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  3. LEOQUIN 500EC TABLET

LEOQUIN 500EC TABLET, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Leoquin EC 500 mg Tablet is used to treat malaria. It provides a degree of protection against malaria for individuals travelling to areas where malaria cases are prevalent. It is effective against Plasmodium vivax, Plasmodium ovale, and Plasmodium malariae. It is not effective against Plasmodium falciparum. It is occasionally used to reduce the symptoms of rheumatoid arthritis and to treat conditions such as systemic and discoid lupus erythematosus, sarcoidosis, and porphyria cutanea tarda. Leoquin EC 500 mg Tablet targets malaria parasites inside red blood cells and disrupts their process of breaking down haemoglobin. This leads to the accumulation of toxic substances, which destroy the parasites and clear the infection. The common side effects of Leoquin EC 500 mg Tablet include vomiting, nausea, hair loss, stomach pain, stomach upset, loss of appetite, diarrhoea and itchy skin. Most of these side effects are temporary and gradually resolve over time. However, please consult the doctor if any of these side effects persist or worsen.

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Composition :

CHLOROQUINE-500MG

Manufacturer/Marketer :

Leo Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Leoquin EC 500 mg Tablet

Leoquin EC 500 mg Tablet belongs to the class of medications called 'quinolines', primarily used to treat malaria. It is occasionally used to reduce the symptoms of rheumatoid arthritis and to treat conditions such as systemic and discoid lupus erythematosus, sarcoidosis, and porphyria cutanea tarda. Malaria is a life-threatening disease caused by the Plasmodium parasites, which are transmitted through the bite of infected female Anopheles mosquitoes. It typically causes high fever, chills, sweating, and body aches. Without timely treatment, malaria can lead to serious complications, including organ failure and death.

Leoquin EC 500 mg Tablet contains chloroquine. Leoquin EC 500 mg Tablet targets malaria parasites inside red blood cells and disrupts their process of breaking down haemoglobin. This leads to the accumulation of toxic substances, which destroy the parasites and clear the infection.

The dose and duration of treatment with Leoquin EC 500 mg Tablet can be determined by the doctor based on your medical condition. The common side effects of Leoquin EC 500 mg Tablet include vomiting, nausea, hair loss, stomach pain, stomach upset, loss of appetite, diarrhoea and itchy skin. Most of these side effects are temporary and gradually resolve over time. However, consult the doctor if any of these side effects persist or worsen.

Do not take Leoquin EC 500 mg Tablet if you are allergic to Leoquin EC 500 mg Tablet or any of its contents. Inform your doctor if you have or have ever had any of the following conditions such as liver or heart disease, a prolonged QT interval (a rare heart condition that can cause irregular heartbeat, fainting, or sudden death), irregular heartbeat, low magnesium or potassium levels, G6PD deficiency (a hereditary blood disorder), hearing issues, porphyria or other blood disorders, psoriasis, seizures, vision problems, diabetes, or muscle weakness in the knees and ankles. Also, let your doctor know if you consume large amounts of alcohol or if you have experienced vision changes while taking Leoquin EC 500 mg Tablet . Inform your doctor if you are pregnant or breastfeeding before taking Leoquin EC 500 mg Tablet . Leoquin EC 500 mg Tablet should be used for children only if prescribed by the doctor.

Uses of Leoquin EC 500 mg Tablet

Leoquin EC 500 mg Tablet is used to treat various infections and autoimmune conditions. The detailed uses of Leoquin EC 500 mg Tablet are as follows:<br/> • Treatment of Malaria: Leoquin EC 500 mg Tablet is commonly used to prevent and treat malaria caused by Plasmodium parasites sensitive to this drug.<br/> • Manages Intestinal Amoebiasis: It is used as an adjunct therapy in the treatment of intestinal amoebiasis to help clear the infection.<br/> • Relieves Rheumatoid Arthritis Symptoms: Leoquin EC 500 mg Tablet helps reduce joint pain, swelling, and stiffness in individuals with rheumatoid arthritis.<br/> • Treatment of Lupus: It is effective in managing systemic and discoid lupus erythematosus by controlling inflammation and autoimmune activity.<br/> • Used in Sarcoidosis: Leoquin EC 500 mg Tablet may be used to treat sarcoidosis by reducing inflammation in affected organs.<br/> • Manages Porphyria Cutanea Tarda: It is also used in the treatment of porphyria cutanea tarda, a disorder that affects the skin and liver.<br/>

Directions for Use

  • Leoquin EC 500 mg Tablet can be taken with food to prevent stomach upset, or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Leoquin EC 500 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

Leoquin EC 500 mg Tablet belongs to the class of medications called 'quinolines', primarily used to treat malaria. It is occasionally used to reduce the symptoms of rheumatoid arthritis and to treat conditions such as systemic and discoid lupus erythematosus, sarcoidosis, and porphyria cutanea tarda. Leoquin EC 500 mg Tablet targets malaria parasites inside red blood cells and disrupts their process of breaking down haemoglobin. This leads to the accumulation of toxic substances, which destroy the parasites and clear the infection.

How Leoquin EC 500 mg Tablet Works

Leoquin EC 500 mg Tablet contains chloroquine. Leoquin EC 500 mg Tablet targets malaria parasites inside red blood cells and disrupts their process of breaking down haemoglobin. This leads to the accumulation of toxic substances, which destroy the parasites and clear the infection.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Leoquin EC 500 mg Tablet

Do not exceed the prescribed dose of Leoquin EC 500 mg Tablet , as an overdose may lead to symptoms such as vomiting, nausea, drowsiness, headache, visual disturbances, convulsions, or irregular heartbeat. If you suspect you have taken an overdose, seek medical attention immediately.

Drug Warnings

Do not take Leoquin EC 500 mg Tablet if you are allergic to Leoquin EC 500 mg Tablet or any of its contents. Inform your doctor if you have or have ever had any of the following conditions such as liver or heart disease, a prolonged QT interval (a rare heart condition that can cause irregular heartbeat, fainting, or sudden death), irregular heartbeat, low magnesium or potassium levels, G6PD deficiency (a hereditary blood disorder), hearing issues, porphyria or other blood disorders, psoriasis, seizures, vision problems, diabetes, or muscle weakness in the knees and ankles. Also, let your doctor know if you consume large amounts of alcohol or if you have experienced vision changes while taking Leoquin EC 500 mg Tablet . Inform your doctor if you are pregnant or breastfeeding before taking Leoquin EC 500 mg Tablet . It is used for children only if advised by the doctor. It is not recommended for children below 6 years of age.

Drug-Drug Interactions

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ChloroquineCisapride
Critical
ChloroquineAuranofin
Critical

Drug-Drug Interactions

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ChloroquineCisapride
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Leoquin 500ec Tablet with Cisapride can increase the risk of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Cisapride is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately.
ChloroquineAuranofin
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Auranofin with Leoquin 500ec Tablet can increase the risk of blood disorders and other severe side effects

How to manage the interaction:
Taking Auranofin with Leoquin 500ec Tablet is not recommended, as it may lead to an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineSaquinavir
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using saquinavir together with Leoquin 500ec Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Saquinavir is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquinePazopanib
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking pazopanib with Leoquin 500ec Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazopanib with Leoquin 500ec Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
ChloroquineLevacetylmethadol
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Levacetylmethadol together with Leoquin 500ec Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Levacetylmethadol is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineZiprasidone
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Leoquin 500ec Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Ziprasidone is not recommended, it can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, drowsiness, confusion, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
ChloroquinePimozide
Critical
How does the drug interact with Leoquin 500ec Tablet:
When Pimozide and Leoquin 500ec Tablet are taken together, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Pimozide is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineThioridazine
Critical
How does the drug interact with Leoquin 500ec Tablet:
When Thioridazine and Leoquin 500ec Tablet are taken together, can increase the chance of a serious abnormal heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Thioridazine is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ChloroquineSparfloxacin
Critical
How does the drug interact with Leoquin 500ec Tablet:
Using Leoquin 500ec Tablet together with sparfloxacin can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Leoquin 500ec Tablet with Sparfloxacin is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.
ChloroquineMesoridazine
Critical
How does the drug interact with Leoquin 500ec Tablet:
Taking Leoquin 500ec Tablet with Mesoridazine together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Leoquin 500ec Tablet with Mesoridazine is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Always take Leoquin EC 500 mg Tablet with meals for reduced gastric irritation.
  • Adequate nutrition is crucial for improving malaria-induced weakness.
  • It is essential to allow the patient to eat regularly in small amounts to help them tolerate the food. 
  • Increase fluid and protein intake to combat malaria-induced weight loss.
  • Proper rest and mosquito-free premises are essential for the patient to recover.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Leoquin EC 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Leoquin EC 500 mg Tablet may cause interaction with alcohol. Therefore, it is advised to avoid the consumption of alcohol while taking Leoquin EC 500 mg Tablet .

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Pregnancy

Caution

Please consult the doctor if you are pregnant before taking Leoquin EC 500 mg Tablet . The doctor may prescribe this medication only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Leoquin EC 500 mg Tablet should be used with caution during breastfeeding, and only after consulting a doctor, as it may pass into breast milk and potentially harm the nursing infant.

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Driving

Caution

Leoquin EC 500 mg Tablet may cause dizziness in some individuals. Therefore, avoid driving or operating heavy machinery until you know how it affects you.

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Liver

Caution

Leoquin EC 500 mg Tablet should be taken with caution if you have any history of liver diseases. Please consult the doctor before taking Leoquin EC 500 mg Tablet .

bannner image

Kidney

Caution

Leoquin EC 500 mg Tablet should be taken with caution if you have any history of kidney diseases. Please consult the doctor before taking Leoquin EC 500 mg Tablet .

bannner image

Children

Caution

Leoquin EC 500 mg Tablet should be given to children only if prescribed by the doctor. However, it should not be given to children under 6 years of age due to the risk of overdose and serious toxicity.

Have a query?

FAQs

Leoquin EC 500 mg Tablet is used to treat malaria. It is occasionally used to reduce the symptoms of rheumatoid arthritis and to treat conditions such as systemic and discoid lupus erythematosus, sarcoidosis, and porphyria cutanea tarda.

Leoquin EC 500 mg Tablet contains chloroquine. Leoquin EC 500 mg Tablet targets malaria parasites inside red blood cells and disrupts their process of breaking down haemoglobin. This leads to the accumulation of toxic substances, which destroy the parasites and clear the infection.

Leoquin EC 500 mg Tablet can be taken with antibiotics only if prescribed by the doctor. If you are taking ampicillin, ensure that you take it at least 2 hours before or 2 hours after taking Leoquin EC 500 mg Tablet .

No such effect has been reported yet. Always consult your doctor for the change of dose regimen or an alternative medicine if needed.

No such harmful interaction has been reported in patients who take this drug under strict doctors&#039; surveillance. However, some patients may experience eye (retinal) damage, which can cause a pounding heart. Therefore, patients taking Leoquin EC 500 mg Tablet are advised to consult a doctor and have regular check-ups periodically.

There may be a risk of hemolysis in patients with G6PD deficiency while using Leoquin EC 500 mg Tablet . Doctor&#039;s consultation is mandatory before you start this medication.

The common side effects of Leoquin EC 500 mg Tablet include vomiting, nausea, hair loss, stomach pain, stomach upset, loss of appetite, diarrhoea and itchy skin. Most of these side effects are temporary and gradually resolve over time. However, please consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

LEO Pharma A/S, Industriparken 55, DK-2750 Ballerup, Danmark
Other Info - LEO0018

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 22, 2025 | 8:49 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a682318.html
  2. https://www.webmd.com/drugs/2/drug-8633/chloroquine-oral/details
  3. https://dermnetnz.org/topics/chloroquine#:~:text=Children%20aged%20under%206%20years,excreted%20unchanged%20in%20the%20urine.
  4. https://www.drugs.com/mtm/chloroquine.html

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