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Leuxa Depot 11.25 mg Injection 1's is a gonadotropin-releasing hormone medicine used in the treatment of prostate cancer, endometriosis and precocious puberty. This medicine works by inhibiting the synthesis of the testosterone in men and oestrogen in women, thereby lowers the hormone levels. Common side effects include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach and injection site reaction.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Hetero Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Leuxa Depot 11.25 mg Injection 1's

Leuxa Depot 11.25 mg Injection 1's is a prescription injection used to manage advanced prostate cancer in men, endometriosis or uterine fibroids in women, and early-onset puberty in children. It works as a hormone-regulating therapy to help slow down or stop the growth of abnormal tissues that depend on certain hormones to thrive.

This injection is given at highly regular intervals, which may range from once a month to once every several months depending on your treatment plan. Because Leuxa Depot 11.25 mg Injection 1's is administered as an injection, it can be taken without regard to food, but staying consistent with your treatment schedule is vital to keep your hormone levels stable. To support your body during treatment, incorporating a diet rich in calcium and engaging in regular weight-bearing exercise can help maintain your bone health.

Common side effects of this medicine include hot flashes, increased sweating, and mild pain or redness at the injection site. However, you must contact your doctor immediately if you experience severe symptoms, such as sudden chest pain, difficulty breathing, or trouble passing urine.

Before you begin taking Leuxa Depot 11.25 mg Injection 1's, tell your doctor if you have a history of osteoporosis, heart disease, diabetes, or depression. You must not take this medicine if you are pregnant, planning to become pregnant, or have unexplained vaginal bleeding.

This medication can interact with other drugs that affect your heart rhythm, potentially increasing the risk of serious heart issues. Additionally, smoking or drinking alcohol during your treatment can accelerate bone loss, which is why lifestyle modifications are highly recommended. Leuxa Depot 11.25 mg Injection 1's may harm an unborn baby.

Do not use this medicine if you are pregnant or planning to become pregnant, and speak to your doctor about suitable non-hormonal contraception before and during treatment. Always consult your doctor if you are breastfeeding or belong to specific user groups, such as elderly patients, to ensure this medicine is safe for your situation. 

Uses of Leuxa Depot 11.25 mg Injection 1's

Leuxa Depot 11.25 mg Injection 1's is used to treat hormone-dependent conditions and disorders caused by early hormone production. The detailed uses of Leuxa Depot 11.25 mg Injection 1's are as follows:

  • Advanced prostate cancer: It helps slow down the growth and spread of cancer cells by significantly lowering testosterone levels in the body.
  • Endometriosis: It reduces estrogen levels to shrink painful endometrial tissue that grows outside the uterus, helping to relieve severe pelvic pain.
  • Uterine fibroids: It shrinks these non-cancerous uterine tumours and reduces heavy menstrual bleeding, often as a preparatory step before surgery.
  • Central precocious puberty: It temporarily pauses the early release of sex hormones in children, delaying early-onset puberty

Key Benefits

Leuxa Depot 11.25 mg Injection 1's helps manage hormone-dependent conditions by reducing the production of certain hormones in the body. This medicine provides several important health benefits:

  • Relieves Symptoms of Advanced Prostate Cancer: For men managing advanced prostate cancer, Leuxa Depot 11.25 mg Injection 1's provides significant relief from disease-related symptoms. By lowering testosterone levels, it helps reduce bone pain and urinary difficulties, making daily activities much more comfortable.
  • Reduces Endometriosis Symptoms: For women suffering from endometriosis, this treatment helps shrink painful lesions and reduce chronic pelvic pain. This brings real-world relief, allowing for pain-free movement and a faster return to normal daily routines without debilitating cramps.
  • Controls Heavy Menstrual Bleeding: In cases of uterine fibroids, the medicine helps control heavy menstrual bleeding. By reducing blood loss, it helps prevent fatigue and anaemia, which can significantly improve your overall energy levels and physical well-being.
  • Supports Normal Growth and Development: In children with central precocious puberty, Leuxa Depot 11.25 mg Injection 1's helps pause early hormone production, allowing growth and physical development to occur at a more appropriate age. This can improve adult height potential and support emotional and social well-being.

Directions for Use

  • Follow your doctor's recommendations on the dosage and timing of this medication to achieve optimal results.
  • Leuxa Depot 11.25 mg Injection 1's will be administered by a healthcare professional.
  • Do not self-administer.

How Leuxa Depot 11.25 mg Injection 1's Works

Leuxa Depot 11.25 mg Injection 1's contains Leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist (a type of medicine that acts like a natural hormone to reduce the production of sex hormones in the body). It works by acting on the pituitary gland in the brain to temporarily stop the signals that tell the testicles or ovaries to produce testosterone or oestrogen. Although hormone levels may briefly increase when treatment begins, continuous use lowers testosterone (in men) or oestrogen (in women) to very low levels. By reducing these hormone levels, Leuprolide acetate helps slow the growth of hormone-sensitive tissues, such as prostate cancer cells or patches of endometrial tissue growing outside the uterus, and relieves associated symptoms.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Leuxa Depot 11.25 mg Injection 1's to avoid unpleasant side-effects. Alcohol intake, along with Leuxa Depot 11.25 mg Injection 1's, may cause increased dizziness.

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Pregnancy

Unsafe

Leuxa Depot 11.25 mg Injection 1's is a pregnancy category X drug. Leuxa Depot 11.25 mg Injection 1's should not be used during pregnancy because it causes harm to the fetus (newborn baby). Women of childbearing potential must use an effective method of contraception while taking Leuxa Depot 11.25 mg Injection 1's. Please consult your doctor if you have any concerns regarding this.

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Breast Feeding

Unsafe

Leuxa Depot 11.25 mg Injection 1's should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Leuxa Depot 11.25 mg Injection 1's causes dizziness and affects your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with Leuxa Depot 11.25 mg Injection 1's.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Leuxa Depot 11.25 mg Injection 1's. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Leuxa Depot 11.25 mg Injection 1's. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Caution

Leuxa Depot 11.25 mg Injection 1's is not recommended in children younger than two years of age and should be used with caution and only if absolutely warranted in children under 12.

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Heart

Caution

Leuxa Depot 11.25 mg Injection 1's should be administered with caution in patients with heart problems. Therefore, please talk to your doctor before receiving Leuxa Depot 11.25 mg Injection 1's.

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Geriatrics

Consult your doctor

Leuxa Depot 11.25 mg Injection 1's is generally safe for elderly patients, but should be administered under medical supervision. Seek advice from your doctor if you have any concerns.

What if I have taken an overdose of Leuxa Depot 11.25 mg Injection 1's

Because this medicine is typically administered or closely monitored by a healthcare professional, an overdose is highly unlikely. However, if you suspect an overdose or experience severe symptoms, seek immediate medical attention.

Diet & Lifestyle Advise

  • Increase calcium and vitamin D: Eat calcium-rich foods like yoghurt, leafy greens, and almonds, and discuss vitamin D supplements with your doctor to help protect your bones from thinning.
  • Incorporate weight-bearing exercise: Engage in regular, low-impact activities like walking or light strength training to maintain bone density and muscle strength.
  • Avoid smoking and limit alcohol: Both smoking and drinking can accelerate bone loss and make hot flashes worse, so it is best to avoid them during treatment.
  • Monitor blood sugar: Since this medicine can affect how your body processes glucose, focus on eating balanced meals with plenty of fibre, lean proteins, and whole grains.
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How Soon It Starts Working

The time required for Leuxa Depot 11.25 mg Injection 1's to start to work: The effect of Leuxa Depot 11.25 mg Injection 1's is observed within 4 to 5 hours after administration. The time for which the effects of Leuxa Depot 11.25 mg Injection 1's last: The effect of Leuxa Depot 11.25 mg Injection 1's lasts for 18 hours.

What if you forget to take Leuxa Depot 11.25 mg Injection 1's

If you miss an appointment for your injection or forget a scheduled self-injection, contact your healthcare provider immediately to schedule your next dose. Do not inject a double dose to make up for a missed one, as keeping a consistent schedule is crucial for the medication to work properly.

Storage

• Store Leuxa Depot 11.25 mg Injection 1's precisely as directed by the manufacturer and your pharmacist.

Drug Warnings

  • Inspect the Medicine Before Use: Always inspect the liquid inside the syringe before injecting; do not use it if it looks cloudy, discoloured, or contains floating particles.
  • Do Not Reuse Needles or Syringes: Never reuse needles or syringes, and place all used injection materials into a designated sharps container immediately.
  • Rotate Injection Sites: Be sure to rotate your injection sites every time to prevent skin thickening, bruising, or discomfort.
  • Monitor Blood Sugar Levels: If you have diabetes, check your blood sugar levels more frequently, as this medicine can cause your blood sugar to rise.
  • Use Non-Hormonal Contraception: Use an effective, non-hormonal method of birth control (such as condoms) during treatment, as this medicine can cause harm to an unborn baby.
  • Attend Follow-Up Appointments: Keep all scheduled appointments for blood tests, bone density scans, or other monitoring tests, such as PSA tests or hormone level assessments when appropriate, so your doctor can safely monitor your response to treatment.

Drug-Drug Interactions

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  • Heart rhythm medicines (such as amiodarone or sotalol): Medicines that affect the electrical activity of your heart may increase the risk of serious heart rhythm problems.
  • Antipsychotic medicines (such as haloperidol or ziprasidone): Some antipsychotic medicines can increase the risk of heart rhythm problems when taken with Leuxa Depot 11.25 mg Injection 1's.
  • Certain antibiotics (such as erythromycin or moxifloxacin): Some antibiotics may affect your heart's electrical activity and increase the risk of serious heart rhythm problems when used with Leuxa Depot 11.25 mg Injection 1's.
LeuprorelinVandetanib
Critical

Drug-Drug Interactions

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LeuprorelinVandetanib
Critical
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking Leuxa Depot 11.25 mg Injection with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Coadministration of Leuxa Depot 11.25 mg Injection and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Leuxa Depot 11.25 mg Injection with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking Leuxa Depot 11.25 mg Injection with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Leuxa Depot 11.25 mg Injection with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Leuxa Depot 11.25 mg Injection:
Co-administration of Leuxa Depot 11.25 mg Injection and clozapine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Leuxa Depot 11.25 mg Injection and clozapine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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  • Alcohol: Drinking alcohol can worsen bone density loss and increase the frequency or severity of hot flashes during treatment.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Leuxa Depot 11.25 mg Injection 1's belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis. It is also used to treat precocious puberty (early puberty) in children and in combination with other medicines to treat anaemia caused by uterine fibroids.
Leuxa Depot 11.25 mg Injection 1's contains Leuprolide acetate, a synthetic hormone that helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell growth in prostate cancer in men and shrinks endometriosis in women.
Leuxa Depot 11.25 mg Injection 1's affects the hair, making it thin which further causes loss of hair. Hair reduction possibly happens due to the estrogen lowering effect of Leuxa Depot 11.25 mg Injection 1's. These effects are not long-lasting and may return after some time. If you have any concerns, contact your doctor for further advice.
Leuxa Depot 11.25 mg Injection 1's may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting Leuxa Depot 11.25 mg Injection 1's.
Leuxa Depot 11.25 mg Injection 1's should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, regular monitoring of blood sugar levels is recommended while taking Leuxa Depot 11.25 mg Injection 1's and inform your doctor if you have diabetes before taking Leuxa Depot 11.25 mg Injection 1's.
Leuxa Depot 11.25 mg Injection 1's may worsen your mood disorders like depression. Hence it is advised to use Leuxa Depot 11.25 mg Injection 1's only when you are free from any kind of mental problems. Please consult your doctor for more information.
Leuxa Depot 11.25 mg Injection 1's may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Leuxa Depot 11.25 mg Injection 1's.
Leuxa Depot 11.25 mg Injection 1's is not recommended for patients suffering from heart rhythm problems such as arrhythmia (irregular heartbeat) as it may increase the risk of cardiac disease. Therefore, inform your doctor if you have any heart problems before taking Leuxa Depot 11.25 mg Injection 1's.
Leuxa Depot 11.25 mg Injection 1's is not a chemotherapy medication. Leuxa Depot 11.25 mg Injection 1's belongs to the class of medicines called gonadotropin-releasing hormone (GnRH) agonists primarily used to treat prostate cancer and endometriosis.
Leuxa Depot 11.25 mg Injection 1's may stop periods because it alters reproductive hormones in females. Additionally, people treated with Leuxa Depot 11.25 mg Injection 1's may experience menstruation or spotting in the first 2 months. If bleeding persists beyond 2 months, consult your doctor.
Yes, Leuxa Depot 11.25 mg Injection 1's is a hormonal medicine. Leuprolide acetate is a pregnancy category X drug. It should not be used during pregnancy because it may cause harm to the foetus.
The common side effects of Leuxa Depot 11.25 mg Injection 1's include hot flashes, decreased sexual interest, dizziness, headache, nausea, vomiting, diarrhoea, upset stomach, and injection site reaction. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.
Yes, because this medicine lowers your sex hormone levels, it can alter your metabolism and lead to weight gain or changes in body fat. Staying active and eating a balanced diet can help manage this side effect. Talk to your doctor if you notice sudden or troublesome weight changes.
No, this medicine is not a reliable contraceptive, even though it usually stops your period. You must use a reliable, non-hormonal birth control method (like condoms) during treatment to prevent pregnancy. Talk to your doctor to discuss safe birth control options.
You should contact your healthcare provider immediately to reschedule your injection. Keeping a consistent dosing schedule is very important to ensure the medicine remains effective. Talk to your doctor or pharmacist if you frequently miss appointments.
It is best to limit or avoid alcohol during your treatment, as alcohol can increase the risk of bone thinning and make side effects like hot flashes more severe. Talk to your doctor or pharmacist for personalised guidance.
Yes. Your doctor may recommend regular monitoring depending on your condition. This may include PSA blood tests for prostate cancer, hormone level tests, and bone density (DEXA) scans during long-term treatment. Your doctor will decide how often these tests are needed.

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Country of origin

India

Manufacturer/Marketer address

HALL NO 3, BASEMENT, A37, MANGOLPURI, INDUSTRIALAREA, PHASE 11, NEW DELHI, DELHI, 110034.
Other Info - LEU0223
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