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compositionComposition:MEFLOQUINE-250MG
prescription
Prescription Medicine
info
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Larimef 250 mg Tablet is used to treat malaria. It contains Mefloquine which works by killing malaria-causing parasites. In some cases, this medicine may cause side effects such as sleeping problems, headache, dizziness, vertigo (loss of balance), itching, nausea, vomiting, stomach pain or diarrhoea. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MEFLOQUINE-250MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Larimef 250 mg Tablet

Larimef 250 mg Tablet is an oral prescription medication primarily used to prevent and treat malaria, a serious and sometimes life-threatening infection transmitted by mosquitoes. By targeting and destroying the malaria parasites that enter the red blood cells, this medicine helps protect travellers and treat those who have contracted the disease. It is a vital tool for safeguarding your health when visiting regions where malaria is highly active.

For preventing infection, Larimef 250 mg Tablet is typically taken once a week on the exact same day, starting before your journey and continuing during your stay and after your return. It is crucial to always take this medication with a full glass of water and a main meal to ensure it is absorbed properly by your body. Combining this therapy with lifestyle measures like sleeping under treated mosquito nets and wearing protective clothing offers the best defence against infection.

While taking Larimef 250 mg Tablet, some individuals may experience common side effects like nausea, mild dizziness, or vivid dreams. However, if you experience sudden mood changes, severe anxiety, confusion, or a ringing sensation in your ears, you should contact your doctor immediately. These symptoms can occasionally become serious, and early medical advice is essential to manage them safely.

Before starting this medicine, you must discuss your medical history thoroughly with your healthcare provider. Do not take this if you have a history of seizures, active depression, generalised anxiety disorder, schizophrenia, or other major psychiatric conditions. Your doctor will help evaluate if this option is safe for your specific health profile.

This medicine can interact with alcohol, which can significantly worsen dizziness and impair your coordination, so it is best to avoid drinking during your course. If you are pregnant, planning to become pregnant, breastfeeding, or an older adult, consult your doctor before taking Larimef 250 mg Tablet to discuss the benefits and potential risks to your health.

Uses of Larimef 250 mg Tablet

Larimef 250 mg Tablet is used to prevent and treat malaria. The detailed uses of Larimef 250 mg Tablet are as follows:

  • Malaria Prevention (Prophylaxis): Helps prevent malaria infection in people travelling to areas where malaria is common. It stops the malaria parasite from growing in the body if you are bitten by an infected mosquito.
  • Malaria Treatment: Treats active, uncomplicated malaria infections caused by certain malaria parasites, helping to clear the infection from your bloodstream.

Key Benefits

Larimef 250 mg Tablet helps prevent and treat malaria by targeting the parasites responsible for the infection. By eliminating malaria parasites or preventing them from multiplying, it helps protect your health during travel and supports recovery from active malaria.

  • Convenient dosing schedule for travel: Since it is typically taken only once a week for prevention, it is easy to manage and remember compared to daily medications, making your travel preparation much simpler.
  • Effective defence in high-risk areas: It provides strong, reliable protection against specific types of malaria parasites, helping you stay healthy and safe during your travels to tropical regions.
  • Promotes recovery from active infection: For those treating malaria, it works to quickly clear the parasites from the blood, helping you feel better faster and reducing the risk of severe illness.
Side effects of Larimef 250 mg Tablet
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Concentration, stress and anxiety can be improved by meditation and deep breathing.
  • You can increase your energy, memory and capacity to avoid distractions by exercising regularly.
  • Avoiding multitasking is advised.
  • Fruits, vegetables, whole foods and oily fish help to improve your nutrition.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Take Larimef 250 mg Tablet preferably after a meal or as advised by a doctor.
  • Adhere to your doctor's guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow Larimef 250 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Larimef 250 mg Tablet Works

Larimef 250 mg Tablet contains mefloquine, which works by targeting the asexual blood stages of malaria parasites. Once you take the tablet, the active ingredients enter your red blood cells, where the parasites live and multiply. The medicine interferes with the parasite's internal feeding and survival mechanisms, making it impossible for them to grow. This action effectively destroys the parasites and stops the infection from spreading further in your body.
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Alcohol

Unsafe

A person should limit the consumption of alcohol as it may worsen the side effects. It may lead to liver damage.

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Pregnancy

Caution

Larimef 250 mg Tablet is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Caution

It is not safe to breastfeed while taking Larimef 250 mg Tablet. A patient is advised to take this drug only at a doctor's consultation.

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Driving

Caution

Larimef 250 mg Tablet may cause dizziness, so one should avoid driving or doing any activity that needs mental alertness.

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Liver

Caution

Larimef 250 mg Tablet should be used with caution in patients with impaired liver function. Consult your doctor before using Larimef 250 mg Tablet.

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Kidney

Caution

Larimef 250 mg Tablet should be used with caution in patients with impaired kidney function. Consult your doctor before using Larimef 250 mg Tablet.

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Children

Caution

Larimef 250 mg Tablet should not be used for children below 3 months. Larimef 250 mg Tablet should be used only when prescribed by a child specialist.

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Heart

Caution

Larimef 250 mg Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Larimef 250 mg Tablet.

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Geriatrics

Caution

Larimef 250 mg Tablet should be taken with caution in geriatric patients. Please consult your doctor before using Larimef 250 mg Tablet.

What if I have taken an overdose of Larimef 250 mg Tablet

If you or someone else takes too much of this medicine, seek immediate medical attention right away, even if there are no immediate symptoms. Overdose can lead to severe neurological and cardiac complications.

Diet & Lifestyle Advise

  • Avoid mosquito bites: Use an EPA-approved insect repellent containing DEET, wear long-sleeved shirts and long pants, and sleep under a permethrin-treated bed net to maximise your protection against malaria.
  • Coordinate with fatty meals: Always take your dose with a major meal. Eating food that contains some fat can help your body absorb the medicine much more effectively.
  • Stay hydrated: Drink plenty of safe, bottled, or purified water to avoid dehydration, which can worsen dizziness or stomach upset.
  • Protect your skin: Wear sunscreen and protective clothing, as some antimalarial medications can make your skin more sensitive to the sun.
health query

Have a query?

How Soon It Starts Working

The time required for Larimef 250 mg Tablet to start to work: Larimef 250 mg Tablet ideally shows its action within 7 to 10 hours after administration. The time for which the effects of Larimef 250 mg Tablet last: The effect of Larimef 250 mg Tablet lasts for 2 to 3 weeks.

What if you forget to take Larimef 250 mg Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are taking it for prevention and miss a dose, talk to your doctor or pharmacist to ensure your protection is not compromised.

Storage

• Store Larimef 250 mg Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F).• Keep the tablets in their original packaging to protect them from moisture and light.

Drug Warnings

  • Watch your mental health: Stop taking this medicine and call your doctor immediately if you experience sudden changes in mood, severe anxiety, depression, or unusual thoughts.
  • Avoid driving or operating machinery: This medicine can cause severe dizziness and loss of balance, which can last for some time. Do not drive or do dangerous tasks until you know how it affects you.
  • Complete the full course: If you are travelling, you must start taking this medicine before you enter the malaria-risk area and continue taking it for the entire duration prescribed after you leave. Stopping early can lead to infection.
  • Do not take if you have a history of certain conditions: Do not take this medicine if you have a history of seizures, active depression, generalised anxiety disorder, or other major psychiatric conditions.

Drug-Drug Interactions

verifiedApollotooltip
  • Certain heart medications (such as beta-blockers or calcium channel blockers): May increase the risk of abnormal heart rhythms or slow heart rate when taken with Larimef 250 mg Tablet.
  • Anticonvulsants (seizure medications): Taking Larimef 250 mg Tablet may lower the effectiveness of these medicines, increasing the risk of seizures.
  • Other antimalarial medicines (like halofantrine or ketoconazole): Combining these can cause serious, life-threatening heart rhythm problems.
MefloquineZiprasidone
Critical
MefloquineOlanzapine
Severe

Drug-Drug Interactions

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MefloquineZiprasidone
Critical
How does the drug interact with Larimef 250 mg Tablet:
Taking Larimef 250 mg Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Larimef 250 mg Tablet with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
MefloquineOlanzapine
Severe
How does the drug interact with Larimef 250 mg Tablet:
The combined use of Larimef 250 mg Tablet and Olanzapine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Larimef 250 mg Tablet and Olanzapine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MefloquineCeritinib
Severe
How does the drug interact with Larimef 250 mg Tablet:
Taking ceritinib together with Larimef 250 mg Tablet can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Ceritinib with Larimef 250 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
MefloquineOxytocin
Severe
How does the drug interact with Larimef 250 mg Tablet:
Taking oxytocin with Larimef 250 mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Oxytocin with Larimef 250 mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience if you develop sudden dizziness, lightheadedness, fainting, shortness of breath contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MefloquineSotalol
Severe
How does the drug interact with Larimef 250 mg Tablet:
Using Larimef 250 mg Tablet together with sotalol can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Larimef 250 mg Tablet, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
MefloquineDisopyramide
Severe
How does the drug interact with Larimef 250 mg Tablet:
The combined use of Larimef 250 mg Tablet and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Larimef 250 mg Tablet and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
MefloquineKetoconazole
Severe
How does the drug interact with Larimef 250 mg Tablet:
Coadministration of Larimef 250 mg Tablet and ketoconazole can increase the blood levels and can result in a possibly harmful heart rhythm irregularity.

How to manage the interaction:
Although taking Ketoconazole and Larimef 250 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats, you should consult a doctor immediately. Ketoconazole should not be taken with Larimef 250 mg Tablet or within 15 weeks of your last dose of Larimef 250 mg Tablet. Do not stop using any medications without a doctor's advice.
MefloquineMoxifloxacin
Severe
How does the drug interact with Larimef 250 mg Tablet:
Using Moxifloxacin together with Larimef 250 mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Moxifloxacin and Larimef 250 mg Tablet, but it can be taken if prescribed by a doctor. If you experience irregular heart rhythm, dizziness, or difficulty breathing, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
MefloquineIvabradine
Severe
How does the drug interact with Larimef 250 mg Tablet:
Coadministration of Ivabradine with Larimef 250 mg Tablet can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Ivabradine with Larimef 250 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
MefloquineMifepristone
Severe
How does the drug interact with Larimef 250 mg Tablet:
Co-administration of Larimef 250 mg Tablet with mifepristone can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Larimef 250 mg Tablet with mifepristone together can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, weakness, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking this medicine, as it can significantly increase the risk and severity of dizziness, drowsiness, and balance issues.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- MALARIALS]

FAQs

Malaria infection can be very dangerous during pregnancy for both the mother and the baby. However, this medicine should only be used during pregnancy if the potential benefit justifies the potential risk to the unborn child. Talk to your doctor to weigh your options safely.
If you vomit within 30 to 60 minutes of taking your dose, you may need to take another dose to ensure you remain protected. If you vomit later than that, or if you continue to feel sick, talk to your doctor or pharmacist.
For malaria prevention, you must continue taking this medicine weekly for several weeks after leaving the malaria-risk area. This ensures any parasites that entered your system are completely cleared. Talk to your doctor for your specific schedule.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can worsen side effects like dizziness, sleep problems, and poor coordination. Talk to your doctor if you have questions about alcohol use.
In some cases, neurological or psychiatric side effects, such as dizziness, balance issues, or anxiety, can persist for weeks or months even after stopping the medicine. If you notice any unusual symptoms, talk to your doctor immediately.
Some heart medicines can interact with this medicine, leading to heart rhythm changes. Always provide your healthcare provider with a complete list of all the prescriptions, over-the-counter drugs, and supplements you take. Talk to your doctor to ensure there are no dangerous interactions.
Taking this medicine with a main meal, especially one containing some fat, helps your body absorb the active ingredients much better. It also helps protect your stomach lining to prevent nausea and vomiting. Talk to your doctor if you find it hard to take with food.
Yes, this medicine can be prescribed to children for malaria prevention, with the dose determined strictly by the child's body weight. However, it is not recommended for infants under a certain weight. Talk to your doctor or paediatrician for safe guidance.

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Country of origin

INDIA

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - LAR0050
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