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compositionComposition:TERBINAFINE-250MG
prescription
Prescription Medicine
info
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Koztafit 250 Tablet is an antifungal medicine that is used to treat fungal infections of toenails, fingernails, and tinea capitis (scalp ringworm). This medicine contains terbinafine, which works by inhibiting the fungal cell membrane and thereby kills the infection-causing fungus. Common side effects include diarrhoea, stomach pain, headache, and a change in taste or loss of taste.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

TERBINAFINE-250MG

Manufacturer/Marketer :

H&B Wellness

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Koztafit 250 Tablet

Koztafit 250 Tablet is a prescription medicine used to treat fungal infections of the fingernails, toenails, and skin. It is primarily prescribed for stubborn or deep-seated fungal issues that topical creams cannot reach. By targeting the infection from within the body, it helps clear the fungus and allows healthy tissue to grow back.

For best results, this medicine must be taken consistently every day exactly as prescribed by your doctor. You can take it with or without food, but taking it at the same time each day helps keep a steady amount of the medicine in your system. Incorporating simple lifestyle habits, such as keeping the infected areas clean and dry, can also help speed up your recovery.

While most people tolerate this medicine well, some may experience mild side effects like upset stomach, headache, or temporary taste changes. However, you must contact your doctor immediately if you experience signs of serious liver damage, such as dark urine, unusual tiredness, or yellowing of your eyes and skin.

Talk to your doctor before starting this medicine if you have a history of liver or kidney problems, or if you suffer from autoimmune conditions like lupus. Do not take this if you have active or chronic liver disease, or if you have had an allergic reaction to this medicine in the past.

This medicine can interact with certain other prescriptions, alcohol, and caffeine, which may alter its effectiveness or increase your risk of side effects. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to ensure this treatment is safe for your specific situation.

Uses of Koztafit 250 Tablet

Koztafit 250 Tablet is used to treat fungal infections of the fingernails, toenails, and skin. The detailed uses of Koztafit 250 Tablet are as follows:

  • Fungal nail infections (onychomycosis): Koztafit 250 Tablet penetrates the nail bed to clear deep-seated fungal infections of the fingernails and toenails.
  • Ringworm (tinea corporis and tinea cruris): Koztafit 250 Tablet treats widespread or stubborn fungal infections on the body and groin area that have not responded to topical creams.
  • Athlete's foot (tinea pedis): Koztafit 250 Tablet helps clear severe, spreading, or highly persistent fungal infections on the feet and between the toes.

Key Benefits

Koztafit 250 Tablet treats fungal infections from within the body by reaching areas that topical medicines may not effectively penetrate. With regular use as prescribed, it helps eliminate the infection, relieve symptoms, and promote healthy skin and nail regrowth.

  • Treats Fungal Infections from Within: By circulating through the bloodstream, this medicine reaches the deeper layers of the skin and nail bed, helping eliminate the fungus at its source.
  • Relieves Symptoms and Promotes Healing: This medicine helps reduce itching, redness, scaling, and other symptoms of fungal infections while supporting the skin's natural healing process.
  • Supports Healthy Skin and Nail Regrowth: As the infection clears, this medicine promotes the growth of healthy, infection-free skin and nails, reducing nail discolouration and improving their overall appearance.

Directions for Use

  • Koztafit 250 Tablet can be taken with or without food as advised by your doctor.
  • It is usually taken once daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, chew or break it.

How Koztafit 250 Tablet Works

Koztafit 250 Tablet contains terbinafine, which works by stopping the growth of fungi. It does this by interfering with the fungus's ability to produce sterols, specifically a compound called ergosterol, which is an essential component of the fungal cell membrane. Without a stable cell membrane, the fungal cells develop holes, leak vital contents, and ultimately die. Additionally, this process causes a buildup of a substance called squalene inside the fungal cell, which is toxic to the fungus. This dual action, stopping membrane production and causing toxic buildup, effectively clears the infection and prevents it from spreading further in your body.
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Alcohol

Consult your doctor

Interaction of alcohol with Koztafit 250 Tablet is unknown. Please consult a doctor before consuming alcohol with Koztafit 250 Tablet.

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Pregnancy

Consult your doctor

Koztafit 250 Tablet is a Category B pregnancy drug and is given to a pregnant woman only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Unsafe

Koztafit 250 Tablet may be excreted in human milk and harm the baby. Therefore, it is not advised for breastfeeding mothers.

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Driving

Caution

Koztafit 250 Tablet may cause dizziness. Therefore, drive only if you alert after taking Koztafit 250 Tablet.

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Liver

Consult your doctor

If you have liver disease, inform your doctor before taking Koztafit 250 Tablet. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Consult your doctor

If you have kidney problems, inform your doctor before taking Koztafit 250 Tablet. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Koztafit 250 Tablet is not recommended for children below 12 years as the safety and effectiveness were not established.

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Heart

Caution

Koztafit 250 Tablet should be used with caution in patients with heart problems. Therefore, please consult your doctor before using Koztafit 250 Tablet.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Koztafit 250 Tablet to geriatric patients. Your doctor will prescribe Koztafit 250 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Koztafit 250 Tablet

If you take more than the prescribed dose, seek immediate medical attention. Symptoms of an overdose may include dizziness, stomach pain, headache, or nausea.

Diet & Lifestyle Advise

  • Avoid consuming alcohol while taking this medicine to minimise stress on your liver.
  • Keep your skin and nails clean and dry, as fungi thrive in warm, moist environments.
  • Wear breathable cotton socks and loose-fitting clothing, and change them daily.
  • Do not share personal items like towels, nail clippers, socks, or shoes to prevent spreading the infection or getting reinfected.
  • Wear protective footwear, such as sandals or shower shoes, in public damp areas like locker rooms, communal showers, and pool decks.
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How Soon It Starts Working

The time required for Koztafit 250 Tablet to start to work: The onset time of Koztafit 250 Tablet has not been clinically established. 

The time for which the effects of Koztafit 250 Tablet last: The duration of Koztafit 250 Tablet’s effect is clinically not established.

What if you forget to take Koztafit 250 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Koztafit 250 Tablet tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Get your liver function tested regularly if your doctor recommends it, as this medicine can affect liver health.
  • Avoid prolonged exposure to direct sunlight or UV rays, as this medicine can make your skin more sensitive to sunburn.
  • Contact your doctor immediately if you notice any changes in your sense of taste or smell, as these are recognised side effects that typically resolve after stopping treatment.
  • Inform your dentist or any surgeon that you are taking Koztafit 250 Tablet before undergoing any medical procedures.
  • Never share your medication with anyone else, even if they have the exact same symptoms.

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants: Koztafit 250 Tablet may interact with certain antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) or tricyclic antidepressants, potentially increasing their levels in your bloodstream and raising the risk of side effects. Your doctor may monitor your treatment and adjust the dose if necessary.
  • Beta-Blockers: Taking Koztafit 250 Tablet with beta-blockers used to treat high blood pressure or heart conditions may affect how these medicines are processed. Your doctor may monitor your response and adjust your dose if needed.
  • Rifampin: The antibiotic rifampin may speed up the breakdown of Koztafit 250 Tablet in your body, reducing its effectiveness. Your doctor may recommend an alternative treatment or adjust your dose.
  • Cimetidine: Cimetidine, a medicine used to reduce stomach acid, may slow the breakdown of Koztafit 250 Tablet, increasing its levels in your bloodstream and raising the risk of side effects. Your doctor may recommend closer monitoring during treatment.
TerbinafineThioridazine
Critical
TerbinafinePimozide
Critical

Drug-Drug Interactions

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TerbinafineThioridazine
Critical
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Thioridazine together with Koztafit 250 Tablet can increase the blood levels of Thioridazine and increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Thioridazine and Koztafit 250 Tablet is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TerbinafinePimozide
Critical
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Pimozide and Koztafit 250 Tablet can increase the blood levels of pimozide and the risk of side effects.

How to manage the interaction:
Co-administration of pimozide and Koztafit 250 Tablet is not recommended as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TerbinafineEliglustat
Severe
How does the drug interact with Koztafit 250 Tablet:
Coadministration of Koztafit 250 Tablet with Eliglustat can increase the levels and side effects of Eliglustat.

How to manage the interaction:
Although there is a possible interaction between Koztafit 250 Tablet and Eliglustat, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, upset stomach, abdominal pain, gas/bloating, diarrhea, headache, back pain, arm/leg pain, dizziness, or weakness, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbinafineTeriflunomide
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Teriflunomide and Koztafit 250 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Koztafit 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
TerbinafineTamoxifen
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Tamoxifen with Koztafit 250 Tablet may reduce the effectiveness of Tamoxifen.

How to manage the interaction:
Although taking Tamoxifen and Koztafit 250 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbinafinePitolisant
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Pitolisant and Koztafit 250 Tablet can increase the risk of an irregular heart rhythm and increase the blood levels of Pitolisant.

How to manage the interaction:
Co-administration of Pitolisant and Koztafit 250 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like headache, insomnia, nausea, anxiety, increased heart rate, hallucinations, abdominal pain, and muscle pain, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TerbinafineDextromethorphan
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Dextromethorphan and Koztafit 250 Tablet may increase the side effects of Dextromethorphan.

How to manage the interaction:
Taking Dextromethorphan and Koztafit 250 Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like difficulty breathing, dizziness, drowsiness, anxiety, restless feeling, nervousness, confusion, or diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbinafineLeflunomide
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Leflunomide and Koztafit 250 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between leflunomide and Koztafit 250 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
TerbinafineLomitapide
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Lomitapide and Koztafit 250 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Koztafit 250 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
TerbinafineVortioxetine
Severe
How does the drug interact with Koztafit 250 Tablet:
Co-administration of Vortioxetine and Koztafit 250 Tablet can increase the blood levels and side effects of vortioxetine like serotonin syndrome (A condition in which a chemical called serotonin builds up in your body)

How to manage the interaction:
Co-administration of Vortioxetine and Koztafit 250 Tablet can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramps, nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Caffeine: Avoid excessive consumption of caffeine-containing products, such as coffee, tea, cola, energy drinks, and chocolate, while taking Koztafit 250 Tablet. This medicine may slow the breakdown of caffeine, increasing the risk of headaches, nervousness, jitteriness, and a rapid heart rate.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS - ORAL]

FAQs

Koztafit 250 Tablet is used to treat fungal infections of toenails and fingernails.
Koztafit 250 Tablet works by damaging the fungal cell membranes that are essential for their survival, as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Thereby, kills fungi and clears the fungal infection.
You are recommended to avoid foods containing chocolate and caffeine, such as cocoa beans, tea, coffee, cola and energy drinks, while taking Koztafit 250 Tablet as it may increase the adverse effects of caffeine.
Koztafit 250 Tablet may increase the skin sensitivity to sunlight. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn. However, if you notice any unusual skin sensitivity while using Koztafit 250 Tablet, such as a rash, please consult a doctor.
Koztafit 250 Tablet may cause changes in taste or loss of taste as a side effect. It may usually improve within several weeks after stopping Koztafit 250 Tablet, but may become permanent or last for a long time. However, if you have a poor appetite, unintended weight loss, loss of taste or changes in taste or a change in mood or depressive symptoms, inform your doctor.
You are not recommended to stop using Koztafit 250 Tablet without consulting your doctor, as it may cause recurring infections. Therefore, take Koztafit 250 Tablet for as long as your doctor has prescribed it, and if you experience any difficulty while taking Koztafit 250 Tablet, please consult your doctor.
Koztafit 250 Tablet is not recommended for patients with chronic or active liver disease. Your doctor may recommend a liver function test to monitor whether your liver is functioning effectively. This is done since the medicine gets metabolised by liver enzymes, and any inefficiency in liver function can lead to increased levels of Koztafit 250 Tablet in the blood, resulting in increased side effects and toxicity. Therefore, inform your doctor if you have any liver disease or cirrhosis and about the medicines you may be taking, as taking Koztafit 250 Tablet with another medicine can lead to liver toxicity.
Yes, Koztafit 250 Tablet may cause skin reactions in sensitive people. There are rare reports of people developing serious skin/hypersensitivity reactions like toxic epidermal necrolysis, Stevens-Johnson syndrome, and other severe skin reactions with Koztafit 250 Tablet. Therefore, do not take Koztafit 250 Tablet without consulting your doctor. If you experience any type of skin reaction or rashes, stop taking it immediately and inform your doctor.
Koztafit 250 Tablet is effective as an antifungal medicine if taken in the dose and duration advised by your doctor. Do not discontinue taking it even if you see improvement in your condition. If you stop taking Koztafit 250 Tablet too early, the fungus may continue to grow and the infection may recur or worsen.
Yes, Koztafit 250 Tablet can be taken with or without food.
Koztafit 250 Tablet may cause side effects such as nausea, indigestion, diarrhea, stomach pain, taste disturbance and headache. If these side effects persist or worsen, please consult your doctor.
Avoid alcohol consumption while taking Koztafit 250 Tablet and use sunscreen while going out in the sun, as Koztafit 250 Tablet may increase skin sensitivity. Regular monitoring of liver function is recommended while taking Koztafit 250 Tablet.
If you suspect an overdose of Koztafit 250 Tablet, seek medical help immediately. Symptoms may include dizziness, nausea, and vomiting.
It is highly recommended to avoid alcohol while taking this medicine. Both alcohol and Koztafit 250 Tablet are processed by the liver, and combining them can significantly increase your risk of liver damage. Talk to your doctor or pharmacist if you have concerns.
Yes, your doctor will likely order blood tests to monitor your liver function before you start taking this medicine and periodically during your treatment course. This is a safety measure to ensure your liver remains healthy.
If you are pregnant, planning to become pregnant, or breastfeeding, you should consult your doctor before taking this medicine. It is typically not recommended during pregnancy or breastfeeding unless absolutely necessary. Talk to your doctor for personalised advice.
Yes, this medicine can slow down how your body clears caffeine, which might make you feel jittery, anxious, or cause a rapid heartbeat. It is best to limit your intake of coffee, tea, energy drinks, and chocolate while on this medication.
Early warning signs of liver damage include unexplained nausea, persistent tiredness, loss of appetite, dark-coloured urine, light-coloured stools, and yellowing of your skin or the whites of your eyes. If you notice any of these, stop taking the medicine and call your doctor right away.

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Reference

  1. U.S. Food and Drug Administration (FDA). 020539S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 022071S009Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Terbinafine - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Ema.Terbinafine. [Accessed on 27 Oct 2025]Check here
  5. Webmd. Terbinafine. [Accessed on 27 Oct 2025]Check here
  6. Lactmed.Terbinafine. [Accessed on 27 Oct 2025]Check here
  7. Luke Maxfield; Charles V. Preuss; Rene Bermudez. Terbinafine. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. October 2022. [Accessed on 10th January 2023]Check here

Country of origin

India
Other Info - KO19221
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