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  3. Lithowel 450mg Tablet CR

Lithowel 450mg Tablet CR, Pack of 1 Tablet
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
Lithowel 450mg Tablet CR belongs to the class of antipsychotic medicine used in the treatment of bipolar disorder and mania. This medicine suppresses the excess and abnormal activity of nerve cells in the brain by increasing the activity of chemical messengers in the brain. Common side effects include loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination.
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Composition :

LITHIUM CARBONATE-450MG

Manufacturer/Marketer :

Sigmund Promedica

Consume Type :

ORAL

Return Policy :

Not Returnable

About Lithowel 450mg Tablet CR

Lithowel 450mg Tablet CR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low mood depression.

Lithowel 450mg Tablet CR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lithowel 450mg Tablet CR as prescribed. Your doctor will advise you on how often you need to take Lithowel 450mg Tablet CR based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lithowel 450mg Tablet CR do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lithowel 450mg Tablet CR or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lithowel 450mg Tablet CR. Regular blood tests are recommended while taking Lithowel 450mg Tablet CR to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or had weight loss surgery, please inform your doctor before taking Lithowel 450mg Tablet CR.

Uses of Lithowel 450mg Tablet CR

Treatment of Bipolar disorder and Mania

Directions for Use

• Take Lithowel 450mg Tablet CR with food for better absorption or take it as advised by the doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Swallow it as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Lithowel 450mg Tablet CR is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lithowel 450mg Tablet CR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lithowel 450mg Tablet CR relaxes nerves and calms the mood, which helps in having a better social life and enables to do daily activities comfortably.

How Lithowel 450mg Tablet CR Works

Lithowel 450mg Tablet CR contains Lithium carbonate that helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

• Store in a cool and dry place away from sunlight.• Keep Lithowel 450mg Tablet CR out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Lithowel 450mg Tablet CR
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Lithowel 450mg Tablet CR

Take Lithowel 450mg Tablet CR only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include vomiting, diarrhoea, muscular weakness, drowsiness, and lack of coordination. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Regular blood tests are recommended while taking Lithowel 450mg Tablet CR to check lithium levels in the blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lithowel 450mg Tablet CR. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lithowel 450mg Tablet CR as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCidofovir
Critical
LithiumCisapride
Critical

Drug-Drug Interactions

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LithiumCidofovir
Critical
How does the drug interact with Lithowel 450mg Tablet CR:
Cidofovir can cause higher levels of Lithowel 450mg Tablet CR carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithowel 450mg Tablet CR with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumCisapride
Critical
How does the drug interact with Lithowel 450mg Tablet CR:
Taking Cisapride with Lithowel 450mg Tablet CR can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithowel 450mg Tablet CR with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumChloroquine
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Taking chloroquine with Lithowel 450mg Tablet CR together can increase the risk ofabnormal heart rhythm.

How to manage the interaction:
Taking chloroquine and Lithowel 450mg Tablet CR together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumBenazepril
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Coadministration of Lithowel 450mg Tablet CR with Benazepril may significantly increases the blood levels of Lithowel 450mg Tablet CR.

How to manage the interaction:
Co-administration of Benazepril with Lithowel 450mg Tablet CR can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, tremor(shaking of hands & legs), blurred vision, ringing in the ear, excessive thirst, and increased urination. Do not stop using any medications without talking to a doctor.
LithiumMifepristone
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Co-administration of Lithowel 450mg Tablet CR with mifepristone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithowel 450mg Tablet CR with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, shortness of breath, or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
LithiumTrazodone
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Combining Lithowel 450mg Tablet CR carbonate with Trazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Trazodone and Lithowel 450mg Tablet CR, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumEverolimus
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Taking Lithowel 450mg Tablet CR with Everolimus may increase the risk of kidney problems.

How to manage the interaction:
Although taking Everolimus and Lithowel 450mg Tablet CR together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
LithiumTorasemide
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Taking torasemide together with Lithowel 450mg Tablet CR may increase the effects of Lithowel 450mg Tablet CR.

How to manage the interaction:
Taking Lithowel 450mg Tablet CR with torasemide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumVenlafaxine
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Taking Venlafaxine with Lithowel 450mg Tablet CR may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Venlafaxine and Lithowel 450mg Tablet CR, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumIbuprofen
Severe
How does the drug interact with Lithowel 450mg Tablet CR:
Coadministration of Lithowel 450mg Tablet CR and Ibuprofen can increases the blood levels of Lithowel 450mg Tablet CR.

How to manage the interaction:
Co-administration of Lithowel 450mg Tablet CR and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like drowsiness, dizziness, confusion, diarrhea, vomiting, muscle weakness, muscle inco-ordination, tremor, blurred vision, ringing in the ear, excessive thirst, and increased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a constant sodium diet as it may affect lithium levels in the blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lithowel 450mg Tablet CR.
  • Do regular exercise and maintain a stable weight as Lithowel 450mg Tablet CR may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink the same amount of water every day as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lithowel 450mg Tablet CR Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lithowel 450mg Tablet CR as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lithowel 450mg Tablet CR is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lithowel 450mg Tablet CR as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Lithowel 450mg Tablet CR may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lithowel 450mg Tablet CR.

bannner image

Liver

Safe if prescribed

Lithowel 450mg Tablet CR is safe to use in patients with liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Lithowel 450mg Tablet CR with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lithowel 450mg Tablet CR is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Lithowel 450mg Tablet CR is generally not recommended for children below 12 years. However, Lithowel 450mg Tablet CR may be used in children above 7 years for treating bipolar disorder only if prescribed by a doctor.

Have a query?

FAQs

Lithowel 450mg Tablet CR belongs to a psychological class of drugs called 'anti-manic agents' or 'mood stabilizers' primarily used to prevent and treat mood disorders like mania and bipolar disorder.

Lithowel 450mg Tablet CR helps to treat mental disorders by increasing the activity of chemical messengers in the brain; thereby, suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Lithowel 450mg Tablet CR is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lithowel 450mg Tablet CR.

Lithowel 450mg Tablet CR may cause weight gain but it is not necessary for everyone taking Lithowel 450mg Tablet CR to experience this side effect. However, in order to avoid gaining weight while taking Lithowel 450mg Tablet CR, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Lithowel 450mg Tablet CR may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong-smelling urine or a decrease in urination, it indicates that you are dehydrated, and this may affect lithium levels in the blood. Therefore, you are recommended to drink plenty of fluids while taking Lithowel 450mg Tablet CR to avoid dehydration.

You are not recommended to stop taking Lithowel 450mg Tablet CR without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lithowel 450mg Tablet CR for as long as your doctor has prescribed it and if you experience any difficulty while taking Lithowel 450mg Tablet CR, please consult your doctor so that the dose may be gradually reduced.

You are not recommended to take Lithowel 450mg Tablet CR with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking, or shivering, please consult a doctor immediately. However, before using Lithowel 450mg Tablet CR with any other medicines, you are advised to contact your doctor.

The effects of Lithowel 450mg Tablet CR can vary from person to person, but it generally takes 1-3 weeks for you to see the full benefits. However, it's important to continue taking the Lithowel 450mg Tablet CR regularly as prescribed by your doctor to maintain its effectiveness.

It's important to inform your doctor about your hypertension and the medications you're taking for it as Lithowel 450mg Tablet CR can interact with certain blood pressure medications, and your doctor may need to adjust your treatment plan to ensure your safety.

No, you should not increase the dose of Lithowel 450mg Tablet CR on your own. It can take 1-3 weeks to feel the full effects, and increasing the dose without medical advice can be dangerous and may lead to adverse effects. However consult your doctor if you have any concerns.

Yes, Lithowel 450mg Tablet CR can cause sleepiness as a side effect. It's important to be cautious when performing activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.

Yes, Lithowel 450mg Tablet CR can affect the kidneys. Long-term use of lithium can lead to kidney problems, and regular monitoring of kidney function is necessary during treatment. It's important to inform your doctor if you have any pre-existing kidney conditions or if you experience any symptoms of kidney problems while taking Lithowel 450mg Tablet CR.

Lithowel 450mg Tablet CR should only be started if adequate facilities for assessing Lithowel 450mg Tablet CR levels are available. Because elevated levels of Lithowel 450mg Tablet CR are linked to Lithowel 450mg Tablet CR toxicity. Lithowel 450mg Tablet CR toxicity can even occur at dose which is effective for treatment. Therefore, your doctor may closely monitor your Lithowel 450mg Tablet CR levels weekly until stabilization is achieved, then weekly for one month and then at monthly intervals thereafter.

Lithowel 450mg Tablet CR should be taken as prescribed by your doctor. It is recommended to take with food to reduce nausea. Lithowel 450mg Tablet CR may be taken before or after meals. Swallow it as a whole with a glass of water. Do not crush, chew or break it.

Certain medications which decrease the levels of Lithowel 450mg Tablet CR in blood include carbonic anhydrase inhibitors, chlorpromazine, sodium-containing preparations, theophylline, urea and herbal medicines. Therefore, before starting Lithowel 450mg Tablet CR, inform your doctor about all the medicines you are taking.

The common side effects of Lithowel 450mg Tablet CR are loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India
Other Info - LI34722

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 18, 2025 | 6:59 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/
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