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  1. Home
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  3. Leflunovac 10 Tablet 10's

Prescription drug
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Leflunovac 10 Tablet 10's, Pack of 10 TabletS
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Composition :

LEFLUNOMIDE-10MG

Manufacturer/Marketer :

Prevego Healthcare & Research Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Leflunovac 10 Tablet 10's

Leflunovac 10 Tablet 10's is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis and Psoriatic arthritis are autoimmune diseases characterised by joint inflammation, stiffness, and pain.

Leflunovac 10 Tablet 10's contains 'Leflunomide', an isoxazole immunomodulatory agent which works by suppressing the activated immune system. Thereby, it helps reduce pain, inflammation and swelling. 

In some cases, Leflunovac 10 Tablet 10's may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Do not take Leflunovac 10 Tablet 10's if you are pregnant or planning for pregnancy, as Leflunovac 10 Tablet 10's may cause serious congenital disabilities. Leflunovac 10 Tablet 10's should not be taken by breastfeeding mothers as it passes into breast milk. Leflunovac 10 Tablet 10's may cause dizziness, so drive with caution.

Uses of Leflunovac 10 Tablet 10's

Leflunovac 10 Tablet 10's is used in the treatment of Rheumatoid arthritis and Psoriatic arthritis. The detailed uses of Leflunovac 10 Tablet 10's are as follows:

  • Rheumatoid Arthritis (RA): Leflunovac 10 Tablet 10's reduces joint pain, swelling, and stiffness; slows progression of joint damage.
  • Psoriatic Arthritis: Leflunovac 10 Tablet 10's eases symptoms like joint inflammation and skin lesions associated with psoriasis.

Have a query?

Directions for Use

  • Take Leflunovac 10 Tablet 10's with or without food as advised by your doctor.
  • It is usually taken once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow Leflunovac 10 Tablet 10's as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Leflunovac 10 Tablet 10's relieves symptoms of rheumatoid arthritis and psoriatic arthritis.
  • It inhibits dihydroorotate dehydrogenase, reducing excessive immune cell activity.
  • It has antiproliferative properties, helping suppress abnormal cell growth.
  • Leflunovac 10 Tablet 10's reduces inflammation, redness, pain, and swelling in affected joints.
  • It improves joint function and mobility, enhancing the quality of life in arthritis patients.

How Leflunovac 10 Tablet 10's Works

Leflunovac 10 Tablet 10's contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Leflunovac 10 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.

What if I have taken an overdose of Leflunovac 10 Tablet 10's

Do not take more than the prescribed dose of Leflunovac 10 Tablet 10's as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Leflunovac 10 Tablet 10's if you are allergic to leflunomide, have severe liver or kidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections.
  • Leflunovac 10 Tablet 10's is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age.
  • Talk to your doctor before taking Leflunovac 10 Tablet 10's if you have/had serious infections like interstitial lung disease (inflammation of the lungs), tuberculosis (TB), or pneumonia.
  • Leflunovac 10 Tablet 10's may cause dizziness, so drive with caution.
  • Leflunovac 10 Tablet 10's may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
  • Inform your doctor if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

verifiedApollotooltip
LeflunomidePyrazinamide
Severe
LeflunomideAbemaciclib
Severe

Drug-Drug Interactions

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LeflunomidePyrazinamide
Severe
How does the drug interact with Leflunovac 10 Tablet:
Co-administration of Leflunovac 10 Tablet with pyrazinamide may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunovac 10 Tablet and Pyrazinamide together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideAbemaciclib
Severe
How does the drug interact with Leflunovac 10 Tablet:
Taking Abemaciclib with Leflunovac 10 Tablet can lead to or increase the risk or severity of developing liver problems or serious infections.

How to manage the interaction:
Taking Abemaciclib with Leflunovac 10 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms of fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in sputum, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideCladribine
Severe
How does the drug interact with Leflunovac 10 Tablet:
Combining Cladribine with Leflunovac 10 Tablet can increase the risk of serious infections.

How to manage the interaction:
Taking Leflunovac 10 Tablet with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhoea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, it is recommended to contact your doctor right away. Do not discontinue any medications without consulting your doctor.
LeflunomideEthionamide
Severe
How does the drug interact with Leflunovac 10 Tablet:
Coadministration of Leflunovac 10 Tablet with Leflunovac 10 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Ethionamide with Leflunovac 10 Tablet can result in an interaction, they can be taken together if prescribed by your doctor. However, consult a doctor immediately if you experience fever, joint pain or swelling, skin rash, vomiting, abdominal pain, dark urine, or yellowing of the skin or eyes. Do not discontinue using any medications without consulting a doctor.
LeflunomideAspirin
Severe
How does the drug interact with Leflunovac 10 Tablet:
Coadministration of aspirin and Leflunovac 10 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between aspirin and Leflunovac 10 Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideTemozolomide
Severe
How does the drug interact with Leflunovac 10 Tablet:
Taking Temozolomide with Leflunovac 10 Tablet can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and Leflunovac 10 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
LeflunomideDisulfiram
Severe
How does the drug interact with Leflunovac 10 Tablet:
Coadministration of Disulfiram and Leflunovac 10 Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Disulfiram and Leflunovac 10 Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, vomiting, stomach pain, dark urine, or yellowing of skin and eyes, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
LeflunomideTerbinafine
Severe
How does the drug interact with Leflunovac 10 Tablet:
Co-administration of Leflunovac 10 Tablet and Terbinafine can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Leflunovac 10 Tablet and terbinafine, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideTacrolimus
Severe
How does the drug interact with Leflunovac 10 Tablet:
Taking Leflunovac 10 Tablet together with tacrolimus may increase the risk of serious infections.

How to manage the interaction:
Although taking tacrolimus and Leflunovac 10 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
LeflunomideTolvaptan
Severe
How does the drug interact with Leflunovac 10 Tablet:
Co-administration of Leflunovac 10 Tablet with tolvaptan can increase the risk of liver problems.

How to manage the interaction:
Although taking Leflunovac 10 Tablet and tolvaptan together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
  • Performing yoga may also help in improving joint flexibility and pain management.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Acupuncture, massage and physical therapy may also be helpful.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTIRHEUMATICS

Leflunovac 10 Tablet 10's Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Leflunovac 10 Tablet 10's. Alcohol intake, along with Leflunovac 10 Tablet 10's, may cause liver disease.

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Pregnancy

Unsafe

It is not recommended to take Leflunovac 10 Tablet 10's while you are pregnant. Leflunovac 10 Tablet 10's may cause serious birth defects.

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Breast Feeding

Unsafe

It is not recommended to take Leflunovac 10 Tablet 10's while you are breastfeeding. Leflunovac 10 Tablet 10's passes into breast milk.

bannner image

Driving

Caution

Leflunovac 10 Tablet 10's may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.

bannner image

Liver

Consult your doctor

Please consult your doctor if you have liver impairment before taking Leflunovac 10 Tablet 10's.

bannner image

Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking Leflunovac 10 Tablet 10's.

bannner image

Children

Unsafe

Leflunovac 10 Tablet 10's is not approved for children under the age of 18 years.

FAQs

Leflunovac 10 Tablet 10's is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis.

Leflunovac 10 Tablet 10's is a disease-modifying antirheumatic drug (DMARD) which stops the DNA (genetic material) of the provoked immune system cells required for their survival. It thereby helps in treating inflammation, redness, and swelling at the damaged site (especially joints).

Leflunovac 10 Tablet 10's may cause diarrhoea. Drink plenty of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

It might take 4-6 weeks before you notice any benefit. In some cases, it might also take 6 months for you to feel the full effect of Leflunovac 10 Tablet 10's. Take Leflunovac 10 Tablet 10's for as long as your doctor has prescribed to treat your condition effectually.

Inform your doctor if you have liver disease, kidney disease, a weak immune system and serious infections like pneumonia, or tuberculosis (TB).

The best time to take leflunomide is usually in the morning, with food, to help minimize stomach upset. However, following your doctor's specific instructions for taking leflunomide is essential, as the optimal timing may vary depending on your needs and health status.

Leflunovac 10 Tablet 10's is not a steroid. It contains leflunomide, which is an immunomodulatory medication used to treat rheumatoid arthritis and psoriatic arthritis. Leflunomide works by reducing inflammation and slowing the progression of the disease.

Leflunovac 10 Tablet 10's may cause weight loss as a side effect. This weight loss is usually insignificant and may be due to a loss of appetite. If you experience significant weight loss, it is essential to consult your doctor.

Patients taking leflunomide should notify their doctor if they experience any unusual symptoms, side effects, or concerns. They should also keep their doctor informed about any changes in their health or medications.

Leflunovac 10 Tablet 10's takes a long time to be eliminated from your body. It is generally recommended to wait at least 2 years after stopping Leflunovac 10 Tablet 10's before planning a pregnancy. It is essential to consult your healthcare provider for personalized advice and to discuss the best plan for pregnancy after stopping Leflunovac 10 Tablet 10's.

While taking leflunomide, it's reassuring to know that the risk of cancer is extremely low. Although there's a slight increase in the risk of certain types of cancer, such as lymphoma, this is very rare. Your healthcare provider will closely monitor you and address any concerns. Regular check-ups make you feel confident and safe while managing your condition with leflunomide.

Country of origin

India

Manufacturer/Marketer address

4-6, Bora Bazar St, Borabazar Precinct, Ballard Estate, Fort, Mumbai, Maharashtra 400001
Other Info - LEF0105

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 22, 2025 | 12:45 PM IST

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Reference

  1. https://mri.cts-mrp.eu/human/downloads/NL_H_4276_003_FinalPL.pdf
  2. https://www.drugs.com/uk/leflunomide-10-mg-tablets-leaflet.html
  3. https://www.drugs.com/cdi/leflunomide.html
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
  5. https://www.gwh.nhs.uk/media/190756/leflunomide2.pdf

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