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compositionComposition:CABOZANTINIB-60MG
prescription
Prescription Medicine
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Lupizotib 60 mg Tablet is used to treat renal cell carcinoma. It contains Cabozantinib as an active ingredient, which works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding. Lupizotib 60 mg Tablet may cause side effects such as diarrhoea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, reduced weight, dizziness, and constipation.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CABOZANTINIB-60MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lupizotib 60 mg Tablet

Lupizotib 60 mg Tablet is a prescription medicine used to treat advanced kidney cancer. It is also prescribed for certain types of liver cancer and specific forms of thyroid cancer that have progressed. This medicine works by targeting specific proteins to help slow down the growth and spread of cancer cells.

To get the best results, you must take Lupizotib 60 mg Tablet consistently at the same time every day. Always take this medicine on an empty stomach, which means you should not eat anything for at least 2 hours before taking your dose and for 1 hour after taking it. Maintaining a balanced diet and staying well-hydrated are helpful lifestyle habits to support your body during this treatment.

While taking Lupizotib 60 mg Tablet , you may experience some common side effects such as diarrhoea, fatigue, or high blood pressure. Most of these can be managed, but you must contact your doctor immediately if you experience severe symptoms like unusual bleeding, severe stomach pain, or chest pain.

Before starting Lupizotib 60 mg Tablet , you should talk to your doctor about your complete medical history, especially if you have high blood pressure, liver issues, or upcoming dental procedures. Do not take this if you are pregnant, planning to become pregnant, or have an active, severe bleeding disorder.

This medicine can interact with other prescriptions, over-the-counter drugs, and herbal supplements because they may alter how your body processes the treatment. Avoid drinking alcohol or smoking while taking this medication, as they can increase your risk of stomach irritation and liver strain. If you are pregnant, breastfeeding, or an elderly patient, consult your healthcare provider to discuss the risks and benefits before starting treatment.

Uses of Lupizotib 60 mg Tablet

Your doctor may prescribe this medicine to help manage the following conditions:

  • Advanced Renal Cell Carcinoma (Kidney Cancer): Lupizotib 60 mg Tablet is used to treat advanced kidney cancer by slowing tumour growth and delaying the spread of cancer cells to other parts of the body.
  • Hepatocellular Carcinoma (Liver Cancer): It is used to treat adults with advanced liver cancer who have previously received certain anticancer treatments, helping slow disease progression.
  • Differentiated Thyroid Cancer: It helps treat progressive, locally advanced, or metastatic differentiated thyroid cancer that no longer responds to radioactive iodine therapy.

Key Benefits

When used as prescribed, Lupizotib 60 mg Tablet offers several important benefits in the treatment of advanced cancers.

  • Slows cancer progression: By blocking multiple proteins involved in tumour growth and blood vessel formation, this medicine helps slow the growth and spread of cancer cells.
  • Helps control tumour growth: In many patients, Lupizotib 60 mg Tablet helps shrink tumours or prevents them from becoming larger, helping keep the disease under control for longer.
  • Delays disease progression: This medicine may extend the period during which the cancer remains stable before it worsens, improving treatment outcomes.
  • Supports quality of life: By slowing tumour growth, Lupizotib 60 mg Tablet may help reduce cancer-related symptoms such as pain or discomfort, allowing many patients to maintain their daily activities for longer.
Side effects of Lupizotib 60 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Maintain your magnesium levels and general health by drinking lots of water.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • Lupizotib 60 mg Tablet should be taken on an empty stomach at least one hour before food and 2 hours after food, or as advised by your doctor.
  • It is recommended to take Lupizotib 60 mg Tablet once daily or as advised by your doctor.
  • Swallow the whole tablet with a glass of water.
  • Do not break, chew or crush Lupizotib 60 mg Tablet .

How Lupizotib 60 mg Tablet Works

Lupizotib 60 mg Tablet contains cabozantinib which belongs to a class of medicines known as multi-kinase inhibitors. Cancer cells and the blood vessels that support them rely on specific protein signals, called kinases, to grow and multiply. This medicine works by blocking these signals. By blocking these pathways, Lupizotib 60 mg Tablet cuts off the blood supply that tumors need to grow. Without a proper blood and nutrient supply, the cancer cells find it difficult to multiply, which helps to shrink the tumor or slow down the progression of the disease.
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Lupizotib 60 mg Tablet as it may cause serious side effects.

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Pregnancy

Unsafe

Lupizotib 60 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Lupizotib 60 mg Tablet . You should not become pregnant while you are taking Lupizotib 60 mg Tablet for at least four months from the last dose of Lupizotib 60 mg Tablet . Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Lupizotib 60 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.

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Driving

Unsafe

In some cases, Lupizotib 60 mg Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Lupizotib 60 mg Tablet therapy.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Lupizotib 60 mg Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Lupizotib 60 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

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Children

Unsafe

Lupizotib 60 mg Tablet is not recommended for use in children as the safety and efficacy are not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Lupizotib 60 mg Tablet if you have pre-existing heart problems. Your doctor will prescribe Lupizotib 60 mg Tablet if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before administering Lupizotib 60 mg Tablet to geriatric patients. Your doctor will prescribe Lupizotib 60 mg Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Lupizotib 60 mg Tablet

If you suspect an overdose or have accidentally taken more than your prescribed dose, seek emergency medical care immediately or contact a poison control center.

Diet & Lifestyle Advise

  • Protect your hands and feet: To manage hand-foot syndrome, avoid exposing your hands and feet to hot water, wear thick socks and comfortable shoes, and apply a thick, alcohol-free moisturizer regularly.
  • Monitor your blood pressure: Check your blood pressure daily at home as directed by your doctor, and keep a log of your readings to share at your appointments.
  • Stay hydrated: Drink plenty of fluids, such as water or clear broths, to prevent dehydration if you experience diarrhea.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating smaller portions throughout the day can help you maintain your nutrition.
health query

Have a query?

How Soon It Starts Working

The time required for Lupizotib 60 mg Tablet to start to work: Lupizotib 60 mg Tablet ideally shows its action within 2 to 5 hours after administration. The time for which the effects of Lupizotib 60 mg Tablet last: The effect of Lupizotib 60 mg Tablet lasts for 55 hours.

What if you forget to take Lupizotib 60 mg Tablet

If you miss a dose and your next scheduled dose is more than 12 hours away, take the missed dose as soon as you remember. If your next dose is less than 12 hours away, skip the missed dose entirely and take your next dose at your usual scheduled time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Lupizotib 60 mg Tablet at room temperature between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Inspect your tablets before use: Do not take any tablet that is broken, chipped, crushed, or cracked.
  • Handle the tablets carefully: Wash your hands thoroughly with soap and water after handling the tablets. Caregivers should wear disposable gloves when handling the medication, especially if pregnant or planning pregnancy.
  • Tell your dentist you are taking Lupizotib 60 mg Tablet : Inform your dentist before any dental procedure, as this medicine may increase the risk of jawbone problems (osteonecrosis of the jaw), particularly after tooth extractions or other invasive dental work.
  • Pregnancy warning: Use highly effective contraception during treatment and for at least 4 months after your final dose. Do not become pregnant while taking this medicine because it can harm an unborn baby.
  • Check before taking new medicines: Do not start any prescription medicines, over-the-counter products, vitamins, or herbal supplements without consulting your doctor or pharmacist first.
  • When to seek urgent medical care: Seek immediate medical attention if you develop severe jaw pain, loose teeth, swelling of the jaw, severe allergic reactions, persistent thigh or groin pain, or any unusual symptoms that worsen rapidly.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong CYP3A4 inhibitors (such as ketoconazole or clarithromycin): May increase the levels of Lupizotib 60 mg Tablet in your body, raising your risk of experiencing serious side effects.
  • Strong CYP3A4 inducers (such as rifampin or phenytoin): May lower the levels of Lupizotib 60 mg Tablet in your blood, making the treatment less effective.
  • Blood thinners (such as warfarin): May significantly increase your risk of severe, life-threatening bleeding.
CabozantinibBicalutamide
Severe
CabozantinibCiprofloxacin
Severe

Drug-Drug Interactions

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CabozantinibBicalutamide
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Co-administration of Bicalutamide and Lupizotib 60 mg Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Bicalutamide and Lupizotib 60 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CabozantinibCiprofloxacin
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
When Lupizotib 60 mg Tablet is taken with Ciprofloxacin, it can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Although there is a possible interaction between Ciprofloxacin and Lupizotib 60 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
CabozantinibBuprenorphine
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Taking buprenorphine with carbozantinib increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of buprenorphine alongside carbozantinib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibGoserelin
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Taking Goserelin and Lupizotib 60 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Lupizotib 60 mg Tablet together can possibly result in an interaction; it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibPrasugrel
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
When Lupizotib 60 mg Tablet is taken with Prasugrel, it can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Prasugrel with Lupizotib 60 mg Tablet together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
CabozantinibCarbamazepine
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
When Lupizotib 60 mg Tablet is taken with Carbamazepine, it may decrease the blood levels of Lupizotib 60 mg Tablet, which may make Lupizotib 60 mg Tablet less effective in treating your cancer.

How to manage the interaction:
Taking Carbamazepine with Lupizotib 60 mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
CabozantinibClopidogrel
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Taking Lupizotib 60 mg Tablet together with clopidogrel may increase the risk of bleeding.

How to manage the interaction:
Taking Clopidogrel with Lupizotib 60 mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. Contact your doctor immediately if you notice symptoms like bleeding, bruising, dizziness, or black stools. Do not stop using any medications without a doctor's advice.
CabozantinibIdarubicin
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Taking Idarubicin and Lupizotib 60 mg Tablet together can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Idarubicin and Lupizotib 60 mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CabozantinibAzithromycin
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Taking azithromycin with cabozantinb may increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although using azithromycin alongside cabozantinb can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
CabozantinibClofazimine
Severe
How does the drug interact with Lupizotib 60 mg Tablet:
Co-administration of Lupizotib 60 mg Tablet with clofazimine can increase the risk of irregular heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Lupizotib 60 mg Tablet with clofazimine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: May increase the amount of this medicine in your bloodstream, which can lead to dangerous side effects. Avoid these products entirely during treatment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Lupizotib 60 mg Tablet is used to treat Renal Cell Carcinoma and Hepatocellular carcinoma.
Lupizotib 60 mg Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.
Lupizotib 60 mg Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.
No, you must take Lupizotib 60 mg Tablet on an empty stomach. Do not eat any food for at least 2 hours before your dose and for 1 hour after taking it. Talk to your doctor or pharmacist if you struggle to manage this schedule.
This is a common side effect known as hand-foot skin reaction. You should apply thick moisturizing creams, avoid hot water, protect your skin from friction, and contact your doctor for guidance on managing the symptoms.
It is highly recommended to avoid alcohol while taking this medicine. Alcohol can irritate your stomach lining and place extra strain on your liver. Talk to your doctor if you have questions about alcohol use.
Yes, high blood pressure is a very common side effect of this medicine. Your doctor will likely ask you to monitor your blood pressure daily at home and may prescribe blood pressure-lowering medication if needed.
You must inform your dentist and your oncologist before any dental work. This medicine can cause serious healing problems in your jawbone, and you may need to stop taking it temporarily before and after any invasive dental procedures. Talk to your doctor before scheduling any dental work.
If you have severe or persistent diarrhea, contact your doctor right away. They may recommend specific anti-diarrheal medicines, suggest dietary changes, or adjust your dose of Lupizotib 60 mg Tablet to help manage the issue safely.
No, you must not take this medicine if you are pregnant, as it can cause serious harm to an unborn baby. You must use effective birth control during treatment and for at least 4 months after your last dose. Talk to your doctor immediately if you suspect you are pregnant.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 208692S010Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A616037 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Cabozantinib [Prescribing Information]. 2025. [Accessed on 02 Jan. 2026]Check here
  4. Cabozantinib Cabozantinib. 2025. [Accessed on 14/04/2026]Check here
  5. Patheon France. CABOMETYX 20 mg, 40 mg, 60 mg film-coated tablets. Cabozantinib. Electronic Medicines Compendium (EMC). [Revised in July 2022]. [Accessed on 29th March 2023]Check here
  6. Exelixis, Inc. CABOMETYX® (cabozantinib) tablets, for oral use. U.S. Food and Drug Administration. [Revised in January 2019]. [Accessed on 29th March 2023] docs/label/2019/208692s003lbl.pdfCheck here
  7. Medscape Clinical Reference. Cometriq Cabometyx Cabozantinib 999791 Dosage & Guidelines. New York, NY: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3Rd Floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country Of Origin: India
Other Info - LUP0367
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