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compositionComposition:RIFAMPICIN-300MG
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Prescription Medicine
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Macox 300 mg Capsule is used in combination with other medicines to treat tuberculosis (TB). It contains Rifampicin, which inhibits the growth of bacteria. In some cases, you may experience certain common side effects, such as drowsiness, dizziness, headache, weakness, muscle pain, heartburn, diarrhoea, gas, and numbness or tingling sensations. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

RIFAMPICIN-300MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Macox 300 mg Capsule

Macox 300 mg Capsule is an oral antibiotic used to treat serious bacterial infections, primarily tuberculosis. It is also prescribed to eliminate bacteria from the nose and throat of individuals who may spread meningitis, even if they do not currently feel sick. This medicine is highly effective when used as part of a combination therapy plan to ensure the infection is completely cleared from your body.

For the best results, you must take Macox 300 mg Capsule consistently and exactly as your doctor prescribes, typically once daily. It is best taken on an empty stomach, either one hour before or two hours after a meal, to ensure your body absorbs the maximum amount of medicine. Implementing a structured daily schedule can help you remain consistent with your doses and support your recovery.

While taking Macox 300 mg Capsule, you will likely notice a harmless orange-red discolouration of your urine, sweat, and saliva. However, you should contact your doctor immediately if you experience severe side effects, such as persistent abdominal pain, unusual fatigue, or yellowing of your skin or eyes.

Do not take this if you have a known allergy to rifampicin antibiotics or have severe liver disease. Before starting, talk to your doctor if you have a history of liver problems, diabetes, or porphyria, as special monitoring may be required to keep you safe.

This medicine can interact significantly with other treatments, including hormonal birth control and blood thinners, reducing their effectiveness. If you are pregnant, breastfeeding, or an older adult, consult your healthcare provider to discuss the risks and benefits before taking this medication.

Uses of Macox 300 mg Capsule

Macox 300 mg Capsule is used to treat tuberculosis mainly. The detailed uses of Macox 300 mg Capsule are as follows:

  • Tuberculosis: Macox 300 mg Capsule helps by stopping the growth and replication of the bacteria causing this deep lung infection, usually in combination with other tuberculosis medications to prevent drug resistance.
  • Meningococcal carrier state: Macox 300 mg Capsule helps by eliminating bacteria from the nose and throat of asymptomatic carriers, stopping the spread of bacterial meningitis to other people.
     

Key Benefits

Macox 300 mg Capsule offers several key benefits for individuals fighting serious bacterial infections, providing a reliable path toward recovery and protecting those around them.

  • Deep-seated infection clearance: By aggressively targeting bacteria, it helps clear persistent pulmonary infections, allowing your lungs to heal and relieving chronic cough and fatigue.
  • Prevention of community spread: It quickly sanitises the respiratory tract of carriers, ensuring that dangerous, life-threatening pathogens are not passed to family members or close contacts.
  • Targeted therapeutic action: It works specifically on bacterial cells, minimising damage to healthy human tissue while delivering potent antibacterial effects.
     
Side effects of Macox 300 mg Capsule
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink plenty of fluids and stay hydrated.
  • Avoid foods containing sugars, salts and processed food.
  • Avoid consumption of alcohol.
  • Take healthy diet containing fiber, carbohydrates and lean proteins.
  • Exercise regularly and maintain a healthy lifestyle.

Directions for Use

  • Take Macox 300 mg Capsule 30 minutes before or 2 hours after food on an empty stomach.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Macox 300 mg Capsule as a whole with a glass of water.
  • Do not chew, crush or break it.

How Macox 300 mg Capsule Works

Macox 300 mg Capsule works by targeting the vital cellular machinery of bacteria. It specifically binds to and blocks a bacterial enzyme called RNA polymerase, which is responsible for copying genetic material and building essential proteins. Without this enzyme, the bacteria are unable to multiply, grow, or maintain their structure. Because human cells have a different structure and do not use this specific enzyme in the same way, Macox 300 mg Capsule acts selectively on the bacteria. By halting bacterial reproduction, the medicine weakens the infection, allowing your body's natural immune system to easily target and eliminate the remaining bacteria.
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Alcohol

Caution

Macox 300 mg Capsule intake is not recommended with alcohol. A patient is not advised to take alcohol with Macox 300 mg Capsule as it may increase chances of liver damage.

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Pregnancy

Unsafe

Not recommended during pregnancy. Tell your doctor if you are pregnant or planning to become pregnant. Macox 300 mg Capsule should not be taken during pregnancy as it can affect your unborn baby's growth and may cause complications to the mother and baby after birth.

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Breast Feeding

Unsafe

Not recommended while breastfeeding. A patient should not breast-feed while taking Macox 300 mg Capsule. This is because a small amount of Macox 300 mg Capsule may pass into the mother’s milk. So, if you are breastfeeding or planning to breastfeed, talk to your doctor.

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Driving

Caution

Caution should be maintained by a patient while driving a motor vehicle or doing hazardous work. A patient may experience dizziness, have problems with vision or have other side effects that could affect his ability to drive after taking this medicine. If this happens, do not drive.

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Liver

Caution

Not recommended to be taken in liver patients without a doctor's consultation as Macox 300 mg Capsule has been found to affect liver function with raised ALT enzymes.

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Kidney

Caution

Not recommended for kidney patients without a doctor's consultation. Intake of Macox 300 mg Capsule in these people may result in symptoms like blood in the urine, a change in the amount of urine passed and feeling drowsy or weak.

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Children

Safe if prescribed

Macox 300 mg Capsule is safe to be prescribed in children below 12 years. Dose adjustments by the doctor are done according to age, weight, and severity of infection.

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Heart

Caution

Macox 300 mg Capsule can be used in cardiac patients if prescribed by the physician. However caution should be exercised.

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Geriatrics

Caution

Macox 300 mg Capsule should be used in elderly people only if prescribed by the physician. If recommended, careful monitoring of any side effects is advised.

What if I have taken an overdose of Macox 300 mg Capsule

If you suspect an overdose or experience severe symptoms like extreme drowsiness, vomiting, or a pronounced orange-brown discolouration of the skin, seek immediate medical attention or call a poison control centre right away.

Diet & Lifestyle Advise

  • Avoid alcohol: Do not drink alcohol while taking this medicine. Both alcohol and the medication place stress on your liver, and combining them increases the risk of serious liver damage.
  • Skip contact lenses: Avoid wearing soft contact lenses during your treatment. The harmless reddish-orange tears caused by the medicine can permanently stain your lenses. Opt for glasses instead.
  • Eat nutrient-dense meals: Focus on a balanced diet rich in protein, vitamins, and minerals to support your body's immune system as it recovers from chronic infections like tuberculosis.
  • Maintain a hydration routine: Drink plenty of water throughout the day to support kidney function and help your body flush out bacterial waste products.
     
health query

Have a query?

How Soon It Starts Working

The time required for Macox 300 mg Capsule to start to work: The time required for Macox 300 mg Capsule to start to work is 1 to 3 hours after administration. The time for which the effects of Macox 300 mg Capsule last: The effect of Macox 300 mg Capsule lasts for 15 hours.

What if you forget to take Macox 300 mg Capsule

If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take two doses at the same time to make up for a missed one. If you miss multiple doses, talk to your doctor or pharmacist for advice.

Storage

•Store the medication at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Do not be alarmed if your urine, sweat, saliva, or tears turn a bright reddish-orange; this is a completely harmless, temporary effect of the medication.
  • Complete your full course of treatment exactly as prescribed, even if your symptoms disappear early, to prevent the bacteria from returning and becoming resistant to the antibiotic.
  • Monitor your skin and eyes daily for any signs of yellowing, and contact your healthcare provider immediately if you notice these changes.
  • Use a reliable, non-hormonal backup birth control method (such as condoms) during treatment, as this medicine makes hormonal contraceptives less effective.
  • Avoid wearing soft contact lenses to prevent permanent orange-red staining of the lens material.
     

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions

  • Hormonal Contraceptives: May significantly decrease the effectiveness of birth control pills, patches, rings, or implants, increasing the risk of unplanned pregnancy.
  • Blood Thinners (e.g., Warfarin): May reduce the thinning effect of these medications, requiring close monitoring and dosage adjustments of your blood thinner.
  • Antifungals and Antivirals: May lower the levels of these drugs in your bloodstream, making them less effective at treating other infections.


Drug-Food Interactions

  • Food: Taking this medicine with food dramatically reduces its absorption, making it less effective. Always take it on an empty stomach.


Drug-Disease Interactions

  • Liver Disease: May worsen existing liver impairment or accelerate liver damage. Regular liver function tests are highly recommended.
  • Porphyria: May trigger acute, painful attacks in patients who have this genetic blood disorder.
RifampicinDarunavir
Critical
RifampicinVoriconazole
Critical

Drug-Drug Interactions

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RifampicinDarunavir
Critical
How does the drug interact with Macox 300 mg Capsule:
Taking darunavir with Macox 300 mg Capsule can decrease the blood levels of darunavir, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between darunavir and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinVoriconazole
Critical
How does the drug interact with Macox 300 mg Capsule:
Taking Voriconazole with Macox 300 mg Capsule can increase blood level of Voriconazole.

How to manage the interaction:
Although there is an interaction between Voriconazole with Macox 300 mg Capsule, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinPirfenidone
Critical
How does the drug interact with Macox 300 mg Capsule:
Taking pirfenidone with Macox 300 mg Capsule can reduce the levels and effects of pirfenidone

How to manage the interaction:
Although there is an interaction between pirfenidone and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinRanolazine
Critical
How does the drug interact with Macox 300 mg Capsule:
When ranolazine is taken with Macox 300 mg Capsule, it can reduce the blood levels and effects of ranolazine.

How to manage the interaction:
Although there is an interaction between ranolazine and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinIndinavir
Critical
How does the drug interact with Macox 300 mg Capsule:
When Indinavir is taken with Macox 300 mg Capsule, it can reduce the blood levels and effects of Indinavir.

How to manage the interaction:
Although there is an interaction between indinavir and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinSaquinavir
Critical
How does the drug interact with Macox 300 mg Capsule:
Taking saquinavir with Macox 300 mg Capsule can increase the risk or severity of side effects.

How to manage the interaction:
Although there is an interaction between pyrazinamide and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience fever, stomach pain, less desire to eat, nausea, yellowing of the skin or eyes, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinApremilast
Severe
How does the drug interact with Macox 300 mg Capsule:
Taking apremilast with Macox 300 mg Capsule can decrease the blood levels of apremilast, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between apremilast and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
RifampicinCariprazine
Severe
How does the drug interact with Macox 300 mg Capsule:
Taking cariprazine with Macox 300 mg Capsule can decrease the blood levels of cariprazine, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between cariprazine and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.
RifampicinNorethisterone
Severe
How does the drug interact with Macox 300 mg Capsule:
Taking norethisterone with Macox 300 mg Capsule can decrease the blood levels of norethisterone, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between norethisterone and Macox 300 mg Capsule, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
RifampicinLeflunomide
Severe
How does the drug interact with Macox 300 mg Capsule:
Taking leflunomide with Macox 300 mg Capsule can increase the risk of liver problems.

How to manage the interaction:
Although taking Macox 300 mg Capsule together with Leflunomide can result in an interaction, they can be taken together if prescribed by a doctor. However, contact a doctor immediately if you experience joint pain or swelling, unusual bleeding, fatigue, abdominal pain, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Macox 300 mg Capsule belongs to the group of medicines called macrolide antibiotics, primarily used to treat tuberculosis (TB).
Macox 300 mg Capsule is a bactericidal drug, which means it kills bacteria. It acts by blocking the activity of a bacterial enzyme called DNA-dependent RNA polymerase, which is essential for bacterial survival, thereby killing the bacteria.
Macox 300 mg Capsule has no known serious drug interaction with ibuprofen or aspirin. Inform your doctor about all the medications you are currently taking to avoid harmful interactions that may reduce treatment effectiveness.
Yes, in some cases, a headache can be caused as a side effect of Macox 300 mg Capsule. A patient must consult a doctor if it progresses over time.
Macox 300 mg Capsule is safe when used at prescribed doses for the prescribed duration. Constant monitoring of liver function is important while on treatment with Macox 300 mg Capsule. Please consult your doctor if you have any liver problems before taking Macox 300 mg Capsule as it may worsen the situation. However, prolonged use of Macox 300 mg Capsule can cause raised ALT (liver enzyme), and the person taking the treatment can develop jaundice symptoms like yellowing of the eyes, skin, etc. In this case, stop taking Macox 300 mg Capsule and immediately contact a doctor.
No, Macox 300 mg Capsule is not a penicillin, amoxicillin, or sulfa drug. It is an antibiotic in the rifamycin class, combined with other medicines to treat tuberculosis.
Macox 300 mg Capsule is an inducer (increases enzyme activity) of cytochrome P450 enzymes.
Macox 300 mg Capsule may lead to side effects like weight loss, hair loss, and yeast infections, though constipation is less common. Consult your doctor if you experience any of these effects.
Macox 300 mg Capsule causes side effects such as drowsiness, dizziness, headache, muscle pain, weakness, heartburn, diarrhoea, gas, and numbness or tingling sensation. Most of these are temporary and do not require any medical attention, as they will gradually reduce over time. Please contact a doctor if these persist for longer periods.
This is a harmless, expected side effect. The medicine naturally has a red-brown colour that temporarily stains bodily fluids like urine, sweat, saliva, and tears. Your fluids will return to their normal colour after you finish your treatment. Talk to your doctor or pharmacist if you have concerns.
No, you should avoid alcohol entirely. Combining alcohol with this medicine increases the stress on your liver and significantly raises your risk of experiencing severe liver damage. Talk to your doctor if you need support with avoiding alcohol.
Yes, it can make hormonal birth control, including pills, patches, vaginal rings, and implants, less effective. You must use a reliable non-hormonal barrier method (like condoms) during your treatment and for at least 28 days after stopping. Talk to your doctor to discuss your birth control options.
No, you should take this medicine on an empty stomach, either 1 hour before a meal or 2 hours after. Taking it with food reduces how much of the drug your body absorbs, which can make it less effective at clearing your infection. Talk to your doctor or pharmacist if you experience stomach discomfort.
You should avoid wearing soft contact lenses while taking this medicine. The reddish-orange tears caused by the medication can permanently stain and damage soft lenses. Use glasses instead. Talk to your doctor or eye care specialist for more advice.
Take the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for a missed one. Talk to your doctor if you miss several doses.
The duration of your treatment depends on the specific infection being treated and your body's response. For tuberculosis, treatment usually lasts for several months. You must finish the entire course, even if you feel completely better. Talk to your doctor about your specific timeline.
This medicine is only prescribed during pregnancy or breastfeeding if the benefits outweigh the potential risks, as it can cross the placenta and enter breast milk. It may also affect blood clotting in newborns. Talk to your doctor to discuss the safest treatment plan for you and your baby.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.8789 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A682403 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Center for Biotechnology Information (NCBI). Nbk557488 Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  4. MIMS Drug Reference Compendium. Rifampicin Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Ema. Rifampicin. [[Accessed on 21 Aug].2019]Check here
  6. Webmd. Rifampicin. [[Accessed on 21 Aug].2019]Check here
  7. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-S198Check here

Country of origin

INDIA

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0036
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