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  3. Leuben 100 mg Injection 1's

Leuben 100 mg Injection 1's, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Leuben 100 mg Injection 1's is used to treat Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia. Leuben 100 mg Injection 1's contains Bendamustine; it works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medication is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

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Synonym :

BENDAMUSTINE HYDROCHLORIDE

Composition :

BENDAMUSTINE-100MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Leuben 100 mg Injection 1's

Leuben 100 mg Injection 1's belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Leuben 100 mg Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Leuben 100 mg Injection 1's may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Leuben 100 mg Injection 1's. Hence, do not self-administer.

Leuben 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Leuben 100 mg Injection 1's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Leuben 100 mg Injection 1's

Treatment of Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia

Directions for Use

A trained healthcare professional will administer Leuben 100 mg Injection 1's. Hence, do not self-administer. 

Medicinal Benefits

Leuben 100 mg Injection 1's contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

How Leuben 100 mg Injection 1's Works

Leuben 100 mg Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Leuben 100 mg Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.

What if I have taken an overdose of Leuben 100 mg Injection 1's

As Leuben 100 mg Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Leuben 100 mg Injection 1's may cause rapid, irregular, or pounding heartbeat.

Drug Warnings

Leuben 100 mg Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Leuben 100 mg Injection 1's may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Leuben 100 mg Injection 1's may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Leuben 100 mg Injection 1's is not recommended for use in children as the safety and efficacy are not established.

Drug-Drug Interactions

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BendamustineCladribine
Severe
BendamustineTofacitinib
Severe

Drug-Drug Interactions

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BendamustineCladribine
Severe
How does the drug interact with Leuben 100 mg Injection:
Combining Cladribine with Leuben 100 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Leuben 100 mg Injection and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineTofacitinib
Severe
How does the drug interact with Leuben 100 mg Injection:
Using tofacitinib together with Leuben 100 mg Injection may increase the risk of developing serious infections.

How to manage the interaction:
Taking Tofacitinib with Leuben 100 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
BendamustineBaricitinib
Severe
How does the drug interact with Leuben 100 mg Injection:
Combining Leuben 100 mg Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Leuben 100 mg Injection and Baricitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BendamustineClozapine
Severe
How does the drug interact with Leuben 100 mg Injection:
Combining Leuben 100 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Although there is a possible interaction between Leuben 100 mg Injection and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult your doctor immediately If you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without talking to a doctor.
BendamustineInfliximab
Severe
How does the drug interact with Leuben 100 mg Injection:
When Leuben 100 mg Injection is taken with Infliximab, it can cause the metabolism of Leuben 100 mg Injection to speed up. This can increase the risk of developing serious infections.

How to manage the interaction:
Taking Leuben 100 mg Injection with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Do not stop using any medications without talking to a doctor.
BendamustineLeflunomide
Severe
How does the drug interact with Leuben 100 mg Injection:
Combining Leuben 100 mg Injection with Leflunomide can increase the likelihood of negative side effects.

How to manage the interaction:
There may be a possibility of interaction between Leuben 100 mg Injection and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms - like an infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Leuben 100 mg Injection 1's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Leuben 100 mg Injection 1's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Leuben 100 mg Injection 1's. Use reliable methods of birth control while on treatment with Leuben 100 mg Injection 1's.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Leuben 100 mg Injection 1's. You should not breastfeed while on treatment with Leuben 100 mg Injection 1's.

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Driving

Not applicable

-

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Leuben 100 mg Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Leuben 100 mg Injection 1's is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Leuben 100 mg Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

bannner image

Children

Unsafe

Leuben 100 mg Injection 1's is not recommended for use in children as the safety and efficacy is not established.

Have a query?

FAQs

Leuben 100 mg Injection 1's is used to treat Non-Hodgkin’s disease and Chronic Lymphocytic Leukaemia.

Leuben 100 mg Injection 1's contains Bendamustine, which inhibits the DNA and RNA transcription essential for cancer cell growth.

Leuben 100 mg Injection 1's may cause reactivation of serious infections, myelosuppression, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Leuben 100 mg Injection 1's is safe when used as per the dose and duration advised by a doctor.

Leuben 100 mg Injection 1's has the vesicant (irritant) properties.

Yes, the use of Leuben 100 mg Injection 1's can cause hair loss and constipation as a side effect. This will gradually reduce over time and does not require any medical attention. However, please contact a doctor if this condition persists for longer or worsens.

Leuben 100 mg Injection 1's can cross the blood-brain barrier and can be utilized for treating cancers that have spread to the brain.

Leuben 100 mg Injection 1's may cause side effects such as diarrhoea, back pain, vomiting, stomach pain, cough, pain at the site of injection, fever, constipation, decreased blood pressure, rashes, and decreased weight. Please, contact a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

7-2-A2, Hetero Corporate Indl Estates, Sanath Nagar Hyderabad, 500 018
Other Info - LEU0147

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 9:32 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/022303lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a608034.html#
  3. https://reference.medscape.com/drug/bendeka-belrapzo-bendamustine-342133
  4. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/bendamustine
  5. https://www.bendeka.com/
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