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compositionComposition:MAGNESIUM VALPROATE-300MG
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Prescription Medicine
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Macorate CR 300 Tablet is an anticonvulsant medication used in the treatment of severe epileptic seizures/fits, bipolar disorder, and migrane. This medicine works by decreasing the abnormal electrical activity in the brain and thus reduces seizures. Common side effects include sleepiness, dizziness, nausea, headache, and weakness.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

MAGNESIUM VALPROATE-300MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macorate CR 300 Tablet

Macorate CR 300 Tablet is a prescription medication used to manage and prevent various types of seizures in individuals with epilepsy. It is also prescribed to treat the manic phase of bipolar disorder and to help prevent migraine headaches in adults. By targeting specific electrical signals in the brain, it helps restore stability and balance to your daily life.

For this medicine to work effectively, you must take it consistently at the same times every day without skipping doses. Your doctor will likely advise you to take it with or immediately after food to help prevent stomach upset. Making supportive lifestyle changes, such as keeping a consistent sleep schedule and staying well-hydrated, can also greatly improve your overall treatment results.

While taking Macorate CR 300 Tablet , you may experience some mild and temporary side effects, such as drowsiness, dizziness, or mild stomach discomfort. However, you must contact your doctor immediately if you notice serious symptoms like severe abdominal pain, unexplained bruising, or yellowing of your skin and eyes. Your health and safety require prompt medical evaluation if these rare signs appear.

Do not take this medicine if you have active liver disease, inherited mitochondrial disorders (such as Alpers-Huttenlocher syndrome or disorders caused by POLG gene mutations), or a family history of severe valproate-related liver problems. Before starting this treatment, always tell your doctor if you have kidney problems, a history of depression or mood swings, or if you are planning to become pregnant. This medication may not be suitable for everyone, and your doctor will help determine if it is safe for you.

This medication can interact with other prescription drugs, alcohol, and certain over-the-counter pain relievers, which can increase your risk of severe side effects or reduce how well the medicine works. If you are pregnant, breastfeeding, or caring for an elderly patient, consult your doctor for specialised safety guidance before using this medicine.

Uses of Macorate CR 300 Tablet

Macorate CR 300 Tablet is prescribed to help manage the following neurological and mental health conditions:

  • Epilepsy (Seizures): Macorate CR 300 Tablet helps control and prevent various types of seizures by calming overactive electrical activity in the brain.
  • Bipolar Disorder (Manic Episodes): Macorate CR 300 Tablet helps stabilize mood swings and manages periods of intense excitement, overactivity, or irritability.
  • Migraine Prevention: Macorate CR 300 Tablet reduces the frequency and severity of migraine headaches when taken regularly, though it does not treat an active headache.

Key Benefits

Macorate CR 300 Tablet provides real-world relief by stabilising brain activity, helping you regain control over your daily routine and feel more consistent from day to day.

  • Fewer seizure disruptions: By keeping the brain's electrical activity stable, it reduces the frequency of seizures, allowing you to go about your daily routine with greater confidence and safety.
  • More stable moods: For people living with bipolar disorder, this medicine helps smooth out extreme emotional highs and lows, making it easier to maintain relationships and manage daily tasks.
  • Fewer migraine days: By preventing the brain changes that trigger severe headaches, it helps you experience fewer painful migraine days and reduces your reliance on rescue pain medicines.
Side effects of Macorate CR 300 Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.

Directions for Use

  • Macorate CR 300 Tablet should be taken with or after food.
  • Macorate CR 300 Tablet is usually taken once or twice a day, or as prescribed by your doctor.
  • Swallow Macorate CR 300 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Macorate CR 300 Tablet Works

Macorate CR 300 Tablet works through several complementary mechanisms to stabilise electrical activity in the brain. It increases the levels of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that helps calm overactive nerve cells. It also helps stabilise nerve cell membranes by blocking voltage-gated sodium channels and T-type calcium channels, reducing the abnormal electrical activity that can trigger seizures. These combined actions also contribute to mood stabilisation in bipolar disorder and help prevent migraine attacks. When nerve cells become hyperactive, it can trigger seizures, severe mood shifts, or migraine pathways. By boosting GABA activity, Macorate CR 300 Tablet helps calm these overexcited nerve cells, preventing the electrical storms that cause seizures and stabilising overall brain activity.
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Alcohol

Caution

Avoid consumption of alcohol while taking Macorate CR 300 Tablet as it may increase dizziness and sleepiness.

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Pregnancy

Unsafe

Macorate CR 300 Tablet belongs to pregnancy category D. Avoid taking Macorate CR 300 Tablet if you are pregnant, as it could lead to severe birth defects.

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Breast Feeding

Caution

Macorate CR 300 Tablet may pass into breastmilk. Consult your doctor before taking Macorate CR 300 Tablet if you are breastfeeding.

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Driving

Unsafe

Macorate CR 300 Tablet causes dizziness, sleepiness and tiredness. Do not drive or operate machinery unless you are alert.

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Liver

Unsafe

Should not use the Macorate CR 300 Tablet if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have any concerns regarding this.

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Kidney

Caution

May need dose adjustment in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Safe if prescribed

Macorate CR 300 Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight.

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Heart

Caution

Macorate CR 300 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Macorate CR 300 Tablet .

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Geriatrics

Caution

Macorate CR 300 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Macorate CR 300 Tablet

If you or someone else takes too much of this medicine, seek emergency medical help or call your local poison control centre immediately. Signs of an overdose may include extreme sleepiness, confusion, shallow breathing, or loss of consciousness.

Diet & Lifestyle Advise

  • Prioritise regular sleep: Lack of sleep is a well-known trigger for both seizures and mood episodes. Aim for 7 to 9 hours of quality sleep every night.
  • Avoid alcohol completely: Drinking alcohol can significantly increase drowsiness, worsen mood stability, and trigger seizures.
  • Keep a health diary: Write down when your seizures, manic moods, or migraines occur, along with your daily doses. This helps your doctor see how well the medicine is working.
  • Stay consistently hydrated: Drink plenty of water throughout the day to support your kidney function and general health.
  • Eat regular meals: Skipping meals can trigger migraines and affect your blood sugar levels, which may impact your overall stability.
health query

Have a query?

How Soon It Starts Working

The time required for Macorate CR 300 Tablet to start to work: Macorate CR 300 Tablet ideally shows its action within 1 to 4 hours after administration. The time for which the effects of Macorate CR 300 Tablet last: The duration of action for Macorate CR 300 Tablet is clinically unknown.

What if you forget to take Macorate CR 300 Tablet

Take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and return to your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Macorate CR 300 Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not stop taking this medicine suddenly: Stopping abruptly can cause continuous, life-threatening seizures or severe mood setbacks. Always consult your doctor before making any changes.
  • Use highly effective birth control: This medicine carries a very high risk of causing birth defects and developmental delays in an unborn baby. Talk to your doctor about the safest birth control options.
  • Avoid driving or operating machinery: This medication can make you feel sleepy or dizzy, especially when you first start taking it. Do not perform tasks requiring alertness until you know how it affects you.
  • Get regular blood tests: Your doctor will schedule regular blood tests to check your liver function, pancreas health, and the level of medicine in your body. Make sure you do not miss these appointments.
  • Check for skin rash: If you develop a severe skin rash with peeling, a fever, or swollen glands, contact your doctor immediately, as this can be a sign of a rare but serious reaction.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with Macorate CR 300 Tablet and affect its safety or effectiveness:

  • Other anti-seizure medicines (such as phenytoin or carbamazepine): Taking these together can alter the blood levels of one or both medicines, increasing the risk of reduced seizure control or side effects.
  • Blood thinners (such as warfarin or aspirin): Combining these medicines may increase the risk of bruising or bleeding.
  • Central nervous system depressants (such as sleeping tablets, opioid pain relievers, or sedatives): Taking these with Macorate CR 300 Tablet can increase drowsiness, dizziness, and reduced alertness.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

The following foods and beverages may interact with Macorate CR 300 Tablet :

  • Alcohol: Avoid drinking alcohol while taking this medicine, as it can increase drowsiness, impair coordination, and reduce your ability to perform tasks requiring alertness.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

FAQs

Macorate CR 300 Tablet belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Macorate CR 300 Tablet also treats bipolar disorder and prevents migraine symptoms (like a headache).
Macorate CR 300 Tablet decreases the excessive and abnormal nerve activity in the brain. It balances the brain's chemical messenger and prevents overactivity of the brain, thereby controlling seizure episodes.
Macorate CR 300 Tablet helps treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.
Adults aged 18 and above can take it to prevent migraines. Macorate CR 300 Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition that is characterized by intense headaches.
Macorate CR 300 Tablet may also be effective as an acute treatment option for headaches such as migraines, tension headaches, and cluster headaches. It should, however, only be used under the supervision of a doctor.
Macorate CR 300 Tablet is safe if taken in the dose and for the term prescribed by your doctor. Take it exactly as directed, and do not miss any doses. Follow your doctor's instructions carefully and notify him or her if any of the adverse effects bother you.
Macorate CR 300 Tablet does not cure epilepsy, however, it helps to prevent seizures. You may need to continue taking it for several years. It’s important not to stop taking it suddenly. Take it as directed by your doctor.
Do not stop taking Macorate CR 300 Tablet without consulting your doctor as stopping it suddenly can cause the symptoms to reoccur or worsen your condition. If you experience any difficulty while taking Macorate CR 300 Tablet , consult your doctor.
You may gain weight after using Macorate CR 300 Tablet as it is one of its side effects. To control weight, you need to make changes in your diet and lifestyle. Exercise regularly. Have a balanced diet and avoid alcohol consumption. Consult a doctor if you have any other concerns.
Macorate CR 300 Tablet doesn’t affect the working of birth control pills, but contraceptives may reduce its effectiveness, and seizures may reoccur. Inform your doctor if you are on birth control pills, so they can monitor your response to the treatment and check the levels of Macorate CR 300 Tablet in your blood.
Macorate CR 300 Tablet may cause hair thinning, changes in colour or texture of hair and even hair loss. Consult your doctor if you have any concerns regarding this. The hair growth will be noticed after either reducing the dose of Macorate CR 300 Tablet or using a different remedy for the hair loss.
Macorate CR 300 Tablet may cause side effects such as stomach pain, diarrhoea, dry or sore mouth, swollen gums, headache, weight gain, thinning hair, delayed or irregular periods, unusual eye movements and changes in colour or texture of hair. Consult the doctor if these persist longer.
No, you should avoid alcohol while taking Macorate CR 300 Tablet . Alcohol can worsen drowsiness, increase the risk of liver problems, and make your condition harder to control. Talk to your doctor.
Contact your doctor immediately if you suspect you are pregnant. Do not stop taking Macorate CR 300 Tablet suddenly without medical advice, as this can be dangerous, but your doctor will need to evaluate your treatment options urgently. Talk to your doctor.
Yes, your doctor will order regular blood tests to monitor your liver function, blood cell counts, and the amount of medicine in your system to ensure it is working safely. Talk to your doctor.
You should not switch between different brands or generic versions of Macorate CR 300 Tablet without first consulting your healthcare provider, as even small differences can affect how your body absorbs the medicine. Talk to your doctor.
If you or your family notice any unusual changes in your mood, behaviour, or if you develop thoughts of self-harm, contact your doctor right away. Talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MAC0077

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