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Lupride Injection is used to treat prostate cancer in men, breast cancer and endometriosis in women and precocious puberty (early puberty) in children. It contains Leuprolide which works by inhibiting the synthesis of testosterone in men and oestrogen in women. In some cases, this medicine may cause side effects such as headache, nausea, vomiting, diarrhoea, upset stomach and injection site pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

LEUPROLIDE-1MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lupride Injection

Lupride Injection is a prescription injection used to treat advanced prostate cancer in men, hormone-sensitive conditions such as endometriosis and uterine fibroids in women, and central precocious puberty (early-onset puberty) in children. It works by reducing the production of certain sex hormones, helping slow disease progression and relieve symptoms.

To achieve the best results, it is important to receive Lupride Injection exactly as scheduled by your healthcare provider. Because this medicine is given as an injection, it can be administered without regard to meals. Maintaining a healthy lifestyle, including regular weight-bearing exercise and adequate calcium and vitamin D intake, can help support bone health during treatment.

While receiving Lupride Injection , you may experience common side effects such as hot flashes, increased sweating, headache, or mild pain at the injection site. However, contact your doctor immediately if you develop severe bone pain, difficulty urinating, chest pain, sudden weakness, or signs of an allergic reaction. Your healthcare provider will monitor your progress with regular examinations and blood tests throughout treatment.

Lupride Injection is a prescription injection used to treat advanced prostate cancer in men, hormone-sensitive conditions such as endometriosis and uterine fibroids in women, and central precocious puberty (early-onset puberty) in children. It works by reducing the production of certain sex hormones, helping slow disease progression and relieve symptoms.

To achieve the best results, it is important to receive Lupride Injection exactly as scheduled by your healthcare provider. Because this medicine is given as an injection, it can be administered without regard to meals. Maintaining a healthy lifestyle, including regular weight-bearing exercise and adequate calcium and vitamin D intake, can help support bone health during treatment.

While receiving Lupride Injection , you may experience common side effects such as hot flashes, increased sweating, headache, or mild pain at the injection site. However, contact your doctor immediately if you develop severe bone pain, difficulty urinating, chest pain, sudden weakness, or signs of an allergic reaction. Your healthcare provider will monitor your progress with regular examinations and blood tests throughout treatment.

Before starting this medicine, tell your doctor if you have heart disease, diabetes, osteoporosis, seizures, or high blood pressure. Do not use this medicine if you are pregnant or breastfeeding, as it can cause serious harm to an unborn baby. Women of childbearing potential should use effective non-hormonal contraception during treatment if advised by their doctor.

This medicine may interact with medicines that affect heart rhythm and other prescription medications. Inform your healthcare provider about all medicines, vitamins, and herbal supplements you are taking before starting treatment. Older adults and people with chronic medical conditions may require closer monitoring during therapy.

Uses of Lupride Injection

Your doctor may prescribe this medicine to treat several conditions, including:

  • Advanced Prostate Cancer: Lupride Injection lowers testosterone levels to slow the growth and spread of hormone-sensitive prostate cancer.
  • Endometriosis: This medication reduces estrogen levels to relieve pelvic pain, painful menstrual periods, and other symptoms caused by endometrial tissue growing outside the uterus.
  • Uterine Fibroids: It helps shrink uterine fibroids, reducing heavy menstrual bleeding and pelvic pressure, and may be used before surgery.
  • Central Precocious Puberty: This medication temporarily suppresses the hormones responsible for early puberty, helping delay premature physical development in children.

Key Benefits

Lupride Injection helps manage hormone-sensitive conditions by lowering the production of specific sex hormones. This helps slow disease progression, relieve symptoms, and improve quality of life. Key benefits include:

  • Helps Manage Advanced Prostate Cancer: By lowering testosterone levels, this medication slows the growth of prostate cancer cells and helps relieve symptoms such as bone pain and urinary problems.
  • Relieves Symptoms of Endometriosis and Fibroids: It reduces pelvic pain, painful menstrual periods, heavy bleeding, and pressure symptoms by lowering estrogen levels and shrinking hormone-dependent tissue.
  • Delays Early Puberty: In children with central precocious puberty, this medication temporarily delays early sexual development, allowing for more normal growth and development.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Lupride Injection will be administered by a nurse or doctor.
  • Do not self-administer.

How Lupride Injection Works

Lupride Injection contains leuprolide, belongs to a group of medicines called gonadotropin-releasing hormone (GnRH) agonists. It works by acting on the pituitary gland, which controls the production of sex hormones. During the first few days of treatment, it temporarily increases hormone levels before suppressing the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). With continued treatment, testosterone levels in men and estrogen levels in women decrease significantly. By lowering these hormone levels, Lupride Injection slows the growth of hormone-dependent prostate cancer, reduces endometrial tissue and uterine fibroids, and suppresses the hormonal signals responsible for early puberty.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Lupride Injection to avoid unpleasant side-effects. Alcohol intake, along with Lupride Injection , may cause increased drowsiness.

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Pregnancy

Unsafe

Lupride Injection is a pregnancy category X drug. Lupride Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective method of contraception while taking fluorouracil and for at least 6 months afterwards. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Lupride Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Lupride Injection causes dizziness and affects your ability to drive. Do not drive or operate machinery if you experience any unmanageable side effects with Lupride Injection .

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Lupride Injection . Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Lupride Injection . Your doctor will weigh the benefits and any potential risks before prescribing it to you.

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Children

Caution

Lupride Injection is not recommended in children younger than two years of age.

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Heart

Caution

Lupride Injection should be administered with caution, especially if you have a history of heart problems. Please inform your doctor about any existing heart problems before receiving Lupride Injection .

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Geriatrics

Consult your doctor

Lupride Injection is generally safe for elderly patients, but should be administered under medical supervision. Seek advice from your doctor if you have any concerns.

What if I have taken an overdose of Lupride Injection

Since this medicine is typically injected by a healthcare professional or provided in pre-filled, single-use syringes, an overdose is very unlikely. However, if you suspect an overdose or experience severe symptoms like extreme dizziness or trouble breathing, seek immediate medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Protect your bones: Since long-term hormone therapy can lead to bone thinning, ensure you get enough calcium and Vitamin D through your diet. Foods like leafy greens, dairy products, and fortified foods are excellent sources. Talk to your doctor about whether you need calcium supplements.
  • Do weight-bearing exercises: Engaging in regular, low-impact weight-bearing exercises like walking, jogging, or light strength training helps keep your bones strong and supports joint health.
  • Monitor your heart health: Eat a heart-healthy diet low in saturated fats and rich in whole grains, fruits, and vegetables to help manage cholesterol and blood pressure levels.
  • Avoid smoking and limit alcohol: Both smoking and excessive alcohol intake can accelerate bone loss and increase your risk of heart-related issues during treatment.
  • Stay hydrated: Drinking plenty of water can help manage symptoms like hot flashes and support overall kidney health.
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How Soon It Starts Working

The time required for Lupride Injection to start to work: Lupride Injection ideally shows its action within 4 to 5 hours after administration. The time for which the effects of Lupride Injection last: The effect of Lupride Injection lasts for 18 hours.

What if you forget to take Lupride Injection

If you miss a scheduled injection or an appointment for your dose, contact your doctor or clinic immediately to get instructions on when to receive your next dose. Do not inject a double dose to make up for a missed one.

Storage

• Most formulations should be stored at room temperature, between 20°C and 25°C (68°F to 77°F), while some may require refrigeration.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution: Always check the liquid inside the syringe before injecting. It should be clear and colourless. Do not use it if you notice any cloudiness, discolouration, or floating particles.
  • Rotate your injection sites: Never inject into the exact same spot twice in a row. Rotate between your thigh, abdomen, and upper arm to prevent hard lumps or skin irritation.
  • Check your blood sugar: If you have diabetes, monitor your blood sugar levels more frequently, as this medicine can affect how your body processes sugar.
  • Use reliable non-hormonal birth control: Since this medicine can harm an unborn baby, use effective barrier methods of birth control (such as condoms) during treatment. Do not rely on birth control pills, as hormone-based contraceptives may not work effectively.
  • Monitor for bone pain: Be aware that you may experience a brief increase in bone pain or disease symptoms during the first few weeks of starting treatment. This is normal, but let your doctor know if it becomes severe.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor about all medicines you are taking before starting this medicine, as they may interact with Lupride Injection and affect your treatment.

  • Heart rhythm medicines: Combining Lupride Injection with medicines used to treat irregular heartbeats (like amiodarone, sotalol, or quinidine) can increase the risk of serious heart rhythm problems.
  • Certain antibiotics and antipsychotics: Medications that are known to affect your heart's electrical activity may interact and cause heart complications when used together with this injection.
LeuprorelinVandetanib
Critical

Drug-Drug Interactions

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LeuprorelinVandetanib
Critical
How does the drug interact with Lupride Injection 0.5 ml:
Taking Lupride Injection 0.5 ml with Vandetanib together can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Vandetanib together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Lupride Injection 0.5 ml:
Coadministration of Lupride Injection 0.5 ml and citalopram can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Injection 0.5 ml and citalopram together can possibly result in an interaction; they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Lupride Injection 0.5 ml:
Taking leuprolide with cisapride can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Lupride Injection 0.5 ml with Cisapride is not recommended, it can be taken if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or an irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Lupride Injection 0.5 ml:
Using nilotinib together with leuprolide can increase the risk of an irregular heart rhythm that may be serious

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Nilotinib is not recommended, as it can result in an interaction. It can be taken if your doctor has suggested it. However, if you experience prolonged diarrhea, vomiting, dizziness, lightheadedness, fainting, or difficulty breathing, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
LeuprorelinDofetilide
Critical
How does the drug interact with Lupride Injection 0.5 ml:
Taking leuprolide with dofetilide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Dofetilide together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lupride Injection 0.5 ml:
Taking Lupride Injection 0.5 ml with Pimozide together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Pimozide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinIbutilide
Critical
How does the drug interact with Lupride Injection 0.5 ml:
Using ibutilide together with leuprolide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Ibutilide together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
LeuprorelinEliglustat
Critical
How does the drug interact with Lupride Injection 0.5 ml:
Taking Leuprolide and Eliglustat together can raise the risk of an abnormal heart rhythm that may be serious.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Eliglustat together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
LeuprorelinSaquinavir
Critical
How does the drug interact with Lupride Injection 0.5 ml:
Taking leuprolide with Saquinavir together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Taking Lupride Injection 0.5 ml with Saquinavir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, shortness of breath, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Lupride Injection 0.5 ml:
Co-administration of Lupride Injection 0.5 ml and clozapine can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction between Lupride Injection 0.5 ml and clozapine, they can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Lupride Injection when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Lupride Injection is used to treat prostate cancer in men, breast cancer & endometriosis in women and precocious puberty (early puberty) in children.
Lupride Injection contains Leuprolide, a synthetic hormone that helps reduce the testosterone and oestrogen hormones in men and women, respectively. This process of lowering hormone levels can decrease cancer cell's growth in prostate cancer in men and shrinks endometriosis in women.
Yes, Lupride Injection commonly affects the hair by making them thin which further causes loss of hair. However, it is not very common. Hair reduction possibly happens due to the estrogen lowering effect of Lupride Injection . These effects are not long-lasting and may return after some time. If it matters to you then inform your doctor for further advice.
Lupride Injection may cause impotence and affect fertility in men. It is advised to speak to your doctor if you plan to have a family in the future before starting Lupride Injection .
Lupride Injection should be used with caution in diabetic patients as it may increase the risk of high blood sugar levels. Therefore, regular monitoring of blood sugar levels is recommended while taking Lupride Injection and inform your doctor if you have diabetes before taking Lupride Injection .
Lupride Injection may worsen your mood disorders like depression. Hence it is advised to use Lupride Injection only when you are free from any kind of mental problems. Please consult your doctor for more information.
Lupride Injection is not recommended for patients suffering from heart rhythm problems such as arrhythmia (irregular heartbeat) as it may increase the risk of heart rhythm problems. Therefore, inform your doctor if you have any heart problems before taking Lupride Injection .
Lupride Injection may cause osteoporosis (bone thinning) due to the reduction of estrogen in the body. Regular bone density tests may help you monitor osteoporosis. Contact your doctor if you observe any sign of tendon pain or swelling while taking Lupride Injection .
Before starting treatment with Lupride Injection , you should inform your doctor if you are allergic to any of its ingredients. Let your doctor know if you are pregnant or breastfeeding, as Lupride Injection could harm the unborn baby. Lupride Injection may also affect fertility in men, so discuss with your doctor if you plan to start a family in the future. Also, make sure to inform your doctor if you have a history of liver or kidney disease, heart disease, recent heart attack, depression, brain tumours, electrolyte imbalances, diabetes, seizures, weak bones, or high cholesterol levels.
No, Lupride Injection does not need to be refrigerated. It should be stored at room temperature, away from direct sunlight.
Lupride Injection is typically administered by a healthcare provider either under the skin (subcutaneously) or into a muscle (intramuscularly). Please do not self-administer Lupride Injection .
No, Lupride Injection is not a chemotherapy medicine. Lupride Injection is a hormonal medicine that belongs to the class of gonadotropin-releasing hormone (GnRH) agonists. It is a synthetic hormone that acts similarly to the GnRH hormone produced by the hypothalamus in the brain.
Yes, Lupride Injection can stop periods. It is used to treat endometriosis, a condition where tissue similar to the lining of the uterus (womb) grows outside the uterus and causes painful or irregular periods. Lupride Injection works by suppressing the production of hormones that regulate the menstrual cycle, which can create a temporary menopause-like state, stopping periods for a while.
Yes, Lupride Injection is a hormonal medicine that works by suppressing the production of reproductive hormones in females. Using Lupride Injection during pregnancy is not recommended, as it may harm the developing foetus (newborn baby). Its use should be avoided during pregnancy unless prescribed by your doctor.
Taking Lupride Injection may affect your bone health by lowering certain hormone levels (such as oestrogen or testosterone), which can lead to decreased bone mineral density over time. Please consult your doctor about the potential risks of using Lupride Injection and ask about steps you can take to help protect your bones.
Lupride Injection may increase blood sugar levels (hyperglycaemia) or make existing diabetes worse. It is important to monitor your blood sugar levels while using Lupride Injection and consult your doctor if you have any concerns before or during treatment.
No, you must not use this medicine if you are pregnant, as it can cause serious harm to an unborn baby. If you suspect you might be pregnant, stop the treatment and speak to your healthcare provider immediately. Talk to your doctor.
You may notice a temporary increase in symptoms during the first week or two of starting the injections. After this initial period, your hormone levels will drop, and your symptoms should begin to improve. Talk to your doctor.
Yes, some patients experience weight gain or changes in body fat due to the drop in sex hormone levels during treatment. Staying active and eating a balanced diet can help manage weight changes. Talk to your doctor.
Yes, you must use a reliable, non-hormonal birth control method, such as condoms, during your treatment. Hormone-based birth control methods may not work effectively while using this medication. Talk to your doctor.
Yes, it is common to experience a temporary surge in hormones during the first two weeks, which can briefly worsen symptoms like bone pain or pelvic pressure. This reaction is normal and typically goes away as hormone levels decrease. Talk to your doctor.
Yes, the changes in hormone levels caused by this medicine can lead to mood swings, irritability, or feelings of depression. If you notice severe changes in your mood, seek support from your medical team. Talk to your doctor.
No, you should not stop your injection schedule without consulting your healthcare provider, as your symptoms may return. Your doctor will advise you on how to safely finish your treatment course. Talk to your doctor.

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - LUP0022
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