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compositionComposition:DABIGATRAN ETEXILATE-75MG
prescription
Prescription Medicine
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Macdaxa 75 Capsule is an anticoagulant medicine used to prevent blood clot formation. This medicine prevents/treats conditions like deep vein thrombosis (blood clots in leg veins), pulmonary embolism (blood clots in the lung), heart attack, and stroke. This medicine works by inhibiting the production of the clotting factor Xa, also known as thrombin. thereby preventing the conversion of fibrinogen to fibrin, a protein that helps prevent blood clot formation. Common side effects include bleeding, anaemia, nausea, stomach pain, and vomiting.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DABIGATRAN ETEXILATE-75MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macdaxa 75 Capsule

Macdaxa 75 Capsule is an oral medication primarily prescribed to prevent blood clots from forming in your blood vessels. It is commonly used to lower the risk of stroke in people with a specific type of irregular heartbeat, as well as to treat and prevent blood clots in the legs or lungs. By keeping your blood flowing smoothly, this medicine plays a crucial role in preventing serious cardiovascular events.

To get the best results, you must take Macdaxa 75 Capsule consistently at the same times every day, exactly as prescribed. You can take this medicine with or without food, but taking it with a full glass of water is highly recommended to protect your stomach. Incorporating heart-healthy habits, such as low-impact exercise and a balanced diet, can further support your overall circulatory health.

While using Macdaxa 75 Capsule , some people may experience mild side effects like an upset stomach or easy bruising. However, you must contact your doctor immediately if you experience serious side effects, such as unusual or heavy bleeding, blood in your urine, or black stools. Your safety depends on monitoring how your body responds to the treatment.

Before starting Macdaxa 75 Capsule , tell your doctor if you have any history of kidney problems, liver damage, or stomach ulcers. Do not take this if you have active bleeding, an artificial heart valve, or severe kidney disease. It is also unsafe for individuals with certain bleeding disorders.

This medicine can interact with pain relievers like ibuprofen, certain herbal supplements, and alcohol, which can significantly increase your risk of bleeding. If you are pregnant, planning to breastfeed, or are an older adult, talk to your doctor or pharmacist to weigh the risks and benefits of starting this therapy.

Uses of Macdaxa 75 Capsule

Macdaxa 75 Capsule is used in the prevention of blood clot formation, deep vein thrombosis, and pulmonary embolism. The detailed uses of Macdaxa 75 Capsule are as follows:

  • Stroke prevention in atrial fibrillation: Macdaxa 75 Capsule helps prevent blood clots from forming in the heart due to an irregular heart rhythm, reducing the risk of a stroke.
  • Deep vein thrombosis (DVT): Macdaxa 75 Capsule treats clots that form in the deep veins, usually in the legs, and helps prevent them from returning.
  • Pulmonary embolism (PE): Macdaxa 75 Capsule treats blood clots that have traveled to the lungs, helping to restore normal blood flow and breathing.
  • Prevention of recurrent blood clots: Macdaxa 75 Capsule acts as a long-term preventive measure to lower the chances of developing future clots in the veins or lungs.

Key Benefits

Macdaxa 75 Capsule helps you maintain a safer, more active life by lowering your risk of dangerous blood clots.

Benefits may include:

  • Lowers the risk of blood clots that can lead to serious complications such as stroke, deep vein thrombosis (DVT), or pulmonary embolism (PE).
  • Helps prevent existing clots from growing larger while allowing the body's natural processes to gradually break them down, which may help relieve pain, swelling, and discomfort.
  • Helps lower the chances of developing new blood clots when taken as prescribed.
  • Unlike some older blood thinners, Macdaxa 75 Capsule generally does not require routine blood tests to monitor its anticoagulant effect.
  • Helps reduce the risk of clot-related complications, allowing many people to continue their daily activities with greater confidence when used as directed.
Side effects of Macdaxa 75 Capsule
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid other medicines that increase the risk of bleeding.
  • Use an electric razor and a soft-bristled toothbrush.
  • Monitor for signs of bleeding like bleeding gums, unusual bruising, blood in stool, nosebleeds, or heavy menstrual bleeding.
  • If you experience severe bleeding, apply direct pressure on the wound and consult a doctor promptly.
  • If the risk of bleeding is high, discuss with your doctor about possibility of switching to different medicine with a lower bleeding risk.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Macdaxa 75 Capsule can be taken with or without food.
  • It is usually taken twice daily, or as prescribed by your doctor.
  • Swallow the whole Macdaxa 75 Capsule with a glass of water.
  • Do not break, chew, or open it.

How Macdaxa 75 Capsule Works

Macdaxa 75 Capsule belongs to a class of medicines known as direct oral anticoagulants. Inside your body, it works by targeting a specific protein called thrombin (a protein your body uses to form clots), which is a key enzyme responsible for making blood clots. By directly binding to and blocking thrombin, Macdaxa 75 Capsule prevents blood cells from sticking together to form a clot. This keeps your blood thin and moving freely through your veins and arteries, preventing blockages that could lead to a stroke or organ damage.
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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Macdaxa 75 Capsule as it may increase the risk of bleeding.

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Pregnancy

Consult your doctor

Please consult your doctor if you are planning to become pregnant or are already pregnant before starting Macdaxa 75 Capsule . Your doctor will prescribe Macdaxa 75 Capsule only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Macdaxa 75 Capsule . Consult your doctor if you have any concerns.

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Driving

Consult your doctor

Macdaxa 75 Capsule usually does not affect your ability to drive or operate machinery. Consult your doctor if you have any concerns.

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Liver

Caution

Let your doctor know if you have/had liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 75 Capsule . However, it is not recommended for patients with severe liver diseases.

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Kidney

Caution

Let your doctor know if you have/had kidney diseases. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 75 Capsule . However, it is not recommended for patients with severe kidney diseases.

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Children

Unsafe

Macdaxa 75 Capsule is not recommended for children below the age of 18 years, as the safety and efficacy of Macdaxa 75 Capsule have not been established in children.

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Heart

Caution

Macdaxa 75 Capsule should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using Macdaxa 75 Capsule .

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Geriatrics

Caution

Macdaxa 75 Capsule should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Macdaxa 75 Capsule .

What if I have taken an overdose of Macdaxa 75 Capsule

If you think you have taken more Macdaxa 75 Capsule than prescribed dose, seek emergency medical attention immediately or go to the nearest hospital. Symptoms of overdose include unusual bruising or bleeding, pink or brown urine, red or black, tarry stools, vomiting material that is bloody or looks like coffee grounds, and coughing up blood.

Diet & Lifestyle Advise

  • Avoid high-risk activities: Stay away from contact sports or activities that carry a high risk of falling or injury to minimize bleeding risks.
  • Use safety grooming tools: Switch to a soft-bristled toothbrush and use an electric razor to prevent cuts and bleeding gums.
  • Limit alcohol consumption: Drinking alcohol can increase the risk of stomach bleeding while taking this medication.
  • Be cautious with pain relievers: Avoid over-the-counter pain medications like ibuprofen or aspirin unless specifically approved by your doctor.
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Have a query?

How Soon It Starts Working

  • The time required for Macdaxa 75 Capsule to start to work: Macdaxa 75 Capsule ideally shows its action within 0.5 to 2 hours after administration.
  • The time for which the effects of Macdaxa 75 Capsule last: The effect of Macdaxa 75 Capsule lasts for 12 to 17 hours.

What if you forget to take Macdaxa 75 Capsule

If you miss a dose of Macdaxa 75 Capsule , take it as soon as you remember on the same day. However, if your next scheduled dose is less than 6 hours away, skip the missed dose and take your next dose at the usual time. Do not take two doses at the same time or double your dose to make up for a missed one.

Storage

• Store Macdaxa 75 Capsule at room temperature between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Swallow capsules whole: Never open the capsule shell or sprinkle the medicine on food, as this alters how your body absorbs the drug and increases bleeding risk.
  • Carry medical identification: Carry a medical alert card in your wallet to inform emergency responders that you take Macdaxa 75 Capsule .
  • Inform healthcare providers: Always inform any dentist, surgeon, or healthcare specialist that you are taking this medication before undergoing any procedure.
  • Watch for signs of bleeding: Monitor your body daily for unusual bruises, dark stools, or pink urine, which can indicate internal bleeding.

Drug-Drug Interactions

verifiedApollotooltip
  • Pain relievers (e.g., aspirin): Taking these alongside Macdaxa 75 Capsule can significantly increase your risk of stomach ulcers and serious bleeding.
  • Other blood thinners (e.g., warfarin or heparin): May dangerously increase the risk of bleeding.
  • Certain antifungals (e.g., ketoconazole) and antibiotics (e.g., rifampin): May affect how your body processes Macdaxa 75 Capsule , making it either less effective or increasing side effects.
Dabigatran etexilateMifepristone
Critical
Dabigatran etexilateDronedarone
Severe

Drug-Drug Interactions

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Dabigatran etexilateMifepristone
Critical
How does the drug interact with Macdaxa 75 Capsule:
When Mifepristone is taken with Macdaxa 75 Capsule, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Mifepristone with Macdaxa 75 Capsule is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
Dabigatran etexilateDronedarone
Severe
How does the drug interact with Macdaxa 75 Capsule:
When Macdaxa 75 Capsule is taken with Dronedarone, the amount of Macdaxa 75 Capsule in the blood can go up.

How to manage the interaction:
Taking Macdaxa 75 Capsule with Dronedarone together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor.
Dabigatran etexilateTirofiban
Severe
How does the drug interact with Macdaxa 75 Capsule:
Taking Macdaxa 75 Capsule with Tirofiban can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 75 Capsule with Tirofiban together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateRegorafenib
Severe
How does the drug interact with Macdaxa 75 Capsule:
Taking Macdaxa 75 Capsule with Regorafenib can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 75 Capsule with Regorafenib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateMefenamic acid
Severe
How does the drug interact with Macdaxa 75 Capsule:
Coadministration of Mefenamic acid with Dabigatran can increase the risk or severity of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Mefenamic acid with Macdaxa 75 Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Dabigatran etexilateCarbamazepine
Severe
How does the drug interact with Macdaxa 75 Capsule:
Taking Macdaxa 75 Capsule with carbamazepine may significantly reduce the blood levels of dabigatran, which may make the medication less effective.

How to manage the interaction:
Although taking carbamazepine and Macdaxa 75 Capsule together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateNaproxen
Severe
How does the drug interact with Macdaxa 75 Capsule:
Coadministration of Naproxen and Macdaxa 75 Capsule may increase the risk or severity of unusual bleeding problems.

How to manage the interaction:
Taking Naproxen and Dabigatran together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateAcalabrutinib
Severe
How does the drug interact with Macdaxa 75 Capsule:
Taking Macdaxa 75 Capsule with Acalabrutinib can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 75 Capsule with Acalabrutinib together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
Dabigatran etexilateDiclofenac
Severe
How does the drug interact with Macdaxa 75 Capsule:
Concomitant use of diclofenac with dabigatran may increase the risk of stomach bleeding.

How to manage the interaction:
Taking diclofenac with dabigatran together possibly results in an interaction, it can be taken if your doctor has advised it. You should consult a doctor immediately if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness, light headedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache and weakness. Do not stop using any medications without first talking to your doctor.
Dabigatran etexilateVorapaxar
Severe
How does the drug interact with Macdaxa 75 Capsule:
Taking Macdaxa 75 Capsule with Vorapaxar can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Macdaxa 75 Capsule with Vorapaxar together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • St. John's Wort: This herbal supplement can decrease the level of Macdaxa 75 Capsule in your blood, making it less effective at preventing clots.
DABIGATRAN ETEXILATE-75MGHerbal products/medicines

Drug-Food Interactions

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DABIGATRAN ETEXILATE-75MGHerbal products/medicines
Common Foods to Avoid:
St. John’S Wort, Garlic Pill

How to manage the interaction:
Herbs and supplements may interact with Macdaxa 75 Capsule. Avoid St. John's Wort, herbs including garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba during Macdaxa 75 Capsule treatment.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICOAGULANT/ANTITHROMBOTIC]

FAQs

Macdaxa 75 Capsule is used to prevent blood clot formation, deep vein thrombosis (blood clots in deep veins), and pulmonary embolism (blood clots in the lungs).
Macdaxa 75 Capsule is a thrombin inhibitor. The inhibition of thrombin reduces the formation of blood-clotting material fibrin, thereby leading to fewer clots and aiding the free flow of blood.
Please consult your doctor if you are due to undergo surgery. The doctor might ask you to stop taking Macdaxa 75 Capsule a few days before surgery since it can cause an increased risk of bleeding during surgery.
Taking Macdaxa 75 Capsule during pregnancy may cause bleeding in the mother or the newborn baby. However, please consult your doctor if you are planning to become pregnant or already pregnant before starting Macdaxa 75 Capsule .
No, you are not recommended to stop taking Macdaxa 75 Capsule without consulting your doctor as it may worsen the condition. Therefore, take Macdaxa 75 Capsule for as long as your doctor has prescribed it.
You can take Macdaxa 75 Capsule with or without food but try to take it at the same time every day. Swallow the capsules whole with a drink of water. Do not open dabigatran capsules before taking them, as this increases the risk of side effects.
Take Macdaxa 75 Capsule as prescribed by your doctor. Depending on your medical conditions, you are advised to take Macdaxa 75 Capsule as long as your doctor has prescribed it for you.
You are recommended to avoid consumption of alcohol with Macdaxa 75 Capsule as it may increase the risk of bleeding.
Hair loss is not a known side effect of Macdaxa 75 Capsule . However, it is known to occur with anticoagulants. Consult your doctor if you observe hair loss. Your doctor will guide you on how to cope with this situation.
It varies from person to person and depends on the conditions that we treat.
Limited research available. Let your doctor know if you have/had liver diseases or hepatic impairment. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 75 Capsule . However, it is not recommended in patients with severe liver diseases.
Store in a cool and dry place away from sunlight. Keep Macdaxa 75 Capsule out of the sight and reach of children.
Yes, bleeding is the main risk associated with Macdaxa 75 Capsule treatment; patients should be monitored for signs of bleeding.
Macdaxa 75 Capsule is not suitable for some people with existing medical conditions. So, to ensure safety, let your doctor know about all your medical conditions and medications. Your doctor will weigh the benefits and potential risks before prescribing Macdaxa 75 Capsule .
Common side effects of Macdaxa 75 Capsule may include bleeding, anaemia, nausea, stomach pain, and vomiting.
No, you must swallow Macdaxa 75 Capsule capsules whole. Opening, crushing, or chewing the capsules causes too much medicine to be absorbed at once, which severely increases your risk of bleeding. Talk to your doctor if you have trouble swallowing capsules.
For minor cuts, apply firm, direct pressure with a clean cloth for at least 10 to 15 minutes. If the bleeding does not stop after this time, or if you experience a deep cut or head injury, seek emergency medical care immediately.
No, you should avoid taking common pain medicines (called NSAIDs) like ibuprofen or aspirin, unless your doctor specifically tells you to. These medicines can significantly increase your risk of stomach bleeding. Talk to your doctor or pharmacist for safe pain relief alternatives.
Macdaxa 75 Capsule is highly sensitive to moisture. Keeping the capsules in their original bottle or blister pack protects them from breaking down. Never store them in a daily pill organizer.
Unlike older blood thinners, Macdaxa 75 Capsule does not require routine, regular blood tests to check how thin your blood is. However, your doctor will still perform occasional blood tests to monitor your kidney function.
Macdaxa 75 Capsule is generally not recommended during pregnancy or breastfeeding, as its effects on the baby are not fully known. If you are pregnant or planning to become pregnant, talk to your doctor immediately to discuss safer alternatives.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Dabigatran Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Dabigatran - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.6229 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). 022512S007Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Dabigatran etexilate mesylate [Prescribing Information]. 2023. [Accessed on 15 Mar. 2019]Check here
  6. Pradaxa 150 mg hard capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 27 May 2022]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, India.
Other Info - MAC0416
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