Lonohold Tablet 4's
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About Lonohold Tablet
Lonohold Tablet is a combination oral medication prescribed to treat two common male sexual health issues: erectile dysfunction and premature ejaculation. It helps men achieve and maintain an erection while providing better control over climaxing, allowing for a more satisfying sexual experience. This medicine is designed specifically for adult men experiencing these combined symptoms.
Lonohold Tablet is typically taken on an as-needed basis, rather than as a daily treatment. You can take this tablet with or without food, but taking it with a heavy meal may delay how quickly it starts working. Making simple lifestyle adjustments, such as managing your daily stress and eating a heart-healthy diet, can also help you get the best results from this treatment.
While taking Lonohold Tablet, some people may experience mild side effects like a headache, facial flushing, or an upset stomach. These effects are usually temporary and go away on their own. However, if you experience rare but serious symptoms, such as sudden changes in your vision or hearing, you must stop taking the medicine and consult your doctor immediately.
Talk to your doctor before starting Lonohold Tablet if you have any history of heart disease, liver damage, kidney problems, or mental health conditions like depression. Do not take this if you are a woman, a child under the age of 18, or if you have severe heart problems. It is crucial to share your complete medical history with your healthcare provider to ensure this medication is safe for you.
This medication can interact dangerously with certain other substances. For example, taking it with alcohol can increase your risk of dizziness and fainting, while smoking can reduce its overall effectiveness by affecting blood vessel health. Elderly individuals should consult their doctor before using Lonohold Tablet, as they may be more sensitive to its effects. Doctors generally recommend starting with a lower dose in older adults and adjusting treatment only if needed based on effectiveness and tolerability.
Uses of Lonohold Tablet
Lonohold Tablet is used in the treatment of erectile dysfunction and premature ejaculation. The detailed uses of Lonohold Tablet are as follows:
- Erectile Dysfunction: Lonohold Tablethelps increase blood flow to the penis, allowing you to achieve and maintain a firm erection when you are sexually aroused.
- Premature Ejaculation: It helps delay climax by regulating specific chemical signals in the nervous system, giving you greater control over ejaculation.
Key Benefits
- Lonohold Tablet is a combination drug containing 'impotent agents', primarily used to treat erectile dysfunction (impotence) and premature ejaculation in men.
- Lonohold Tablet contains Tadalafil and Dapoxetine.
- Tadalafil works by inhibiting the phosphodiesterase enzyme, which leads to the breakdown of cGMP and causes relaxation of smooth muscles and vasodilation (widening) of blood vessels in the penis.
- Lonohold Tablet helps to treat erectile dysfunction and symptoms of an enlarged prostate.
- Dapoxetine works by increasing the serotonin level in nerves, which improves control over ejaculation and increases the time taken to ejaculate.
- Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
- Divide your daily food intake into smaller, more frequent meals to reduce nausea.
- Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
- Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
- Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
- Use ginger (tea, ale, or candies) to help relieve nausea.
- Get adequate rest and also avoid strenuous activities that can worsen nausea.
- Talk to your doctor about taking anti-nausea medication if your nausea is severe.
- Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
- Hydrate your body: Drink enough water to prevent dehydration and headaches.
- Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
- Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
- Take rest: lie down in a quiet, dark environment.
- Cold or warm compresses can help reduce tension.
- Stay Upright: Maintain good posture to keep symptoms from getting worse.
- To treat headaches naturally, try acupuncture or massage therapy.
- Over-the-counter pain relievers include acetaminophen and ibuprofen.
- Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
- Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
- Frequent Headaches: If you get reoccurring headaches, consult your doctor.
- Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
- Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
- Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
- When standing up, do so slowly and carefully to avoid sudden dizziness.
- Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
- Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
- If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
- Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
- Do not stand up suddenly. Lie down and get up slowly only when you feel better.
- Avoid alcohol and large meals.
- Drink enough water before standing for long periods.
- Exercise regularly; however, avoid exercising in extreme heat.
- Eat small, low-carb meals.
- Wear compression stockings.
- Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
- Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
- Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
- Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
- Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
- Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Directions for Use
- Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
- Take the medication about 1 to 3 hours before you expect to engage in sexual activity.
- Do not take more than one tablet within a 24-hour period.
- Always follow your doctor's exact instructions regarding when and how often to take this medicine.
How Lonohold Tablet Works
Alcohol
Caution
It is best to avoid alcohol while using this medicine. Alcohol can worsen erectile dysfunction, make it harder to delay climax, and increase the risk of dangerous side effects like severe dizziness and fainting. Talk to your doctor for more information.
Pregnancy
Unsafe
Lonohold Tablet contains Tadalafil, which belongs to pregnancy category B. Lonohold Tablet is not intended for use in women.
Breast Feeding
Unsafe
Lonohold Tablet is not intended for use in women.
Driving
Caution
Lonohold Tablet may cause dizziness. Therefore, you are advised to drive and operate machinery only if you are alert.
Liver
Consult your doctor
Dose adjustment may be needed. Please consult your doctor before taking Lonohold Tablet if you have liver impairment/liver disease or any concerns regarding this.
Kidney
Consult your doctor
Dose adjustment may be needed. Please consult your doctor before taking Lonohold Tablet if you have kidney impairment/kidney disease or any concerns regarding this.
Children
Unsafe
Lonohold Tablet should not be given to children as safety and effectiveness have not been established.
Heart
Unsafe
This medicine is contraindicated in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.
Geriatrics
Caution
Lonohold Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.
What if I have taken an overdose of Lonohold Tablet
Diet & Lifestyle Advise
Limit alcohol consumption: Drinking alcohol can make it harder to get an erection and can increase your risk of experiencing dizziness or low blood pressure with this medicine.
Avoid grapefruit juice: Grapefruit can interfere with how your body processes this medicine, potentially raising the amount of the drug in your system and increasing the risk of side effects.
Practice pelvic floor exercises: Strengthening your pelvic muscles (Kegel exercises) can support better control over ejaculation and improve overall erectile function.
Eat a balanced diet: A diet rich in fruits, vegetables, and whole grains supports healthy circulation, which is essential for the medication to work effectively.

Have a query?
How Soon It Starts Working
- The time required for Lonohold Tablet to start to work: It usually takes 30-60 minutes for Lonohold Tablet to show its effect. You should be able to get an erection at any time between 30 minutes to 36 hours after taking Lonohold Tablet.
- The time for which the effects of Lonohold Tablet last: The duration of action for Lonohold Tablet is unknown.
What if you forget to take Lonohold Tablet
Storage
Drug Warnings
- Do not take this medicine if you are currently taking nitrates (medications prescribed for chest pain or heart problems), as this combination can cause a life-threatening drop in blood pressure.
- Avoid driving or operating machinery after taking Lonohold Tabletif you feel dizzy, sleepy, or notice any temporary changes in your vision.
- Never take this medication in combination with recreational drugs, especially those containing amyl or butyl nitrite ('poppers').
- If you experience a painful erection or one that lasts for more than 4 hours, seek emergency medical care immediately to prevent permanent tissue damage.
- Do not take Lonohold Tabletif you have a history of bipolar disorder, severe depression, or mania.
Drug-Drug Interactions
Drug-Drug Interaction Summary:
- Nitrates: May cause a dangerous, sudden drop in blood pressure. Do not take together.
- Blood Pressure Medications: May increase the risk of feeling dizzy or fainting due to low blood pressure.
- Antidepressants (MAOIs or SSRIs): May cause severe reactions when combined. Do not take within 14 days of stopping an MAOI.
- Certain Antifungals and Antivirals: May slow down how your body clears Lonohold Tablet, increasing the risk of side effects.
Drug-Drug Interactions
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Taking dapoxetine and tadalafil with amyl Nitrite can increase the risk or severity of low blood pressure.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil and amyl nitrite, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache, flushing. Do not discontinue any medications without consulting a doctor.
Coadministration of dapoxetine and tadalafil with isosorbide mononitrate can increase the risk or severity of low blood pressure.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil, and isosorbide mononitrate, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, or headache. Do not discontinue any medications without consulting a doctor.
Taking dapoxetine and tadalafil with isosorbide dinitrate can increase the risk or severity of low blood pressure.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil, and isosorbide dinitrate they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, or headache. Do not discontinue any medications without consulting a doctor.
Taking dapoxetine and tadalafil with riociguat may increase the risk or severity of low blood pressure.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil and riociguat, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache, and stuffy nose. Do not discontinue any medications without consulting a doctor.
Taking dapoxetine and tadalafil with nitroprusside can increase the risk or severity of low blood pressure.
How to manage the interaction:
Although there is an interaction between dapoxetine and tadalafil and nitroprusside they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, headache. Do not discontinue any medications without consulting a doctor.
Taking dapoxetine and tadalafil with voriconazole may increase the blood levels and effects of dapoxetine and tadalafil.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil, and voriconazole they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, ringing in the ears, vision or hearing loss, or chest pain. Do not discontinue any medications without consulting a doctor.
Coadministration of dapoxetine and tadalafil with miconazole may increase blood levels and effects of dapoxetine and tadalafil. This can increase the risk or severity of side effects.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil, and miconazole and tadalafil, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, ringing in the ears, or chest pain. Do not discontinue any medications without consulting a doctor.
Taking tadalafil with dapoxetine and tadalafil increases the risk or severity of low blood pressure.
How to manage the interaction:
Although there is a possible interaction between dapoxetine, tadalafil, and avanafil, they can be taken together if prescribed by a doctor. However, if you experience dizziness, lightheadedness, fainting, or headache, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Coadministration of ketoconazole with dapoxetine and tadalafil may increase the blood levels and effects of dapoxetine and tadalafil.
How to manage the interaction:
Although there is an interaction between dapoxetine and tadalafil and ketoconazole they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, visual disturbances, ringing in the ears, vision loss, or hearing loss. Do not stop using any medications without a doctor's advice.
Taking dapoxetine and tadalafil with telithromycin may increase the blood levels and effects of dapoxetine and tadalafil.
How to manage the interaction:
Although there is an interaction between dapoxetine, tadalafil and telithromycin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, shortness of breath, dizziness, lightheadedness, fainting, ringing in the ears, chest pain or tightness. Do not discontinue any medications without consulting a doctor.
Drug-Food Interactions
Drug-Food Interaction Summary:
- Alcohol: May increase the risk of drowsiness, dizziness, slow reflexes, and fainting.
- Grapefruit Juice: May increase the levels of the medicine in your bloodstream, raising the risk of severe side effects.
Drug-Food Interactions
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Grapefruit, Grapefruit Juice
How to manage the interaction:
Consuming grapefruit juice with dapoxetine and tadalafil can increase their blood levels and effects. Limit or avoid consuming grapefruit juice while taking dapoxetine and tadalafil.
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Reference
- U.S. Food and Drug Administration (FDA). 021368S20S21Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
- National Health Service (NHS). Tadalafil - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
- Drugs.com Clinical Review Team. Tadalafil Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
- Electronic Medicines Compendium (EMC). Pil.1269 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
- Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed on 7th July 2022].Check here
- CDSCO [Internet]. Cdscoonline.gov.in. 2022 [Accessed on 20 June 2025]Check here



















