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compositionComposition:LEUCOVORIN-15MG
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Leevarin 15 Tablet 10's is used to treat methotrexate (cancer medicine) overdose. It is used to prevent the harmful effects of methotrexate. It contains Leucoverin, which protects the healthy cells from the toxic effects of methotrexate while allowing methotrexate to enter and kill the cancer cells. It may cause side effects such as nausea, vomiting, diarrhoea, and constipation.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

LEUCOVORIN-15MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

Oral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Leevarin 15 Tablet 10's

Leevarin 15 Tablet 10's is a prescription medicine used to protect healthy cells from the toxic effects of certain chemotherapy treatments, such as methotrexate. Although this article focuses on the oral formulation, Leevarin 15 Tablet 10's is also commonly given by intravenous (IV) infusion or injection in hospital settings, particularly during chemotherapy rescue treatment. It is also prescribed in selected cases of folate-deficiency anaemia where an active form of folate is required. By providing a usable form of folate, this medicine helps your body maintain healthy cell division and function during intensive medical therapies.

For the best results, you must take Leevarin 15 Tablet 10's exactly as scheduled by your healthcare team, without missing any doses. You can take this medication with or without food, but taking it with a full glass of water is recommended. To support your body's recovery, focus on eating a balanced diet, staying well-hydrated, and getting plenty of rest.

While taking Leevarin 15 Tablet 10's, some people may experience mild side effects like nausea, vomiting, or mild skin rashes. However, you must contact your doctor immediately if you face severe allergic reactions, such as trouble breathing, swelling of the face, or a severe skin rash.

Talk to your doctor before starting this medicine if you have a history of severe anaemia or vitamin B12 deficiency, or if you are experiencing severe vomiting that makes it difficult to keep oral medicines down. Do not take this if you have had a severe allergic reaction to this medication in the past.

Leevarin 15 Tablet 10's can interact with certain seizure medications, potentially reducing their effectiveness and increasing the risk of seizures. Always consult your doctor or pharmacist if you are pregnant, planning to become pregnant, breastfeeding, or if you regularly consume alcohol, as these factors can influence how your treatment is managed.

Uses of Leevarin 15 Tablet 10's

Leevarin 15 Tablet 10's is used to reduce the harmful effects of certain medicines and to treat conditions caused by folate deficiency, including:

  • Chemotherapy rescue therapy: Leevarin 15 Tablet 10's is used to protect healthy cells and reduce harmful side effects after high-dose cancer treatments or to treat accidental overdoses of methotrexate.naemia caused b
  • Folate-deficiency anaemia: It may be used to treat megaloblastic ay folate deficiency in selected clinical situations where an active form of folate is required. For most uncomplicated cases of folate-deficiency anaemia, standard folic acid is usually the preferred treatment.

Key Benefits

Leevarin 15 Tablet 10's offers several important benefits that help protect healthy tissues during treatment and restore normal blood cell production, including:

  • Protects Healthy Cells During Chemotherapy: Leevarin 15 Tablet 10's acts as a protective shield for healthy tissues during high-dose methotrexate therapy, helping reduce severe side effects such as mouth sores, digestive problems, and low blood cell counts.
  • Supports the Completion of Cancer Treatment: By reducing treatment-related toxicity, it helps patients continue chemotherapy more safely and comfortably.
  • Restores Healthy Red Blood Cell Production: In people with folate-deficiency anaemia, Leevarin 15 Tablet 10's helps normalise red blood cell formation, correcting the underlying deficiency.
  • Improves Energy and Reduces Fatigue: As healthy blood cell levels recover, symptoms such as tiredness, weakness, and shortness of breath gradually improve, helping restore daily energy and physical stamina

Directions for Use

  • Take Leevarin 15 Tablet 10's with or without food or as advised by a doctor.
  • Adhere to your doctor’s guidance regarding the dosage and timing of this medication for optimal effectiveness.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Leevarin 15 Tablet 10's Works

Leevarin 15 Tablet 10's contains an active form of folate that your body can use immediately. Certain chemotherapy medications work by blocking a key enzyme in the body that converts inactive folic acid into its active form, which stops cancer cells—and healthy cells—from growing. By taking Leevarin 15 Tablet 10's, you are providing your body with pre-activated folate. Because it bypasses the blocked enzyme, it enters healthy cells directly and allows them to survive and multiply, effectively rescuing them from the chemotherapy's toxicity without reducing the effectiveness of the cancer treatment.
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Alcohol

Caution

Avoid intake of alcohol as it may cause some side effects and make the effect of Leevarin 15 Tablet 10's less effective.

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Pregnancy

Caution

Leevarin 15 Tablet 10's should be used in pregnancy only when the benefit to the mother outweighs the risk to the fetus.

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Breast Feeding

Caution

It is not known that Leevarin 15 Tablet 10's may pass with breast milk. Discuss with your doctor about the benefits and risks of using this Leevarin 15 Tablet 10's.

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Driving

Safe

Leevarin 15 Tablet 10's does not show any effect on the ability to drive.

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Liver

Caution

Leevarin 15 Tablet 10's to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Leevarin 15 Tablet 10's to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Safe if prescribed

Leevarin 15 Tablet 10's is safe in children if prescribed by your doctor.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Safe if prescribed

Leevarin 15 Tablet 10's is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Leevarin 15 Tablet 10's

If you suspect an overdose, seek immediate medical attention or contact a poison control centre right away

Diet & Lifestyle Advise

  • Stay Well Hydrated: Drink plenty of fluids, especially water, to help flush chemotherapy medications out of your kidneys and stay hydrated.
  • Include Folate-Rich Foods: Incorporate folate-rich foods like leafy green vegetables, citrus fruits, and beans into your diet, unless your doctor advises otherwise during your active chemotherapy cycle.
  • Avoid Unnecessary Folic Acid Supplements: Avoid taking high-dose folic acid supplements while using Leevarin 15 Tablet 10's unless specifically directed, as they can interfere with your treatment's balance.
  • Limit Alcohol Consumption: Limit or avoid alcohol consumption, as alcohol can interfere with folate absorption and put additional strain on your liver.
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How Soon It Starts Working

The time required for Leevarin 15 Tablet 10's to start to work: The time required for Leevarin 15 Tablet 10's to show its action is unknown. The time for which the effects of Leevarin 15 Tablet 10's last: The duration of action for Leevarin 15 Tablet 10's is unknown.

What if you forget to take Leevarin 15 Tablet 10's

If you miss a dose of Leevarin 15 Tablet 10's, contact your doctor or pharmacist immediately. Because this medicine's protective effects depend heavily on precise timing, do not take a double dose to make up for a missed one without professional medical guidance.

Storage

• Store Leevarin 15 Tablet 10's tablets at a controlled room temperature between 20°C and 25°C (68°F to 77°F)..

Drug Warnings

  • Take Every Dose on Time: Never delay or skip a dose of Leevarin 15 Tablet 10's, as precise timing is essential to protect your organs from permanent chemotherapy damage.
  • Report Vomiting After a Dose: If you experience sudden vomiting within an hour of taking your tablet, contact your healthcare provider immediately to see if you need a replacement dose or an injection.
  • Carry an Updated Medication List: Always keep a complete list of all your medications with you, especially during emergency visits, so healthcare providers know you are taking this rescue therapy.
  • Attend All Blood Test Appointments: Complete all scheduled blood tests, as your doctor uses these results to monitor drug levels in your body and adjust your treatment safely.

verifiedApollotooltip

Leevarin 15 Tablet 10's may interact with certain medicines, affecting their effectiveness or increasing the risk of side effects. Inform your doctor about all prescription medicines, over-the-counter products, vitamins, and herbal supplements you are taking, including:

  • Anti-Seizure Medicines: May decrease the effectiveness of certain seizure medications (such as phenobarbital, phenytoin, and primidone), potentially increasing the risk of seizures.
  • Fluorouracil (5-FU): Leevarin 15 Tablet 10's is intentionally combined with fluorouracil in many chemotherapy regimens because it enhances fluorouracil's anticancer activity. However, this combination can also increase the risk of side effects such as severe diarrhoea, mouth sores, and low blood cell counts, so it should only be used under close medical supervision.
  • Trimethoprim-Sulfamethoxazole: May reduce the efficacy of trimethoprim-sulfamethoxazole (an antibiotic) when used for specific infections.

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verifiedApollotooltip

No clinically significant food interactions are known with Leevarin 15 Tablet 10's when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[VITAMINS]

FAQs

Leevarin 15 Tablet 10's is primarily used to treat an overdose of methotrexate (cancer medicine). It is used to prevent the harmful effects of methotrexate.
Leevarin 15 Tablet 10's contains leucovorin. Leevarin 15 Tablet 10's works by preventing healthy cells from the toxic effects of methotrexate (cancer medicines) while accepting it to enter and kill the cancer cells.
Leevarin 15 Tablet 10's is an antidote to the side effects of various chemotherapy medications, such as methotrexate.
Yes, you can take Leevarin 15 Tablet 10's with or without food. If you experience an upset stomach, taking it with a small meal may help improve tolerance. Talk to your doctor or pharmacist.
If you vomit shortly after taking your dose, contact your healthcare provider immediately. You may need an alternative form of this medicine, such as an injection, to ensure you receive the proper protective dose. Talk to your doctor or pharmacist.
No. Leevarin 15 Tablet 10's is an active form of folate that does not require conversion by your body's enzymes. This allows it to work even when certain medicines, such as methotrexate, block normal folate metabolism. For most people with uncomplicated folate deficiency, standard folic acid is usually the preferred treatment, while Leevarin 15 Tablet 10's is reserved for specific medical situations determined by your doctor. Talk to your doctor or pharmacist.
When used after chemotherapy, Leevarin 15 Tablet 10's must be taken at very precise times to protect healthy cells before they suffer permanent damage. Missing your dose window can reduce its protective benefits. Talk to your doctor or pharmacist.
Leevarin 15 Tablet 10's is sometimes used during pregnancy for specific conditions, but it must only be taken under strict medical supervision to ensure safety for both you and your baby. Talk to your doctor or pharmacist.
No, Leevarin 15 Tablet 10's is only effective for specific types of anaemia caused by folate deficiency, such as megaloblastic anaemia. It does not treat iron-deficiency anaemia or vitamin B12 deficiency. Talk to your doctor or pharmacist.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can interfere with folate absorption and increase strain on your liver during medical treatments. Talk to your doctor or pharmacist.
Because timing is critical to protect your healthy cells, you should contact your doctor or healthcare team immediately for guidance if you miss a dose. Do not take a double dose to catch up. Talk to your doctor or pharmacist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.
Other Info - LEE0176
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