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compositionComposition:NINTEDANIB-100MG
prescription
Prescription Medicine
info
Mantedanib-100 Softgel Cap 10'S
Mantedanib-100 Softgel Cap 10'S
Mantedanib-100 Softgel Cap 10'S

Mantedanib-100 Softgel Cap is used to treat idiopathic pulmonary fibrosis (a disease that causes scarring of the lungs). It contains Nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. In some cases, this medicine may cause side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

NINTEDANIB-100MG

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mantedanib-100 Softgel Cap

Mantedanib-100 Softgel Cap is primarily used to treat idiopathic pulmonary fibrosis (IPF) in adults. IPF is an irreversible disease marked by a progressive decline in lung function. The tissues in the lungs become swollen and scarred over time, which makes it difficult to breathe deeply.

Mantedanib-100 Softgel Cap contains nintedanib, which helps reduce the scarring and swelling in the lungs by decreasing the release of naturally occurring growth factors in the body, allowing you to breathe better.

In some cases, you may experience common side effects such as nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are allergic to Mantedanib-100 Softgel Cap . Consult your doctor before taking Mantedanib-100 Softgel Cap if you are pregnant or breastfeeding. Mantedanib-100 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established. Consult your doctor if you are breastfeeding; your doctor will decide whether Mantedanib-100 Softgel Cap can be taken by breastfeeding mothers or not.

Uses of Mantedanib-100 Softgel Cap

Mantedanib-100 Softgel Cap is used in the treatment of Idiopathic pulmonary fibrosis. The detailed uses of Mantedanib-100 Softgel Cap are as follows: Treatment of Idiopathic pulmonary fibrosis

  • Idiopathic pulmonary fibrosis: Mantedanib-100 Softgel Cap aids in the breakdown and thinning of mucus in the airways, facilitating coughing and removal. It is especially beneficial in conditions like Idiopathic pulmonary fibrosis.

Key Benefits

  • Mantedanib-100 Softgel Cap is an anti-fibrotic medicine used to treat idiopathic pulmonary fibrosis (IPF) in adults.
  • Mantedanib-100 Softgel Cap can help effectively slow the rate of lung function decline by 50%.
  • Mantedanib-100 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better.
  • Mantedanib-100 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.
Side effects of Mantedanib-100 Softgel Cap
  • Do not scratch the affected region to avoid discomfort and infection.
  • Avoid spicy and fatty foods and caffeine and alcohol as they can worsen diarrhoea and irritate the skin.
  • Frequently wash your hands to avoid infection.
  • Clean the skin with fragrance-free, soft wipes to reduce inflammation.
  • Let your doctor know if the rash is severe, widespread, or painful.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • To minimize pain and swelling, apply an ice pack or cold compress wrapped in a cloth as soon as there is bleeding or bruises.
  • Use a warm compress 48 hours later to promote blood flow and hasten the healing process.
  • Rest and limit activity to prevent further injury.
  • Elevate the affected area above the level of your heart to reduce blood flow.
  • To treat discomfort, your doctor may offer over-the-counter pain medicines.
  • Inform your doctor if you develop large bruises without injury or experience frequent bruising, as this may indicate an underlying condition.
  • Follow a low-fiber, soft food diet with easily digestible liquids and pureed foods.
  • Begin with clear liquids like water, broth, and electrolyte drinks.
  • Progress to soft foods like mashed potatoes, applesauce, plain yogurt, scrambled eggs, and well-cooked rice.
  • Avoid high-fiber foods, raw vegetables, tough meats, spicy foods, and irritants to the digestive tract.
  • Eat smaller, frequent meals to reduce digestive strain.
  • Stay hydrated with plenty of fluids, avoiding sugary drinks.
  • Chew food thoroughly to aid digestion.
  • Avoid strenuous activities and rest when needed.
  • Before altering your diet, seek guidance from your healthcare provider.
  • Always follow your doctor's instructions on dietary restrictions and medical supervision.

Directions for Use

  • Mantedanib-100 Softgel Cap should be taken with meals to enhance its effectiveness.
  • It is recommended to take Mantedanib-100 Softgel Cap twice daily or as advised by your doctor.
  • Swallow Mantedanib-100 Softgel Cap as a whole with a glass of water.
  • Do not crush, chew, or open it.

How Mantedanib-100 Softgel Cap Works

Mantedanib-100 Softgel Cap contains 'Nintedanib', which helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, allowing you to breathe better. Mantedanib-100 Softgel Cap helps in slowing down the progress of idiopathic pulmonary fibrosis.
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Alcohol

Caution

It is not known if alcohol interacts with Mantedanib-100 Softgel Cap . However, as a precautionary measure, you are recommended not to consume alcohol with the Mantedanib-100 Softgel Cap to avoid unpleasant side effects.

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Pregnancy

Unsafe

Mantedanib-100 Softgel Cap is listed as pregnancy category D. Because Mantedanib-100 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-100 Softgel Cap .

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Breast Feeding

Consult your doctor

Consult your doctor if you are breastfeeding; your doctor will decide whether Mantedanib-100 Softgel Cap can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Mantedanib-100 Softgel Cap may significantly influence your ability to drive and use machines. You should not drive or operate machinery if you feel sick.

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Liver

Consult your doctor

Dose adjustment may be needed. Mantedanib-100 Softgel Cap is not recommended for patients with severe hepatic impairment. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Dose adjustment may be needed. Mantedanib-100 Softgel Cap is not recommended for patients with an end-stage renal disease requiring dialysis. Please consult your doctor if you have kidney impairment or any concerns.

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Children

Unsafe

Mantedanib-100 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

Inform your doctor if you have any existing heart disease. Your doctor will prescribe this medicine only if the potential benefits outweigh the risks.

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Geriatrics

Caution

Mantedanib-100 Softgel Cap should be given with caution in elderly patients due to an increased risk of side effects. Please consult your doctor before using Mantedanib-100 Softgel Cap .

What if I have taken an overdose of Mantedanib-100 Softgel Cap

Take Mantedanib-100 Softgel Cap only as prescribed by the physician. Do not exceed the recommended dose, as it might cause serious adverse effects. If you suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Have a query?

How Soon It Starts Working

The time required for Mantedanib-100 Softgel Cap to start to work: The exact onset time of Mantedanib-100 Softgel Cap has not been clinically established. 

The time for which the effects of Mantedanib-100 Softgel Cap last: The duration of Mantedanib-100 Softgel Cap ’s effect is clinically not established.

What if you forget to take Mantedanib-100 Softgel Cap

If you forget to take a dose of Mantedanib-100 Softgel Cap , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not double the dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Mantedanib-100 Softgel Cap out of sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Do not use Mantedanib-100 Softgel Cap if you are allergic to any components present in Mantedanib-100 Softgel Cap .
  • Mantedanib-100 Softgel Cap can cause harm to the fetus, women of childbearing potential should be advised to avoid becoming pregnant while receiving treatment with Mantedanib-100 Softgel Cap .
  • Consult your doctor if you are breastfeeding; your doctor will decide whether the Mantedanib-100 Softgel Cap can be taken by breastfeeding mothers or not.
  • Keep your doctor informed about your health condition and medicines to rule out any side effects. 
  • Mantedanib-100 Softgel Cap may cause tiredness and dizziness, so drive with caution.
  • Avoid consuming alcohol with Mantedanib-100 Softgel Cap as it could lead to increased dizziness.
  • Mantedanib-100 Softgel Cap is not recommended for children below 18 years as safety and effectiveness have not been established.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Mantedanib-100 Softgel Cap may have interaction with medicines used to treat fungal infections (e.g. ketoconazole), medications used to treat bacterial infections/CYP3A4 inhibitors (e.g. erythromycin), drugs that affect your immune system (e.g. cyclosporine), antibiotic medicines used to treat tuberculosis (e.g. rifampicin), medicines to treat seizures (e.g. carbamazepine, phenytoin), and herbal medicines to treat depression (e.g. St. John’s Wort).

Drug-Food Interactions: Avoid grapefruit juice and chargrilled meats.

Drug-Disease Interactions: Mantedanib-100 Softgel Cap may interact with smoking and severe hepatic and end-stage renal impairment requiring dialysis.

NintedanibLomitapide
Severe
NintedanibFosphenytoin
Severe

Drug-Drug Interactions

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NintedanibLomitapide
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Co-administration of Lomitapide and Mantedanib-100 Softgel Cap can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lomitapide and Mantedanib-100 Softgel Cap can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
NintedanibFosphenytoin
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap with Fosphenytoin can reduce the levels of Mantedanib-100 Softgel Cap. This can lead to low treatment outcomes.

How to manage the interaction:
Although there is a possible interaction between Mantedanib-100 Softgel Cap and Fosphenytoin, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
NintedanibPhenobarbital
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Taking Phenobarbital and Mantedanib-100 Softgel Cap can drastically lower Mantedanib-100 Softgel Cap levels in the blood, making the medicine less effective in treating the illness.

How to manage the interaction:
Although taking phenobarbital with Mantedanib-100 Softgel Cap can lead to interaction, they can be taken if recommended by a doctor. Contact a doctor if your symptoms do not improve. Do not stop using any medications without talking to a doctor.
NintedanibDexamethasone
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Dexamethasone may lower the blood levels of Mantedanib-100 Softgel Cap, making the medication less effective in treating your condition.

How to manage the interaction:
Although there is a possible interaction, Dexamethasone can be taken with Mantedanib-100 Softgel Cap if prescribed by the doctor. Contact a doctor if your symptoms do not improve. Do not discontinue any medications without consulting a doctor.
NintedanibLeflunomide
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Co-administration of Leflunomide and Mantedanib-100 Softgel Cap can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Mantedanib-100 Softgel Cap can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibPhenytoin
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Phenytoin and Mantedanib-100 Softgel Cap may decrease the blood levels of Mantedanib-100 Softgel Cap, which may reduce Mantedanib-100 Softgel Cap's effectiveness.

How to manage the interaction:
Although taking Phenytoin and Mantedanib-100 Softgel Cap together can result in an interaction, it can be taken when your doctor has prescribed it. Contact a doctor if your symptoms do not improve. Do not stop taking any drugs without consulting a doctor.
NintedanibRifapentine
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap and Rifapentine can reduce the blood levels of Mantedanib-100 Softgel Cap.

How to manage the interaction:
There may be a possibility of interaction between Mantedanib-100 Softgel Cap and Rifapentine, but it can be taken if prescribed by a doctor. Contact your doctor if your symptoms do not improve. Do not discontinue any medications without consulting your doctor.
NintedanibPrimidone
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap and primidone can reduce the blood levels of Mantedanib-100 Softgel Cap.

How to manage the interaction:
Although there is an interaction between Mantedanib-100 Softgel Cap and primidone, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NintedanibCarbamazepine
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Mantedanib-100 Softgel Cap with Carbamazepine can reduce the levels and effects of Mantedanib-100 Softgel Cap.

How to manage the interaction:
Although taking carbamazepine and Mantedanib-100 Softgel Cap together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop using any medications without first talking to your doctor.
NintedanibTeriflunomide
Severe
How does the drug interact with Mantedanib-100 Softgel Cap:
Coadministration of Teriflunomide and Mantedanib-100 Softgel Cap can increase the risk of liver problems.

How to manage the interaction:
Coadministration of Teriflunomide and Mantedanib-100 Softgel Cap can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, skin rash, loss of appetite, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact your doctor immediately.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[MISCELLANEOUS]

FAQs

Mantedanib-100 Softgel Cap is used to treat idiopathic pulmonary fibrosis (IPF), a disease marked by a progressive decline in lung function.
Mantedanib-100 Softgel Cap helps reduce the scarring and swelling in the lungs by decreasing the release/activity of naturally occurring growth factors in the body, thereby helping you breathe better.
Avoid smoking before starting the treatment while taking Mantedanib-100 Softgel Cap as smoking might alter the effectiveness of Mantedanib-100 Softgel Cap .
Mantedanib-100 Softgel Cap should be stopped when a person faces a serious side effect that affects life quality. Otherwise, it would be best to keep taking Mantedanib-100 Softgel Cap until your doctor asks you to stop it.
If you have any surgery, including dental surgery, please inform your doctor if you are taking Mantedanib-100 Softgel Cap as your doctor might stop Mantedanib-100 Softgel Cap before undergoing surgery.
In elderly patients, the risk of side effects is higher if you are taking Mantedanib-100 Softgel Cap . For the patients who are elderly, dose adjustment might be required, or your doctor might prescribe any other medication safe for the elderly.
It is not recommended to discontinue the Mantedanib-100 Softgel Cap without consulting your healthcare provider. Abruptly stopping the medication can lead to disease progression or other complications. Consult your healthcare provider for personalised guidance if you have concerns or experience side effects.
If you forget to take a dose of Mantedanib-100 Softgel Cap , take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for the missed one, as this can increase the risk of side effects.
Common side effects of Mantedanib-100 Softgel Cap may include nausea, tiredness, diarrhoea, indigestion, loss of appetite, headache, and photosensitivity in some individuals. Most of these side effects do not require medical attention and will resolve gradually over time. However, if you experience these side effects persistently, inform your doctor.
Mantedanib-100 Softgel Cap is not recommended for use in patients with severe liver impairment. Please consult your doctor if you have a liver impairment or any concerns before Mantedanib-100 Softgel Cap .

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Treatment - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.1786 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Nintedanib Nintedanib. 2014. [Accessed on 26 Mar. 2019] Check here
  5. Nintedanib esilate. 2015. [Accessed on 26 Mar. 2019] Check here
  6. NINTIB Capsules [Internet]. CiplaMed. 2025 [Accessed on 27 March 2025] Check here
  7. Conditions G. Idiopathic pulmonary fibrosis: MedlinePlus Genetics [Internet]. Medlineplus.gov. 2025 [Accessed on 27 March 2025]Check here

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase 3, New Delhi - 110020.
Other Info - MAN0479

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