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compositionComposition:ALLOPURINOL-300MG
prescriptionPrescription Medicine
Lopnol 300mg Tablet DT

Lopnol 300mg Tablet DT is used to reduce blood uric acid levels. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It contains Allopurinol, which stops uric acid production in the body and prevents crystal buildup. Common side effects include stomach upset, diarrhoea, skin rash, and drowsiness.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ALLOPURINOL-300MG

Manufacturer/Marketer :

West Coast Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Lopnol 300mg Tablet DT

Lopnol 300mg Tablet DT is primarily used to reduce blood uric acid levels. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, and bladder stones.

Lopnol 300mg Tablet DT contains allopurinol, which works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. It inhibits uric acid formation in the body and prevents crystal formation, making it effective in managing gout and kidney/bladder stones.

Take Lopnol 300mg Tablet DT exactly as prescribed by your doctor. Swallow it whole with a glass of water, and do not crush or chew it. Common side effects of Lopnol 300mg Tablet DT include stomach upset, diarrhoea, skin rash, and drowsiness. Please talk to your doctor if any of these side effects persist.

Do not take Lopnol 300mg Tablet DT if you are allergic to any of its ingredients. If you are pregnant, planning to get pregnant, or breastfeeding, consult your doctor for advice before using Lopnol 300mg Tablet DT. Seek medical advice immediately if you notice unexplained weight loss while on treatment with Lopnol 300mg Tablet DT.

Uses of Lopnol 300mg Tablet DT

Lopnol 300mg Tablet DT is used to decrease uric acid levels in the body. The detailed uses of Lopnol 300mg Tablet DT are as follows:

  • Long-term management of gout: Lopnol 300mg Tablet DT effectively prevents and treats gout by stopping the buildup of uric acid crystals in the joints.
  • Prevention of kidney stones: Lopnol 300mg Tablet DT helps prevent the formation of uric acid kidney stones by lowering uric acid levels in the urine.
  • Prevention of bladder stones: Lopnol 300mg Tablet DT helps prevent the formation of bladder stones composed of uric acid.

Have a query?

Directions for Use

  • Take Lopnol 300mg Tablet DT with food to avoid stomach upset or as advised by a doctor.
  • Recommended to take the medicine once or twice a day or as advised by your doctor.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

  • Lopnol 300mg Tablet DT is used to reduce serum uric acid levels.
  • It helps prevent and treat gout by stopping the formation and buildup of uric acid crystals in the joints.
  • It decreases urinary uric acid concentration, thereby reducing the risk of kidney stone formation.
  • It helps prevent uric acid from forming stones in the bladder.
  • It lowers uric acid levels in patients undergoing chemotherapy, protecting the kidneys and minimising complications.

How Lopnol 300mg Tablet DT Works

Lopnol 300mg Tablet DT contains allopurinol, which works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. It inhibits uric acid formation in the body and prevents crystal formation, making it effective in managing gout and kidney/bladder stones.
Side effects of Lopnol 300mg Tablet DT
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of Lopnol 300mg Tablet DT

Do not take more than the prescribed dose of Lopnol 300mg Tablet DT, as it may cause adverse effects. If you suspect you have taken an overdose or notice any unusual symptoms, please consult a doctor immediately.

Drug Warnings

  • Do not take Lopnol 300mg Tablet DT if you are allergic to any of its ingredients.
  • If you are pregnant, planning to get pregnant, or breastfeeding, consult your doctor for advice before using Lopnol 300mg Tablet DT.
  • Inform your doctor if you have thyroid problems, high blood pressure, or heart, liver, or kidney disease.
  • In rare cases, Lopnol 300mg Tablet DT may cause bone marrow depression, especially in patients who are already taking other medications with similar effects.
  • Seek medical advice immediately if you notice unexplained weight loss while on treatment with Lopnol 300mg Tablet DT.
  • Lopnol 300mg Tablet DT may cause drowsiness, so avoid operating machinery or driving until you are fully alert.

Drug-Drug Interactions

verifiedApollotooltip
AllopurinolDidanosine
Critical
AllopurinolAzathioprine
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Lopnol 300mg Tablet DT:
When Didanosine is taken with Lopnol 300mg Tablet DT, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Lopnol 300mg Tablet DT with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Lopnol 300mg Tablet DT, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AllopurinolPegloticase
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Pegloticase can increase the chances of side effects.

How to manage the interaction:
Co-administration of Lopnol 300mg Tablet DT with Pegloticase can possibly result in an interaction, but it can be taken if your doctor has advised it. This is more common in people who already have high uric acid levels, which may not be obvious if they are taking other uric acid-lowering medications. Do not stop using any medications without first talking to your doctor.
AllopurinolFosinopril
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Fosinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Lopnol 300mg Tablet DT and Fosinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolRamipril
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Lopnol 300mg Tablet DT and Ramipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolEnalapril
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Coadministration of Lopnol 300mg Tablet DT with Enalapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Lopnol 300mg Tablet DT and Enalapril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not stop using any medications without consulting your doctor.
AllopurinolMercaptopurine
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Mercaptopurine together may increase the effects of mercaptopurine.

How to manage the interaction:
If you take Lopnol 300mg Tablet DT and Mercaptopurine together, a doctor may adjust the dose or recommend special tests to use both medications safely. However, contact a doctor immediately if you develop any symptoms such as chills, fever, sore throat, mouth sores, body pains, weakness, muscle pain, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea. Do not discontinue any medications without a doctor's advice.
AllopurinolEntecavir
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Coadministration of Lopnol 300mg Tablet DT with Entecavir may increase the blood levels of one or both medicines and increase side effects.

How to manage the interaction:
If you are supposed to take Lopnol 300mg Tablet DT and Entecavir together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience increased side effects, contact your doctor.
AllopurinolCaptopril
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Lopnol 300mg Tablet DT and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolLisinopril
Severe
How does the drug interact with Lopnol 300mg Tablet DT:
Co-administration of Lopnol 300mg Tablet DT with Lisinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Lopnol 300mg Tablet DT and Lisinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Dietary choices:

  • Avoid or restrict foods high in purine, such as alcohol, fish, meat, and bacon, as they can increase uric acid levels.
  • Avoid soft drinks and fruit juices high in fructose.
  • Maintain a diet rich in fruits, whole grains, vegetables, and low-fat dairy products to support overall health.

Lifestyle habits:

  • Losing weight can help lower uric acid levels in the body.
  • Engage in moderate physical activity daily.
  • Drink plenty of fluids to help flush uric acid from the body.
  • Limit or avoid alcohol and tobacco, as they can raise uric acid levels.
  • Stress may sometimes trigger gout attacks, so activities like yoga and meditation can be helpful.

Habit Forming

No

Therapeutic Class

[GOUT THERAPY]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Lopnol 300mg Tablet DT should not be taken along with alcohol, as it increases uric acid levels.

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Pregnancy

Caution

Lopnol 300mg Tablet DT is a Category C pregnancy drug. If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

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Breast Feeding

Unsafe

Lopnol 300mg Tablet DT is excreted in human breast milk, so it is not recommended during breastfeeding.

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Driving

Unsafe

Lopnol 300mg Tablet DT may cause some individuals to feel drowsy. Do not drive or operate dangerous machinery if you are affected.

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Liver

Caution

Lopnol 300mg Tablet DT to be taken with caution, especially if you have a history of Liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Lopnol 300mg Tablet DT to be taken with caution, especially if you have a history of Kidney diseases/conditions. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Lopnol 300mg Tablet DT hasn’t been studied and shouldn’t be used in people younger than 18 years to treat gout or kidney stones.

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Heart

Caution

Lopnol 300mg Tablet DT should be taken with caution in patients with heart disease. Please consult your physician.

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Geriatrics

Caution

Lopnol 300mg Tablet DT should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Lopnol 300mg Tablet DT.

FAQs

Lopnol 300mg Tablet DT is used to treat gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It decreases blood uric acid levels in the body.

Lopnol 300mg Tablet DT contains allopurinol, which works by blocking the action of xanthine oxidase, the enzyme responsible for the production of uric acid. It stops uric acid formation inside the body and prevents crystal buildup, making it effective in managing gout and kidney/bladder stones.

If you are taking Lopnol 300mg Tablet DT and it makes you vomit, then your contraceptive pill would not be effective, and it could lead to an unwanted pregnancy. If you are of childbearing age, inform your doctor before starting Lopnol 300mg Tablet DT and use another form of contraceptive like condoms.

Initially, when you start Lopnol 300mg Tablet DT, it can increase the number of gout attacks. Please do not stop taking Lopnol 300mg Tablet DT on having an acute attack (sudden attack) of gout, as it can make the attack even worse. Co-administration with an anti-inflammatory agent (e.g., colchicine) is recommended, and the dose of Lopnol 300mg Tablet DT should be increased slowly.

Generally, when Lopnol 300mg Tablet DT is administered to elderly patients (aged> 65 years), the dose is reduced based on the patient’s condition. Also, if you mention all underlining disease you suffer from, which could affect Lopnol 300mg Tablet DT, the dose will be adjusted accordingly by your doctor.

Yes, Lopnol 300mg Tablet DT can cause drowsiness in some people. It can even make you feel dizzy or have a problem with coordination. It is advisable to avoid driving or operating machinery to avoid any unpleasant side effects.

No, Lopnol 300mg Tablet DT is not an anti-inflammatory medicine. It works by inhibiting the enzyme xanthine oxidase, which catalyses the formation of uric acid. It inhibits uric acid formation within the body without affecting essential cellular and systemic mechanisms.

It may take several weeks to lower uric acid levels before you begin to feel better or notice a significant reduction in gout attacks.

Lopnol 300mg Tablet DT may cause side effects such as nausea, vomiting, diarrhoea, stomach upset, or drowsiness. If these side effects persist or worsen, please consult your doctor.

It is preferable to take Lopnol 300mg Tablet DT after a meal to prevent stomach upset. But take it at the same time every day to help you remember to take it. However, follow your doctor’s instructions carefully.

You may experience an increase in gout attacks after you have started taking Lopnol 300mg Tablet DT. However, with several months of therapy, these attacks typically become less severe and shorter. This increase in attacks may be due to the slow dissolution of uric acid crystals, which can cause fluctuations in blood uric acid levels. If you still have any concerns, please consult your physician.

If you consume alcohol while taking Lopnol 300mg Tablet DT, it increases uric acid levels and worsen your condition. Therefore, avoid alcohol consumption while taking Lopnol 300mg Tablet DT.

If you forget to take a dose of Lopnol 300mg Tablet DT, take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for a forgotten dose.

Store Lopnol 300mg Tablet DT in a cool, dry and dark place. Protect from direct sunlight and moisture. Keep it out of sight and reach of children.

Country of origin

India
Other Info - LO27112

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