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compositionComposition:GABAPENTIN-100MG+METHYLCOBALAMIN-500MCG
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Laregab-M 100/500 Tablet is used to treat neuropathic pain. It contains Gabapentin and Methylcobalamin, which rejuvenate and protect damaged nerve cells. In some cases, this medicine may cause side effects such as dizziness, sleepiness, tiredness, nausea and vomiting. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GABAPENTIN-100MG+METHYLCOBALAMIN-500MCG

Manufacturer/Marketer :

La Renon Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Laregab-M 100/500 Tablet

For the best results, take Laregab-M 100/500 Tablet consistently at the same times every day as directed by your doctor. You can take this medicine with or without food. Making simple lifestyle adjustments, such as keeping active and protecting your hands and feet from extreme temperatures, can significantly support your treatment journey.

While taking Laregab-M 100/500 Tablet , you may experience mild side effects like sleepiness or dizziness. However, if you notice severe mood changes, swelling in your hands or feet, or difficulty breathing, contact your healthcare provider immediately.

Talk to your doctor before starting Laregab-M 100/500 Tablet if you have kidney disease, a history of depression, or substance abuse. Do not take this if you have a known allergy to any of the active ingredients in this medication.

This medicine can interact with alcohol, certain antacids, and sleeping pills, which can increase drowsiness. If you are pregnant, breastfeeding, or an older adult, consult your doctor to ensure this treatment is safe for you.

Uses of Laregab-M 100/500 Tablet

The following are the common conditions for which Laregab-M 100/500 Tablet is prescribed:

  • Neuropathic pain: Laregab-M 100/500 Tablet helps relieve chronic pain caused by damaged nerves, which can feel like burning, stabbing, or tingling sensations.
  • Diabetic neuropathy: Laregab-M 100/500 Tablet manages nerve damage in the hands and feet caused by long-term high blood sugar levels in patients with diabetes.
  • Postherpetic neuralgia: Laregab-M 100/500 Tablet treats the persistent nerve pain that can remain after an episode of shingles.
     

Key Benefits

The following benefits show how Laregab-M 100/500 Tablet helps relieve nerve pain, improve daily comfort, support nerve healing, and enhance overall quality of life:

  • Relieves nerve pain: By calming overactive nerves, it helps reduce burning, shooting, stabbing, or tingling sensations associated with nerve damage.
  • Improves mobility and daily comfort: Better pain control makes it easier to perform routine activities such as walking, climbing stairs, and carrying out daily tasks with greater ease.
  • Promotes better sleep quality: Reducing nerve pain, especially at night, helps improve sleep and overall physical well-being.
  • Supports nerve repair: The methylcobalamin component helps nourish damaged nerves and supports the body's natural nerve repair processes, which may gradually improve normal sensation over time.
Side effects of Laregab-M 100 mg/500 mcg Tablet
  • Uncoordinated muscle movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Try to practice deep breathing exercises or repeat calming words or phrases.
  • Seek for medical help if aggression occurs frequently, as it can worsen gradually if not attended.
  • You can also try listening to music or relaxing or writing a journal to express the feeling that aggravates to find a solution.
  • Consume controlled amounts of salt to raise sodium levels.
  • Eat fresh fruits like apples, berries, oranges, mangoes, and bananas.
  • Include fresh vegetables like broccoli, sweet potatoes, beets, okra, spinach, peppers, carrots, and edamame.
  • Choose frozen vegetables without added butter or sauce.
  • Drink electrolyte beverages like sports drinks or electrolyte solutions to replenish sodium and other electrolytes.
  • Avoid excessive salt intake, but allow for controlled increases as needed.
  • Monitor and manage underlying health conditions that may contribute to hyponatremia.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Laregab-M 100/500 Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Laregab-M 100/500 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Laregab-M 100/500 Tablet Works

Laregab-M 100/500 Tablet contains two active components, gabapentin and methylcobalamin, that work together to relieve nerve pain and promote healing. The first component, gabapentin, targets the way the brain and nervous system send pain signals. It binds to specific calcium channels in the nerve cells, reducing the release of pain-transmitting chemicals. This action calms overactive nerves and decreases the intensity of the pain signals sent to your brain. The second component, methylcobalamin, is an active form of vitamin B12. It helps produce myelin, which is the protective sheath that covers and insulates nerve fibres. By restoring this protective covering, it aids in repairing damaged nerve cells and improves nerve signal transmission, addressing the root cause of your discomfort.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Laregab-M 100/500 Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Laregab-M 100/500 Tablet is not recommended during pregnancy unless prescribed by a doctor. Let your doctor know if you are pregnant or planning to conceive before taking Laregab-M 100/500 Tablet .

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Breast Feeding

Caution

Gabapentin in Laregab-M 100/500 Tablet is excreted into breast milk. Please consult your doctor before taking Laregab-M 100/500 Tablet if you are breastfeeding.

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Driving

Unsafe

Laregab-M 100/500 Tablet causes drowsiness, sleepiness and tiredness. Do not drive or operate machinery unless you are mentally and physically alert.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before taking Laregab-M 100/500 Tablet . Dose adjustment may be needed in patients with liver impairment.

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Kidney

Caution

Let your doctor know if you have any history of kidney diseases before taking Laregab-M 100/500 Tablet . Dose adjustment may be needed in patients with kidney impairment.

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Children

Caution

Laregab-M 100/500 Tablet is not recommended in children less than three years of age. The doctor will prescribe the dosage of Laregab-M 100/500 Tablet based on the child's age and weight.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before taking Laregab-M 100/500 Tablet . Your doctor will prescribe it only if the potential benefits outweigh the possible risks.

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Geriatrics

Caution

Laregab-M 100/500 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Dose adjustment may be required based on their health condition.

What if I have taken an overdose of Laregab-M 100/500 Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose may include severe dizziness, double vision, slurred speech, extreme drowsiness, or loss of consciousness.

Diet & Lifestyle Advise

  • Manage blood sugar levels: If you have diabetes, keeping your blood sugar within your target range is crucial to prevent further nerve damage.
  • Eat B-vitamin rich foods: Incorporate foods like lean meats, fish, eggs, and fortified cereals to support nerve health, as methylcobalamin works alongside other B vitamins.
  • Engage in low-impact exercise: Activities like walking, swimming, or stationary cycling can improve blood circulation to your limbs, which helps reduce nerve pain.
  • Inspect your feet daily: Neuropathy can reduce sensation in your feet, making it harder to notice minor injuries. Check your feet regularly for cuts, blisters, or redness.
  • Avoid alcohol and smoking: Alcohol can worsen nerve damage and increase drowsiness, while smoking restricts blood flow to peripheral nerves, slowing down recovery.
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Have a query?

How Soon It Starts Working

The time required for Laregab-M 100/500 Tablet to start to work: The time required for Laregab-M 100/500 Tablet to show its action is unknown.

The time for which the effects of Laregab-M 100/500 Tablet last: The duration of action for Laregab-M 100/500 Tablet is clinically unknown.

What if you forget to take Laregab-M 100/500 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Laregab-M 100/500 Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original packaging to protect it from moisture and direct light.

Drug Warnings

  • Watch for mood changes: Pay close attention to your mental health. If you, your family, or your caregiver notice sudden changes in mood, behaviour, or thoughts of self-harm, contact your doctor immediately.
  • Avoid driving initially: Do not drive, operate heavy machinery, or perform hazardous tasks until you know how Laregab-M 100/500 Tablet affects you, as it can cause significant drowsiness and dizziness.
  • Plan your antacids: If you need to take an antacid, ensure there is a gap of at least two hours before taking Laregab-M 100/500 Tablet , as antacids can lower the absorption of this medicine.
  • Do not stop suddenly: Stopping Laregab-M 100/500 Tablet abruptly can lead to withdrawal symptoms such as anxiety, insomnia, nausea, pain, and sweating, or it can cause your nerve pain to return. Always consult your doctor for a safe plan to perform a gradually decreasing dose.
  • Inspect your medication: Before taking your dose, inspect the tablet. Do not use it if the packaging is damaged, punctured, or if the medicine shows signs of discolouration or degradation.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Laregab-M 100/500 Tablet and affect how it works or increase the risk of side effects:

  • Opioid pain relievers (such as morphine or oxycodone): Combining Laregab-M 100/500 Tablet with opioid pain relievers can increase the risk of severe drowsiness, breathing difficulties, and sedation.
  • Antacids containing aluminum or magnesium: These can reduce the absorption of this medicine. Take them at least two hours apart from Laregab-M 100/500 Tablet .
  • Other central nervous system depressants: Medicines such as sleeping pills, muscle relaxants, or anxiety medications can worsen dizziness and sleepiness when taken with Laregab-M 100/500 Tablet .
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

The following food and drink may affect the safety or effectiveness of Laregab-M 100/500 Tablet :

  • Alcohol: Avoid consuming alcohol while taking Laregab-M 100/500 Tablet , as it can dangerously increase drowsiness, dizziness, and impair your coordination.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Laregab-M 100/500 Tablet contains Gabapentin and Methylcobalamin. Gabapentin calms overactive nerves and interferes with pain signals travelling through the brain and spine. Methylcobalamin rejuvenates and protects damaged nerve cells by producing a substance called myelin.
People taking Laregab-M 100/500 Tablet should be closely monitored for suicidal thoughts or behaviour. Do not be reluctant to speak with your doctor immediately if you experience suicidal tendencies.
If Laregab-M 100/500 Tablet is taken along with antacid medicines containing aluminium and magnesium, it may lower the absorption of Laregab-M 100/500 Tablet from the stomach. To avoid this, maintain a gap of two hours between Laregab-M 100/500 Tablet and antacid medicines.
If you miss a dose, take it as soon as you remember. However, if it is time for the next scheduled dose, skip the missed dose and follow your usual dosage.
Neuropathic pain is a chronic progressive nerve disease that occurs due to damaged sensory nerves. Neuropathic pain is stabbing, tingling, and sharp while muscle pain is dull and steady or crampy and spasmodic.
Inform your doctor before taking Laregab-M 100/500 Tablet if you have a medical history of heart problems, bipolar syndrome, and nervous system disorders. Pregnant and breastfeeding women should consult their doctor before taking Laregab-M 100/500 Tablet .
Laregab-M 100/500 Tablet is a combination medicine containing Gabapentin (an anticonvulsant) and Methylcobalamin (Mecobalamin or vitamin B12). It is used to treat neuropathic (nerve-related) pain. Gabapentin helps reduce abnormal pain signals from damaged nerves, while Methylcobalamin supports nerve repair and maintenance.
Peripheral neuropathy affects the nerves outside your brain or spinal cord. It causes tingling sensation, pain, numbness and burning sensation.
No, do not take a higher than the recommended dose of Laregab-M 100/500 Tablet as it might cause an overdose. Take Laregab-M 100/500 Tablet in the dose and duration prescribed by the doctor.
Store Laregab-M 100/500 Tablet at room temperature, in a dry place. Keep out of sight and reach of children.
Laregab-M 100/500 Tablet may cause side effects like dizziness, sleepiness, tiredness, nausea and vomiting. These side effects do not require medical attention and gradually resolve over time. However, you are advised to talk to your doctor if you experience these side effects for a longer duration.
Laregab-M 100/500 Tablet is specifically prescribed for chronic nerve-related pain (neuropathic pain) rather than acute, sudden musculoskeletal pain. Only use this medication for conditions diagnosed by your healthcare provider. Talk to your doctor to see if this is the right treatment for your pain.
Moderate caffeine intake from coffee is generally safe, but caffeine can sometimes interfere with sleep or affect nerve sensitivity in some individuals. If you experience increased anxiety or sleep disturbances, consult your healthcare provider. Talk to your doctor or pharmacist for personalised advice.
Laregab-M 100/500 Tablet helps manage nerve pain symptoms and supports the repair of the nerve sheath, but it may not fully cure the underlying cause of your nerve damage. Consistent management of health conditions like diabetes is also essential. Talk to your doctor to understand your long-term treatment plan.
This medicine should only be used during pregnancy if the potential benefits outweigh the risks to the unborn baby. There is limited safety data available on its use in pregnant women. Talk to your doctor if you are pregnant or planning to become pregnant.
Yes, some patients taking Laregab-M 100/500 Tablet may experience fluid retention or an increased appetite, which can lead to weight gain. Monitoring your diet and staying physically active can help manage this side effect. Talk to your doctor if you experience sudden or excessive weight gain.
Yes. Sleepiness or drowsiness is a common side effect of Laregab-M 100/500 Tablet , particularly when you first start treatment or after a dose increase. Avoid driving, operating machinery, or performing tasks that require alertness until you know how the medicine affects you. If the drowsiness is severe, persistent, or interferes with your daily activities, contact your doctor.
No. Do not stop taking Laregab-M 100/500 Tablet without consulting your doctor, even if your pain has improved or disappeared. Stopping the medicine suddenly may cause withdrawal symptoms and your nerve pain may return. Your doctor will advise you if treatment should be stopped and, if needed, gradually reduce your dose to discontinue it safely.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 020235S064 020882S047 021129S046Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Gabapentin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Methylcobalamin Vitamin B12 Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.4636 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. PubChem PubChem. [Accessed on 22 Apr. 2019]Check here
  6. Ming Zhang, Wenjuan Han, Sanjue Hu and Hui Xu. Methylcobalamin: A Potential Vitamin of Pain Killer. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2013. [Accessed on 11th January 2023]Check here
  7. Milpharm Limited. Gabapentin Milpharm 100/300/400 mg capsules, hard. Electronic Medicines Compendium. [Revised in December 2022] [Accessed on 11th January 2023].Check here

Country of origin

India

Manufacturer/Marketer address

Behind Rajpath Club, Kensville Road, Opp. Infostretch Building, Off S.G. Highway, Ahmedabad- 380059, Gujarat- India
Other Info - LAR0245

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