apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. MACORATE CR 400MG TABLET

MACORATE CR 400MG TABLET, Pack of 10 TABLETS
MACORATE CR 400MG TABLET, Pack of 10 TABLETS
MACORATE CR 400MG TABLET, Pack of 10 TABLETS
MACORATE CR 400MG TABLET, Pack of 10 TABLETS
MACORATE CR 400MG TABLET, Pack of 10 TABLETS
Offers on medicine orders
All offers
axis icici
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

MACORATE CR 400MG TABLET is used to treat seizures. Besides this, it is also used to treat manic episodes associated with bipolar disorder and prevent migraine symptoms. It contains Valproic acid which works by reducing abnormal electrical activity in the brain. It also produces a calming effect and limits the transmission of pain signals. This medicine may sometimes cause side effects such as nausea, upset stomach, tremors, sleepiness, headache, and weight gain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

Read more

Composition :

VALPROIC ACID-400MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About MACORATE CR 400MG TABLET

MACORATE CR 400MG TABLET belongs to a group of anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. In addition, MACORATE CR 400MG TABLET also treats manic episodes associated with bipolar disorder. Besides this, it can also prevent migraine symptoms (like a headache). Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures, sometimes leading to an unconscious state.

MACORATE CR 400MG TABLET contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. MACORATE CR 400MG TABLET raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches.

MACORATE CR 400MG TABLET should be taken as prescribed by the doctor. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects are temporary and will go away on their own. However, if you suffer these adverse effects on a regular basis, you should consult your doctor.

Inform your doctor if you are allergic to any components present in MACORATE CR 400MG TABLET. If you are pregnant, do not take MACORATE CR 400MG TABLET because it may cause serious congenital defects. Use effective contraception if you are of childbearing age while taking MACORATE CR 400MG TABLET. If you are breastfeeding, inform your doctor before taking MACORATE CR 400MG TABLET. As MACORATE CR 400MG TABLET causes sleepiness and dizziness, do not drive or operate machinery. Avoid drinking alcohol with MACORATE CR 400MG TABLET as it may cause dizziness and tiredness. To rule out any negative effects, keep your doctor updated about your health condition and medications.

Uses of MACORATE CR 400MG TABLET

MACORATE CR 400MG TABLET is used for the treatment of Epilepsy (fits), Bipolar disorder, Migraine.

Have a query?

Directions for Use

• MACORATE CR 400MG TABLET can be taken with food to avoid stomach upset.• It is usually taken twice daily; however, your doctor may adjust the dosage and timing based on your medical condition and response to treatment.• Swallow MACORATE CR 400MG TABLET as a whole with a glass of water.• Do not crush or chew this medication.

Medicinal Benefits

MACORATE CR 400MG TABLET contains Valproic acid, an anticonvulsant (or anti-epileptic) medicine that reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. MACORATE CR 400MG TABLET raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches.

How MACORATE CR 400MG TABLET Works

MACORATE CR 400MG TABLET contains Valproic acid, which reduces the brain's excessive and aberrant nerve activity. As a result, it aids in the control of seizures. MACORATE CR 400MG TABLET raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. This contributes to the treatment of bipolar disorder. MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches.

Storage

Keep MACORATE CR 400MG TABLET out of the sight and reach of children.
Side effects of Macorate Cr 400mg Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Eat fiber-rich foods, fruits, and vegetables, and track your food intake to monitor calorie consumption.
  • Limit takeout and restaurant meals, and weigh yourself weekly to stay motivated.
  • Build balanced meals, allow yourself to enjoy treats in moderation, and prioritize sleep and stress management through exercise and relaxation techniques.

What if I have taken an overdose of MACORATE CR 400MG TABLET

Take MACORATE CR 400MG TABLET only as prescribed by the doctor. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include sleepiness, irregular heartbeat, and coma (loss of consciousness for a period of time). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Before taking the MACORATE CR 400MG TABLET, let your doctor know about all your medical conditions, sensitivities, and all medications you are using. And also, inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding. You should not become pregnant while you are receiving MACORATE CR 400MG TABLET. Consult your doctor immediately if you become pregnant while receiving a MACORATE CR 400MG TABLET. Alcohol should be avoided during treatment with this medicine. You must not drive or operate machinery while receiving MACORATE CR 400MG TABLET.

Drug-Drug Interactions

verifiedApollotooltip
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

Login/Sign Up

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • Adolescents and adults are advised to follow the Atkins diet (high fat, low carbohydrate).
  • Exercising on a regular basis aids with weight maintenance and general health.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and drinking alcohol.
  • Meditation and yoga can help reduce stress, reduce pain sensitivity, and increase coping abilities.
  • Have a seizure response plan in place, and make sure everyone around you knows what to do in the event of a seizure.
  • Prepare your living environment; simple changes may help reduce the risk of physical damage during a seizure.
  • Understand what causes seizures and try to reduce or avoid them.
  • Please keep your overall health in mind, as it can aid in the reduction of seizure activity.
  • Install an alarm or an emergency gadget to summon help during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

MACORATE CR 400MG TABLET Substitute

Substitutes safety advice
bannner image

Alcohol

Caution

Do not consume alcohol while taking MACORATE CR 400MG TABLET as alcohol can worsen the side effects of the MACORATE CR 400MG TABLET, including sleepiness and dizziness.

bannner image

Pregnancy

Unsafe

MACORATE CR 400MG TABLET is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with MACORATE CR 400MG TABLET.

bannner image

Breast Feeding

Caution

MACORATE CR 400MG TABLET passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking MACORATE CR 400MG TABLET. Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

bannner image

Driving

Caution

MACORATE CR 400MG TABLET may cause dizziness, drowsiness or tiredness in some people. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking MACORATE CR 400MG TABLET.

bannner image

Liver

Caution

Inform your doctor before receiving the MACORATE CR 400MG TABLET if you have a history of liver diseases/conditions. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing MACORATE CR 400MG TABLET.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

bannner image

Children

Consult your doctor

Use is not recommended for children less than ten years. Your doctor will decide the dose based on your child's condition if more than ten years.

FAQs

MACORATE CR 400MG TABLET is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).

MACORATE CR 400MG TABLET decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

MACORATE CR 400MG TABLET helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

MACORATE CR 400MG TABLET limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

MACORATE CR 400MG TABLET may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with MACORATE CR 400MG TABLET. Avoid getting pregnant while taking MACORATE CR 400MG TABLET as it could lead to serious birth defects. Do not stop taking MACORATE CR 400MG TABLET and consult your doctor immediately if you become pregnant.

MACORATE CR 400MG TABLET may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

MACORATE CR 400MG TABLET may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.

MACORATE CR 400MG TABLET contains Valproic acid as its active ingredient.

Take MACORATE CR 400MG TABLET with or without food as advised by your doctor.

You are recommended to avoid alcohol consumption while taking MACORATE CR 400MG TABLET as it may worsen the side effects of the MACORATE CR 400MG TABLET, including sleepiness and dizziness.

No, MACORATE CR 400MG TABLET does not cause addiction. However, MACORATE CR 400MG TABLET should be used as per dose and duration prescribed by your doctor. Do not self-medicate.

MACORATE CR 400MG TABLET does not cure epilepsy, it only helps to prevent the seizures. However, you have to take MACORATE CR 400MG TABLET for as long as it is advised by your doctor. If you face any difficulty while taking MACORATE CR 400MG TABLET, consult your doctor.

If you stop taking MACORATE CR 400MG TABLET suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to stop taking MACORATE CR 400MG TABLET, please consult your doctor.

Some birth control pills (oestrogen-containing birth control pills) may lower the levels of MACORATE CR 400MG TABLET in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about the suitable method of contraception.

MACORATE CR 400MG TABLET is safe to take for long time in many patients if prescribed by a doctor. In rare cases, prolonged use of MACORATE CR 400MG TABLET may weaken your bones, thereby increasing their risk of breaking easily (osteopenia and osteoporosis). Get regular checkups done for bone health if you are taking MACORATE CR 400MG TABLET for a long time.

MACORATE CR 400MG TABLET may cause hair thinning, hair colour changes and even hair loss. If you have any concerns regarding this, please ask your doctor if it is possible to lower the dose of MACORATE CR 400MG TABLET. Your hair may regrow after either lowering your dose or changing medication.

Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MAC0113

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.drugs.com/mtm/valproic-acid.html
  2. https://www.medicines.org.uk/emc/files/pil.6102.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018081s065_018082s048lbl.pdf
  4. https://www.nhs.uk/medicines/valproic-acid/

Buy best C.n.s Drugs products by

whatsapp Floating Button

Recommended for a 30-day course: 3 Strips

Buy Now
Add 3 Strips