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Composition :

OLAPARIB-150MG

Manufacturer/Marketer :

Astra Zeneca Pharma India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lynparza 150Mg Tablet

Lynparza 150Mg Tablet is an 'anti-cancer' drug used to treat various cancers, including ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.

To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop using the Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. While on Lynparza 150Mg Tablet treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.

Uses of Lynparza 150Mg Tablet

Lynparza 150Mg Tablet is used in the treatment of Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. The detailed uses of Lynparza 150Mg Tablet are as follows:<br/>• Ovarian Cancer: Lynparza 150Mg Tablet helps in maintenance treatment for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer after response to platinum-based chemotherapy and especially effective in patients with BRCA mutations or homologous recombination deficiency (HRD).<br/>• Breast Cancer: Lynparza 150Mg Tablet is used for HER2-negative, BRCA-mutated metastatic or high-risk early breast cancer and used after chemotherapy and sometimes endocrine therapy.<br/>• Pancreatic Cancer: Lynparza 150Mg Tablet helps in maintenance treatment for germline BRCA-mutated metastatic pancreatic cancer that hasn’t progressed after platinum-based chemotherapy.<br/>• Prostate Cancer: Lynparza 150Mg Tablet is for BRCA-mutated metastatic castration-resistant prostate cancer, often after prior hormonal therapy.<br/>

Directions for Use

• Lynparza 150Mg Tablet can be taken with or without food as prescribed by your doctor.• It is usually taken twice a day in the morning and evening, or as prescribed by your doctor.• Swallow the medicine as a whole with a glass of water.• Do not break, crush or chew Lynparza 150Mg Tablet.

Medicinal Benefits

Lynparza 150Mg Tablet belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate.  Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

How Lynparza 150Mg Tablet Works

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Lynparza 150Mg Tablet

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Lynparza 150Mg Tablet or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Lynparza 150Mg Tablet for as long as your doctor has prescribed. Do not stop Lynparza 150Mg Tablet midway. Talk to your doctor before taking Lynparza 150Mg Tablet if you have severe allergic reactions to Lynparza 150Mg Tablet or other medicines or suffer from any medical illness. Avoid taking Lynparza 150Mg Tablet if you are pregnant or breastfeeding because this Lynparza 150Mg Tablet can cause harmful effects on the unborn baby. Both women and men using this Lynparza 150Mg Tablet should use birth control to avoid pregnancy. Do not start Lynparza 150Mg Tablet unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Lynparza 150Mg Tablet and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Lynparza 150Mg Tablet.

Drug-Drug Interactions

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OlaparibMitotane
Severe

Drug-Drug Interactions

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How does the drug interact with Lynparza 150 mg Tablet:
Coadministration of Lynparza 150 mg Tablet and bosentan may significantly reduce the blood levels of Lynparza 150 mg Tablet, making the medication less effective in treating your condition.

How to manage the interaction:
Taking Bosentan and Lynparza 150 mg Tablet can lead to an interaction, but it can be taken if advised by your doctor. Do not stop using any medications without first talking to your doctor.
OlaparibMitotane
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Mitotane together with Lynparza 150 mg Tablet can reduce the blood levels of Lynparza 150 mg Tablet.

How to manage the interaction:
Although taking Lynparza 150 mg Tablet and Mitotane together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
When Lynparza 150 mg Tablet and Clozapine are taken together, can increase the risk of neutropenia (low white blood count).

How to manage the interaction:
Taking Lynparza 150 mg Tablet with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Combining Lynparza 150 mg Tablet with Modafinil may significantly reduce the blood levels of Lynparza 150 mg Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
There may be a possibility of interaction between Lynparza 150 mg Tablet and Modafinil, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
OlaparibBCG vaccine
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Combining BCG vaccine with Lynparza 150 mg Tablet can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between Lynparza 150 mg Tablet and BCG vaccine, you can take these medicines together if prescribed by your doctor. If you notice any signs of infection, it's important to contact your doctor right away. They can provide the necessary help and treatment to address the issue. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Taking Armodafinil and Lynparza 150 mg Tablet may reduce the blood levels of Lynparza 150 mg Tablet, which may reduce the effect of Lynparza 150 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Armodafinil and Lynparza 150 mg Tablet, you can take these medicines together if prescribed by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without consulting a doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Using Ribociclib and Lynparza 150 mg Tablet can increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Ribociclib and Lynparza 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
The concentration of Lynparza 150 mg Tablet can be increased when it is taken along with Imatinib which may lead to side effects.

How to manage the interaction:
Co-administration of Lynparza 150 mg Tablet with Imatinib can result in an interaction, but it can be taken if a doctor has advised it. However, if you have paleness, exhaustion, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or inflamed skin, body sores, or discomfort or burning when urinating, you should consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
OlaparibEtravirine
Severe
How does the drug interact with Lynparza 150 mg Tablet:
Using Etravirine together with Lynparza 150 mg Tablet can reduce the blood levels of Lynparza 150 mg Tablet.

How to manage the interaction:
Although taking Lynparza 150 mg Tablet and Etravirine together can evidently cause an interaction, it can be taken if your doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Lynparza 150 mg Tablet:
Fluconazole may increase the blood levels of Lynparza 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low blood cell count.

How to manage the interaction:
Although there is a possible interaction, fluconazole can be taken with Lynparza 150 mg Tablet if prescribed by the doctor. Consult the doctor if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Lynparza 150Mg Tablet.

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Pregnancy

Unsafe

Lynparza 150Mg Tablet should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Lynparza 150Mg Tablet and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.

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Breast Feeding

Unsafe

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.

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Driving

Caution

Lynparza 150Mg Tablet may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.

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Liver

Caution

In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.

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Kidney

Caution

In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.

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Children

Caution

The safety and effectiveness of Lynparza 150Mg Tablet in pediatric patients have not been established.

Have a query?

FAQs

Lynparza 150Mg Tablet is used to treat ovarian, breast, pancreatic, and prostate cancers.

Lynparza 150Mg Tablet contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.

If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Lynparza 150Mg Tablet.

Yes, Lynparza 150Mg Tablet can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.

Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.

Lynparza 150Mg Tablet is not a traditional chemotherapy pill. It's a targeted therapy, also known as a PARP inhibitor, which works differently from chemotherapy.

When taking Lynparza 150Mg Tablet, avoid or limit foods high in grapefruit or grapefruit juice, as these can interact with the medication. Additionally, consult your doctor or pharmacist for personalized dietary advice.

The duration of Lynparza 150Mg Tablet treatment can vary depending on the type of cancer being treated and the patient's response to the medication. Generally, Lynparza 150Mg Tablet is taken until disease progression, unacceptable toxicity, or completion of a specified treatment period. Therefore, follow your doctor's instructions carefully.

Before taking Lynparza 150Mg Tablet, inform your doctor about all your medical conditions, sensitivities, and medications. Also, mention if you're pregnant, planning to become pregnant, or breastfeeding. This will ensure safe use and help avoid any potential interactions.

Lynparza 150Mg Tablet can interact with other medications, so do not use any other medications unless your doctor advises. Your doctor will check for potential interactions and advise you on how to take them safely with Lynparza 150Mg Tablet.

No, Lynparza 150Mg Tablet is not recommended for use during pregnancy and breastfeeding, and it causes unwanted side effects. However, please consult your doctor if you have any concerns.

The common side effects of Lynparza 150Mg Tablet are feeling very tired, pale skin, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Please consult your doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Corporate & Registered Office, Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road, 560045, Bangalore
Other Info - LYN0034

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