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compositionComposition:MECOBALAMIN-750MCG+PREGABALIN-75MG
prescription
Prescription Medicine
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Kopreg Plus Capsule is used to treat neuropathic pain. It contains Mecobalamin and Pregabalin which work by lowering pain signals to the brain and rejuvenating & protecting the nerves. In some cases, this medicine may cause side effects such as nausea, vomiting, stomach pain, diarrhoea, loss of appetite, heartburn, and dry mouth. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MECOBALAMIN-750MCG+PREGABALIN-75MG

Manufacturer/Marketer :

Kivi Labs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Kopreg Plus Capsule

Kopreg Plus Capsule is a prescription combination medication primarily used to manage neuropathic pain, which is pain caused by damaged nerves. It is commonly prescribed to treat pain associated with conditions like diabetes, shingles, or spinal cord injuries. This medicine helps calm overactive nerves to relieve symptoms such as burning, stabbing, or shooting pain. It is a controlled medicine; it has abuse/dependence potential.

To achieve the best results, you must take Kopreg Plus Capsule regularly at the same times every day as directed by your doctor. You can take this medication either with or without food, swallowing it whole with water. Making positive lifestyle changes, such as keeping your blood sugar stable and engaging in light physical activity, can significantly support your treatment outcomes.

While taking Kopreg Plus Capsule , you may experience common side effects like mild dizziness, sleepiness, or a dry mouth. However, you must consult your doctor immediately if you experience serious side effects, such as unusual mood changes, severe swelling in your limbs, or signs of an allergic reaction.

Before you begin taking Kopreg Plus Capsule , talk to your doctor if you have a history of kidney disease, heart problems, or mood disorders. Do not take this medicine if you have a known allergy to any of its active components or ingredients.

This medication can interact with other substances; for example, combining it with alcohol can severely increase drowsiness and impair your coordination. Always talk to your doctor or pharmacist if you are pregnant, breastfeeding, or if you are an older adult, as specific dose adjustments may be necessary for your safety.

Uses of Kopreg Plus Capsule

Kopreg Plus Capsule is used to manage neuropathic pain, which is pain caused by damaged nerves. The detailed uses of Kopreg Plus Capsule are as follows:

  • Neuropathic pain: Kopreg Plus Capsule helps relieve chronic pain caused by nerve damage associated with diabetes (diabetic neuropathy) or spinal cord injuries by calming overactive nerve signals.
  • Postherpetic neuralgia: It helps ease the persistent, burning nerve pain that can remain after an infection of shingles has cleared.

Key Benefits

Kopreg Plus Capsule offers targeted relief by directly addressing both the symptoms and may help with nerve discomfort. This medicine brings several key health benefits:

  • Reduce nerve pain: By calming overactive pain signals, it may help reduce the intensity of constant, exhausting pain, making daily movement much easier and more comfortable.
  • Supports nerve repair: This medication may support the body's natural nerve repair processes.
  • Improves nerve function: This dual action helps restore normal nerve sensitivity over time, which can improve your sleep quality, reduce sudden pain flare-ups, and help you get back to your regular daily routine.
Side effects of Kopreg Plus Capsule
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Kopreg Plus Capsule can be taken with or without food as prescribed by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Kopreg Plus Capsule as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Kopreg Plus Capsule Works

Kopreg Plus Capsule works through the combined action of its two active ingredients to target nerve pain at its source. The first active ingredient is pregabalin, which binds to the special gateway (alpha-2-delta subunit of calcium channels) in overactive nerve cells, reducing the release of pain-signalling chemicals. The second active ingredient, mecobalamin, is a highly active form of vitamin B12. It may support the synthesis of myelin, which is the protective sheath that covers and insulates your nerve fibres. It may promote myelin regeneration; it may help repair damaged nerves and may restore proper nerve signalling over time.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Kopreg Plus Capsule as it may increase drowsiness and sleepiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Kopreg Plus Capsule ; your doctor will decide whether Kopreg Plus Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Kopreg Plus Capsule causes drowsiness, sleepiness, and blurred vision. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Kopreg Plus Capsule should not be given to children as the safety and efficacy have not been established.

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Heart

Caution

Kopreg Plus Capsule should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Kopreg Plus Capsule .

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Geriatrics

Caution

Kopreg Plus Capsule should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Kopreg Plus Capsule

If you suspect an accidental overdose, seek emergency medical care immediately. Symptoms of an overdose may include extreme sleepiness, confusion, agitation, or restlessness.

Diet & Lifestyle Advise

  • Control blood sugar level: If you have diabetes, keep your blood sugar levels under tight control, as high blood sugar can cause further damage to your nerves.
  • Add vitamin B food in you diet: Include foods rich in B-complex vitamins, such as eggs, dairy products, and fish, to support your nerve health naturally.
  • Exercise regularly: Engage in low-impact physical exercises, like walking or swimming, to improve blood circulation and ease nerve stiffness.
  • Check your hands and feet daily: Inspect your feet and hands daily for any cuts, blisters, or redness, especially if you experience numbness, to prevent unrecognised injuries from worsening.
  • Avoid Alcohol: Limit or avoid alcohol completely, as it can worsen nerve damage and increase the drowsiness caused by this medication.
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How Soon It Starts Working

The time required for Kopreg Plus Capsule to start to work: Kopreg Plus Capsule ideally shows its action within 1 hour after administration. The time for which the effects of Kopreg Plus Capsule last: The effect of Kopreg Plus Capsule lasts for 2 days.

What if you forget to take Kopreg Plus Capsule

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your normal routine. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you are unsure.

Storage

• Store in a cool and dry place away from sunlight.• Keep Kopreg Plus Capsule out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not stop suddenly: Do not stop taking Kopreg Plus Capsule suddenly, as this can cause withdrawal symptoms like anxiety, insomnia, nausea, or an immediate return of your pain.
  • Avoid driving if drowsy: Avoid driving, operating machinery, or performing dangerous tasks until you know how this medication affects you, as it frequently causes drowsiness and dizziness.
  • Check the medicine before use: Always inspect the packaging before opening to ensure the seals are intact and the medicine is not damaged or discoloured.
  • Tell your healthcare provider: Inform your doctor, dentist, or surgeon that you are taking Kopreg Plus Capsule before undergoing any medical procedures or surgeries.
  • Keep an updated medicine list: Keep a complete, updated list of all prescription drugs, over-the-counter medicines, and herbal supplements you use, and share it with your healthcare provider.
  • Monitor kidney function: The doctor will monitor kidney function and may adjust the dose over time.
  • Not for Children: Use of this is not recommended for children (below 18 years).

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Central Nervous System (CNS) depressants (such as anxiety medications, sleeping pills, or narcotic painkillers): Taking these may severely increase the risk of extreme drowsiness, dizziness, and slow breathing.
  • ACE inhibitors (certain blood pressure medications): They may increase your risk of swelling (oedema) and allergic reactions.
  • Antidiabetic medicines: For example, thiazolidinedione may increase the risk of fluid retention and weight gain when taken together.
Mecobalamin + PregabalinSufentanil
Severe
Mecobalamin + PregabalinNalbuphine
Severe

Drug-Drug Interactions

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Mecobalamin + PregabalinSufentanil
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Sufentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking sufentanil and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinNalbuphine
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Nalbuphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Nalbuphine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinFentanyl
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Fentanyl can increase the risk or severity of side effects.

How to manage the interaction:
Although taking Fentanyl together with Pregabalin can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you have dizziness, sleepiness, difficulty concentrating, or impairment in judgment. Do not stop taking any medication without consulting a doctor.
Mecobalamin + PregabalinBuprenorphine
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Buprenorphine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Buprenorphine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Mecobalamin + PregabalinSodium oxybate
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Sodium oxybate together with Pregabalin may increase the risk of side effects.

How to manage the interaction:
Although taking Pregabalin with Sodium oxybate together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience drowsiness, dizziness, lightheadedness, confusion, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination, consult the doctor. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinButorphanol
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Butorphanol causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Butorphanol and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinAlfentanil
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Alfentanil causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Pregabalin and Alfentanil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
Mecobalamin + PregabalinDezocine
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Dezocine causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate and loss of consciousness).

How to manage the interaction:
Although taking Dezocine and Pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Mecobalamin + PregabalinTapentadol
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Tapentadol together with Pregabalin may cause central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Taking Pregabalin with Tapentadol can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience signs such as drowsiness, lightheadedness, palpitations, confusion, severe weakness, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
Mecobalamin + PregabalinHydromorphone
Severe
How does the drug interact with Kopreg Plus Capsule:
Using Pregabalin together with Hydromorphone causes central nervous system depression (a physiological state that can result in a decreased rate of breathing, decreased heart rate, and loss of consciousness).

How to manage the interaction:
Although taking Hydromorphone and pregabalin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience impaired judgment, reaction time, and motor coordination, dizziness, sleepiness, and difficulty concentrating, consult the doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol while taking this medicine can heavily increase drowsiness, dizziness, and impair your coordination.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Kopreg Plus Capsule is used to treat neuropathic pain.
Kopreg Plus Capsule is a combination of two drugs: Pregabalin (antiepileptic) and Mecobalamin (vitamin B12). Pregabalin improves nerve signal conduction of damaged nerves. Methylcobalamin is a form of Vitamin B12 that helps in the regeneration of damaged nerves and helps produce the myelin sheath (outer protecting layer of nerves). Thus, Kopreg Plus Capsule promotes healing of damaged nerve and improves nerve conduction in diabetes or traumatic conditions.
Dry mouth could be a side-effect of Kopreg Plus Capsule . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Kopreg Plus Capsule may cause weight gain due to an increase in appetite. Maintain a healthy weight by regular exercise and following a proper diet.
No. Do not stop taking Kopreg Plus Capsule without consulting your doctor, even if your pain improves or you feel well. Stopping suddenly may cause withdrawal symptoms such as headache, anxiety, difficulty sleeping, nausea, or a return of nerve pain. If treatment needs to be stopped, your doctor will gradually reduce the dose.
Kopreg Plus Capsule is used to treat neuropathic pain due to diabetic neuropathy. Diabetic neuropathy is a condition in which nerve damage occurs due to high blood glucose levels. It mostly damages the nerves in the legs and feet.
No, Kopreg Plus Capsule is a specialized painkiller specifically designed to treat neuropathic pain (nerve damage) and support nerve health. Unlike traditional painkillers, it targets nerve signals to reduce pain. It promotes regeneration through the combined effects of Pregabalin and Methylcobalamin.
Neuropathic pain is caused by nerve damage, leading to feelings like burning, tingling, or shooting pain. It's often chronic and can come from conditions like diabetes or neurological disorders. whereas, muscle pain is from muscle strain or injury and feels more like a dull ache or throb, often from physical activity or overuse.
Kopreg Plus Capsule combines two drugs: Methylcobalamin (vitamin B12) and Pregabalin (anti-convulsant). Mecobalamin protects nerve fibers and rejuvenates nerve cells by producing a substance called myelin. Pregabalin works by changing how nerves send messages to the brain. Together, Kopreg Plus Capsule helps to treat neuropathic pain (pain due to nerve damage).
To manage weight gain with Kopreg Plus Capsule , focus on eating healthy foods such as fruits, vegetables, lean meats, and whole grains. Regular exercise, like walking or swimming, is also important. Be mindful of your portion sizes to avoid overeating, and drink plenty of water daily.
Yes. Sleepiness and dizziness are common side effects, especially when starting treatment or after a dose increase. Avoid driving or operating machinery until you know how the medicine affects you. If these symptoms are severe or persistent, consult your doctor.
Kopreg Plus Capsule may rarely cause serious side effects. These include severe dizziness or fainting, suicidal thoughts and significant mood or behaviour changes. Although these effects are infrequent, seek medical attention immediately if experienced.
Generally, the effects of Kopreg Plus Capsule may start to be felt within a week of treatment, but it can take up to a few weeks to experience its full benefits. However, its effectiveness depends on your body's response, disease situation, and dose administered.
If you forget a dose of Kopreg Plus Capsule , take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.
A higher dose of Kopreg Plus Capsule than recommended will not increase its effectiveness. It may lead to negative complications due to overdose, and a higher dose may not be suitable for your health condition. Always consult your doctor, as they will determine the best dose suitable to your specific needs by reducing potential complications. If you have concerns about your dosage, never adjust it without discussing it with your doctor; they will decide the correct dosage for you.
It's best to avoid drinking alcohol while taking Kopreg Plus Capsule . Alcohol can increase the medication's side effects, like dizziness and sleepiness.
The frequency of doctor visits depends on your specific health condition, treatment plan, and your doctor's recommendation. It's essential to follow up with the visits suggested by your doctor. If you have any concerns regarding side effects, dosage, or effectiveness, don't hesitate to schedule an appointment and consult your doctor immediately.
Store Kopreg Plus Capsule in a cool, dry, and out of sunlight. Keep it out of the reach of children. Regularly check the expiration date. When you need to dispose of the medicine by placing it in a plastic bag and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink to prevent harm to others and the environment.
Yes, you can take Kopreg Plus Capsule along with food. But make sure to take it at the same time each day; this will help you not forget the dose.
Caution is advised if you are pregnant or planning to become pregnant. Consult your doctor before taking Kopreg Plus Capsule , as they will assess the potential risks and benefits of treatment. Your doctor will help determine whether Kopreg Plus Capsule is suitable for you during pregnancy, ensuring your and your baby's health and well-being.
Common side effects of Kopreg Plus Capsule may include nausea, vomiting, stomach pain, diarrhoea, heartburn, dryness in the mouth, dizziness, and blurred vision. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
No, you should not stop taking this medication suddenly, even if your symptoms improve. Stopping abruptly can cause withdrawal symptoms like headaches, anxiety, and trouble sleeping, or cause your pain to return. Talk to your doctor.
Yes, some people may experience weight gain or fluid retention while taking this medicine. If you notice rapid weight gain or severe swelling in your hands or feet, talk to your doctor.
If you experience blurry vision or any changes in your eyesight, avoid driving or operating machinery and report these symptoms to your healthcare provider. Talk to your doctor.
Generally, there are no direct major interactions between this medicine and standard painkillers like paracetamol or ibuprofen, but you should always confirm your complete medication list with your healthcare provider. Talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

147-148, GIDC POR, Ramangamdi, Vadodara, P.O 391243, Gujarat India.
Other Info - KOP0010

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