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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Lefgrip 20 Tablet 10's is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

LEFLUNOMIDE-20MG

Manufacturer/Marketer :

Zynovia Lifecare

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lefgrip 20 Tablet 10's

Lefgrip 20 Tablet 10's is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis and Psoriatic arthritis are autoimmune diseases characterised by joint inflammation, stiffness, and pain.

Lefgrip 20 Tablet 10's contains 'Leflunomide', an isoxazole immunomodulatory agent which works by suppressing the activated immune system. Thereby, it helps reduce pain, inflammation and swelling. 

In some cases, Lefgrip 20 Tablet 10's may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Do not take Lefgrip 20 Tablet 10's if you are pregnant or planning for pregnancy, as Lefgrip 20 Tablet 10's may cause serious congenital disabilities. Lefgrip 20 Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. Lefgrip 20 Tablet 10's may cause dizziness, so drive with caution.

Uses of Lefgrip 20 Tablet 10's

Lefgrip 20 Tablet 10's is used in the treatment of Rheumatoid arthritis and Psoriatic arthritis. The detailed uses of Lefgrip 20 Tablet 10's are as follows:

  • Rheumatoid Arthritis (RA): Lefgrip 20 Tablet 10's reduces joint pain, swelling, and stiffness; slows progression of joint damage.
  • Psoriatic Arthritis: Lefgrip 20 Tablet 10's eases symptoms like joint inflammation and skin lesions associated with psoriasis.

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Directions for Use

  • Take Lefgrip 20 Tablet 10's with or without food as advised by your doctor.
  • It is usually taken once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Lefgrip 20 Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Lefgrip 20 Tablet 10's relieves symptoms of rheumatoid arthritis and psoriatic arthritis.
  • It inhibits dihydroorotate dehydrogenase, reducing excessive immune cell activity.
  • It has antiproliferative properties, helping suppress abnormal cell growth.
  • Lefgrip 20 Tablet 10's reduces inflammation, redness, pain, and swelling in affected joints.
  • It improves joint function and mobility, enhancing the quality of life in arthritis patients.

How Lefgrip 20 Tablet 10's Works

Lefgrip 20 Tablet 10's contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Lefgrip 20 Tablet 10's

Do not take more than the prescribed dose of Lefgrip 20 Tablet 10's as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Lefgrip 20 Tablet 10's if you are allergic to leflunomide, have severe liver or kidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections.
  • Lefgrip 20 Tablet 10's is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age.
  • Talk to your doctor before taking Lefgrip 20 Tablet 10's if you have/had serious infections like interstitial lung disease (inflammation of the lungs), tuberculosis (TB), or pneumonia.
  • Lefgrip 20 Tablet 10's may cause dizziness, so drive with caution.
  • Lefgrip 20 Tablet 10's may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Inform your doctor if you are taking any other medicines, including supplements and herbal products.

Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lefgrip 20 Tablet 10's. Alcohol intake, along with Lefgrip 20 Tablet 10's, may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Lefgrip 20 Tablet 10's while you are pregnant. Lefgrip 20 Tablet 10's may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Lefgrip 20 Tablet 10's while you are breastfeeding. Lefgrip 20 Tablet 10's passes into breast milk.

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Driving

Caution

Lefgrip 20 Tablet 10's may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking Lefgrip 20 Tablet 10's.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Lefgrip 20 Tablet 10's.

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Children

Unsafe

Lefgrip 20 Tablet 10's is not approved for children under the age of 18 years.

FAQs

Lefgrip 20 Tablet 10's is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Lefgrip 20 Tablet 10's is a disease-modifying antirheumatic drug (DMARD) which stops the DNA (genetic material) of the provoked immune system cells required for their survival. It thereby helps in treating inflammation, redness, and swelling at the damaged site (especially joints).

Lefgrip 20 Tablet 10's may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Lefgrip 20 Tablet 10's. Take Lefgrip 20 Tablet 10's for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, a weak immune system and serious infections like pneumonia, or tuberculosis (TB).

The best time to take leflunomide is usually in the morning, with food, to help minimize stomach upset. However, following your doctor's specific instructions for taking leflunomide is essential, as the optimal timing may vary depending on your needs and health status.

Lefgrip 20 Tablet 10's is not a steroid. It contains leflunomide, which is an immunomodulatory medication used to treat rheumatoid arthritis and psoriatic arthritis. Leflunomide works by reducing inflammation and slowing the progression of the disease.

Lefgrip 20 Tablet 10's may cause weight loss as a side effect. This weight loss is usually insignificant and may be due to a loss of appetite. If you experience significant weight loss, it is essential to consult your doctor.

Patients taking leflunomide should notify their doctor if they experience any unusual symptoms, side effects, or concerns. They should also keep their doctor informed about any changes in their health or medications.

Lefgrip 20 Tablet 10's takes a long time to be eliminated from your body. It is generally recommended to wait at least 2 years after stopping Lefgrip 20 Tablet 10's before planning a pregnancy. It is essential to consult your healthcare provider for personalized advice and to discuss the best plan for pregnancy after stopping Lefgrip 20 Tablet 10's.

While taking leflunomide, it's reassuring to know that the risk of cancer is extremely low. Although there's a slight increase in the risk of certain types of cancer, such as lymphoma, this is very rare. Your healthcare provider will closely monitor you and address any concerns. Regular check-ups make you feel confident and safe while managing your condition with leflunomide.

Country of origin

India

Manufacturer/Marketer address

Sco 1, G.K Complex, New Chandigarh-140901
Other Info - LEF0120

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