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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Litholent SR-400 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Whats That

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Composition :

LITHIUM-400MG

Manufacturer/Marketer :

Talent India Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Litholent SR-400 Tablet

Litholent SR-400 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low-mood depression.

Litholent SR-400 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Litholent SR-400 Tablet as prescribed. Your doctor will advise how often you take Litholent SR-400 Tablet based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Litholent SR-400 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Litholent SR-400 Tablet or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Litholent SR-400 Tablet . Regular blood tests are recommended while taking Litholent SR-400 Tablet to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or have had weight loss surgery, please inform your doctor before taking Litholent SR-400 Tablet .

Uses of Litholent SR-400 Tablet

Litholent SR-400 Tablet is used in the treatment of Bipolar disorder, Mania. The detailed uses of Litholent SR-400 Tablet are as follows:<br/>• Bipolar Disorder Treatment: Litholent SR-400 Tablet is used to treat bipolar disorder by stabilizing mood and reducing episode severity through its action on the brain.<br/>• Mania Management: Litholent SR-400 Tablet is effective in managing symptoms of mania, such as elevated mood, increased energy, and impulsive behavior, allowing patients to regain control and function normally.<br/>

Directions for Use

Take Litholent SR-400 Tablet as prescribed by your doctor.

Medicinal Benefits

Litholent SR-400 Tablet is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Litholent SR-400 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Litholent SR-400 Tablet relaxes nerves and calms the mood, which helps in having a better social life and enables one to do daily activities comfortably.

How Litholent SR-400 Tablet Works

Litholent SR-400 Tablet contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Keep Litholent SR-400 Tablet out of the sight and reach of children.

What if I have taken an overdose of Litholent SR-400 Tablet

Do not take more than the prescribed dose of Litholent SR-400 Tablet as too much Lithium may be dangerous. The symptoms include blurred vision, feeling or being sick, vomiting, fainting, sleepiness, lightheadedness, increased urge to urinate, lack of control over pee or poo, shaking or muscle weakness, muscle twitches, spasms or jerks affecting the face, eyes, neck or tongue, confusion and blackouts. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Regular blood tests are recommended while taking Litholent SR-400 Tablet to check lithium levels in blood. If you are pregnant or breastfeeding, please inform your doctor before taking Litholent SR-400 Tablet . If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Litholent SR-400 Tablet as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Litholent SR-400 Tablet:
Taking Cisapride with Litholent SR-400 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Litholent SR-400 Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Cidofovir can cause higher levels of Litholent SR-400 Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Litholent SR-400 Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Taking Litholent SR-400 Tablet with olmesartan medoxomil may significantly increase the blood levels of Litholent SR-400 Tablet .

How to manage the interaction:
Although taking olmesartan medoxomil alongside Litholent SR-400 Tablet can lead to interaction, they can be taken if prescribed by a doctor. However, if you develop sleepiness, dizziness, confusion, loose stools, vomiting, muscular weakness, muscle incoordination, a shaking sensation, blurred vision, ringing in the ears, excessive thirst, and/or increased urination, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Taking Gatifloxacin with Litholent SR-400 Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gatifloxacin with Litholent SR-400 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or unusual memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Co-administration of Litholent SR-400 Tablet carbonate with Tenofovir Disoproxil can increase the risk of developing kidney problems.

How to manage the interaction:
Although there is a possible interaction between Tenofovir disoproxil and Litholent SR-400 Tablet, you can take these medicines when prescribed by your doctor. Consult the doctor immediately if you experience symptoms such as vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, shortness of breath, muscle cramps, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Taking ondansetron with Litholent SR-400 Tablet can increase the risk of serotonin syndrome a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking ondansetron along with Litholent SR-400 Tablet can result in an interaction but can be taken together if prescribed by a doctor. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools, or fast or rapid heartbeats during therapy, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Taking tramadol with Litholent SR-400 Tablet can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of tramadol along with Litholent SR-400 Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties , lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Co-administration of Litholent SR-400 Tablet with mifepristone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Litholent SR-400 Tablet with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Litholent SR-400 Tablet:
Taking Litholent SR-400 Tablet with indomethacin may significantly increase the blood levels of Litholent SR-400 Tablet.

How to manage the interaction:
Taking Indometacin with Litholent SR-400 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience drowsiness, dizziness, confusion, diarrhoea, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and increased urination consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Litholent SR-400 Tablet:
Co-administration of Amiodarone together with Litholent SR-400 Tablet may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Litholent SR-400 Tablet interact, they can be used if prescribed by a doctor. If you have heart problems or electrolyte imbalances, you may be at greater risk. If you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical attention. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid low-sodium diet as it may increase lithium levels in blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Litholent SR-400 Tablet .
  • Do regular exercise and maintain a stable weight as Litholent SR-400 Tablet may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink same amount of water everyday as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Litholent SR-400 Tablet as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Litholent SR-400 Tablet is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Litholent SR-400 Tablet as it may be excreted in breast milk and cause adverse effects in the baby.

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Driving

Unsafe

Litholent SR-400 Tablet may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Litholent SR-400 Tablet .

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Liver

Safe if prescribed

Litholent SR-400 Tablet is safe to use in patients with Liver diseases/conditions if prescribed by a doctor.

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Kidney

Caution

Take Litholent SR-400 Tablet with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Litholent SR-400 Tablet is not recommended for patients with severe kidney problems.

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Children

Caution

Litholent SR-400 Tablet is generally not recommended for children below 12 years. However, Litholent SR-400 Tablet may be used in children above 7 years for treating bipolar I disorder only if prescribed by a doctor.

Have a query?

FAQs

Litholent SR-400 Tablet is used to prevent and treat mood disorders like mania and bipolar disorder. It works by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping to stabilize a person’s mood.

No, you are not recommended to take Litholent SR-400 Tablet with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking or shivering, please consult a doctor immediately. However, before using Litholent SR-400 Tablet with any other medicines, you are advised to contact your doctor.

Litholent SR-400 Tablet is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Litholent SR-400 Tablet . Also, thyroid levels are checked generally before starting treatment with Litholent SR-400 Tablet so that if the levels are too low, Litholent SR-400 Tablet is not advised.

Yes, Litholent SR-400 Tablet may cause weight gain but it is not necessary for everyone taking Litholent SR-400 Tablet to experience this side effect. However, in order to avoid gaining weight while taking Litholent SR-400 Tablet , you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Yes, Litholent SR-400 Tablet may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong smelling urine or decrease in urination, it indicates that you are dehydrated and may affect lithium levels in blood. Therefore, you are recommended to drink plenty of fluids while taking Litholent SR-400 Tablet to avoid dehydration.

No, you are not recommended to stop taking Litholent SR-400 Tablet without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Litholent SR-400 Tablet for as long as your doctor has prescribed it and if you experience any difficulty while taking Litholent SR-400 Tablet , please consult your doctor so that the dose may be gradually reduced.

Litholent SR-400 Tablet may cause side effects such as slurred speech, confusion, mood changes, bloating, or lightheadedness. If these side effects persist or worsen, please consult your doctor.

Litholent SR-400 Tablet takes some time to show improvement in your symptoms but it varies from person to person. This is because each patient reacts differently to particular medication. It may take 1 to 3 weeks or longer for you to see the full effects of Litholent SR-400 Tablet . Continue taking Litholent SR-400 Tablet even if you are not improving and consult your doctor.

Yes, Litholent SR-400 Tablet can cause drowsiness or sleepiness. If you feel dizzy or sleepy, avoid driving or using machines or performing any tasks that require your attention.

Yes, Litholent SR-400 Tablet may cause kidney problems. Litholent SR-400 Tablet is not advised in patients who already have severe kidney impairment. Before starting treatment with Litholent SR-400 Tablet , your doctor will recommend blood tests to see if your kidney function is normal. During treatment with Litholent SR-400 Tablet , any gradual or sudden changes in kidney function, may indicate that the treatment needs re-evaluation.

Litholent SR-400 Tablet should only be started if sufficient facilities are available for evaluating Litholent SR-400 Tablet levels as increased blood levels of Litholent SR-400 Tablet is related to Litholent SR-400 Tablet toxicity. Even at dose which is effective for treatment, Litholent SR-400 Tablet toxicity can occur. Therefore, your doctor may closely monitor your Litholent SR-400 Tablet levels weekly until stabilization is reached, then weekly for one month and then every month after that.

Take Litholent SR-400 Tablet with or without food or as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.

Some medicines decrease Litholent SR-400 Tablet levels in blood which means that it will not work well. These include caffeine, theophylline (for asthma), medicines containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea (used to treat skin conditions). Therefore, please inform your doctor about the medicines you are taking before starting Litholent SR-400 Tablet to avoid drug interactions.

Country of origin

INDIA

Manufacturer/Marketer address

1601, Karnavati Estate, Gidc, Phase Iii, Vatva, Ahmedabad 382445, Gujarat, India.
Other Info - LIT0186

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