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compositionComposition:PYRAZINAMIDE-750MG
prescription
Prescription Medicine
info
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Macrozide-750 Tablet is used to treat and prevent tuberculosis. It contains Pyrazinamide which converts a special enzyme to an active form that inhibits the synthesis of fatty acids; this disrupts the cell membrane and disables energy production necessary for the survival of the TB bacteria. It may cause common side effects such as muscle/joint pain, nausea, vomiting and loss of appetite. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

PYRAZINAMIDE-750MG

Manufacturer/Marketer :

Macleods Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Macrozide-750 Tablet

Macrozide-750 Tablet is an oral prescription medication used to treat tuberculosis (TB) in combination with other medicines. It works by stopping the growth of the bacteria that cause this serious lung infection. Because tuberculosis requires multi-drug therapy, this medication is always prescribed alongside other antibiotics to ensure the infection is completely cleared.

For this medicine to work effectively, you must take it consistently and exactly as prescribed by your healthcare provider. You can take Macrozide-750 Tablet with or without food, but taking it with a full glass of water at the same time every day is highly recommended to maintain steady levels in your body. To support your body’s recovery, focus on eating a nutrient-rich diet, staying well-hydrated, and getting plenty of rest.

While taking Macrozide-750 Tablet , some people may experience side effects such as joint pain or mild stomach upset. However, you must contact your doctor immediately if you notice serious symptoms, particularly signs of liver damage. These include yellowing of your eyes or skin, dark urine, persistent nausea, or severe abdominal pain.

Do not take this if you have severe liver disease or active gout. Before starting Macrozide-750 Tablet , it is crucial to tell your doctor if you have kidney problems, diabetes, or a history of gout, as this medication can worsen these conditions or require special monitoring.

This medicine can interact with alcohol, which significantly increases your risk of experiencing serious liver damage. You should also consult your doctor before taking this medicine if you are pregnant, breastfeeding, or planning a pregnancy, as treatment plans must be carefully managed for these specific groups.

Uses of Macrozide-750 Tablet

Macrozide-750 Tablet is used in the treatment of Tuberculosis (TB). The detailed uses of Macrozide-750 Tablet are as follows:

  • Tuberculosis (TB) treatment: Macrozide-750 Tablet is used as part of a combination regimen to treat active tuberculosis infections, helping to kill the bacteria in your body and prevent the spread of the infection to others.

Key Benefits

Macrozide-750 Tablet helps treat tuberculosis (TB) by working as part of a combination of anti-tuberculosis medicines to clear the infection.

Benefits may include:

  • Helps treat tuberculosis as part of a complete treatment plan.
  • Reduces symptoms such as persistent cough, fever, and fatigue.
  • Improves lung health as the infection clears.
  • Supports a faster and more complete recovery from tuberculosis.
  • Promotes the prevention of treatment failure and drug-resistant tuberculosis when taken as prescribed.
Side effects of Macrozide-750 Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
Managing Medication-Triggered malaise (Feeling Unwell): A Step-by-Step Guide:
  • If you experience persistent or severe malaise (a general feeling of discomfort, illness, or unease) after taking medication, seek medical attention immediately.
  • Inform your doctor about the medication you're taking and the symptoms you're experiencing.
  • Your treatment plan may be modified, which may include adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage malaise symptoms, follow your doctor's advice, such as getting plenty of rest, staying hydrated, and practicing stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to ensure the malaise is managed effectively.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.

Directions for Use

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless your doctor specifically tells you to do so.
  • You can take this medicine with or without food. If it upsets your stomach, taking it with meals may help reduce nausea or discomfort.
  • Always take Macrozide-750 Tablet exactly as your doctor has instructed. Do not skip doses or stop taking the medication early, even if you start to feel better, as the infection can return and become harder to treat.
  • Talk to your doctor or pharmacist if you have questions about how to take your medicine.

How Macrozide-750 Tablet Works

Macrozide-750 Tablet contains Pyrazinamide, an antibacterial medicine that specifically targets the bacteria causing tuberculosis. It is active in acidic environments, such as inside the inflammatory cells, where the tuberculosis bacteria often hide and multiply. Once inside these cells, the medicine is converted into its active form. This active form disrupts the bacteria's ability to create vital proteins and energy, effectively stopping their growth and leading to their destruction. Because it targets bacteria in a unique stage of their life cycle, it is highly effective when used alongside other tuberculosis medications.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Macrozide-750 Tablet . Alcohol intake, along with Macrozide-750 Tablet , may cause increased liver damage. Please consult your doctor for more information.

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Pregnancy

Caution

Macrozide-750 Tablet should be used with caution during pregnancy. Please consult your doctor before taking Macrozide-750 Tablet if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Macrozide-750 Tablet is not recommended for use during breastfeeding since it is excreted into the breast milk and may harm a nursing baby. Please consult your doctor if you are a breastfeeding mother.

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Driving

Caution

It is not known if Macrozide-750 Tablet alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to drive or operate machinery.

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Liver

Caution

Macrozide-750 Tablet is not recommended in patients with severe liver damage. Please consult your doctor since Macrozide-750 Tablet should be used with caution in patients with liver impairment/liver disease. Regular monitoring of the liver with liver function tests is also advised.

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Kidney

Caution

Please consult your doctor since Macrozide-750 Tablet should be used with caution in patients with kidney impairment/kidney disease. Your doctor may adjust the dosage in case of renal dysfunction.

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Children

Caution

Macrozide-750 Tablet is recommended in children below 12 years of age only after doctor's advice.

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Heart

Safe if prescribed

Macrozide-750 Tablet can be used in cardiac patients if prescribed by the physician.

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Geriatrics

Caution

Exercise caution while giving Macrozide-750 Tablet in elderly patients due to the risk of age-related sid eeffcets.

What if I have taken an overdose of Macrozide-750 Tablet

If you suspect an overdose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose may include severe nausea, vomiting, or abnormal liver function signs.

Diet & Lifestyle Advise

  • Avoid alcohol completely: Drinking alcohol while taking Macrozide-750 Tablet significantly increases the risk of severe liver damage.
  • Stay well-hydrated: Drink plenty of fluids, especially water, to help your kidneys flush out uric acid and reduce the risk of painful gout attacks.
  • Monitor your blood sugar: If you have diabetes, check your blood glucose levels regularly, as this medication can affect blood sugar control.
  • Eat a balanced, nutritious diet: Focus on protein-rich foods, fresh fruits, and vegetables to help your body rebuild strength and recover from tuberculosis.
health query

Have a query?

How Soon It Starts Working

  • The time required for Macrozide-750 Tablet to start to work: Macrozide-750 Tablet ideally shows its action within 2 hours after administration.
  • The time for which the effects of Macrozide-750 Tablet last: The effect of Macrozide-750 Tablet lasts for 27 to 30 hours.

What if you forget to take Macrozide-750 Tablet

If you miss a dose of Macrozide-750 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. Talk to your doctor or pharmacist if you miss multiple doses.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Get regular liver tests: Your doctor will schedule regular blood tests to monitor your liver function while you are taking this medication. Do not skip these appointments.
  • Watch for gout symptoms: This medicine can raise uric acid levels in your blood. Alert your healthcare provider immediately if you experience sudden, severe joint pain, particularly in your big toe.
  • Complete the full course: Never stop taking Macrozide-750 Tablet early, even if your symptoms disappear. Stopping treatment too soon can cause the tuberculosis infection to return and become resistant to antibiotics.
  • Inform all healthcare providers: Let any doctor, dentist, or pharmacist you visit know that you are currently taking Macrozide-750 Tablet for tuberculosis treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Gout medications (e.g., allopurinol, probenecid): Macrozide-750 Tablet can raise uric acid levels, which may decrease the effectiveness of medicines used to treat gout.
  • Other Tuberculosis Medicines (e.g., rifampin, isoniazid): Combining these medicines is necessary for treatment but increases the risk of liver damage, requiring close monitoring by your doctor.
  • Immunosuppressants (e.g., cyclosporine): Macrozide-750 Tablet may decrease cyclosporine levels in your body, reducing its effectiveness.
PyrazinamideTeriflunomide
Severe
PyrazinamideLomitapide
Severe

Drug-Drug Interactions

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PyrazinamideTeriflunomide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Teriflunomide with Macrozide-750 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Teriflunomide and Macrozide-750 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideLomitapide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Lomitapide with Macrozide-750 Tablet may increase in the risk or severity of liver problems.

How to manage the interaction:
Although taking Lomitapide and Macrozide-750 Tablet together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact your doctor immediately: fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, or bleeding. Do not stop using any medications without a doctor's advice. Do not discontinue the medication without consulting a doctor.
PyrazinamideKetoconazole
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of Ketoconazole with Macrozide-750 Tablet may increase the risk or severity of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Macrozide-750 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, lack of appetite, nausea, vomiting, abdominal pain, dark urine, light stools, and/or yellowing of the skin or eyes, consult a doctor immediately. Do not discontinue the medication without consulting a doctor.
PyrazinamideRifampicin
Severe
How does the drug interact with Macrozide-750 Tablet:
Taking rifampicin together with Macrozide-750 Tablet can cause liver problems.

How to manage the interaction:
Although there is an interaction between Macrozide-750 Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience fever, rash, less desire to eat, nausea, vomiting, fatigue, right upper abdominal pain, or dark urine, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PyrazinamideLeflunomide
Severe
How does the drug interact with Macrozide-750 Tablet:
Co-administration of leflunomide with Macrozide-750 Tablet may increase the risk or severity of liver problems.

How to manage the interaction:
Although taking Leflunomide and Macrozide-750 Tablet together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Consuming alcohol while taking Macrozide-750 Tablet may increase the risk of liver damage and may worsen side effects such as nausea.
  • Foods High in Purines: Consuming foods such as red meat, organ meats, shellfish, or beer while taking Macrozide-750 Tablet may increase uric acid levels and may raise the risk of gout attacks.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- TUBERCULOSIS]

FAQs

Macrozide-750 Tablet is used to treat and prevent tuberculosis.
Macrozide-750 Tablet contains Pyrazinamide. It is bactericidal and works by stopping the growth of Mycobacterium tuberculosis, a bacterium that causes tuberculosis.
Macrozide-750 Tablet is not recommended for use in the medical history of liver or kidney diseases, diabetes, gout, high uric acid level in the blood, alcohol use and undergoing dialysis treatment. Please let your doctor know if you have any other medical problems before starting Macrozide-750 Tablet .
Macrozide-750 Tablet can affect the live vaccines like typhoid vaccine and decrease its effectiveness. Please consult a doctor before you start Macrozide-750 Tablet if you are undergoing any vaccinations.
It is advised to take Macrozide-750 Tablet 30 minutes before food or 2 hours after food. Please consult your doctor for more information.
Macrozide-750 Tablet gets converted in the body to Pyrazinoic acid that blocks the excretion of urates (salt form of uric acid) by the kidneys. Increased blood levels of uric acid (hyperuricemia) causes pain, swelling, redness and stiffness in joints (gout). Hence, Macrozide-750 Tablet should be avoided if you have a history of gout.
Macrozide-750 Tablet is an antibiotic that belongs to the group of anti-tuberculosis (TB) drugs. It is used for the treatment of tuberculosis which is an infectious disease that mainly affects lungs but can also impact other parts of the body.
Yes, Macrozide-750 Tablet is bactericidal. It works by inhibiting the growth of Mycobacterium tuberculosis, the bacteria that is responsible for causing tuberculosis.
Macrozide-750 Tablet causes hyperuricemia and gout by inhibiting the renal excretion of uric acid, which can lead to the precipitation or worsening of gout. It should be used with caution in individuals with hyperuricemia or a history of gout.
The side effects of Macrozide-750 Tablet include nausea, vomiting, muscle/joint pain, nausea and loss of appetite. Consult the doctor if any of these symptoms persist or worsen.
No, you should avoid alcohol completely while taking Macrozide-750 Tablet . Alcohol increases your risk of experiencing severe liver damage. Talk to your doctor if you have concerns about stopping alcohol use.
The duration of your treatment depends on your specific tuberculosis treatment plan, which usually lasts several months. Always complete the entire course prescribed by your doctor, even if you feel better. Talk to your doctor before stopping the medicine.
Yes, Macrozide-750 Tablet can cause joint pain because it can raise uric acid levels in the blood. If you experience severe, sudden joint pain, especially in your big toe, contact your doctor immediately, as this could be a sign of gout.
You can take Macrozide-750 Tablet with or without food. If you experience stomach upset or nausea, taking it with a meal can help ease these symptoms. Talk to your doctor or pharmacist if stomach discomfort persists.
If you are pregnant or planning to become pregnant, you must discuss the risks and benefits with your doctor. Macrozide-750 Tablet is used during pregnancy only when clearly needed and prescribed by a specialist. Talk to your doctor to understand your options.
No, Macrozide-750 Tablet does not typically change the colour of your urine. However, if you notice your urine becoming very dark, it could be a sign of liver damage. Contact your doctor immediately if this happens.
Mild nausea can occur when you start taking Macrozide-750 Tablet . Taking the tablet with food can help. However, if the nausea is severe, persistent, or accompanied by vomiting or yellowing of your eyes, contact your doctor right away.
Yes, but you must inform your doctor before starting treatment. If you have kidney disease, your doctor may need to adjust your dose or monitor your kidney function more closely. Talk to your doctor to ensure safe use.

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Country of origin

India

Manufacturer/Marketer address

Atlanta Arcade, Marol Church Road, Andheri (East), Mumbai - 400059, INDIA.
Other Info - MAC0037
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