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compositionComposition:MEROPENEM-1000MG+SULBACTAM-500MG
prescription
Prescription Medicine
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Kupen 500 mg Injection is an anti-infective medicine used in treating bacterial infections. This medicine stops the growth of bacteria and thereby helps reduce various bacterial infections. It helps by inhibiting the bacterial cell synthesis and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include swelling, pain, itching, nausea, vomiting, diarrhoea, headache, and rash.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

MEROPENEM-1000MG+SULBACTAM-500MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Kupen 500 mg Injection

Kupen 500 mg Injection is a specialized prescription medicine used to treat serious, deep-seated bacterial infections in various parts of the body, including the lungs, stomach, and urinary tract. Because it is given as an injection, it enters your bloodstream directly to stop the spread of harmful bacteria. This prompt delivery makes it highly effective for treating complicated or severe illnesses that standard oral medicines cannot handle. This combination is often reserved for difficult-to-treat infections caused by drug-resistant bacteria, particularly Acinetobacter baumannii.

Kupen 500 mg Injection is injected on a strict, regular schedule determined by your healthcare provider to ensure a constant level of medicine remains in your blood. Since it is given directly into a vein, it does not matter if you have eaten recently. To support your recovery during treatment, it is highly recommended to rest as much as possible, eat a balanced diet, and drink plenty of fluids to help your body heal.

While using Kupen 500 mg Injection, you may experience some mild side effects such as nausea, headaches, or minor irritation where the needle was inserted. While receiving treatment, it helps to pay attention to how you feel each day and let your doctor know about any new or worsening symptoms, such as severe watery diarrhea, sudden skin rashes, or extreme dizziness.

Do not take this if you have ever had a severe allergic reaction to penicillin, cephalosporins, or similar antibiotics. Before starting Kupen 500 mg Injection, it is vital to tell your doctor if you have kidney disease, a history of seizures, or chronic stomach issues. Your doctor will use this information to determine if this medication is safe for you or if a lower dose is needed.

Certain medicines can interact poorly with Kupen 500 mg Injection, including some gout medications and seizure treatments, which can change how well either drug works in your body. It is also important to tell your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are managing the health of an elderly patient, as special monitoring may be required.

Uses of Kupen 500 mg Injection

Kupen 500 mg Injection is used in the treatment of Bacterial infections. The detailed uses of Kupen 500 mg Injection are as follows:

  • Severe pneumonia: Treats deep, complex lung infections, helping to clear the airways and make breathing easier.
  • Complicated urinary tract infections (UTIs): Fights advanced infections that have reached the bladder or kidneys and are resistant to lighter treatments.
  • Intra-abdominal infections: Resolves serious bacterial infections that occur inside the stomach or abdominal cavity, such as peritonitis.
  • Skin and soft tissue infections: Heals deep, painful, and rapidly spreading infections in the deep layers of the skin and muscles.
  • Bacterial meningitis: Meropenem is sometimes used to treat bacterial meningitis under specialist supervision. In certain situations, sulbactam may be added when resistant bacteria, such as Acinetobacter baumannii, are suspected or confirmed.
  • Bloodstream infections: Fights severe, body-wide infections (sepsis) by targeting bacteria directly in the blood.

Key Benefits

Kupen 500 mg Injection helps treat serious bacterial infections by providing rapid and effective antibacterial action. Combining a powerful antibiotic with a beta-lactamase inhibitor, it helps control infection and supports faster recovery, particularly in hospital-treated infections.

Benefits may include:

  • Helps treat serious and susceptible bacterial infections.
  • Starts working quickly after administration to help reduce fever, inflammation, and other infection-related symptoms.
  • Provides enhanced antibacterial activity against certain bacteria, including some difficult-to-treat and resistant strains.
  • Supports faster recovery and helps reduce the risk of infection-related complications.
  • Helps prevent the infection from spreading or worsening when used as prescribed.
  • Completing the full treatment course helps ensure effective bacterial clearance and supports responsible antibiotic use.
Side effects of Kupen 500 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Stay hydrated by drinking plenty of water to help reduce swelling.
  • Include anti-inflammatory foods like turmeric, ginger, and omega-3 rich foods in your diet.
  • Avoid processed and high-sodium foods that can exacerbate swelling.
  • Utilize an ice pack wrapped in a cloth to cool the affected area, helping to alleviate swelling and discomfort.
  • Gently massage the site, if recommended by your healthcare provider, to promote lymphatic drainage.
  • Rotate injection sites to minimize irritation and swelling.
  • Allow your body time to rest and recuperate, limiting physically demanding tasks to facilitate a smoother recovery.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of Kupen 500 mg Injection. Typically, it is administered every 6 to 8 hours.
  • Kupen 500 mg Injection will be administered by a doctor or nurse in a hospital setting.
  • Do not self-administer this medication.

How Kupen 500 mg Injection Works

Kupen 500 mg Injection contains Meropenem and Sulbactam. Meropenem: It is an antibiotic that helps kill bacteria by damaging their protective outer layer. This helps the body clear serious bacterial infections effectively. Sulbactam: It helps protect Meropenem from being inactivated by certain bacteria. It also has activity against some difficult-to-treat bacteria, helping improve the effectiveness of treatment.
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Alcohol

Caution

Alcohol may increase the side effects of Kupen 500 mg Injection. Hence, it is advised to limit the intake of alcohol while using Kupen 500 mg Injection.

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Pregnancy

Caution

Kupen 500 mg Injection should be used in pregnant women only if clinically needed when the benefits outweigh the risks. Your doctor will weigh the benefits and any potential risks before prescribing Kupen 500 mg Injection.

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Breast Feeding

Caution

Consult your doctor as there is no substantial research yet on the use of Kupen 500 mg Injection in breastfeeding/nursing mothers.

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Driving

Caution

It is not known whether Kupen 500 mg Injection alters the ability to drive. Do not drive or operate machinery if you experience any symptoms that affect your ability to concentrate and react. Seek medical attention if the symptoms persist longer.

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Liver

Caution

Kupen 500 mg Injection should be used with caution in patients with liver diseases as it may affect liver function. The dose may have to be adjusted by your doctor. Please consult the doctor.

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Kidney

Caution

Kupen 500 mg Injection should be used with caution in patients with kidney diseases. Your doctor will weigh the benefits and any potential risks before prescribing Kupen 500 mg Injection.

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Children

Caution

Kupen 500 mg Injection should be used in children only if clinically needed. The doctor may have to adjust the dose based on age, body weight and medical history.

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Heart

Caution

Kupen 500 mg Injection should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Kupen 500 mg Injection.

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Geriatrics

Caution

Kupen 500 mg Injection should be administered with caution in older adults. Always seek medical advice before receiving it.

What if I have taken an overdose of Kupen 500 mg Injection

An overdose is highly unlikely when Kupen 500 mg Injection is given by a medical professional. However, if you suspect an overdose, indicated by severe symptoms like confusion, muscle twitching, or seizures, seek emergency medical attention immediately.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink plenty of water and clear fluids throughout the day to help support your kidneys as they process and eliminate the medication from your body.
  • Choose bland foods if needed: Eat simple, bland foods if you experience mild nausea, and avoid rich, spicy, or fried meals that may worsen stomach upset.
  • Get adequate rest: Prioritize physical rest to help your immune system focus on fighting the infection and supporting recovery.
  • Avoid alcohol consumption: Do not drink alcohol during your treatment course, as it may increase side effects such as dizziness and nausea and place additional strain on your body.
  • Support gut health after treatment: Consider taking a probiotic supplement or eating yogurt with live cultures after completing your full course of therapy to help restore healthy gut bacteria.
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How Soon It Starts Working

The time required for Kupen 500 mg Injection to start to work: Kupen 500 mg Injection ideally shows its action within 30 minutes after administration. The time for which the effects of Kupen 500 mg Injection last: The effect of Kupen 500 mg Injection lasts for 6 to 8 hours.

What if you forget to take Kupen 500 mg Injection

If you are receiving Kupen 500 mg Injection in a hospital or clinic, your healthcare team will ensure you receive your doses on time. If you are injecting this medication at home and miss a scheduled dose, contact your doctor or nurse immediately for advice. Do not inject a double dose to try and make up for the missed one.

Storage

• Store the dry powder vials of Kupen 500 mg Injection at room temperature, strictly between 20°C and 25°C (68°F to 77°F). • Keep the vials inside their original cardboard carton to protect Kupen 500 mg Injection from direct light and moisture.

Drug Warnings

  • Inspect the solution before use: Do not use the mixed liquid if it appears cloudy, discolored, or contains visible particles.
  • Rotate administration sites: Change the injection or IV site slightly with each dose to help reduce irritation and protect your veins.
  • Do not reuse injection equipment: Never reuse syringes, needles, or IV tubing. Dispose of all sharps safely after each use.
  • Complete the full course of treatment: Continue treatment for the entire prescribed duration, even if you feel better, to help prevent the infection from returning and reduce antibiotic resistance.
  • Watch for signs of fungal infections: Contact your doctor if you develop symptoms such as a white coating on the tongue or vaginal itching during treatment.
  • Attend regular monitoring appointments: Keep all scheduled blood tests, cultures, and follow-up visits so your healthcare team can monitor your response to treatment and ensure Kupen 500 mg Injection is working safely.

Drug-Drug Interactions

verifiedApollotooltip
  • Anti-seizure medicines (e.g., valproic acid): Kupen 500 mg Injection may significantly reduce the levels of valproic acid in the body, increasing the risk of seizures.
  • Gout medicines (e.g., probenecid): These medicines may slow the removal of Kupen 500 mg Injection from the body, increasing the risk of side effects.
  • Oral blood thinners (e.g., warfarin): Although significant interactions are uncommon, your doctor may monitor your blood clotting tests more closely while you are receiving Kupen 500 mg Injection.
MeropenemIomeprol
Severe
MeropenemDivalproex
Severe

Drug-Drug Interactions

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MeropenemIomeprol
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Iomeprol and Kupen 500 mg Injection together can increase the risk of causing seizures.

How to manage the interaction:
Taking Kupen 500 mg Injection with Iomeprol together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - close monitoring, seizures, or head injury - contact a doctor right away." Do not stop using any medications without talking to a doctor.
MeropenemDivalproex
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Divalproex and Kupen 500 mg Injection can reduce the blood levels of Divalproex sodium.

How to manage the interaction:
Co-administration of Divalproex with Kupen 500 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
MeropenemSodium Valproate
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Meropenam and Sodium valproate together can reduce the effect of Sodium valproate.

How to manage the interaction:
Co-administration of Meropenam and Sodium valproate can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MeropenemMetrizamide
Severe
How does the drug interact with Kupen 500 mg Injection:
Co-administration of Metrizamide and Kupen 500 mg Injection together can increase the risk of seizures.

How to manage the interaction:
Taking Kupen 500 mg Injection with Metrizamide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these signs - being closely monitored by your doctor, having seizures, or having a condition or head injury - contact a doctor right away. Do not stop using any medications without a doctor's advice.
MeropenemTramadol
Severe
How does the drug interact with Kupen 500 mg Injection:
Taking Tramadol with Kupen 500 mg Injection together may cause higher levels of Kupen 500 mg Injection in the blood.

How to manage the interaction:
Taking Kupen 500 mg Injection with Tramadol together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MeropenemBCG vaccine
Severe
How does the drug interact with Kupen 500 mg Injection:
When BCG vaccine is used with Kupen 500 mg Injection, its effectiveness may be reduced.

How to manage the interaction:
Taking Kupen 500 mg Injection with the BCG vaccine together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Kupen 500 mg Injection when used as directed. 
 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- INFECTIVES]

FAQs

Kupen 500 mg Injection belongs to the group of medications called anti-infectives used to treat bacterial infections.
Kupen 500 mg Injection is used to treat bacterial infections. It contains Meropenem and Sulbactam. Meropenem reduces the infection by inhibiting bacterial growth. It disrupts the cell wall formation (outer layer), which is essential for bacteria's survival. Sulbactam inhibits the action of beta-lactamase, an enzyme produced by the bacteria to destroy antibiotics (Meropenem).
Take the missed dose as soon as possible. However, skip the missed dose and return to your regular dosing schedule if it is time for the next dose. Do not take a double dose to make up for the dose that you missed.
Do not stop using Kupen 500 mg Injection even if you feel better. It should be strictly used as advised by your doctor to avoid the recurrence of symptoms and to worsening of the disease.
Kupen 500 mg Injection should not be given to the people with infectious mononucleosis (viral infection with sore throat and fever) and colitis (inflammation of the intestine) as Kupen 500 mg Injection worsen these conditions.
Yes, you can inject Kupen 500 mg Injection at home if your healthcare provider decides it is safe and provides you with comprehensive training on sterile preparation and injection techniques. Talk to your doctor to see if this is an option for you.
While receiving treatment, it helps to pay attention to how you feel each day and let your doctor know about any new or worsening symptoms, such as severe watery diarrhea, sudden skin rashes, or extreme dizziness.
The safety of Kupen 500 mg Injection in pregnant or breastfeeding women has not been fully established. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor to carefully weigh the benefits against any potential risks.
It is best to avoid alcohol during your treatment. Alcohol can worsen side effects like dizziness, headache, and nausea, and can put extra stress on your body while it is recovering from a severe infection. Talk to your doctor for personalized advice.
Because Kupen 500 mg Injection is injected directly into your vein, it begins fighting bacteria almost immediately. While you may begin to feel better within a couple of days, you must finish the entire course of treatment. Talk to your doctor if your symptoms do not improve.
No, Kupen 500 mg Injection is an antibacterial medicine and is only effective against infections caused by bacteria. It will not work to treat viral infections like the common cold, flu, or COVID-19. Talk to your doctor if you suspect you have an infection.
Mild irritation at the injection site is common. However, if the area becomes increasingly red, hot to the touch, swollen, or leaks fluid, it could indicate a localized infection or vein irritation. Contact your healthcare provider immediately for guidance.
Yes, in rare cases, Kupen 500 mg Injection can trigger seizures, particularly in patients who have a history of epilepsy, kidney problems, or brain injuries. If you or a loved one experiences a seizure while using Kupen 500 mg Injection, seek emergency medical care immediately and talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Center for Biotechnology Information (NCBI). Meropenem + Sulbactam Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 050706S032S034Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.9074 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Merrem (meropenem) injection [package insert]. Silver Spring (MD): U.S. Food and Drug Administration; 2016 Dec 12 [Accessed on 2025 Jun 30]Check here
  5. Milpharm Limited. Meropenem. Electronic Medicines Compendium (EMC). [Revised in July 2020] [Accessed on 1st February 2023].Check here
  6. Central Drugs Standard Control Organisation. Drugs [Internet]. New Delhi: Ministry of Health and Family Welfare, Government of India; [Accessed on 2025 Jun 30]Check here

Country of origin

INDIA

Manufacturer/Marketer address

2Nd Floor, 8-3-166/7/1 Erragadda, Hyderabad-500018
Other Info - KUP0006
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