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  3. Kyprolis 60 mg Injection 1's

Kyprolis 60 mg Injection 1's, Pack of 1 INJECTION
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Composition :

CARFILZOMIB-60MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Kyprolis 60 mg Injection

Kyprolis 60 mg Injection belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Kyprolis 60 mg Injection contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Kyprolis 60 mg Injection is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Kyprolis 60 mg Injection, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Kyprolis 60 mg Injection can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Uses of Kyprolis 60 mg Injection

Kyprolis 60 mg Injection is used in the treatment of Multiple Myeloma. The detailed uses of Kyprolis 60 mg Injection are as follows:<br/>• Relapsed or refractory multiple myeloma: Kyprolis 60 mg Injection is used for the treatment of multiple myeloma in adult patients whose cancer has relapsed or is refractory to one or more lines of therapy. It is specifically indicated when the disease becomes resistant to previous treatments, helping to slow disease progression and extend survival. By targeting cancer cells that have adapted to earlier therapies, Kyprolis 60 mg Injection provides a critical second-line or later treatment option.<br/>• Combination therapy support: Kyprolis 60 mg Injection is used in combination with other agents such as dexamethasone or lenalidomide to enhance overall treatment efficacy in patients with relapsed or refractory multiple myeloma. These combinations have shown improved response rates and longer progression-free survival compared to monotherapy. The synergy between Kyprolis 60 mg Injection and these medications helps increase cancer cell death while maintaining manageable toxicity profiles.<br/>• Proteasome inhibition in cancer therapy: Kyprolis 60 mg Injection is used as a selective proteasome inhibitor that blocks the activity of proteasomes, which are cellular structures responsible for breaking down unneeded or damaged proteins. In cancer cells, this inhibition disrupts protein homeostasis and causes toxic proteins to accumulate, leading to cellular stress and programmed cell death (apoptosis). By targeting the increased protein turnover demands of myeloma cells, Kyprolis 60 mg Injection effectively eliminates cancer cells while leaving most normal cells relatively unaffected.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Kyprolis 60 mg Injection will be administered by a doctor or nurse in a healthcare facility.• Do not self-administer.

Medicinal Benefits

Carfilzomib, a proteasome inhibitor, is present in Kyprolis 60 mg Injection. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

How Kyprolis 60 mg Injection Works

Kyprolis 60 mg Injection contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Kyprolis 60 mg Injection
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.

What if I have taken an overdose of Kyprolis 60 mg Injection

As Kyprolis 60 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Kyprolis 60 mg Injection may cause chills, dizziness, and decreased urination.

Drug Warnings

Before taking Kyprolis 60 mg Injection, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Kyprolis 60 mg Injection if you are pregnant or breastfeeding or allergic to any component present in Kyprolis 60 mg Injection. Both women and men using this Kyprolis 60 mg Injection should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Kyprolis 60 mg Injection. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

Drug-Drug Interactions

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CarfilzomibConjugated Estrogens
Severe
CarfilzomibEltrombopag
Severe

Drug-Drug Interactions

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CarfilzomibConjugated Estrogens
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Combining Kyprolis 60 mg Injection with Conjugated Estrogens can increase the risk of developing blood clots.

How to manage the interaction:
Although taking Conjugated estrogen and Kyprolis 60 mg Injection together can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience chest discomfort, shortness of breath, weakness, or blurred vision, consult a doctor. Do not stop using any medications without consulting a doctor.
CarfilzomibEltrombopag
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Coadministration of Eltrombopag with Kyprolis 60 mg Injection can increase the risk or severity of blood clots that can lead to complications such as heart attack, pulmonary embolism (blockage of an artery in the lung), and stroke.

How to manage the interaction:
Although taking Eltrombopag and Kyprolis 60 mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, swelling in an arm or leg, or weakness on one side of your body it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
CarfilzomibTestosterone
Severe
How does the drug interact with Kyprolis 60 mg Injection:
The combined use of Testosterone and Kyprolis 60 mg Injection can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Testosterone and Kyprolis 60 mg Injection can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
CarfilzomibPrasterone
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Taking Prasterone with Kyprolis 60 mg Injection can increase the risk of clotting.

How to manage the interaction:
Co-administration of Prasterone with Kyprolis 60 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience sudden loss of eyesight, chest pain, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor, immediately. Do not stop using any medications without a doctor's advice.
CarfilzomibClozapine
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Combining Kyprolis 60 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Clozapine with Kyprolis 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of the following symptoms, contact your doctor immediately: severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain or burning when urinating. Do not discontinue any medications without consulting a doctor.
CarfilzomibDesogestrel
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Kyprolis 60 mg Injection can occasionally cause dangerous blood clots and using it together with ethinyl estradiol may increase the risk.

How to manage the interaction:
Co-administration of Desogestrel with Kyprolis 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like rapid loss of eyesight, chest pain, shortness of breath, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, contact a doctor. Do not stop using any medications without a doctor's advice.
CarfilzomibEstradiol
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Kyprolis 60 mg Injection can cause serious blood clots and taking it alongside estradiol may enhance the risk.

How to manage the interaction:
Co-administration of Estradiol with Kyprolis 60 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarfilzomibStanozolol
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Coadministration of Kyprolis 60 mg Injection and sulfasalazine can increase the risk or severity of developing blood clots.

How to manage the interaction:
Although taking Kyprolis 60 mg Injection and sulfasalazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarfilzomibLevonorgestrel
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Kyprolis 60 mg Injection can occasionally cause dangerous blood clots and using it together with levonorgestrel may increase the risk.

How to manage the interaction:
Co-administration of Kyprolis 60 mg Injection with Levonorgestrel can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: blood clots that can be harmful, high blood pressure or cholesterol, heart problems like heart attack or blockage in the lung, stroke, complications, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of your body. Do not discontinue any medications without consulting a doctor.
CarfilzomibTamoxifen
Severe
How does the drug interact with Kyprolis 60 mg Injection:
Taking Kyprolis 60 mg Injection with tamoxifen may increase the risk of blood clots. The risk is also increased with age, cigarette smoking, high blood pressure, or high cholesterol.

How to manage the interaction:
Although taking tamoxifen and Kyprolis 60 mg Injection together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Kyprolis 60 mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Kyprolis 60 mg Injection.

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Pregnancy

Unsafe

Kyprolis 60 mg Injection should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

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Breast Feeding

Unsafe

Do not breastfeed while you are receiving Kyprolis 60 mg Injection and for two weeks after your final dose.

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Driving

Caution

Kyprolis 60 mg Injection may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.

bannner image

Liver

Caution

Extreme caution is exercised while using Kyprolis 60 mg Injection in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.

bannner image

Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Kyprolis 60 mg Injection if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Kyprolis 60 mg Injection.

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Children

Caution

The safety and effectiveness of Kyprolis 60 mg Injection in pediatric patients have not been established.

Have a query?

FAQs

Kyprolis 60 mg Injection is used to treat Multiple Myeloma.

Kyprolis 60 mg Injection contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.

No, it is unsafe to father a child while taking Kyprolis 60 mg Injection. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Kyprolis 60 mg Injection.

Based on the medical condition, Kyprolis 60 mg Injection may be given alone or together with other medicines used to treat multiple myeloma.

Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.

Kyprolis 60 mg Injection can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.

Kyprolis 60 mg Injection treats multiple myeloma that has returned or no longer responds to treatment. It's often used with other medications. If you have questions or concerns, talk to your doctor. They will help you understand if Kyprolis 60 mg Injection is right for you.

Kyprolis 60 mg Injection is to be administered by intravenous infusion in a hospital setting under the supervision of a physician qualified to administer cancer chemotherapeutic agents.

Kyprolis 60 mg Injection is given on two consecutive days each week for three weeks followed by a 12-day rest period or it may be given once a week for 3 weeks followed by a 13-day rest period. However, the pattern and duration of treatment may vary. Please consult the doctor if you have any concerns.

You may experience nausea and extreme tiredness from Kyprolis 60 mg Injection. To cope with nausea, try eating small meals, avoiding strong smells, and staying hydrated. For tiredness, prioritize rest, break tasks into smaller chunks, and take regular breaks. Practice relaxation techniques like deep breathing, meditation, or yoga, and stay hydrated and energized with nutritious food. However, if these are bothering you consult your doctor immediately.

Kyprolis 60 mg Injection can lower your blood cell and platelet counts, increasing the risk of infections, anemia, and bleeding. To keep an eye on this, your doctor will likely order regular blood tests before and during treatment. Consult your doctor if you suspect any symptoms of low immunity like delayed healing or frequent infections.

If you experience any of the following, seek a doctor's advice right away: fever, infection signs, unusual bleeding, shortness of breath, chest pain, severe nausea, weakness, confusion, or severe headache. Also, consult your doctor if you have concerns or questions about your treatment, notice any health changes or side effects, miss a dose, or need to change your treatment schedule.

Kyprolis 60 mg Injection should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are pregnant or think you may be pregnant while on therapy.

Do not breastfeed while you are receiving Kyprolis 60 mg Injection and for two weeks after your final dose as it may pass into the breastmilk. Consult your doctor if you have any concerns regarding it.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy'S Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, India
Other Info - KYP0002

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:05 AM IST

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Reference

  1. https://www.cancer.gov/research/participate/clinical-trials/intervention/carfilzomib#:~:text=Carfilzomib%20works%20by%20blocking%20the,that%20kills%20the%20cancerous%20cells.
  2. https://www.cdc.gov/cancer/myeloma/index.htm
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/202714lbl.pdf
  4. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/carfilzomib-dexamethasone
  5. https://medlineplus.gov/druginfo/meds/a612031.html#:~:text=Carfilzomib%20is%20in%20a%20class,cancer%20cells%20in%20your%20body.
  6. https://ashpublications.org/blood/article/121/6/893/31397/Carfilzomib

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