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compositionComposition:LENVATINIB-4MG
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Prescription Medicine
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Lenvima 4 mg Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer, and Endometrial cancer. It contains Lenvatinib, an anticancer medication that works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. This medicine is known to cause embryo-fetal toxicity, so it is not recommended for use in pregnancy and breastfeeding.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LENVATINIB-4MG

Manufacturer/Marketer :

Eisai Pharmaceuticals India Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lenvima 4 mg Capsule

Lenvima 4 mg Capsule is a prescription medicine used to treat certain advanced cancers, such as thyroid cancer, kidney cancer, liver cancer, and endometrial cancer. It helps manage these serious conditions by slowing or stopping the growth of cancer cells in the body. Your doctor will determine if this targeted oral therapy is appropriate for your specific diagnosis.

You will usually take this medicine once daily, and it is crucial to take it consistently at the same time each day to maintain stable levels in your system. You can take it with or without food. To help support your treatment, focus on simple lifestyle adjustments like eating balanced meals, drinking plenty of water, and getting light, regular exercise.

Some common side effects include high blood pressure, fatigue, diarrhoea, and decreased appetite. It is important to monitor these symptoms closely and consult your doctor immediately if you experience severe headaches, extreme stomach pain, or unusual bleeding.

Talk to your doctor before starting this medicine if you have a history of high blood pressure, heart problems, blood clots, liver damage, or kidney disease. Do not take this if you are allergic to any of the ingredients in this medication or if you are pregnant.

This medicine can interact with other prescription drugs, alcohol, and smoking, which can worsen side effects like high blood pressure or stomach irritation. It is vital to consult your doctor if you are breastfeeding or if you are an elderly individual, as you may require special monitoring during treatment.

Uses of Lenvima 4 mg Capsule

Your doctor may recommend this medicine to help manage the following conditions:

  • Differentiated thyroid cancer: Helps manage thyroid cancer that has spread or progressed and can no longer be treated with radioactive iodine.
  • Advanced kidney cancer: Works in combination with other prescription medicines to treat advanced renal cell carcinoma after previous therapies have failed.
  • Liver cancer: Used as a primary treatment for liver cancer that cannot be removed by surgical procedures.
  • Advanced endometrial cancer: Used alongside specific immunotherapy medicines to treat advanced lining of the womb (uterine) cancer that has worsened and cannot be cured by surgery or radiation.

Key Benefits

It offers targeted control against advanced cancers by focusing on the specific processes that allow tumours to grow. By directly blocking these pathways, the medicine provides several key benefits:

  • Slowing disease progression: It helps delay the growth and spread of cancer cells, giving you more time where your disease remains stable.
  • Tumour shrinkage: By cutting off the blood supply that tumours need to survive, this medicine can help shrink existing tumours or prevent them from getting larger.
  • Preserving daily functioning: Because it is a targeted oral therapy rather than traditional chemotherapy, it allows many patients to manage their disease at home while maintaining a routine with supportive care.
Side effects of Lenvima 4 mg Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Directions for Use

  • Lenvima 4 mg Capsule can be taken with or without food.
  • Take Lenvima 4 mg Capsule once daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow Lenvima 4 mg Capsule as a whole with a glass of water.
  • Do not crush, chew, open, or split it.

How Lenvima 4 mg Capsule Works

Lenvima 4 mg Capsule is a targeted therapy known as a kinase inhibitor. It works by blocking the action of specific proteins called receptor tyrosine kinases. These proteins are located on the surface of cancer cells and the surrounding blood vessels, acting as chemical switches that signal cells to grow and divide. In advanced cancers, tumours require a constant supply of nutrients and oxygen to survive and grow. They achieve this by signalling new blood vessels to grow toward them. By blocking these key protein signals, it starves the tumour of its blood supply, effectively stopping it from expanding while simultaneously slowing down the division of the cancer cells themselves.
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Alcohol

Consult your doctor

It is unknown whether Lenvima 4 mg Capsule interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Lenvima 4 mg Capsule is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Lenvima 4 mg Capsule . You should not become pregnant while you are taking Lenvima 4 mg Capsule for at least 3o days from the last dose of Lenvima 4 mg Capsule . Using effective birth control methods while on treatment with Lenvima 4 mg Capsule is suggested.

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Breast Feeding

Unsafe

Inform your doctor if you are intending to breastfeed. Breastfeeding should be avoided while getting Lenvima 4 mg Capsule and for one week from the final dosage of administration.

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Driving

Unsafe

Lenvima 4 mg Capsule is known to cause dizziness and visual disturbances. Hence, avoid driving and operating machines until you are completely alert.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Notify your doctor if you notice any of the following symptoms: yellowing of your skin or whites of your eyes, fleeing drowsy, abdominal pain, dark-coloured urine, easier bleeding or bruising than usual. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Lenvima 4 mg Capsule . It may cause kidney injury. Notify your doctor if you experience symptoms such as decreased urine output, blood in your urine, ankle edema, or lack of appetite.

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Children

Unsafe

Lenvima 4 mg Capsule is not recommended for use in children, as the safety and efficacy have not been established.

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Heart

Consult your doctor

Please consult your doctor before receiving Lenvima 4 mg Capsule if you have pre-existing heart problems. Your doctor will prescribe Lenvima 4 mg Capsule if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Lenvima 4 mg Capsule to geriatric patients. Your doctor will prescribe Lenvima 4 mg Capsule if the benefits outweigh the risks.

What if I have taken an overdose of Lenvima 4 mg Capsule

If you accidentally take more than your prescribed dose, seek emergency medical assistance, even if you do not feel sick. Bring your medicine packaging with you so the medical staff knows exactly what you took.

Diet & Lifestyle Advise

  • Monitor your blood pressure daily: Since high blood pressure is a very common side effect of this treatment, keep a daily log of your readings and share them with your healthcare team.
  • Prevent dehydration: Drink plenty of clear fluids such as water, broth, or electrolyte solutions throughout the day, especially if you experience loose stools or diarrhoea.
  • Care for your hands and feet: Apply thick, fragrance-free moisturising creams to your palms and soles daily to prevent redness, pain, or peeling skin (hand-foot syndrome).
  • Eat smaller, frequent meals: If you experience nausea or a loss of appetite, try eating five or six small, nutrient-rich meals a day instead of three large ones to maintain your strength.
  • Manage fatigue with planned rest: Keep a regular sleep schedule and plan short rest periods during the day, balancing them with light activities like short walks if you feel up to it.
health query

Have a query?

How Soon It Starts Working

The time required for Lenvima 4 mg Capsule to start to work: The time required for Lenvima 4 mg Capsule to show its action is not clinically established. The time for which the effects of Lenvima 4 mg Capsule last: The duration of action for Lenvima 4 mg Capsule is not clinically established.

What if you forget to take Lenvima 4 mg Capsule

If you miss a dose and your next scheduled dose is more than 12 hours away, take the missed dose as soon as you remember. If your next dose is less than 12 hours away, skip the missed dose entirely and take your next dose at your usual scheduled time. Do not take a double dose to make up for a missed one.

Storage

•Store the capsules at room temperature, between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Check the blister packaging: Always inspect your medicine card before taking a capsule; do not use it if the foil is broken, torn, or damaged.
  • Inform surgeons and dentists: This medicine can severely affect wound healing. Tell your dentist or surgeon you are taking it well in advance of any planned medical or dental procedures, as you may need to stop taking it temporarily.
  • Do not breastfeed: Do not breastfeed during treatment and for at least one week after your final dose, as the medicine may pass into breast milk and harm your baby.
    Use highly effective birth control: Both men and women must use reliable contraception during treatment and for at least 30 days after the last dose to prevent pregnancy.
  • Watch for severe stomach pain: Seek immediate medical attention if you experience sudden, severe stomach pain, as this medicine can cause rare but dangerous tears in the wall of your stomach or intestines.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that affect heart rhythm: Medicines that can change the heart's rhythm, such as anti-arrhythmic medicines or certain antibiotics, may increase the risk of serious heart rhythm problems when taken with this medicine.
  • Medicines that affect liver enzymes: Some medicines can change how your body processes it, which may make it less effective or increase the risk of side effects. Tell your doctor about all prescription medicines, over-the-counter medicines, and herbal supplements you are taking before starting treatment.
LenvatinibSparfloxacin
Critical
LenvatinibMesoridazine
Critical

Drug-Drug Interactions

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LenvatinibSparfloxacin
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Sparfloxacin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenvima 4 mg Capsule and Sparfloxacin is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibMesoridazine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule with Mesoridazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Lenvima 4 mg Capsule and mesoridazine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LenvatinibPimozide
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Coadministration of Lenvima 4 mg Capsule with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibSaquinavir
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibZiprasidone
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Ziprasidone together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Ziprasidone together is not recomended as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibGrepafloxacin
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Coadministration of grepafloxacin and Lenvima 4 mg Capsule can increase the risk irregular heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Grepafloxacin together is not recommended as it can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
LenvatinibHalofantrine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Halofantrine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Halofantrine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibThioridazine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Thioridazine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenvima 4 mg Capsule and Thioridazine is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibToremifene
Severe
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Toremifene together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Lenvima 4 mg Capsule and Toremifene can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience severe or long-lasting diarrhea or vomiting, sudden dizziness or fainting, trouble breathing, or a fluttering feeling in your chest. Do not stop using any medications without talking to a doctor.
LenvatinibLomitapide
Severe
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule with lomitapide may increase the risk of liver problems.

How to manage the interaction:
Taking Lenvima 4 mg Capsule with Lomitapide together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, bleeding, abdominal pain, dark urine, or liver damage. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it may increase the amount of medicine in your blood and raise the risk of side effects. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Lenvima 4 mg Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer and Endometrial cancer.
Lenvima 4 mg Capsule contains Lenvatinib, which works by inhibiting the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
It is advised not to miss any dose of medicine. If you miss it, take the medicine as soon as you remember. However, if it is time for your next dose, avoid taking the missed dose and do not double the dose.
No, you must swallow the capsules whole. If you have difficulty swallowing them, do not open or crush them yourself. Talk to your doctor or pharmacist for approved methods to dissolve the capsules in liquid safely.
If you vomit after taking your daily dose, do not take an extra capsule to replace it. Simply wait and take your next dose at your regularly scheduled time the following day. Talk to your doctor if you experience persistent vomiting.
Yes, high blood pressure is a very common and expected side effect of this medication. Your doctor will monitor your blood pressure closely and will likely prescribe medication to help control it during your treatment.
It is highly recommended to avoid or limit alcohol during treatment. Alcohol can increase your risk of dehydration, liver strain, and stomach irritation, which can make side effects more severe. Talk to your doctor or pharmacist for personalised advice.
This medicine is not a cure, but it is highly effective at slowing down or stopping the progression of certain advanced cancers. It helps manage the disease and can extend your active, stable days. Talk to your doctor to discuss your realistic treatment goals.
Yes, this medication can increase your risk of serious bleeding. You should contact your healthcare provider immediately if you notice severe nosebleeds, blood in your urine or stool, or if you cough up blood.
A sudden, severe headache can indicate a dangerous rise in blood pressure or a rare but serious brain condition. Measure your blood pressure right away and contact your doctor or seek emergency medical help immediately.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. MedlinePlus. A615015 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  2. DrugBank Online. Db09078 Clinical & Chemical Summary. Edmonton, AB: DrugBank; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Lenvatinib Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 206947S021Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Tasigna (nilotinib) Capsules. HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. [Accessed on 01 May 2025]Check here
  6. Tasigna Capsules - Patient Information Leaflet (PIL) - (emc) - 6251 [Internet]. Medicines.org.uk. 2024 [Accessed on 2025 May 1]Check here

Country of origin

INDIA

Manufacturer/Marketer address

1st Floor, B Wing,Marwah Centre, Krishanlal Marwah Marg, Andheri ( East ), Mumbai - 400072, India
Other Info - LEN0091
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