topiramate): May increase the risk of developing lactic acidosis.
     
Saxagliptin + MetforminGatifloxacin
Critical
Saxagliptin + MetforminAcetazolamide
Severe

Drug-Drug Interactions

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Saxagliptin + MetforminGatifloxacin
Critical
How does the drug interact with Kombiglyze Xr 5/1000mg Tab:
Co-administration of Saxagliptin and Metformin with Gatifloxacin can cause low and high blood glucose.

How to manage the interaction:
There is a possibility of interaction between Saxagliptin with Metformin and Gatifloxacin but they can be taken together if a doctor has prescribed them. Consult your doctor immediately if you experience symptoms like headache, weakness, sweating, palpitation, or fast heart rate. Do not discontinue without consulting a doctor.
Saxagliptin + MetforminAcetazolamide
Severe
How does the drug interact with Kombiglyze Xr 5/1000mg Tab:
Co-administration of Metformin and Saxagliptin with Acetazolamide may increase Lactic acid levels.

How to manage the interaction:
Although there is a possible interaction between Metformin and Saxagliptin with Acetazolamide, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, or chest pain contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Saxagliptin + MetforminBexarotene
Severe
How does the drug interact with Kombiglyze Xr 5/1000mg Tab:
Coadministration of Bexarotene with Metformin and Saxagliptin can increase the risk of developing pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Bexarotene and saxagliptin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like persistent nausea, vomiting, abdominal tenderness, and upper abdominal pain, consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Drinking alcohol can dangerously increase the risk of lactic acidosis and make blood sugar levels harder to control.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Kombiglyze XR 5 mg/1000 mg Tablet is used in the treatment of type 2 diabetes in adults. It is prescribed for the condition of type 2 diabetes when diet and exercise alone cannot control blood sugar levels.
Yes, Kombiglyze XR 5 mg/1000 mg Tablet is known to cause stomach upset, indigestion, nausea, and diarrhoea. To avoid these side effects, please take Kombiglyze XR 5 mg/1000 mg Tablet with a meal. Also, Kombiglyze XR 5 mg/1000 mg Tablet should be taken at evenly spaced intervals to avoid any unpleasant side effects and for best results.
Kombiglyze XR 5 mg/1000 mg Tablet has been reported to increase blood cholesterol levels in a normal patient and thus not recommended in patients with hyperlipidemia.
The patient is advised to take the missed dose as soon as possible; otherwise, jump to the next dose. A patient should never take a double dose to compensate for the missed dose. It may aggravate harmful side effects.
According to American Diabetes Association, most of the studies carried out on Kombiglyze XR 5 mg/1000 mg Tablet and its ability to cause cancer resulted in a conclusion that Kombiglyze XR 5 mg/1000 mg Tablet is not associated with any form of cancer & hence is safe to use.
A patient who accidentally takes an overdose of Kombiglyze XR 5 mg/1000 mg Tablet may experience collapse, seizure attack, and troubled breathing. In such a case, without any delay, emergency health services must be contacted, and medical help should be sought.
Before taking Kombiglyze XR 5 mg/1000 mg Tablet inform your doctor if you have any kidney or liver problems, a history of pancreatitis (swollen pancreas), heart disease, alcohol use, or if you are pregnant or breastfeeding. Also, mention any other medications you are taking, especially those for diabetes.
Kombiglyze XR 5 mg/1000 mg Tablet is not advised to be used in individuals with a history of severe allergic reactions such as difficulty breathing, or serious skin conditions. Kombiglyze XR 5 mg/1000 mg Tablet is also not recommended for those with renal dysfunction (kidney problems), pancreatitis, or pancreatic disease. Kombiglyze XR 5 mg/1000 mg Tablet is also contraindicated in pregnant or breastfeeding women. Therefore, always consult a healthcare provider before use.
Kombiglyze XR 5 mg/1000 mg Tablet is not usually associated with significant weight gain. However, some people may experience mild weight changes. It is important to monitor any changes with your healthcare provider.
Kombiglyze XR 5 mg/1000 mg Tablet may not be suitable for individuals with kidney problems, as it can impact kidney function. Kombiglyze XR 5 mg/1000 mg Tablet should be used with caution or avoided in those with renal issues (kidney problems). Always, consult a physician if you have kidney concerns.
Yes, it is essential to maintain a healthy diet and exercise routine while taking Kombiglyze XR 5 mg/1000 mg Tablet. Although Kombiglyze XR 5 mg/1000 mg Tablet helps control blood sugar, proper diet and regular physical activity are crucial for managing diabetes and supporting overall health. Your healthcare provider can offer guidance in best manner on how to include these habits in your treatment plan.
You are recommended to take Kombiglyze XR 5 mg/1000 mg Tablet for as long as it is advised by your doctor for effective results. If your symptoms continue or worsen, seek further advice from your doctor.
Kombiglyze XR 5 mg/1000 mg Tablet, can be safe for the long-term if taken as advised by your doctor. However, potential risks include acute pancreatitis (swollen pancreas), kidney problems, and hypoglycaemia (low blood sugar). Regular check-ups are essential to assess your health, especially if you have a history of kidney, liver, or heart issues. Always, follow your doctor's recommendations to manage any risks and ensure safe long-term use.
Kombiglyze XR 5 mg/1000 mg Tablet causes side effects such as dizziness, sweating, palpitations, dry mouth and skin and hypoglycaemia (low blood glucose levels). Please, contact a doctor if these side effects or any other concerns persist for longer durations.
It is best to take Kombiglyze XR 5 mg/1000 mg Tablet with meals. Taking it with food reduces the chances of experiencing a mild upset stomach, nausea, or diarrhoea. Talk to your doctor if you have persistent stomach discomfort.
Although Kombiglyze XR 5 mg/1000 mg Tablet rarely causes low blood sugar on its own, it can happen if you take it with other diabetes medicines. If you feel shaky, sweaty, or dizzy, consume a fast-acting sugar source like fruit juice or hard candy, then talk to your doctor.
No, it is not recommended to drink large amounts of alcohol while taking Kombiglyze XR 5 mg/1000 mg Tablet. Alcohol can increase the risk of a rare but serious condition called lactic acidosis and can also cause unstable blood sugar levels. Talk to your doctor about safe alcohol consumption.
Kombiglyze XR 5 mg/1000 mg Tablet is not prescribed for weight loss, though some patients may experience slight weight loss or a stable weight while taking it. Its primary goal is to manage blood sugar levels. Talk to your doctor for advice on healthy weight management.
You should not stop taking Kombiglyze XR 5 mg/1000 mg Tablet without consulting your healthcare provider, even if your blood sugar levels improve. Stopping the medication suddenly can cause your blood sugar to spike again. Talk to your doctor before making any changes.
It is generally not recommended to take Kombiglyze XR 5 mg/1000 mg Tablet during pregnancy or while breastfeeding. Your doctor will likely suggest alternative ways to manage your blood sugar during this time. Talk to your doctor to discuss your options.
Signs of lactic acidosis include unusual muscle pain, trouble breathing, deep and rapid breathing, severe tiredness, dizziness, or a sudden slow heartbeat. This is a medical emergency that requires immediate medical help. Talk to your doctor if you have any concerns.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.6675 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Pmc4821002 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. MIMS Drug Reference Compendium. Onglyza Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Saxagliptin/metformin [EMC Label]. 2017. [Accessed on 28 Jan. 2019]Check here
  6. Metformin hydrochloride + saxagliptin hydrochloride [EMC Label]. 2011. [Accessed on 08 Apr. 2019]Check here
  7. Saxagliptin and metformin [Product Information]. 2023. [Accessed on 28th Sept. 2023]Check here

Country of origin

India

Manufacturer/Marketer address

12Th Mile Bellary Road,Bangalore-560063
Other Info - KOM0012
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