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Kronuz 200 mg Injection 1's is used to treat fungal infections. It contains Isavuconazole, which works by fungicidal actions by disrupting the biosynthesis of ergosterol, which is essential for their survival and kills the fungus that causes infection. Common side effects of Kronuz 200 mg Injection 1's are headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ISAVUCONAZOLE-200MG

Manufacturer/Marketer :

AAA Pharma Trade Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Kronuz 200 mg Injection 1's

Kronuz 200 mg Injection 1's belongs to the class of medicines called antifungals used to treat fungal infections such as invasive aspergillosis and mucormycosis (in patients for whom Amphotericin B is not suitable). Invasive aspergillosis is an infection caused by Aspergillus fungus. It occurs by breathing and spreads from the lungs to the kidneys, brain, heart or skin. Mucormycosis is a rare but serious fungal infection of the skin or respiratory system that occurs in people with weakened immune systems.

Kronuz 200 mg Injection 1's contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.

Kronuz 200 mg Injection 1's will be administered by a healthcare professional; do not self-administer. Some people may experience headache, decreased appetite, sleepiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Most of these side effects of Kronuz 200 mg Injection 1's do not require medical attention and gradually resolve over time. However, if the side effects worsen or persist, please consult your doctor.

If you are allergic to Kronuz 200 mg Injection 1's or any other medicines, please tell your doctor. Kronuz 200 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Kronuz 200 mg Injection 1's. Avoid breastfeeding while taking Kronuz 200 mg Injection 1's. Drive only if you are alert after taking Kronuz 200 mg Injection 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Kronuz 200 mg Injection 1's as it may increase the risk of liver damage.

Uses of Kronuz 200 mg Injection 1's

Kronuz 200 mg Injection 1's is used in the treatment of Invasive aspergillosis and Mucormycosis. The detailed uses of Kronuz 200 mg Injection 1's are as follows:

  • Treat invasive aspergillosis: Kronuz 200 mg Injection 1's is approved for managing serious fungal infections caused by Aspergillus species, especially in immunocompromised patients.
  • Manage invasive mucormycosis: Kronuz 200 mg Injection 1's is effective against Mucorales fungi such as Rhizopus oryzae, providing a safer alternative to amphotericin B in patients with renal concerns.
  • Provide broad-spectrum antifungal coverage: Kronuz 200 mg Injection 1's inhibits ergosterol synthesis, disrupting fungal cell membranes and halting growth of various fungi, including Candida, Cryptococcus, and Fusarium.

Key Benefits

Kronuz 200 mg Injection 1's contains Isavuconazole, a broad-spectrum antifungal that is effective against a wide variety of microorganisms. It inhibits the synthesis of fungal cell membranes that are essential for their survival. Thereby, Kronuz 200 mg Injection 1's kills or stops the growth of the fungus.

Side effects of Kronuz 200 mg Infusion Combipack

Directions for Use

  • Kronuz 200 mg Injection 1's is administered only in clinical settings by healthcare professionals.
  • Dosage and frequency are determined by the doctor based on medical needs.
  • Do not self-administer this injection, as improper use may lead to side effects.

How Kronuz 200 mg Injection 1's Works

Kronuz 200 mg Injection 1's contains Isavuconazole which works by fungicidal actions by disrupting the biosynthesis of ergosterol,which are essential for their survival and kills fungus that causes infection.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Kronuz 200 mg Injection 1's as it may increase the risk of liver damage.

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Pregnancy

Consult your doctor

Kronuz 200 mg Injection 1's is not recommended during pregnancy except in patients with severe or potentially life-threatening fungal infections in whom Kronuz 200 mg Injection 1's may be used if the doctor thinks the benefits outweigh the risks. Therefore, please inform your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Kronuz 200 mg Injection 1's. Please inform your doctor if you are breastfeeding.

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Driving

Caution

Drive only if you are alert after taking Kronuz 200 mg Injection 1's as it may cause drowsiness, confusion or dizziness.

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Liver

Caution

Inform your doctor if you have liver problems before receiving Kronuz 200 mg Injection 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Kidney

Caution

The use of Kronuz 200 mg Injection 1's in patients with severe Kidney impairment is not established. Inform your doctor if you have kidney problems before receiving Kronuz 200 mg Injection 1's as may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Children

Unsafe

Kronuz 200 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Caution

Inform your doctor if you have heart problems before receiving Kronuz 200 mg Injection 1's, as it may worsen your condition. Your doctor may adjust the dose as required based on your condition.

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Geriatrics

Consult your doctor

Limited information available about the use of Kronuz 200 mg Injection 1's in geriatric patients. Please consult your physician.

What if I have taken an overdose of Kronuz 200 mg Injection 1's

As Kronuz 200 mg Injection 1's is a parenteral formulation, the chance of overdose may be less. However, keep track of your medicine as an overdose of Kronuz 200 mg Injection 1's may cause serious side effects. Seek immediate medical attention if you observe any side effects.

Diet & Lifestyle Advise

  • Try to avoid areas with a lot of dust like excavation or construction sites. If you can’t avoid it, wear an N95 mask while going to such places.
  • Clean skin injuries with soap and water, especially if they have been exposed to dust or soil to decrease the chances of developing a skin infection.
  • Bandage all wounds until they heal to prevent fungal infections.
  • Wash your hands frequently and keep your hands clean to prevent the spread of germs.
  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt, long pants and a mask while doing outdoor activities such as yard work, gardening or vising wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Have a query?

How Soon It Starts Working

The time required for Kronuz 200 mg Injection 1's to start to work: Kronuz 200 mg Injection 1's shows its action within 1 to 2 hours of IV administration. The time for which the effects of Kronuz 200 mg Injection 1's last: Kronuz 200 mg Injection 1's effect last for a few hours.

What if you forget to take Kronuz 200 mg Injection 1's

If you miss a dose, contact your healthcare provider to reschedule your next dose as needed.

Storage

• Store in a cool and dry place away from sunlight. • Keep Kronuz 200 mg Injection 1's out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC
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Keep Refrigerated. Do not freeze.

Drug Warnings

If you are allergic to Kronuz 200 mg Injection 1's or any other medicines, please tell your doctor. Kronuz 200 mg Injection 1's is not recommended for children below 18 years as the safety and effectiveness were not established. If you are pregnant, it is advised to consult a doctor before using Kronuz 200 mg Injection 1's. Avoid breastfeeding while taking Kronuz 200 mg Injection 1's. Drive only if you are alert after taking Kronuz 200 mg Injection 1's as it may cause drowsiness, confusion or dizziness. Avoid alcohol consumption while taking Kronuz 200 mg Injection 1's as it may increase the risk of liver damage. If you experience severe blistering of the eyes, mouth, skin or genitals, seek immediate medical help.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Inform your doctor if you are taking anti-HIV drugs (ritonavir, efavirenz, etravirine), antibiotics (nafcillin), antitubercular drugs (rifabutin, rifampicin), medicine for rheumatoid arthritis (prednisone), immunosuppressants (tacrolimus, sirolimus, ciclosporin), antidiabetics (pioglitazone, metformin), anticonvulsants (carbamazepine, phenobarbital, phenytoin), antifungal (ketoconazole) or any other medicines before taking Kronuz 200 mg Injection 1's.

Drug-Food Interaction: Kronuz 200 mg Injection 1's may interact with St. John’s wort (herbal medicine to treat depression).

Drug-Disease Interaction: If you have liver or heart problems, inform your doctor before taking Kronuz 200 mg Injection 1's.

Drug-Drug Interactions

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How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Carbamazepine and Kronuz 200 mg Infusion Combipack are taken together, carbamazepine will reduce the effectiveness of the Kronuz 200 mg Infusion Combipack.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Carbamazepine is not recommended, it can be taken if prescribed by the doctor. Do not discontinue any medications without doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir may significantly increase the blood levels of Kronuz 200 mg Infusion Combipack, which may increase the risk of side effects.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking Kronuz 200 mg Infusion Combipack with primidone may decrease the blood levels of Kronuz 200 mg Infusion Combipack and reduce its effectiveness.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with primidone is not recommended, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
IsavuconazoleSaquinavir
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Saquinavir, it can increase the risk of liver damage.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Saquinavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Kronuz 200 mg Infusion Combipack is taken with Phenobarbital, may decrease the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenobarbital is not recommended it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Taking ceritinib with Kronuz 200 mg Infusion Combipack may significantly increase the blood levels of Kronuz 200 mg Infusion Combipack.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
Co-administration of phenytoin and Kronuz 200 mg Infusion Combipack may significantly reduce the blood levels of Kronuz 200 mg Infusion Combipack, which may make Kronuz 200 mg Infusion Combipack less effective in treating your condition.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Kronuz 200 mg Infusion Combipack:
The blood levels and effects of Kronuz 200 mg Infusion Combipack may be significantly enhanced by taking Itraconazole along with it.

How to manage the interaction:
Co-administration of Kronuz 200 mg Infusion Combipack and Itraconazole can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleFosamprenavir
Critical
How does the drug interact with Kronuz 200 mg Infusion Combipack:
When Fosamprenavir is taken with Kronuz 200 mg Infusion Combipack, it can increase the risk of side effects like liver damage.

How to manage the interaction:
Taking Kronuz 200 mg Infusion Combipack with Fosamprenavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Kronuz 200 mg Injection 1's is used to treat Invasive aspergillosis and Mucormycosis.

Kronuz 200 mg Injection 1's contains Isavuconazole which works by inhibiting the synthesis of fungal cell membranes which are essential for their survival. Thereby, Kronuz 200 mg Injection 1's kills or inhibits the growth of the fungus.

Mucormycosis is not contagious. Mucormycosis is a severe fungal infection of the skin or respiratory system that occurs in people with a weakened immune system.

Kronuz 200 mg Injection 1's may cause headaches as a common side effect. However, if the condition persists or worsens, please consult a doctor.

You are not recommended to take Kronuz 200 mg Injection 1's with ketoconazole as it may increase the levels of Kronuz 200 mg Injection 1's in your blood and increase the risk of side effects such as diarrhoea, vomiting, nausea or liver problems. However, please consult your doctor before taking Kronuz 200 mg Injection 1's with other medicines.

Kronuz 200 mg Injection 1's should be used with caution in patients with liver problems as Kronuz 200 mg Injection 1's may increase liver enzymes. Thus, monitoring of liver enzymes is advised while taking Kronuz 200 mg Injection 1's. However, you are recommended to inform your doctor if you have any liver problems.

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Author Details

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Country of origin

India

Manufacturer/Marketer address

E-11, Moti Nagar , New Delhi-110015
Other Info - KRO0055
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