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Ligno-Ad Injection is used to induce local anaesthesia. It contains Lidocaine and Adrenaline which work by preventing initiation and conduction of impulses. In some cases, this medicine may cause side effects such as application site reactions (burning, itching, redness, and irritation), nausea, vomiting and allergy. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Kopran Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ligno-Ad Injection

Ligno-Ad Injection is a sterile injection used to block pain in specific parts of the body during minor medical, surgical, or dental procedures. It acts as a local anesthetic, temporarily numbing the target area so you do not feel discomfort while your healthcare provider performs the procedure. It is injected directly into or around the area requiring treatment.

Because Ligno-Ad Injection is a local anesthetic injected by a trained healthcare professional, it is used on an as-needed basis for specific procedures rather than on a regular daily schedule. You do not need to worry about consistent daily doses, as it is only injected during your clinical appointment. There are no specific food restrictions before receiving this injection, but following your doctor's fasting guidelines for surgery is highly recommended, and eating light meals beforehand can help you feel more comfortable.

Most people tolerate this injection well, but you may experience temporary local side effects like mild swelling, redness, or a tingling sensation at the injection site. These usually fade quickly as the medication wears off. If you experience severe dizziness, breathing difficulties, or a fast or irregular heartbeat, you must alert your medical team immediately.

Before receiving Ligno-Ad Injection, tell your healthcare provider if you have a history of heart disease, high blood pressure, liver damage, or blood circulation problems. Do not use this medicine if you have a known allergy to similar local anesthetics. It is also important to tell your doctor if you have severe heart rhythm disorders or tissue diseases in the area being treated.

This injection can interact with certain blood pressure medications, antidepressants, or heart medicines, which may affect your blood pressure or heart rate during the procedure. It is also wise to avoid drinking alcohol before your appointment, as it can increase drowsiness and alter how your body processes the medicine. If you are pregnant, breastfeeding, or an elderly individual, consult your doctor to ensure this is the safest anesthetic option for your specific situation.

Uses of Ligno-Ad Injection

Here are the common uses of Ligno-Ad Injection:

  • Local anaesthesia: Ligno-Ad Injection is injected to numb a specific, localised area of the body, allowing pain-free minor surgical or diagnostic procedures.
  • Dental procedures: It is used to block pain signals in the teeth and gums during dental work like extractions, fillings, or root canals.
  • Regional nerve blocks: The injection can block nerve pathways to anaesthetise a larger region, such as an entire limb or finger, for complex procedures.
  • Surgical bleeding control: By temporarily narrowing local blood vessels, it helps minimise bleeding at the surgical site, giving the surgeon a clearer view.

Key Benefits

Ligno-Ad Injection provides several benefits by offering effective local pain control while reducing bleeding:

  • Provides Rapid Pain Relief: It quickly blocks pain signals from the treated area, allowing procedures to be performed comfortably.
  • Prolongs the Numbing Effect: The adrenaline component slows the absorption of lignocaine, helping the anaesthetic effect last longer and reducing the need for repeated injections.
  • Reduces Bleeding During Procedures: By narrowing blood vessels at the injection site, it helps minimise bleeding and provides a clearer surgical field.
  • Supports a More Comfortable Procedure: Effective pain control and reduced bleeding help make medical and dental procedures smoother for both the patient and the healthcare professional.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Ligno-Ad Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer.

How Ligno-Ad Injection Works

Ligno-Ad Injection works through a dual-action mechanism that combines two specialised components to provide highly effective local pain relief. The first component is a powerful local anaesthetic. It works by temporarily blocking the pathway of pain signals along your nerves. It achieves this by stopping sodium from entering the nerve endings, which prevents the electrical signals from travelling to your brain. Since the brain does not receive these signals, you do not feel any pain in the treated area. The second component is a vasoconstrictor, which means it temporarily narrows the local blood vessels in the area where it is injected. This narrowing slows down blood flow in that specific spot. By doing so, it keeps the local anesthetic in the target area for a longer period, making the numbing effect last much longer. Additionally, this reduced blood flow helps minimize bleeding during minor surgical procedures.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Ligno-Ad Injection. Alcohol intake, along with Ligno-Ad Injection, may cause increased drowsiness.

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Pregnancy

Unsafe

It is not recommended to take Ligno-Ad Injection while you are pregnant. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe you Ligno-Ad Injection only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Please consult your doctor if you have any concerns regarding this, your doctor will decide whether breastfeeding mothers can take Ligno-Ad Injection or not.

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Driving

Caution

Ligno-Ad Injection may cause drowsiness and vision disturbances, do not drive or operate heavy machinery if you feel drowsy.

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Liver

Caution

Ligno-Ad Injection should be used with caution in patients with liver impairment/liver disease. Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Ligno-Ad Injection should be used with caution in patients with kidney impairment/kidney disease. Dose adjustment may be needed. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Ligno-Ad Injection should not be used by children, as the efficacy and safety have not been established.

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Heart

Consult your doctor

Ligno-Ad Injection will be administered in the hospital setting if needed. Please inforl your doctor if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Your doctor will administer Ligno-Ad Injection if needed in the hospital setting.

What if I have taken an overdose of Ligno-Ad Injection

Because this medication is injected by a trained medical professional in a controlled clinical environment, an overdose is highly unlikely. However, if you experience symptoms like severe shivering, seizures, extreme dizziness, or a rapid heart rate during or immediately after the injection, tell your healthcare provider right away. They are fully equipped to manage any immediate reactions.

Diet & Lifestyle Advise

  • Avoid eating hot food or chewing: If Ligno-Ad Injection was used for a dental procedure, do not eat or chew gum until the numbness has completely worn off to avoid accidentally biting your cheek, tongue, or lips.
  • Do not consume hot beverages: Avoid hot coffee or tea immediately after dental or oral procedures, as you may burn your mouth without realising it due to the lack of sensation.
  • Rest the treated area: Allow the numbed part of your body to rest after the procedure, avoiding strenuous activity or heavy lifting that could strain the injection site.
  • Stay hydrated with water: Drink plenty of water after your procedure to help your body process and clear the medication naturally.
  • Avoid alcohol: Do not drink alcohol for at least 24 hours after your procedure, as it can interact with the remaining anaesthetic in your system and increase drowsiness or dizziness.
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How Soon It Starts Working

The time required for Ligno-Ad Injection to start to work: The time required for Ligno-Ad Injection to show its action is unknown. The time for which the effects of Ligno-Ad Injection last: The duration of action for Ligno-Ad Injection is clinically unknown.

What if you forget to take Ligno-Ad Injection

Since Ligno-Ad Injection is injected only by a healthcare professional as a single-use dose for specific medical procedures, there is no regular dosing schedule. Therefore, missing a dose is not possible.

Storage

•Ligno-Ad Injection is typically stored in a clinical or hospital setting. •It should be kept at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Check the solution: Before injection, ensure the healthcare provider inspects the vial. The liquid should be completely clear and colourless. Do not use if it is cloudy, discoloured, or contains particles.
  • Monitor the injection site: Keep an eye on the area where you were injected for several days. Contact your doctor if you notice worsening pain, redness, warmth, or pus, which could indicate a localised infection.
  • Be careful with numb limbs: If the injection was used to numb an arm or leg, protect the limb from extreme temperatures (like hot water bottles or ice packs) and physical injury until full sensation returns.
  • Do not drive immediately: Avoid driving, operating machinery, or performing tasks that require full alertness until you are certain the anaesthetic has fully worn off and you feel completely back to normal.
  • Report persistent numbness: If the loss of sensation or a tingling feeling lasts for more than 24 hours after your procedure, contact your healthcare provider immediately.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Ligno-Ad Injection and affect its safety or effectiveness:

  • Beta-blockers: Combined use may lead to a severe increase in blood pressure and a dangerously slow heart rate.
  • Tricyclic antidepressants: May increase the risk of severe high blood pressure and abnormal heart rhythms.
  • Inhalation anaesthetics: May increase the risk of serious irregular heartbeats during surgery.
  • Ergot alkaloids: Can cause a severe constriction of blood vessels, significantly increasing blood pressure.
Lidocaine + EpinephrineDihydroergotamine
Critical
Critical

Drug-Drug Interactions

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Lidocaine + EpinephrineDihydroergotamine
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
When Dihydroergotamine is taken with Ligno-Ad Injection 30 ml, the amount of Dihydroergotamine in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Dihydroergotamine with Ligno-Ad Injection 30 ml is not recommended as it can lead to an interaction. It should be taken only if your doctor has advised it. However, if you experience stomach pain, vomiting, numbness or tingling sensation, weakness or pain in the muscles, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe headache, abnormal heartbeat, breathing difficulty, blurred vision, confusion, and/or slurred speech contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Saquinavir can increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Linezolid with Ligno-Ad Injection 30 ml can increase the risk of high blood pressure.

How to manage the interaction:
Taking Linezolid with Ligno-Ad Injection 30 ml is not recommended as it can result in an interaction. It should be taken only if a doctor has advised it. It is advised to maintain your blood pressure. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Coadministration of Penbutolol with Ligno-Ad Injection 30 ml can lead to high blood pressure and low heart rates.

How to manage the interaction:
Taking Penbutolol with Ligno-Ad Injection 30 ml together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Prilocaine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Prilocaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop grayish discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, breathing difficulty, a rapid heartbeat, anxiety, or confusion. Do not stop using any medications without consulting doctor.
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Conivaptan with Ligno-Ad Injection 30 ml may increase the risk of serious side effects such as irregular heart rhythm and other heart problems.

How to manage the interaction:
Although taking Ligno-Ad Injection 30 ml and Conivaptan together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml and Metrizamide may increase the risk of causing seizures(fits).

How to manage the interaction:
Although taking Ligno-Ad Injection 30 ml and Metrizamide together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking Ligno-Ad Injection 30 ml with Nortriptyline can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Ligno-Ad Injection 30 ml with Nortriptyline together can result in an interaction, but it can be taken only if your doctor has advised it. It's important to monitor your blood pressure regularly. However, if you experience dizziness, breathing difficulty, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Ligno-Ad Injection 30 ml:
Taking phenazopyridine with Ligno-Ad Injection 30 ml can increase the risk of methemoglobinemia(a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Co-administration of Phenazopyridine with Ligno-Ad Injection 30 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, breathing difficulty, a rapid heartbeat, anxiety, or confusion. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and drinks may affect the action of Ligno-Ad Injection:

  • Caffeine: Consuming high amounts of caffeine before your procedure may increase heart rate and blood pressure, magnifying the effects of the vasoconstrictor.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[LOCAL ANESTHETICS]

FAQs

Ligno-Ad Injection is used to produce local numbness (anaesthesia) on skin before surgical procedure and reduce pain and discomfort caused by invasive medical procedures such as surgery.
Ligno-Ad Injection contains Lidocaine and Adrenaline. Lidocaine blocks the influx of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses (nerve signal). Hence, it gives an anesthetic effect and decreases the sensation of pain. Adrenaline works by constricting and narrowing blood vessels by acting on alpha receptors that cause muscle contractions. Thus, it decreasing the bleeding and the effects of Ligno-Ad Injection will last longer.
You are not recommended to take duloxetine (antidepressant) with Ligno-Ad Injection as co-administration of these two medicines may increase the risk of high blood pressure and heart rate. However, please consult your doctor before taking other medicines with Ligno-Ad Injection.
Ligno-Ad Injection causes drowsiness and vision disturbances. So, drive only if you are alert and omit driving or operating machinery if you feel dizzy or drowsy.
A person of age 65 or older should use Ligno-Ad Injection with caution, as directed by the doctor as the chances of occurrence of side effects increase in older people.
Ligno-Ad Injection should be used with caution in patients suffering from heart rhythm disorders as it may increase the risk of severe adverse effects. Therefore, inform your doctor if you have any heart problems before taking Ligno-Ad Injection so that the dose may be adjusted appropriately or an alternate medicine may be prescribed.
The effect of Ligno-Ad Injection may last for about 1 to 2 hours, depending on the dosage, and the site of administration. For some individuals, the effect may last longer or shorter than the average duration. However, the duration may vary from person to person.
Ligno-Ad Injection is generally well-tolerated, and patients often report mild or no pain during administration. However, individual experiences may vary, and some patients might feel slight discomfort at the injection site. To minimize potential pain, healthcare providers may use techniques such as buffering the lidocaine with sodium bicarbonate or employing smaller gauge needles.
Ligno-Ad Injection is contraindicated in individuals with a known hypersensitivity to amide-type local anaesthetics or any ingredients of the injection formulation.
No, Ligno-Ad Injection may not cause abuse as it is typically administered by the doctor or nurse. This ensures the dosage and usage are carefully monitored to avoid misuse or harmful effects.
The side effects of Ligno-Ad Injection include nausea, vomiting, reactions at the application site (burning, itching, redness, and irritation), and allergy. Most of these symptoms will resolve gradually over time. However, consult the doctor if these side effects persist or worsen.
If the injection was in or around your mouth, you should wait to eat until the numbness completely wears off to avoid biting your tongue or cheek. For other injection areas, you can usually eat when you feel ready, but talk to your doctor for specific post-procedure advice.
This injection is used during pregnancy only if the potential benefits outweigh the risks to the unborn baby. Your healthcare team will carefully evaluate your situation, so always talk to your doctor before any planned procedure.
Mild tenderness is normal, but worsening redness, swelling, warmth, or discharge could indicate a local infection. If you notice these symptoms, talk to your doctor immediately.
It is highly recommended to avoid alcohol for at least 24 hours after your procedure. Alcohol can increase drowsiness, interact with the remaining medication, and slow down your recovery. Talk to your doctor or pharmacist if you have questions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Parijat House,1076, Dr. E. Moses Road, Worli, Mumbai - 400 018, Maharashtra (India)
Other Info - LIG0061
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