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  3. Lenvima 4 mg Capsule 10's

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Lenvima 4 mg Capsule 10's, Pack of 10 CAPSULES
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Lenvima 4 mg Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer, and Endometrial cancer. It contains Lenvatinib, an anticancer medication that works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells. This medicine is known to cause embryo-fetal toxicity, so it is not recommended for use in pregnancy and breastfeeding.

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Composition :

LENVATINIB-4MG

Manufacturer/Marketer :

Eisai Pharmaceuticals India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lenvima 4 mg Capsule

Lenvima 4 mg Capsule is an anti-cancer medicine used in the treatment of various types of cancers. Cancer is a disease caused by the abnormal growth of cells that divide uncontrollably. This medicine is used in treating hepatocellular carcinoma as a first-line therapy, differentiated thyroid cancer in patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory, advanced renal cell carcinoma in combination with pembrolizumab, and advanced endometrial cancer in combination with pembrolizumab.

Lenvima 4 mg Capsule contains Lenvatinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Lenvima 4 mg Capsule may cause certain side effects such as diarrhoea, decreased appetite, nausea, vomiting, tiredness, itching, rash, headache, cough, abdominal pain, hoarseness, and dizziness. Inform your doctor if any of these side effects bother you. Lenvima 4 mg Capsule should be taken as prescribed by your doctor. Do not take more than the recommended dose of medicine.

If you are allergic to Lenvima 4 mg Capsule or its components, inform your doctor. Before taking Lenvima 4 mg Capsule , inform your doctor if you have/had liver or kidney disease, calcium deficiency, heart problems, increased blood pressure, seizures, bleeding disorders, vision problems, and a history of blood clots. This medicine is known to cause embryo-fetal toxicity. It is not recommended for use in pregnancy and breastfeeding.

Uses of Lenvima 4 mg Capsule

Lenvima 4 mg Capsule is used in the treatment of Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer and Endometrial cancer. The detailed uses of Lenvima 4 mg Capsule are as follows:

  • Thyroid cancer: Lenvima 4 mg Capsule is used for treatment of specifically differentiated thyroid cancer.
  • Kidney cancer (renal cell carcinoma): Lenvima 4 mg Capsule is often used in combination with everolimus when other treatments have failed.
  • Endometrial cancer: Lenvima 4 mg Capsule is used with pembrolizumab for advanced or recurrent cases that can’t be treated with surgery or radiation.
  • Liver cancer (hepatocellular carcinoma): Lenvima 4 mg Capsule is used for the treatment of liver cancer.

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Directions for Use

  • Lenvima 4 mg Capsule can be taken with or without food.
  • Take Lenvima 4 mg Capsule once daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow Lenvima 4 mg Capsule as a whole with a glass of water.
  • Do not crush, chew, open, or split it.

Medicinal Benefits

Lenvima 4 mg Capsule contains Lenvatinib, which is used in treating different types of cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Lenvima 4 mg Capsule stops the body's production, spread and growth of cancerous cells.

How Lenvima 4 mg Capsule Works

Lenvima 4 mg Capsule contains Lenvatinib, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lenvima 4 mg Capsule out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Lenvima 4 mg Capsule
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Lenvima 4 mg Capsule

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Lenvima 4 mg Capsule or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

To treat your condition effectually, continue taking Lenvima 4 mg Capsule for the period that your doctor has prescribed. Avoid taking Lenvima 4 mg Capsule if you are allergic to it or any other components present in it. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, stroke, blood or bleeding disorders, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause visual disturbances. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established. Lenvima 4 mg Capsule may cause hypertension, thrombotic events, hemorrhagic events, hypothyroidism, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), elevated liver enzymes, kidney impairment, hypocalcemia, wound healing problems, and osteonecrosis in some patients. Hence, inform your doctor about your complete medication and medical history before taking Lenvima 4 mg Capsule .

Drug-Drug Interactions

verifiedApollotooltip
LenvatinibSparfloxacin
Critical
LenvatinibGrepafloxacin
Critical

Drug-Drug Interactions

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LenvatinibSparfloxacin
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Sparfloxacin together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenvima 4 mg Capsule and Sparfloxacin is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibGrepafloxacin
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Coadministration of grepafloxacin and Lenvima 4 mg Capsule can increase the risk irregular heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Grepafloxacin together is not recommended as it can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop taking any medications without consulting a doctor.
LenvatinibMesoridazine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule with Mesoridazine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Lenvima 4 mg Capsule and mesoridazine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LenvatinibHalofantrine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Halofantrine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Halofantrine together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibPimozide
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Coadministration of Lenvima 4 mg Capsule with Pimozide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibZiprasidone
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Ziprasidone together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Ziprasidone together is not recomended as it can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibThioridazine
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Thioridazine together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Using Lenvima 4 mg Capsule and Thioridazine is not recommended, but they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibSaquinavir
Critical
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using Lenvima 4 mg Capsule and Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LenvatinibDisopyramide
Severe
How does the drug interact with Lenvima 4 mg Capsule:
Taking Lenvima 4 mg Capsule and disopyramide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Co-administration of Lenvima 4 mg Capsule with disopyramide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath, severe or long-lasting diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
LenvatinibPanobinostat
Severe
How does the drug interact with Lenvima 4 mg Capsule:
Coadministration of panobinostat with Lenvima 4 mg Capsule can increase the risk of of an irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Lenvima 4 mg Capsule and Panobinostat, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Lenvima 4 mg Capsule Substitute

Substitutes safety advice
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Alcohol

Consult your doctor

It is unknown whether Lenvima 4 mg Capsule interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Lenvima 4 mg Capsule is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Lenvima 4 mg Capsule . You should not become pregnant while you are taking Lenvima 4 mg Capsule for at least 3o days from the last dose of Lenvima 4 mg Capsule . Using effective birth control methods while on treatment with Lenvima 4 mg Capsule is suggested.

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Breast Feeding

Unsafe

Inform your doctor if you are intending to breastfeed. Breastfeeding should be avoided while getting Lenvima 4 mg Capsule and for one week from the final dosage of administration.

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Driving

Unsafe

Lenvima 4 mg Capsule is known to cause dizziness and visual disturbances. Hence, avoid driving and operating machines until you are completely alert.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Notify your doctor if you notice any of the following symptoms: yellowing of your skin or whites of your eyes, fleeing drowsy, abdominal pain, dark-coloured urine, easier bleeding or bruising than usual. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Lenvima 4 mg Capsule . It may cause kidney injury. Notify your doctor if you experience symptoms such as decreased urine output, blood in your urine, ankle edema, or lack of appetite.

bannner image

Children

Unsafe

Lenvima 4 mg Capsule is not recommended for use in children, as the safety and efficacy have not been established.

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Heart

Please consult your doctor before receiving Lenvima 4 mg Capsule if you have pre-existing heart problems. Your doctor will prescribe Lenvima 4 mg Capsule if the benefits outweigh the risks.

bannner image

Geriatrics

Consult your doctor

Please consult a doctor before administering Lenvima 4 mg Capsule to geriatric patients. Your doctor will prescribe Lenvima 4 mg Capsule if the benefits outweigh the risks.

FAQs

Lenvima 4 mg Capsule is used to treat Renal Cell Carcinoma, Hepatocellular carcinoma, Differentiated thyroid cancer and Endometrial cancer.

Lenvima 4 mg Capsule contains Lenvatinib, which works by inhibiting the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

It is advised not to miss any dose of medicine. If you miss it, take the medicine as soon as you remember. However, if it is time for your next dose, avoid taking the missed dose and do not double the dose.

Country of origin

INDIA

Manufacturer/Marketer address

1st Floor, B Wing,Marwah Centre, Krishanlal Marwah Marg, Andheri ( East ), Mumbai - 400072, India
Other Info - LEN0091

Disclaimer

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://medlineplus.gov/druginfo/meds/a615015.html
  2. https://www.lenvima.com/
  3. https://go.drugbank.com/drugs/DB09078
  4. https://www.drugs.com/lenvatinib.html
  5. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/206947s021lbl.pdf

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