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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Liofen 500mcg Injection is a skeletal muscle relaxant which is used in the treatment of muscle spasms and spasticity. This medication works by blocking spinal reflexes, which help with pain relief and enhance muscle function. It helps maintain muscle strength and relieves muscle spasms or stiffness. Some of the common side effects include constipation, dizziness, nausea, headache, weakness, and dry mouth.
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Composition :

BACLOFEN-500MCG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Liofen 500mcg Injection

Liofen 500mcg Injection belongs to the group of medicines called 'skeletal muscle relaxants' used to reduce and relieve the muscle spasms (excessive tension in the muscles) occurring in various illnesses. It is used in the management of severe spasticities such as spasticity of spinal cord origin, and spasticity of cerebral origin. Muscle spasm is the sudden involuntary contractions of the muscle, which can be painful and uncomfortable. Spasticity is the abnormal muscle tightness occurring due to prolonged muscle contraction.

Liofen 500mcg Injection works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements. Liofen 500mcg Injection works on the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness. Thus Liofen 500mcg Injection reduces muscle spasm in the conditions of multiple sclerosis (a disorder that affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders.

Liofen 500mcg Injection will be administered by a healthcare professional; do not self-administer. In some cases, Liofen 500mcg Injection may cause certain common side-effects such as constipation, dizziness, nausea, headache, weakness, and dry mouth. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are suggested to talk to your doctor if you experience these side effects persistently.

Liofen 500mcg Injection should not be stopped suddenly as it could lead to unpleasant side-effects such as rigidity, increased heart rate, changes in mood, fever, mental disorders, confusion, hallucinations, and fits (seizures). Consult your doctor before taking Liofen 500mcg Injection if you are pregnant or breastfeeding. Liofen 500mcg Injection is not recommended for children below 4 years of age and those who weigh below 33kgs. Inform your doctor about all the current medicines you are taking and about your health condition to rule out any unpleasant side effects. Please speak to your doctor immediately if you experience mood swings, depression, or if you have any suicidal thoughts.

Uses of Liofen 500mcg Injection

Treatment of Muscle spasm and spasticity

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Liofen 500mcg Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Liofen 500mcg Injection belongs to the group of medicines called muscle relaxants used to reduce and relieve the muscle spasms/spasticity (excessive tension in the muscles) occurring in various illnesses such as multiple sclerosis (a disorder that affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders. Liofen 500mcg Injection works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements.

How Liofen 500mcg Injection Works

Liofen 500mcg Injection works by inhibiting the reflexes at the spinal level and helps in relieving pain and improves muscle movements. Liofen 500mcg Injection works on the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness. Thus Liofen 500mcg Injection reduces muscle spasm in the conditions of multiple sclerosis (a disorder that affects the brain and spinal cord), cerebrovascular accidents (damage to the brain due to lack of blood supply), cerebral palsy (a disorder of movement, posture and muscle tone), spinal cord diseases and other nervous system disorders.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Liofen 500mcg Injection out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Liofen 500mcg Injection

Liofen 500mcg Injection is administered by a healthcare professional in a hospital setting. Hence, the chances of overdose are less. Baclofen overdose manifests clinically as confusion, delirium, respiratory and central nervous system depression, hypotonia, flaccid paralysis, and hemodynamic instability. Your doctor may take necessary measures if an overdose is suspected.

Drug Warnings

Do not take Liofen 500mcg Injection if you are allergic to any of its contents or if you ever had a stomach ulcer. Talk to your doctor before taking Liofen 500mcg Injection if you have kidney or liver problems, infections, Parkinson's disease, epilepsy, diabetes, breathing problems, blood circulation problems, high blood pressure, anxiety, pounding headache, slow heart rate, excessive sweating, or if you ever had a stroke. Consult your doctor before taking Liofen 500mcg Injection if you are pregnant or breastfeeding. Liofen 500mcg Injection is not recommended for children below 4 years of age and those who weigh below 33 kg. 

Drug-Drug Interactions

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BaclofenEsketamine
Severe
BaclofenMethadone
Severe

Drug-Drug Interactions

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BaclofenEsketamine
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Esketamine may increase the risk or severity of adverse effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Esketamine if prescribed by the doctor. Consult a doctor if you experience drowsiness, confusion, difficulty concentrating, and impairment in thinking, judgment, and reaction speed. Do not stop any medication without doctor's consultation.
BaclofenMethadone
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Methadone may cause serious side effects such as central nervous system depression can lead to serious side effects including respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Methadone if prescribed by the doctor. Inform the prescriber if you are taking these two medicines, the doctor may prescribe alternate medicines a dose adjustment, or more frequent monitoring to safely use both medications. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Tramadol may significantly lead to adverse effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although taking Liofen 500mcg Injection and tramadol together can result in an interaction, it can be taken on a doctor's advice. If you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BaclofenAlfentanil
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Alfentanil can increase the risk of developing side effects.

How to manage the interaction:
Although there is a possible interaction between Liofen 500mcg Injection and Alfentanil, you can take these medicines together if prescribed by a doctor. If you notice any symptoms like dizziness, trouble breathing, drowsiness, or palpitations, let the doctor know. Do not stop using any medications without a doctor's advice.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of fentanyl and Liofen 500mcg Injection can increase sedation and may lead to respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although taking fentanyl and Liofen 500mcg Injection together can result in an interaction, they can be taken if prescribed by a doctor. However, if you experience dizziness, drowsiness, difficulty concentrating, and impairment in judgment, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BaclofenHydrocodone
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection with Hydrocodone may increase sedation and respiratory distress (fluid collects in the air sacs of the lungs)

How to manage the interaction:
Although there is an interaction, Liofen 500mcg Injection can be used with Hydrocodone if prescribed by the doctor. Co-administration of these medications may cause dizziness, drowsiness, difficulty in concentrating, and impaired judgment. Do not stop any medication without doctor's consultation.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection can enhance the sedative effects of Pentazocine on the central nervous system which can lead to side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Liofen 500mcg Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Buprenorphine with Liofen 500mcg Injection can increase the risk of side effects.

How to manage the interaction:
Co-administration of Buprenorphine alongside Liofen 500mcg Injection can result in an interaction. However, it can be taken if a doctor has advised it. If you experience shortness of breath, chest discomfort, dizziness, or palpitations consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BaclofenOxycodone
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection can enhance the sedative effects of Oxycodone on the central nervous system and can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Although there is a possible interaction between Oxycodone and Liofen 500mcg Injection, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
BaclofenPethidine
Severe
How does the drug interact with Liofen 500mcg Injection:
Co-administration of Liofen 500mcg Injection can enhance the sedative effects of Meperidine on the central nervous system which can lead to serious side effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking Pethidine with Liofen 500mcg Injection together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, drowsiness, difficulty concentrating, and impairment in judgment, reaction speed and motor coordination. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Exercising regularly helps in muscle stretching so that they are less likely to spasm, tear, and sprain. Mild exercises such as jogging and walking are helpful for muscle stretching. Massages can also be helpful.
  • Avoid extremely cold and hot temperatures.
  • Avoid wearing tight-fitting clothes. Instead, wear loose garments.
  • Rest well, and get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Stay hydrated, drink plenty of water.

Habit Forming

No

Therapeutic Class

SKELETAL MUSCLE RELAXANTS
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Liofen 500mcg Injection as it may cause increased drowsiness.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Liofen 500mcg Injection; your doctor will decide whether Liofen 500mcg Injection can be taken by breastfeeding mothers or not.

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Driving

Caution

Liofen 500mcg Injection causes drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Liofen 500mcg Injection is not recommended for children below 4 years and those weighing below 33 kgs. Liofen 500mcg Injection should be used in children above 4 years if prescribed by a doctor.

Have a query?

FAQs

Liofen 500mcg Injection belongs to the group of medicines called 'skeletal muscle relaxants' used to reduce and relieve muscle spasms (excessive tension in the muscles) occurring in various illnesses. It is used in the management of severe spasticities such as spasticity of spinal cord origin, and spasticity of cerebral origin.

Liofen 500mcg Injection works on the centres of the spinal cord and brain, thereby helps in maintaining muscle strength and relieves muscle spasms or stiffness.

Dry mouth could be a side-effect of Liofen 500mcg Injection. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

Liofen 500mcg Injection should not be stopped abruptly. Abrupt discontinuation of Liofen 500mcg Injection may cause altered mental status, high fever, muscle rigidity, and exaggerated rebound spasticity. In rare cases, it might even lead to multiple organ-system failures, rhabdomyolysis (breakdown of muscle tissue that releases a damaging protein into the blood) and death.

Liofen 500mcg Injection may cause suicidal thoughts, hallucinations, euphoric mood (extreme happiness), and paranoid thoughts. Consult your doctor immediately if you experience any of these symptoms.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - LIO0003

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