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  3. Koolistin 3miu Injection

Koolistin 3miu Injection, Pack of 1 Injection
Koolistin 3miu Injection, Pack of 1 Injection
Koolistin 3miu Injection, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Koolistin 3miu Injection is used to treat bacterial infections. It contains Colistimethate which works by killing infection-causing bacteria. In some cases, this medicine may cause side effects such as stomach upset, itching, rash, and fever. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

COLISTIMETHATE-3MIU

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Koolistin 3miu Injection

Koolistin 3miu Injection belongs to a class of drugs called antibiotics used in the treatment of severe bacterial infections. Bacterial infection is a condition in which harmful bacteria grow in the body and cause infection. It can infect any part of the body and multiply very quickly. Koolistin 3miu Injection does not work against infections caused by a virus.

Koolistin 3miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Take Koolistin 3miu Injection as prescribed by your doctor. You are advised to take Koolistin 3miu Injection for as long as your doctor has prescribed it for you based on your medical condition. In some cases, you may experience dizziness, stomach upset, tingling, or difficulty in breathing. Most of these side effects of Koolistin 3miu Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Koolistin 3miu Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Koolistin 3miu Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Koolistin 3miu Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Koolistin 3miu Injection may cause confusion, vision problems, or dizziness.  If you are on dialysis, inform your doctor before taking Koolistin 3miu Injection so that the dose may be reduced accordingly.

Uses of Koolistin 3miu Injection

Treatment of Several bacterial infections

Directions for Use

• Your doctor will determine the dosage and timing of Koolistin 3miu Injection based on the severity of your infection. Typically, it is administered every 6-12 hours.• Koolistin 3miu Injection is administered by a healthcare professional as an infusion over 30–60 minutes or as a rapid injection within 5 minutes into a vein. • Do not self-administer it.

Medicinal Benefits

Koolistin 3miu Injection contains Colistimethate, a narrow-spectrum antibiotic that is active against gram-negative bacteria. Koolistin 3miu Injection binds to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria. Koolistin 3miu Injection is used when other antibiotics are not suitable.

How Koolistin 3miu Injection Works

Koolistin 3miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, damaging bacterial cell membranes and kills bacteria.

Storage

Keep Koolistin 3miu Injection out of reach and sight of children.

What if I have taken an overdose of Koolistin 3miu Injection

Use Koolistin 3miu Injection only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include dizziness, confusion, loss of balance/coordination, rapid eye movement, severe numbness/tingling, weak/shallow breathing, problems with speech, and loss of consciousness. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

If you are allergic to Koolistin 3miu Injection or any other medicines, please tell your doctor. If you have myasthenia gravis (muscle weakness), kidney problems, or porphyria (a disorder in the formation of red blood pigment), inform your doctor before taking Koolistin 3miu Injection. If you are pregnant or breastfeeding, please inform your doctor before taking Koolistin 3miu Injection. Special care should be taken in new-born and premature babies as kidneys are not developed fully. Drive only if you are alert as Koolistin 3miu Injection may cause confusion, vision problems, or dizziness. If you are on dialysis, inform your doctor before taking Koolistin 3miu Injection so that the dose may be reduced accordingly. Inform your anesthetist that you are taking Koolistin 3miu Injection as it may increase the effects of muscle relaxants used in general anesthesia. You are recommended to complete the full course of Koolistin 3miu Injection as prescribed by your doctor for effective results.

Drug-Drug Interactions

verifiedApollotooltip
ColistinBCG vaccine
Critical
ColistinPancuronium
Severe

Drug-Drug Interactions

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ColistinBCG vaccine
Critical
How does the drug interact with Koolistin 3miu Injection:
Coadministration of Koolistin 3miu Injection along with BCG vaccine can reduce the treatment outcomes.

How to manage the interaction:
Taking Koolistin 3miu Injection with BCG vaccine is avoided as it may lead to an interaction, please consult your doctor before taking it.
ColistinPancuronium
Severe
How does the drug interact with Koolistin 3miu Injection:
Using Pancuronium with Koolistin 3miu Injection can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Pancuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinRocuronium bromide
Severe
How does the drug interact with Koolistin 3miu Injection:
Coadministration of Rocuronium bromide with Koolistin 3miu Injection may increase the side effects of Rocuronium bromide.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Rocuronium bromide, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinVecuronium
Severe
How does the drug interact with Koolistin 3miu Injection:
Using Vecuronium with Koolistin 3miu Injection can make Vecuronium more effective in therapy.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Vecuronium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinIohexol
Severe
How does the drug interact with Koolistin 3miu Injection:
Combining Koolistin 3miu Injection with Iohexol can increase the effect or side effects of Iohexol.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Iohexol, you can take these medicines if prescribed by your doctor. However, if you experience vomiting, loss of appetite, irregular urination, swelling, shortness of breath, muscle cramps, or weakness, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinAtracurium
Severe
How does the drug interact with Koolistin 3miu Injection:
Coadministration of Atracurium with Koolistin 3miu Injection can increase the risk of Atracurium side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Atracurium, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, rash, dizziness, slurred speech, or fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinStreptomycin
Severe
How does the drug interact with Koolistin 3miu Injection:
Coadministration of Streptomycin with Koolistin 3miu Injection may increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Streptomycin, you can take these medicines together if prescribed by your doctor. However, if you experience shortness of breath, muscle pain, dizziness, or palpitations, call a doctor right away. Do not stop using any medications without a doctor's advice.
ColistinTenofovir alafenamide
Severe
How does the drug interact with Koolistin 3miu Injection:
Combining Koolistin 3miu Injection with Tenofovir alafenamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Tenofovir alafenamide, you can take these medicines together if prescribed by your doctor. However, consult a doctor if you experience an upset stomach, rash, dizziness, or fever. Do not stop using any medications without a doctor's advice.
ColistinNeomycin
Severe
How does the drug interact with Koolistin 3miu Injection:
Combining Koolistin 3miu Injection with Neomycin can increase the risk or severity of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Neomycin, you can take these medicines together if prescribed by your doctor. However, if you experience an upset stomach, Rash, Dizziness, or Fever, consult a doctor. Do not stop using any medications without a doctor's advice.
ColistinAdefovir dipivoxil
Severe
How does the drug interact with Koolistin 3miu Injection:
Combining Koolistin 3miu Injection with Adefovir dipivoxil may decrease Koolistin 3miu Injection's excretion rate, which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Koolistin 3miu Injection and Adefovir dipivoxil, you can take these medicines together if prescribed by your doctor. However, if you experience any irregular urination, swelling, shortness of breath, muscle pain, dizziness, or palpitations call your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take probiotics after completing the full course of Koolistin 3miu Injection to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like cheese, yogurt, kombucha, sauerkraut, and kimchi can restore the good bacteria of the intestine.
  • Include fiber-rich foods, as they can be easily digested by your gut bacteria, which helps stimulate their growth. Thus, fiber-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains such as whole-grain bread and brown rice should be included in your diet.
  • Make sure you drink plenty of water or other fluids every day while you are taking Koolistin 3miu Injection.
  • Avoid alcohol consumption as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS
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Alcohol

Caution

Interaction of Koolistin 3miu Injection with alcohol is unknown. Please consult a doctor before consuming alcohol while using Koolistin 3miu Injection.

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Pregnancy

Caution

Koolistin 3miu Injection is a category C pregnancy drug and is given to pregnant women only if it is essential. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

Koolistin 3miu Injection may be excreted in human milk in small amounts. Therefore, it is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Koolistin 3miu Injection may cause confusion, vision problems or dizziness. Therefore, avoid driving if you experience any of these symptoms after taking Koolistin 3miu Injection.

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Liver

Caution

Take Koolistin 3miu Injection with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Koolistin 3miu Injection with caution, especially if you have a history of Kidney diseases/conditions as Koolistin 3miu Injection may affect kidney function. The dose may be adjusted by your doctor as required.

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Children

Caution

Koolistin 3miu Injection should be used with caution in children and in doses as prescribed by a doctor. Special care should be taken in new-born and premature babies as kidneys are not developed fully.

Have a query?

FAQs

Koolistin 3miu Injection is used to treat bacterial infections.

Koolistin 3miu Injection contains Colistimethate, an antibiotic that works by binding to bacterial cell membranes that are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Thereby, damages bacterial cell membranes and kills bacteria.

You are not recommended to take Koolistin 3miu Injection with gentamicin as co-administration of these two medicines may increase the risk of severe adverse effects such as kidney problems, hearing loss or respiratory depression especially in elderly people and in those who have preexisting kidney disease or who are dehydrated. However, please consult your doctor before taking Koolistin 3miu Injection with other medicines.

Koolistin 3miu Injection may cause dizziness as a common side effect. Avoid driving if you feel dizzy after taking Koolistin 3miu Injection. However, if the condition persists or worsens, please consult a doctor.

Koolistin 3miu Injection should be used with caution in patients receiving dialysis (the process of filtration and purification of blood using a machine). Therefore, if you are receiving dialysis, please inform your doctor before taking Koolistin 3miu Injection so that the dose may be adjusted accordingly.

You are recommended to take Koolistin 3miu Injection with extreme caution if you have kidney disease as it may worsen the condition. Regular monitoring of kidney functioning is recommended while taking Koolistin 3miu Injection. Therefore, inform your doctor if you have any kidney problems before taking Koolistin 3miu Injection.

Before taking Koolistin 3miu Injection, inform your doctor if you have a history of kidney problems, myasthenia gravis (a condition that causes muscle weakness), porphyria (a blood disorder), or asthma. These conditions may affect your treatment or require special monitoring.

Koolistin 3miu Injection is given by a healthcare professional as an infusion over 30–60 minutes or as a rapid injection within 5 minutes into a vein. Do not self-administer.

Do not use Koolistin 3miu Injection if you are allergic to its active substances or any other polymyxins (group of antibiotics to treat bacterial infection). If you are unsure, consult your doctor before receiving Koolistin 3miu Injection.

Koolistin 3miu Injection is prescribed during pregnancy only if your doctor thinks that the benefits are greater than the potential risks. The safety of Koolistin 3miu Injection during pregnancy has not been fully established. Therefore, consult your doctor before taking Koolistin 3miu Injection if you are pregnant.

Koolistin 3miu Injection is safe when used as per the dose and duration advised by a doctor.

Koolistin 3miu Injection causes side effects such as dizziness, stomach upset, tingling, and difficulty in breathing. However, these do not require any medical treatment and gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

20th KM, Hosur Road, Electronic City, Bangalore, India - 560 100
Other Info - KOO0029

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.5648.pdf
  2. https://www.drugs.com/cdi/colistimethate.html

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