Kyprolis 60 mg Injection belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Kyprolis 60 mg Injection contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Kyprolis 60 mg Injection is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Kyprolis 60 mg Injection, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Kyprolis 60 mg Injection can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Kyprolis 60 mg Injection is used in the treatment of Multiple Myeloma. The detailed uses of Kyprolis 60 mg Injection are as follows:

• Relapsed or refractory multiple myeloma: Kyprolis 60 mg Injection is used for the treatment of multiple myeloma in adult patients whose cancer has relapsed or is refractory to one or more lines of therapy. It is specifically indicated when the disease becomes resistant to previous treatments, helping to slow disease progression and extend survival. By targeting cancer cells that have adapted to earlier therapies, Kyprolis 60 mg Injection provides a critical second-line or later treatment option.
• Combination therapy support: Kyprolis 60 mg Injection is used in combination with other agents such as dexamethasone or lenalidomide to enhance overall treatment efficacy in patients with relapsed or refractory multiple myeloma. These combinations have shown improved response rates and longer progression-free survival compared to monotherapy. The synergy between Kyprolis 60 mg Injection and these medications helps increase cancer cell death while maintaining manageable toxicity profiles.
• Proteasome inhibition in cancer therapy: Kyprolis 60 mg Injection is used as a selective proteasome inhibitor that blocks the activity of proteasomes, which are cellular structures responsible for breaking down unneeded or damaged proteins. In cancer cells, this inhibition disrupts protein homeostasis and causes toxic proteins to accumulate, leading to cellular stress and programmed cell death (apoptosis). By targeting the increased protein turnover demands of myeloma cells, Kyprolis 60 mg Injection effectively eliminates cancer cells while leaving most normal cells relatively unaffected.

• Follow your doctor’s instructions on the dosage and timing of this medication.
• Kyprolis 60 mg Injection will be administered by a doctor or nurse in a healthcare facility.
• Do not self-administer.

Carfilzomib, a proteasome inhibitor, is present in Kyprolis 60 mg Injection. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Before taking Kyprolis 60 mg Injection, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Kyprolis 60 mg Injection if you are pregnant or breastfeeding or allergic to any component present in Kyprolis 60 mg Injection. Both women and men using this Kyprolis 60 mg Injection should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Kyprolis 60 mg Injection. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.