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compositionComposition:LEUPRORELIN-3.75MG
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Prescription Medicine
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Leuren Depot 3.75 mg Combikit Injection 1's is used to treat prostate cancer in men, endometriosis & hormone-responsive breast cancer in women and premature puberty in children. It contains Leuprorelin which works by decreasing the levels of testosterone in men and oestrogen in women. It also inhibits the growth of the tumour or causes it to shrink. In some cases, this medicine may cause side effects such as pain, redness, swelling, or skin hardening at the injection site. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEUPRORELIN-3.75MG

Manufacturer/Marketer :

Eris Life Sciences Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Leuren Depot 3.75 mg Combikit Injection 1's

Leuren Depot 3.75 mg Combikit Injection 1's is a prescription injection used to treat advanced prostate cancer in men, endometriosis and uterine fibroids in women, and early puberty in children. It works by reducing the level of certain hormones in the body to manage these conditions. This medicine helps ease symptoms like pelvic pain, heavy menstrual bleeding, or bone pain associated with hormone-sensitive conditions.

This injection is given at regular intervals, which may range from once a month to once every few months depending on your treatment plan. It is crucial to receive every dose consistently and on schedule to keep your hormone levels stable. Because this is an injection, it does not depend on food intake, but adopting a balanced diet rich in calcium and vitamin D can help support your bone health during treatment.

Some people may experience mild side effects, such as hot flashes, sweating, tiredness, or mild irritation at the injection site. However, if you experience serious symptoms like severe bone pain, difficulty urinating, or sudden weakness in your legs, you must consult your doctor immediately.

Talk to your doctor before starting this medicine if you have a history of bone loss (osteoporosis), diabetes, heart problems, or a history of depression. Do not use this medicine if you are pregnant, planning to become pregnant, or have unexplained vaginal bleeding.

Certain medicines, such as those that affect your heart rhythm, can interact with this treatment, so always share your full medication list with your doctor. You should also discuss your use of alcohol and tobacco, as they can further weaken your bones during therapy. If you are breastfeeding or are an older adult, consult your doctor to ensure this medicine is safe for your specific situation.

Uses of Leuren Depot 3.75 mg Combikit Injection 1's

Leuren Depot 3.75 mg Combikit Injection 1's is prescribed to help manage hormone-sensitive conditions by reducing the production of certain hormones in the body. It may be used for:

  • Prostate Cancer: Helps slow or stop the growth of cancer cells by lowering testosterone levels in the body.
  • Endometriosis: Lowers estrogen levels to shrink abnormal uterine tissue growing outside the uterus, reducing pelvic pain and painful periods.
  • Uterine Fibroids: Shrinks non-cancerous growths in the uterus to help control heavy menstrual bleeding and pelvic pressure, often before a planned surgery.
  • Early Puberty (Central Precocious Puberty): Delays the onset of puberty in young children by temporarily pausing the release of sex hormones, allowing for normal physical development.

Key Benefits

Leuren Depot 3.75 mg Combikit Injection 1's is a gonadotropin-releasing hormone (GnRH) agonist that reduces the production of sex hormones. Depending on the condition being treated, it helps manage hormone-sensitive prostate cancer, endometriosis, uterine fibroids, or central precocious puberty.

  • Helps Manage Advanced Prostate Cancer: Lowers testosterone levels, which may slow the growth and progression of hormone-sensitive prostate cancer.
  • Relieves Endometriosis Symptoms: Reduces oestrogen levels, helping relieve pelvic pain and other symptoms associated with endometriosis.
  • Helps Manage Uterine Fibroids: May reduce heavy menstrual bleeding and temporarily shrink fibroids, improving symptoms and supporting pre-operative management when prescribed for this purpose.
  • Controls Early Puberty: In children with central precocious puberty, it suppresses premature sex hormone production, helping delay further pubertal development until a more appropriate age.
  • Improves Daily Comfort: By controlling hormone-related symptoms, it may help reduce pain, improve physical comfort, and support a better quality of life.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Leuren Depot 3.75 mg Combikit Injection 1's will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Leuren Depot 3.75 mg Combikit Injection 1's Works

Leuren Depot 3.75 mg Combikit Injection 1's contains leuprorelin, which belongs to a group of medicines known as gonadotropin-releasing hormone (GnRH) agonists. It works by targeting the pituitary gland in the brain. When you first start treatment, it causes a short-term rise in certain hormones. However, with continuous use, it safely signals the body to stop producing these hormones. In men, this leads to a significant decrease in testosterone levels, which hormone-sensitive prostate cancer cells need to grow. In women, it lowers oestrogen levels, which starves endometriosis tissue and uterine fibroids of the hormones they need to expand. In children, it temporarily pauses the hormones that trigger early puberty.
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Alcohol

Caution

Avoid or limit alcohol consumption with Leuren Depot 3.75 mg Combikit Injection 1's as it may increase the risk of bone density loss.

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Pregnancy

Unsafe

Leuren Depot 3.75 mg Combikit Injection 1's is not recommended for pregnant women as it may cause birth defects. Please consult a doctor if you are pregnant or planning for pregnancy.

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Breast Feeding

Unsafe

Leuren Depot 3.75 mg Combikit Injection 1's is contraindicated in breastfeeding women. Please consult a doctor if you are breastfeeding.

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Driving

Caution

Leuren Depot 3.75 mg Combikit Injection 1's may cause dizziness, drowsiness or disturbance in the vision. Therefore, avoid driving if you experience any of these symptoms after taking Leuren Depot 3.75 mg Combikit Injection 1's.

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Liver

Caution

Take Leuren Depot 3.75 mg Combikit Injection 1's with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

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Kidney

Caution

Take Leuren Depot 3.75 mg Combikit Injection 1's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Caution

Leuren Depot 3.75 mg Combikit Injection 1's should be used for children under the supervision of a paediatric endocrinologist.

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Heart

Caution

Leuren Depot 3.75 mg Combikit Injection 1's should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Leuren Depot 3.75 mg Combikit Injection 1's.

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Geriatrics

Caution

Leuren Depot 3.75 mg Combikit Injection 1's should be administered with caution to elderly patients due to an increased risk of side effects. Please consult your doctor before receiving Leuren Depot 3.75 mg Combikit Injection 1's.

What if I have taken an overdose of Leuren Depot 3.75 mg Combikit Injection 1's

Since this medication is typically injected by a healthcare professional, an overdose is highly unlikely. However, if you suspect an overdose or experience severe symptoms after an injection, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Boost Calcium and Vitamin D: Since this medicine can lower bone mineral density, eat calcium-rich foods like leafy greens, dairy, or fortified plant milks, and talk to your doctor about vitamin D supplements.
  • Engage in Weight-Bearing Exercise: Activities like walking, jogging, or light strength training help keep your bones strong and reduce the risk of bone loss during treatment.
  • Manage Hot Flashes: Wear layered, breathable clothing made of natural fibres, and avoid triggers like spicy foods, caffeine, and hot drinks.
  • Stay Hydrated: Drink plenty of water throughout the day to help manage dry skin and support overall kidney health.
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How Soon It Starts Working

The time required for Leuren Depot 3.75 mg Combikit Injection 1's to start to work: Leuren Depot 3.75 mg Combikit Injection 1's ideally shows its action within 4 to 5 hours after administration. The time for which the effects of Leuren Depot 3.75 mg Combikit Injection 1's last: The effect of Leuren Depot 3.75 mg Combikit Injection 1's lasts for 18 hours.

What if you forget to take Leuren Depot 3.75 mg Combikit Injection 1's

If you miss an appointment for your injection, contact your healthcare provider immediately to reschedule. Keeping a consistent schedule is vital to maintaining the therapeutic effects of the medicine.

Storage

•Keep the medication in its original carton to protect it from light and moisture.•Always keep it out of the reach and sight of children and pets.

Drug Warnings

  • Inspect the Medicine Before Use: Before administration, the healthcare professional should check the prepared injection and avoid using it if there is unexpected discolouration, cloudiness, or visible particles.
  • Rotate Injection Sites: If repeated injections are required, rotate the injection site as recommended to help reduce local irritation or skin changes.
  • Use a New Needle Each Time: Never reuse needles or syringes. Always use sterile, single-use injection equipment and dispose of it safely after use.
  • Monitor Blood Sugar if Needed: If you have diabetes or are at risk of high blood sugar, your doctor may recommend regular monitoring during treatment.
  • Attend Regular Follow-Ups: Keep all scheduled appointments and complete recommended blood tests and bone health assessments so your doctor can monitor your response to treatment and overall health.

Drug-Drug Interactions

verifiedApollotooltip

Leuren Depot 3.75 mg Combikit Injection 1's may interact with certain medicines and affect how they work or increase the risk of side effects. Inform your doctor if you are taking any of the following:

  • Heart Rhythm Medications (such as amiodarone, quinidine, or sotalol): Combining these with Leuren Depot 3.75 mg Combikit Injection 1's may increase the risk of serious irregular heart rhythms.
  • Other Hormone-Based Therapies: May interfere with the action of this medicine or reduce its effectiveness.
LeuprorelinEliglustat
Critical
LeuprorelinSaquinavir
Critical

Drug-Drug Interactions

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LeuprorelinEliglustat
Critical
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking Leuren Depot 3.75 mg Combikit Injection with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Leuren Depot 3.75 mg Combikit Injection with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinVandetanib
Critical
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking Leuren Depot 3.75 mg Combikit Injection with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Coadministration of Leuren Depot 3.75 mg Combikit Injection and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuren Depot 3.75 mg Combikit Injection:
Taking Leuren Depot 3.75 mg Combikit Injection with Fingolimod can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuren Depot 3.75 mg Combikit Injection and Fingolimod together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or shortness of breath, contact your doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No clinically significant food interactions are known with Leuren Depot 3.75 mg Combikit Injection 1's when used as directed. 

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[GONADOTROPHIN-RELEASING HORMONE AGONIST]

FAQs

Leuren Depot 3.75 mg Combikit Injection 1's contains Leuprorelin, a synthetic hormone that works similar to the natural hormone, gonadotropin-releasing hormone (GnRH) by acting on the pituitary gland and decreases the levels of testosterone in men and oestrogen in women. Thereby, Leuren Depot 3.75 mg Combikit Injection 1's is used in the treatment of prostate cancer by inhibiting the growth of tumour or causing it to shrink.
Leuren Depot 3.75 mg Combikit Injection 1's may stop menstrual periods. However, after 7 to 12 weeks of taking the final dose of injection, periods will resume. Please consult a doctor if you have any concerns regarding this.
Leuren Depot 3.75 mg Combikit Injection 1's should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, it is advised to regularly monitor blood sugar levels while taking Leuren Depot 3.75 mg Combikit Injection 1's and inform your doctor if you have diabetes before taking Leuren Depot 3.75 mg Combikit Injection 1's.
Leuren Depot 3.75 mg Combikit Injection 1's may be used to treat endometriosis (tissue lining the uterus known as endometrium grows outside the uterus). Leuren Depot 3.75 mg Combikit Injection 1's reduces oestrogen levels and causes menopause temporarily. Thereby, shrink the tissue outside the uterus or stop its growth.
Leuren Depot 3.75 mg Combikit Injection 1's may decrease bone density, especially when used for the treatment of premature puberty in children. Therefore, regular monitoring of bone density is recommended while taking Leuren Depot 3.75 mg Combikit Injection 1's.
Leuren Depot 3.75 mg Combikit Injection 1's should be used with extreme caution in patients suffering from depression as it may worsen the condition. Therefore, inform your doctor if you have any history of depression before taking Leuren Depot 3.75 mg Combikit Injection 1's.
No, Leuren Depot 3.75 mg Combikit Injection 1's is not a chemotherapy medicine. It is a synthetic hormone which belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists.
Yes, Leuren Depot 3.75 mg Combikit Injection 1's is a hormonal medicine that works by altering reproductive hormones. It is not recommended for use during pregnancy as it can harm the fetus and may lead to abortion. If you are pregnant or planning to become pregnant, please inform your doctor.
The common side effects of Leuren Depot 3.75 mg Combikit Injection 1's are pain, redness, swelling, or skin hardening at the injection site, muscle weakness, bone pain, inability to have an erection, breast tenderness, headache, vaginal dryness, changes in breast size, acne, or mood swings. If any of these side effects persist or worsen, please consult your doctor.
Leuren Depot 3.75 mg Combikit Injection 1's belongs to the class of synthetic hormones used in the treatment of prostate cancer in men, endometriosis, and hormone-responsive breast cancer in women. Also, it is used to treat premature puberty in children.
No, Leuren Depot 3.75 mg Combikit Injection 1's does not cure prostate cancer, but it helps slow down or stop the growth of cancer cells by lowering hormone levels in your body. This can help manage your symptoms and control the disease. Talk to your doctor to learn more about your long-term treatment plan.
While there is no direct chemical reaction between this medicine and alcohol, drinking alcohol can increase your risk of bone loss and worsen hot flashes. It is best to limit your alcohol intake during treatment. Talk to your doctor or pharmacist about how much alcohol is safe for you.
You should seek immediate medical attention if you experience these symptoms, especially during the first few weeks of treatment. These can be signs of spinal cord compression or urinary blockage, which require urgent medical evaluation. Talk to your doctor right away if you notice these changes.
Some people may feel dizzy, tired, or experience blurred vision after receiving this injection. If you experience these side effects, do not drive, operate machinery, or perform tasks that require alertness until you feel safe to do so. Talk to your doctor if these symptoms persist.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

8Th Floor, Commerce House Iv, Prahladnagar, Ahmedabad 380015 Gujarat, India.
Other Info - LEU0213
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