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  3. Labepure 20mg Injection

Labepure 20mg Injection, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Labepure 20mg Injection is used in the treatment of increased blood pressure (hypertension). This medicine blocks the receptors in the cardiovascular system and thus helps decrease the blood pressure in the blood vessels. It is also used in the treatment of hypertension in pregnancy and during anaesthesia.
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Composition :

LABETALOL-20MG

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

About Labepure 20mg Injection

Labepure 20mg Injection belongs to the group of anti-hypertensive medicines called beta-blocking agents used to treat severe hypertension (high blood pressure). Additionally, Labepure 20mg Injection is used to control high blood pressure in pregnancy and during anaesthesia. 
 
Labepure 20mg Injection contains ‘labetalol’ that works by blocking the receptors in the cardiovascular (circulatory) system, this helps in decreasing the blood pressure in the blood vessels. Thus, it helps lower the blood pressure to normal.
 
In some cases, Labepure 20mg Injection may cause common side effects such as postural hypotension, dizziness, fatigue, and headache. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
 
Consult your doctor if you are pregnant or breastfeeding. Labepure 20mg Injection is not recommended for children below 18 years as efficacy and safety have not been established. Inform your doctor about all the medicines you are taking and your health condition to rule out any unpleasant side effects/interactions.

Uses of Labepure 20mg Injection

Treatment of Hypertension (high blood pressure)

Directions for Use

Labepure 20mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Labepure 20mg Injection belongs to the group of anti-hypertensive medicines called alpha and beta-blocking agents used to treat severe hypertension (high blood pressure). Additionally, Labepure 20mg Injection is used to treat severe hypertension of pregnancy (high blood pressure in pregnancy) and to control blood pressure during anaesthesia. Labepure 20mg Injection contains ‘labetalol’ that works by blocking the receptors in the cardiovascular (circulatory) system, this helps in decreasing the blood pressure in the blood vessels. Thereby, helping in lowering the blood pressure to normal.

How Labepure 20mg Injection Works

Labepure 20mg Injection contains ‘labetalol’ that works by blocking the receptors in the cardiovascular (circulatory) system, this helps in decreasing the blood pressure in the blood vessels. Thus, it helps lower the blood pressure to normal.

Storage

Store in a cool and dry place away from sunlight
Side effects of Labepure 20mg Injection
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of Labepure 20mg Injection

Labepure 20mg Injection is a parenteral formulation, hence the chance of overdose may be less. However, keep a track of your medicine as overdose of Labepure 20mg Injection may cause serious side effects. Symptoms may include excessive hypotension that is excessive bradycardia. Seek immediate medical attention if you observe any of these side effects.

Drug Warnings

Do not take Labepure 20mg Injection if you are allergic to any of its contents; if you have heart diseases like heart block or sick sinus syndrome (unless you have a pacemaker), heart failure or cardiogenic shock, ongoing low blood pressure, extremely slow heart rate, Prinzmetal angina, asthma or obstructive airway disease, or phaeochromocytoma (tumour of the adrenal gland). Inform your doctor if you have peripheral vascular disease (Raynaud's syndrome or intermittent claudication), diabetes, overactive thyroid, metabolic acidosis, respiratory system problems, heart, kidney or liver problems. Labepure 20mg Injection should not be given to children and adolescents below 18 years.  Consult your doctor if you are pregnant or breastfeeding. 

Drug-Drug Interactions

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LabetalolLomitapide
Severe
LabetalolTerbutaline
Severe

Drug-Drug Interactions

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LabetalolLomitapide
Severe
How does the drug interact with Labepure 20mg Injection:
Taking Labepure 20mg Injection with Lomitapide can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Labepure 20mg Injection with Lomitapide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
LabetalolTerbutaline
Severe
How does the drug interact with Labepure 20mg Injection:
Co-administration of Labepure 20mg Injection and Terbutaline together can decrease the medical benefits of both medications.

How to manage the interaction:
Although taking Labepure 20mg Injection and Terbutaline together can result in an interaction, it can be taken if a doctor has prescribed it. Do not forget to inform the doctor if you have severe chronic obstructive pulmonary disease (COPD) or a history of asthma, as Labepure 20mg Injection is often not advised in these conditions. Do not discontinue any medications without a doctor's advice.
LabetalolMipomersen
Severe
How does the drug interact with Labepure 20mg Injection:
Taking Labepure 20mg Injection with Mipomersen can increase the risk of liver damage.

How to manage the interaction:
Co-administration of Labepure 20mg Injection with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor. Do not stop using any medications without talking to the doctor.
LabetalolDisopyramide
Severe
How does the drug interact with Labepure 20mg Injection:
When Labepure 20mg Injection is used with Disopyramide, Disopyramide's levels can be enhanced, which may lead to side effects.

How to manage the interaction:
Although taking Labepure 20mg Injection and disopyramide together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you feel dizziness, fainting, or irregular heartbeats, consult a doctor. Do not discontinue any medications without a doctor's advice.
LabetalolAminophylline
Severe
How does the drug interact with Labepure 20mg Injection:
Combination of Aminophylline with Labepure 20mg Injection can make Labepure 20mg Injection less effective and increase the side effects of aminophylline which can be serious.

How to manage the interaction:
Although taking Labepure 20mg Injection and Aminophylline together can result in an interaction, it can be taken only if a doctor has advised it. However, if you experience irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LabetalolCeritinib
Severe
How does the drug interact with Labepure 20mg Injection:
Co-administration of Ceritinib together with Labepure 20mg Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Labepure 20mg Injection and Ceritinib together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience sudden lightheadedness, an irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.
LabetalolEpinephrine
Severe
How does the drug interact with Labepure 20mg Injection:
Taking Labepure 20mg Injection along with Epinephrine can reduce the effects of Epinephrine.

How to manage the interaction:
Taking Labepure 20mg Injection and Epinephrine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LabetalolRitodrine
Severe
How does the drug interact with Labepure 20mg Injection:
Co-administration of Ritodrine and Labepure 20mg Injection combined may reduce the effectiveness of both medications.

How to manage the interaction:
Although taking Labepure 20mg Injection and Ritodrine together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
LabetalolPropranolol
Severe
How does the drug interact with Labepure 20mg Injection:
Taking Propranolol with Labepure 20mg Injection can potentially enhance the effects of orthostatic hypotension (low blood pressure that happens when standing after sitting or lying down).

How to manage the interaction:
Although taking Propranolol together with Labepure 20mg Injection can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience lightheadedness or dizziness upon standing, blurred vision, weakness, fainting, or confusion. Do not discontinue any medicine without consulting a doctor.
LabetalolDiltiazem
Severe
How does the drug interact with Labepure 20mg Injection:
Co-administration of Labepure 20mg Injection and Diltiazem may increase the side effects.

How to manage the interaction:
Although taking Labepure 20mg Injection and Diltiazem together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience fatigue, headache, fainting, swelling of hands and legs, breathing difficulty, chest pain, increased or decreased heartbeat, or irregular heartbeat, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • You are advised to consume low salt and low fat diet.
  • Regular exercise is also recommended.
  • Eat a diet rich in whole grains, vegetables and fruits.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Manage stress with meditation, yoga, and massage.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Labepure 20mg Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

It is unknown if alcohol affects the results of Labepure 20mg Injection. Please consult your doctor.

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Pregnancy

Caution

Labepure 20mg Injection belongs to pregnancy category C. Your doctor may prescribe Labepure 20mg Injection in case of high blood pressure during pregnancy when rapid control of blood pressure is necessary.

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Breast Feeding

Caution

Small amounts of Labepure 20mg Injection may pass into breastmilk. Please inform your doctor if you are breastfeeding. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Driving

Caution

Labepure 20mg Injection may cause dizziness. Hence, do not drive vehicles or operate machines if you fell dizzy after taking Labepure 20mg Injection.

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Liver

Caution

Please inform your doctor if you have liver problems before receiving Labepure 20mg Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

Please inform your doctor if you have kidney problems before receiving Labepure 20mg Injection. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Labepure 20mg Injection is not recommended for children and adolescents below 18 years.

Have a query?

FAQs

Labepure 20mg Injection is an anti-hypertensive medicine used in the treatment of severe hypertension. It is also used to control high blood pressure in pregnancy and during anaesthesia.

Labepure 20mg Injection works by blocking the receptors in the cardiovascular system, this helps in decreasing the blood pressure in the blood vessels. Thereby, helping in lowering the blood pressure to normal.

Postural hypotension could be a side-effect of Labepure 20mg Injection. Postural hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead lie down and get up slowly only when you feel better.

Labepure 20mg Injection is used to treat severe hypertension of pregnancy (high blood pressure in pregnancy) when the blood pressure needs to be lowered rapidly.

Labepure 20mg Injection may cause erectile dysfunction (impotence). Please consult your doctor if you have any concerns regarding these.

Labepure 20mg Injection might mask the effects of sudden blood loss and might affect pupils during cataract surgery, so inform the surgeon ahead of time that you are on treatment with Labepure 20mg Injection if you are due to have surgery.

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, India.
Other Info - LA89909

Disclaimer

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:45 PM IST

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Reference

  1. https://http://www.hpra.ie/img/uploaded/swedocuments/2ba55b97-17f3-408d-a2eb-4625945e9a7d.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/019425s021lbl.pdf
  3. https://www.sandoz.ca/sites/www.sandoz.ca/files/Labetalol%20Hydrochloride%20Injection%20Product%20Monograph.pdf
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