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compositionComposition:ARTESUNATE-60MG
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Prescription Medicine
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Larinate Injection 5 ml is used to treat malaria. It contains Artesunate, which works by forming harmful chemicals within the malarial parasite and killing the parasites. In some cases, this medicine may cause side effects such as dizziness, headache, weakness, and loss of appetite. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ARTESUNATE-60MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Larinate Injection 5 ml

Larinate Injection 5 ml is an injectable medication used for the emergency treatment of severe malaria. It is prescribed when the infection is complicated or life-threatening, requiring rapid action to clear malaria parasites from the body. Because it is a parenteral medication, it is injected directly into the body to ensure it starts working immediately.

This medication is given as a short, intensive course of injections, usually over a period of 24 to 48 hours, depending on how quickly you recover. Since this medicine is injected by a healthcare professional, food intake does not affect how it is absorbed, but staying nourished is vital for your recovery.

While this treatment is highly effective, some people may experience mild side effects like dizziness, headaches, or nausea. In rare cases, more serious side effects can occur, such as a delayed breakdown of red blood cells (anaemia) weeks after treatment. If you notice extreme tiredness, pale skin, or dark urine after your treatment is finished, talk to your doctor immediately.

Before you receive this medication, it is important to tell your healthcare provider about your complete medical history. Do not take this if you have a history of severe allergic reactions to artemisinin-based medicines. Your medical team will carefully evaluate your health, especially if you have pre-existing kidney or liver issues.

This medicine can interact with other drugs, so your doctor must know about all prescription, over-the-counter, and herbal remedies you are taking. You should avoid alcohol and smoking during treatment, as they can place extra stress on your liver and slow down your recovery. If you are pregnant, breastfeeding, or caring for an elderly patient, talk to your doctor or pharmacist to discuss the risks and benefits in your specific situation.

Uses of Larinate Injection 5 ml

Larinate Injection 5 ml is used in the treatment of Malaria. The detailed use of Larinate Injection 5 ml is as follows:

  • Severe Malaria: Treats life-threatening malaria infections caused by the bite of infected mosquitoes, helping to clear parasites rapidly from the bloodstream. It is primarily used to treat severe malaria caused by Plasmodium falciparum. It may also be used for severe malaria caused by other Plasmodium species, although additional treatment may be required for species such as Plasmodium vivax to prevent relapse.
  • Complicated Malaria: Used when malaria infections cause complications in vital organs or when patients are unable to take oral medications due to vomiting or unconsciousness.

Key Benefits

Larinate Injection 5 ml helps provide fast, life-saving treatment for severe malaria by quickly bringing the infection under control.

Benefits may include:

  • Helps rapidly reduce malaria symptoms and parasite levels
  • Reduces the risk of life-threatening complications
  • Supports faster recovery from severe malaria
  • Provides effective treatment when oral medicines cannot be taken
  • Helps protect vital organs from malaria-related damage
  • Improves the chances of recovery with prompt treatment
Side effects of Larinate 5ml Inj
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Changes in kidney function need immediate medical attention.
  • Always monitor your blood pressure and inform your healthcare team if there are any sudden changes.
  • Take medicines as prescribed and eat a balanced diet suggested by your dietician for healthy kidney function.
  • Physical activity and exercise must be included in your daily routine to have proper kidney functioning and to maintain a healthy weight.
  • Get enough sleep to reduce the stress levels that have a direct impact on your kidney functioning.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Larinate Injection 5 ml must be prepared and injected by a qualified healthcare professional in a hospital or clinical setting.
  • The dry powder in the vial is carefully dissolved in a sterile liquid and then injected into a vein (intravenously) or into a large muscle (intramuscularly).
  • Do not attempt to self-inject this medication. Your doctor and medical team will determine the exact schedule and ensure you receive the correct amount of medicine.
  • Always follow your doctor's exact instructions and complete any follow-up oral treatments they prescribe.

How Larinate Injection 5 ml Works

Larinate Injection 5 ml contains Artesunate, which works by rapidly destroying malaria parasites inside the body. Once injected, the drug quickly enters the red blood cells that have been infected by the malaria parasite. Inside these cells, the medication reacts with the iron contained within the parasite. This reaction produces highly reactive molecules called free radicals, which break down and destroy the vital proteins and cell membranes of the parasite, stopping the infection in its tracks.
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Alcohol

Caution

Avoid alcohol while using Larinate Injection 5 ml since it can worsen your side effects.

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Pregnancy

Unsafe

Larinate Injection 5 ml is not safe during pregnancy as it causes severe side effects to both mother and unborn baby.

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Breast Feeding

Caution

Larinate Injection 5 ml is present in breast milk but may not be expected to cause any side effects in the new-born baby especially more than 2 months. Please use only in the condition if your doctor is prescribed.

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Driving

Caution

Larinate Injection 5 ml may make you feel sleepy, dizzy, or generally weak. In such cases, do not drive or operate machinery.

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Liver

Caution

Close monitoring of patients with liver diseases while being treated with Larinate Injection 5 ml is required. Let your doctor know if you have any history of liver diseases before using Larinate Injection 5 ml. No specific dose adjustments are needed.

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Kidney

Caution

Therapy with Larinate Injection 5 ml is to be cautiously administered in patients with renal impairment. Let your doctor know if you have any history of kidney diseases before using Larinate Injection 5 ml. No specific dose adjustments are needed.

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Children

Safe if prescribed

Larinate Injection 5 ml is safely given to the children 6 months or older.

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Heart

Consult your doctor

It is unknown whether Larinate Injection 5 ml is safe for use in cardiac patients. Please consult your physician.

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Geriatrics

Consult your doctor

Limited information available for use of Larinate Injection 5 ml in elderly patients. Please consult your doctor.

What if I have taken an overdose of Larinate Injection 5 ml

This medicine is given under close medical supervision, minimising the risk of an overdose. In the rare event that too much medicine is given, healthcare professionals will monitor your vital signs closely and provide immediate supportive care. If you suspect an issue, talk to your doctor or pharmacist.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink plenty of clean fluids, such as water or oral rehydration solutions, to replace fluids lost through fever, sweating, and vomiting.
  • Eat light meals: Choose small, frequent meals that are easy to digest, such as broths, plain rice, or bananas, to help restore your energy without upsetting your stomach.
  • Get adequate rest: Rest as much as possible during and after treatment to give your body time to recover from the infection.
  • Prevent mosquito bites: Use insect repellent, wear protective clothing, and sleep under mosquito nets to reduce your risk of future mosquito-borne infections.
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Have a query?

How Soon It Starts Working

  • The time required for Larinate Injection 5 ml to start to work: Larinate Injection 5 ml ideally shows its action within 8 to 12 minutes after administration.
  • The time for which the effects of Larinate Injection 5 ml last: The effect of Larinate Injection 5 ml lasts for 7 to 8 hours.

What if you forget to take Larinate Injection 5 ml

Since this medication is injected by healthcare professionals in a hospital, a missed dose is very unlikely. However, if you suspect that a scheduled injection was missed or delayed, notify your medical team immediately so they can adjust your schedule safely.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Check the solution before use: Make sure the prepared solution is clear and free of visible particles before it is injected. Do not use it if it looks cloudy or has changed colour.
  • Watch for signs of anaemia: Be vigilant for signs of delayed anaemia, such as unusual weakness, yellow eyes, or dark urine, for up to 4 to 6 weeks after your treatment is completed, and attend any follow-up blood tests recommended by your doctor to monitor for delayed haemolytic anaemia.
  • Complete your full treatment: Take all follow-up antimalarial tablets exactly as prescribed, even if you feel better. This helps prevent the infection from coming back.
  • Use sterile injection equipment: Make sure a new, sterile needle and syringe are used for every injection. This helps reduce the risk of infection.

Drug-Drug Interactions

verifiedApollotooltip
  • Other antimalarial medicines (e.g., mefloquine, quinine): Taking these medicines alongside Larinate Injection 5 ml may increase the risk of abnormal heart rhythms and may require closer monitoring.
  • Liver enzyme-affecting medicines (e.g., rifampicin, ketoconazole): These medicines may affect how Larinate Injection 5 ml works in the body and may change its effectiveness or increase the risk of side effects.
ArtesunateCabozantinib
Severe
ArtesunateEluxadoline
Severe

Drug-Drug Interactions

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ArtesunateCabozantinib
Severe
How does the drug interact with Larinate 5ml Inj:
Taking Larinate 5ml Inj with Cabozantinib may increase blood levels and effects of Larinate 5ml Inj and increase the risk of side effects.

How to manage the interaction:
Although taking Larinate 5ml Inj with cabozantinib together can result in an interaction, they can be taken if a doctor has prescribed it. Do not discontinue any medication without consulting a doctor.
ArtesunateEluxadoline
Severe
How does the drug interact with Larinate 5ml Inj:
Taking Larinate 5ml Inj with Eluxadoline may significantly increase the blood levels of eluxadoline. This may increase the risk and/or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Larinate 5ml Inj and Eluxadoline, you can take these medicines together if prescribed by a doctor. However, if you experience persistent nausea, vomiting, drowsiness, constipation, stomach tenderness, and upper stomach pain, especially that which worsens after eating or radiates to the back or shoulders, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions are commonly recognised with Larinate Injection 5 ml.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- MALARIALS]

FAQs

Larinate Injection 5 ml is used to treat malaria.
Larinate Injection 5 ml is an antimalarial medicine that interferes with the plasmodium parasite's growth in the red blood cells of the human body. Larinate Injection 5 ml is used to treat malaria caused by a parasite called Plasmodium falciparum, and other Plasmodium species. It works by forming harmful chemicals within the malarial parasite, therefore killing the parasite.
Use of Larinate Injection 5 ml should be prevented in patients who are allergic to Larinate Injection 5 ml or any of its components. Though, if you are not aware of any allergy or if you are using Larinate Injection 5 ml for the first time, inform your doctor.
Before starting Larinate Injection 5 ml, inform your doctor if you have any other health illnesses like a kidney- or heart-related complications. This is because some medical conditions may affect your treatment and you may even require dose adjustments. Also, inform your doctor about all the other medicines you are taking as they may affect, or be affected by, this Larinate Injection 5 ml. Talk to your doctor if you are pregnant, planning to become pregnant or breastfeeding.
If you miss a dose of Larinate Injection 5 ml, take it as soon as you remember. Although, if it is approximately time for your next dose, skip the missed dose and take the next dose in the recommended time. Do not double the dose to make up for the missed one as this may enhance the probabilities of developing side effects.
Store Larinate Injection 5 ml between 10°C to 30°C according to the instructions on the leaflet and away from direct sunlight.
No, finish the prescribed course, even if you start to feel better. Stopping it early may make the infection come back and harder to treat.
Yes, Larinate Injection 5 ml is effective against quinine-resistant malaria, especially severe Plasmodium falciparum infections.
Larinate Injection 5 ml will be administered intravenously (IV) by your doctor. Do not self-administer.
No, Larinate Injection 5 ml is primarily effective in treating severe malaria caused by Plasmodium falciparum. Larinate Injection 5 ml may not be effective for all types or stages of malaria, such as the dormant liver stages of plasmodium vivax. Always, consult a doctor for proper diagnosis and treatment.
Larinate Injection 5 ml is safe when used as prescribed by your doctor in the recommended dosage and duration. Follow your doctor's instructions and consult them if you have any concerns.
No, Larinate Injection 5 ml should only be administered by a healthcare professional to ensure accurate dosing and safe usage. Do not self-administer.
Yes, Larinate Injection 5 ml may cause side effects such as headache, dizziness, weakness, and loss of appetite. However, please contact a doctor if these continue for longer durations.
Pregnant women may use Larinate Injection 5 ml only if prescribed by a doctor, as untreated malaria poses severe risks to both mother and baby. Therefore, always inform your doctor if you are pregnant before taking Larinate Injection 5 ml.
Larinate Injection 5 ml can be used while breastfeeding if prescribed by your doctor. Artesunate passes into breast milk in small amounts but is unlikely to harm a newborn, especially those older than 2 months. However, it does not protect the child from malaria. Always follow your doctor’s advice regarding Larinate Injection 5 ml use during breastfeeding.
If you have kidney or liver disease, inform your doctor before using Larinate Injection 5 ml. Although dose adjustments are generally unnecessary, careful monitoring is essential during treatment. Therefore, always contact a doctor if you have any concerns.
No, Larinate Injection 5 ml is used strictly to treat active, severe malaria infections. It does not prevent malaria from occurring. Talk to your doctor about appropriate preventive medications before travelling to malaria-prone areas.
The most significant serious side effect is delayed haemolytic anaemia, which is the breakdown of red blood cells weeks after treatment. If you experience unusual tiredness, pale skin, or dark urine after recovering, talk to your doctor immediately.
Yes, once you are well enough to swallow, your doctor will usually prescribe a complete course of oral antimalarial tablets to ensure all remaining parasites are destroyed. Talk to your doctor or pharmacist to understand your full treatment plan.
Yes, Larinate Injection 5 ml is widely used and recognised as a primary, safe treatment for severe malaria in infants and children. Talk to your doctor about how the dose is calculated for children.
It is highly recommended to avoid alcohol while recovering, as severe malaria and its treatment can put strain on your liver. Talk to your doctor or pharmacist for personalised recovery advice.

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Country of origin

India

Manufacturer/Marketer address

142 Ab, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra.
Other Info - LAR0026
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