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compositionComposition:COLISTIMETHATE-2MIU
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Prescription Medicine
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Koolistin 2miu Injection is used to treat bacterial infections. It contains Colistimethate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as stomach upset, itching, rash, and fever. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

COLISTIMETHATE-2MIU

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Koolistin 2miu Injection

Koolistin 2miu Injection is a prescription antibiotic injection used to treat severe bacterial infections, particularly those caused by difficult-to-treat Gram-negative bacteria. This medication is typically reserved for serious, systemic infections in the lungs, urinary tract, or bloodstream when other treatments are not effective. It works by targeting and destroying the protective outer layer of harmful bacteria to clear the infection.

Because this medicine is given directly into your body, it is usually administered at regular, evenly spaced intervals throughout the day to keep a constant level of the drug in your system. Since it is given as an injection, it does not depend on meals, meaning you do not need to worry about taking it with or without food. To support your recovery and protect your body during treatment, it is highly recommended to drink plenty of fluids and get plenty of rest.

While this medicine is highly effective, it can sometimes cause common side effects such as mild dizziness, a tingling sensation around the mouth, or temporary changes in kidney function. You should contact your healthcare team immediately if you notice severe signs like a major decrease in urination, persistent muscle weakness, or a severe, watery skin rash.

Before you begin receiving this medication, you must discuss your medical history with your doctor, especially if you have a history of kidney disease or neuromuscular disorders like myasthenia gravis. Do not take this medicine if you have had a severe allergic reaction to it or similar antibiotic injections in the past.

This medicine can interact with other drugs that strain your kidneys or affect your nerves, so your doctor needs to know all the medications you are currently taking. It is also important to avoid alcohol and smoking during treatment as they can place unnecessary stress on your organs. If you are pregnant, breastfeeding, or are an older adult, consult your doctor to discuss the risks and benefits of this treatment.

Uses of Koolistin 2miu Injection

Koolistin 2miu Injection is used in the treatment of several bacterial infections. The detailed use of Koolistin 2miu Injection is as follows:

  • Severe Gram-negative bacterial infections: It helps clear deep-seated infections in the lungs, urinary tract, or blood by targeting and killing resistant bacteria.
  • Multi-drug resistant infections: It acts as a vital treatment option when common antibiotics fail to clear highly resistant bacterial strains.

Key Benefits

Koolistin 2miu Injection offers crucial, targeted relief for patients suffering from severe and complex health issues:

  • Provides a life-saving option for severe, systemic infections when other first-line antibiotics are ineffective.
  • Quickly gets to work in the bloodstream to halt the spread of dangerous bacteria, helping you recover your physical strength faster.
  • Reduces the risk of long-term complications associated with chronic, deep-seated bacterial tissue infections.

Directions for Use

  • Your doctor will determine the dosage and timing of Koolistin 2miu Injection based on the severity of your infection. Typically, it is administered every 6-12 hours.
  • Koolistin 2miu Injection is administered by a healthcare professional as an infusion over 30 to 60 minutes or as a rapid injection within 5 minutes into a vein
  • Do not self-administer it.

How Koolistin 2miu Injection Works

Koolistin 2miu Injection is a powerful antibiotic belonging to the polymyxin class. It functions by acting directly on the cell membrane of susceptible Gram-negative bacteria. The medicine binds specifically to the outer protective envelope of the bacterial cell, disrupting its structure and making it highly permeable. This causes vital cellular components to leak out, which rapidly leads to the destruction and death of the bacteria, allowing your immune system to clear the remaining infection.
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Alcohol

Caution

Interaction of Koolistin 2miu Injection with alcohol is unknown. Please consult a doctor before consuming alcohol while using Koolistin 2miu Injection.

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Pregnancy

Caution

Koolistin 2miu Injection is a category C pregnancy drug and is given to pregnant women only if it is essential. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Koolistin 2miu Injection may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Koolistin 2miu Injection may cause confusion, vision problems or dizziness. Therefore, avoid driving if you experience any of these symptoms after taking Koolistin 2miu Injection.

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Liver

Caution

Take Koolistin 2miu Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Koolistin 2miu Injection with caution, especially if you have a history of Kidney diseases/conditions as Koolistin 2miu Injection may affect kidney function. The dose may be adjusted by your doctor as required.

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Children

Caution

Koolistin 2miu Injection should be used with caution in children and in doses as prescribed by a doctor. Special care should be taken in new-born and premature babies as kidneys are not developed fully.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Koolistin 2miu Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Koolistin 2miu Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Koolistin 2miu Injection

If you suspect an overdose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose can include severe muscle weakness, dizziness, or a sudden, severe decline in kidney function.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water throughout the day to help your kidneys flush the medication safely from your body, unless your doctor tells you to limit fluids.
  • Eat a balanced diet: Focus on nutrient-rich foods that support your immune system during recovery, while avoiding excessive sodium, which can strain your kidneys.
  • Prioritise physical rest: Give your body ample time to rest and heal so your immune system can work efficiently alongside the antibiotic.
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How Soon It Starts Working

The time required for Koolistin 2miu Injection to start to work: The time required for Koolistin 2miu Injection to show its action is unknown. The time for which the effects of Koolistin 2miu Injection last: The duration of action for Koolistin 2miu Injection is clinically unknown.

What if you forget to take Koolistin 2miu Injection

Since this medicine is usually given by a healthcare professional in a clinical setting, missed doses are rare. If you are managing your treatment at home and miss a scheduled dose, contact your doctor or nurse immediately for guidance. Do not administer a double dose to make up for the missed one.

Storage

•Store dry, unmixed vials at room temperature between 20°C and 25°C (68°F and 77°F). •Keep all vials, needles, and preparation supplies completely out of the reach of children and pets.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution: Always check the prepared liquid before administering it. It should be clear and free of any visible floating particles or discolouration; do not use it if it appears cloudy.
  • Rotate injection sites: If you are receiving intramuscular injections, rotate the injection site each time to prevent muscle soreness and tissue irritation.
  • Monitor kidney tests: Attend all scheduled appointments for blood and urine tests so your healthcare provider can ensure your kidneys are functioning safely.
  • Finish the full course: Complete the entire duration of your prescribed therapy, even if your symptoms improve early, to prevent the infection from returning.
  • Dose adjustments: If your kidney function changes during treatment, your doctor may adjust your dose based on blood test results. Do not be concerned if your dosing schedule changes, as this helps improve treatment effectiveness while reducing the risk of side effects.

Drug-Drug Interactions

verifiedApollotooltip
  • Aminoglycoside antibiotics or other kidney-toxic medicines (e.g., gentamicin, vancomycin): Using these medications alongside Koolistin 2miu Injection can significantly increase the risk of severe kidney damage.
  • Muscle relaxants or anaesthetics (e.g., rocuronium, succinylcholine): Combining these medicines can enhance muscle-weakening effects, potentially leading to respiratory issues.
ColistinBCG vaccine
Critical
ColistinPancuronium
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Koolistin 2miu Injection:
Coadministration of Koolistin 2miu Injection along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Koolistin 2miu Injection with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinPancuronium
Severe
How does the drug interact with Koolistin 2miu Injection:
Using Pancuronium with Koolistin 2miu Injection can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinStreptomycin
Severe
How does the drug interact with Koolistin 2miu Injection:
Coadministration of Streptomycin with Koolistin 2miu Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ColistinTobramycin
Severe
How does the drug interact with Koolistin 2miu Injection:
Coadministration of Tobramycin with Koolistin 2miu Injection can increase the blood levels and risk of Koolistin 2miu Injection side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Tobramycin, you can take these medicines together if prescribed by your doctor. However, if you experience, shortness of breath, muscle pain, dizziness, or palpitations, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
ColistinGentamicin
Severe
How does the drug interact with Koolistin 2miu Injection:
Co-administration of Koolistin 2miu Injection with Gentamicin can increase the levels and risk of Koolistin 2miu Injection side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Gentamicin, you can take these medicines together if prescribed by your doctor. However, if you experience weight gain or loss suddenly, muscle pain, dizziness, or palpitations, call your doctor right away. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Koolistin 2miu Injection:
Combining Koolistin 2miu Injection with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinPipecuronium bromide
Severe
How does the drug interact with Koolistin 2miu Injection:
Coadministration of Pipecuronium bromide with Koolistin 2miu Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and pipecuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinVecuronium
Severe
How does the drug interact with Koolistin 2miu Injection:
Using Vecuronium with Koolistin 2miu Injection can make Vecuronium more effective in therapy.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Vecuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinHuman immunoglobulin
Severe
How does the drug interact with Koolistin 2miu Injection:
Taking Human immunoglobulin with Koolistin 2miu Injection, may raise the risk of kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Human immunoglobulin and Koolistin 2miu Injection, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
ColistinAtracurium
Severe
How does the drug interact with Koolistin 2miu Injection:
Coadministration of Atracurium with Koolistin 2miu Injection can increase the risk of Atracurium side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 2miu Injection and Atracurium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions have been found with Koolistin 2miu Injection
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Koolistin 2miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria.
You are not recommended to take Koolistin 2miu Injection with gentamicin as co-administration of these two medicines may increase the risk of severe adverse effects such as kidney problems, hearing loss or respiratory depression especially in elderly people and in those who have preexisting kidney disease or who are dehydrated. However, please consult your doctor before taking Koolistin 2miu Injection with other medicines.
Koolistin 2miu Injection may cause dizziness as a common side effect. Avoid driving if you feel dizzy after taking Koolistin 2miu Injection. However, if the condition persists or worsens, please consult a doctor.
Koolistin 2miu Injection should be used with caution in patients receiving dialysis (the process of filtration and purification of blood using a machine). Therefore, if you are receiving dialysis, please inform your doctor before taking Koolistin 2miu Injection so that the dose may be adjusted accordingly.
You are recommended to take Koolistin 2miu Injection with extreme caution if you have kidney disease as it may worsen the condition. Regular monitoring of kidney functioning is recommended while taking Koolistin 2miu Injection. Therefore, inform your doctor if you have any kidney problems before taking Koolistin 2miu Injection.
Before taking Koolistin 2miu Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.
Koolistin 2miu Injection is administered by a healthcare professional. It may be given as a slow intravenous (IV) infusion over 30–60 minutes, a rapid IV injection over about 5 minutes, or an intramuscular (IM) injection into a large muscle, depending on your medical condition and your doctor's recommendation. Do not self-administer this medicine.
Do not use Koolistin 2miu Injection if you are allergic to its active substances or any other polymyxins (group of antibiotics to treat bacterial infection). If you are unsure, consult your doctor before receiving Koolistin 2miu Injection.
Koolistin 2miu Injection is safe when used as per the dose and duration advised by a doctor.
Koolistin 2miu Injection causes side effects such as dizziness, stomach upset, tingling, and difficulty in breathing. However, these do not require any medical treatment and gradually reduce over time. Contact a doctor if these side effects persist for longer durations.
Koolistin 2miu Injection is an injectable antibiotic used to treat severe bacterial infections, particularly those caused by susceptible or resistant Gram-negative bacteria. It works only against bacterial infections and is not effective against viral illnesses such as the common cold or flu. Your doctor will determine if it is appropriate for your specific infection.
Koolistin 2miu Injection should be used during pregnancy only if your doctor determines that the expected benefit outweighs the potential risk to the unborn baby. Since its safety during pregnancy has not been fully established, inform your doctor if you are pregnant or planning to become pregnant before starting treatment.
Your doctor will regularly monitor your kidney function using tests such as serum creatinine, creatinine clearance (CrCl), or eGFR because Koolistin 2miu Injection is removed from the body through the kidneys. These results help determine whether your dose needs adjustment and reduce the risk of kidney damage. In some patients, especially during prolonged treatment, therapeutic drug monitoring (measuring antibiotic levels when appropriate) may also be used. Talk to your doctor if you have any questions about your monitoring schedule.
Yes, this medication can affect kidney function, particularly at higher doses or in patients with pre-existing kidney issues. Your doctor will monitor your kidney health closely with regular blood tests during treatment. Talk to your doctor if you have concerns.
Dizziness and mild tingling or numbness around the mouth or extremities are known neurotoxic side effects. Report these symptoms to your doctor immediately so they can evaluate your condition. Talk to your doctor.
This medicine is typically only used during pregnancy if the benefit outweighs the potential risks to the unborn baby. If you are pregnant or planning to become pregnant, talk to your doctor.
It is highly recommended to avoid alcohol during treatment to prevent putting extra strain on your liver and kidneys, and to help your body recover. Talk to your doctor or pharmacist.
No, this medication is a highly specific antibiotic that only treats bacterial infections. It is completely ineffective against viral infections like the cold or flu. Talk to your doctor if you have symptoms of an illness.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.5648 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Colistimethate Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Teva. UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 11th July 2024]Check here
  4. Cipla Ltd. XYLISTIN 0.5 MIU Injection (Colistimethate Sodium for Injection IP (Lyophilized)). Ciplamed. [Revised in February 2020]. [Accessed on 11th July 2024]Check here
  5. Monarch Pharmaceuticals, Inc. [Revised in October 2006] [Accessed on 11th July 2024] docs/label/2009/050108s026lbl.pdfCheck here
  6. Biocon Biologics India Limited. Colistimethate Sodium for Injection IP® Koolistin 1MIU/ 2MIU / 3MIU / 4.5MIU. Biocon. Ltd. [Revised in July 2019]. [Accessed on 11th July 2024] 1 2 3 4.5 MIU Leaflet.pdfCheck here

Country of origin

India

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - KOO0030
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