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compositionComposition:GLICLAZIDE-80MG+METFORMIN-500MG
prescription
Prescription Medicine
info
Mclazide Plus M Tablet 15's
Mclazide Plus M Tablet 15's

Mclazide Plus M Tablet is used to treat Type 2 diabetes. It contains Gliclazide and Metformin, which acts by increasing the amount of insulin released by the pancreas. Also, it lowers the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. It shows optimum effects when taken along with healthy lifestyle changes like weight loss, regular exercise, a healthy diet etc. A common side effect of this medicine is hypoglycaemia (low blood glucose levels) characterized by dizziness, sweating, palpitations, hunger pangs, dry mouth and skin etc. So, to avoid hypoglycaemia, you should not miss meals and also should carry some form of sugar along with you. Other side effects include taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

GLICLAZIDE-80MG+METFORMIN-500MG

Manufacturer/Marketer :

Mitoch Pharma Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mclazide Plus M Tablet

Mclazide Plus M Tablet is a prescription medicine used to manage and treat type 2 diabetes in adults. It is prescribed to lower high blood sugar levels when diet, exercise, and single medications alone are not enough. Keeping your blood sugar controlled helps prevent serious health problems such as kidney damage, nerve issues, and vision loss.

For the best results, you must take Mclazide Plus M Tablet regularly and consistently at the same times every day as directed by your doctor. You should take this medicine with meals to help reduce the risk of experiencing an upset stomach. Combining this treatment with regular physical activity and a balanced diet is crucial to achieving optimal blood sugar control.

Some people may experience common side effects such as nausea, diarrhoea, or a metallic taste in the mouth. While these are usually mild, you must consult your doctor immediately if you experience signs of very low blood sugar, severe stomach pain, or unusual muscle fatigue.
Before you begin taking Mclazide Plus M Tablet , talk to your doctor if you have kidney problems, liver damage, or heart failure. Do not take this medication if you have severe kidney failure, diabetic ketoacidosis, or if you are allergic to any of its ingredients.

This medicine can interact with alcohol, which increases the risk of a dangerous buildup of lactic acid, and smoking can make your diabetes harder to manage. If you are pregnant, breastfeeding, or are an older adult, you should consult your healthcare provider before using this medicine.

Uses of Mclazide Plus M Tablet

Mclazide Plus M Tablet is used to help manage blood sugar levels in adults with type 2 diabetes mellitus. The detailed uses of Mclazide Plus M Tablet are as follows: 

  • Type 2 diabetes mellitus: Mclazide Plus M Tablet is used to lower blood glucose levels in adults whose blood sugar is not sufficiently controlled by diet, exercise, or other single oral medications alone.
     

Key Benefits

Mclazide Plus M Tablet helps improve blood sugar control through complementary mechanisms that target multiple aspects of glucose regulation. The key benefits of Mclazide Plus M Tablet include: 

  • Provides Comprehensive Blood Sugar Control: Helps manage blood sugar levels throughout the day and night by combining two different mechanisms of action.
  • Reduces Blood Sugar Levels: Helps lower both fasting and post-meal blood sugar levels, supporting better overall glucose control.
  • Protects Long-Term Health: Maintaining blood sugar within the target range may help reduce the risk of diabetes-related complications affecting the kidneys, nerves, eyes, heart, and blood vessels.
  • Supports Treatment Adherence: Combining two medicines into a single tablet may make treatment more convenient and easier to follow consistently.
     

Directions for Use

To get the maximum benefit from treatment with Mclazide Plus M Tablet , follow these instructions carefully: 

  • Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • Take this medicine with food, usually with your morning or evening meal, to help prevent stomach upset.
  • Try to take your dose at the same time every day to establish a routine and maintain steady medicine levels in your body.

Always follow your doctor's exact instructions regarding how and when to take your medication. Do not change your dose or stop taking it without consulting them first.
 

How Mclazide Plus M Tablet Works

Mclazide Plus M Tablet contains two active medicines that work in different ways to lower your blood sugar levels. The first active ingredient, gliclazide, is a sulfonylurea. It works by stimulating the beta cells in your pancreas to release more insulin, which is the hormone that helps your body use glucose for energy. This helps glucose move from your bloodstream into your cells, where it can be used for energy. The second active ingredient, metformin, belongs to the biguanide class. It works in three ways: it decreases the amount of glucose produced by your liver, reduces the amount of glucose your intestines absorb from food, and increases your body's sensitivity to insulin so that your existing insulin works more effectively. Together, these complementary actions help control both fasting and post-meal blood sugar levels.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Mclazide Plus M Tablet to avoid unpleasant side-effects.

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Pregnancy

Caution

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Let your doctor know if you are a nursing mother before taking Mclazide Plus M Tablet ; your doctor will decide whether Mclazide Plus M Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Mclazide Plus M Tablet may cause hypoglycaemia (low blood sugar levels), whose symptoms include unusual sleepiness, shivering, palpitations, sweating etc. This may affect your ability to drive. Use caution while driving or doing anything that requires concentration.

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Liver

Caution

Tell your doctor before prescribing the Mclazide Plus M Tablet if you have a history of liver disease. Your doctor may adjust your dose depending upon your current liver conditions.

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Kidney

Caution

Tell your doctor before receiving the Mclazide Plus M Tablet if you have a history of kidney disease. Your doctor may adjust your dose depending upon your current kidney conditions.

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Children

Unsafe

The safety and efficacy of Mclazide Plus M Tablet in children have not been established. Mclazide Plus M Tablet is not recommended in children.

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Heart

Consult your doctor

Please consult your physician if you have any heart-related problems before taking Mclazide Plus M Tablet .

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Geriatrics

Consult your doctor

Your doctor will recommend Mclazide Plus M Tablet if needed in the geriatric population. Please consult your doctor.

What if I have taken an overdose of Mclazide Plus M Tablet

Do not take more than the prescribed dose of Mclazide Plus M Tablet as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Eat Regular Balanced Meals: Consume meals at consistent times and avoid skipping meals, as this helps maintain stable blood sugar levels and reduces the risk of low blood sugar.
  • Stay Physically Active: Engage in regular activities such as walking, swimming, or cycling to support healthy blood sugar control and overall well-being.
  • Monitor Your Diabetes Regularly: Keep track of your blood sugar readings and attend routine check-ups, including HbA1c testing, to help assess your long-term diabetes management.
  • Be Prepared for Low Blood Sugar: Carry a fast-acting source of sugar, such as glucose tablets, fruit juice, or hard sweets, in case symptoms of hypoglycaemia occur.
  • Stay Well-Hydrated: Drink adequate fluids throughout the day to support overall health and help maintain normal body functions.
     

Have a query?

How Soon It Starts Working

The time required for Mclazide Plus M Tablet to start to work: The time required for Mclazide Plus M Tablet to start to work is 1 to 2 hours after administration. The time for which the effects of Mclazide Plus M Tablet last: The effect of Mclazide Plus M Tablet lasts for 12 to 24 hours.

What if you forget to take Mclazide Plus M Tablet

If you miss a dose of Mclazide Plus M Tablet , take it as soon as you remember. However, if it is almost time for the next dose, skip the missed one and continue with your regular schedule. Do not take a double dose to make up for the missed one.

Storage

•Store Mclazide Plus M Tablet tablets according to the instructions on the product packaging, generally at room temperature, ideally between 15°C and 30°C (59°F to 86°F), away from excess heat and direct sunlight. •Keep the medicine in its original packaging to protect i

Drug Warnings

  • Avoid Alcohol: Alcohol may increase the risk of low blood sugar and lactic acidosis while taking Mclazide Plus M Tablet .
  • Inform Healthcare Providers Before Procedures: Tell your doctor if you are scheduled for surgery or imaging tests involving contrast dye, as temporary interruption of treatment may be required.
  • Monitor More Closely During Illness: Blood sugar levels may fluctuate during periods of illness, infection, injury, or significant stress, and additional monitoring may be needed.
  • Carry Medical Identification: Keep a diabetes identification card or medical alert bracelet with you in case of emergencies.
  • Check Your Feet Regularly: Inspect your feet for cuts, blisters, redness, or sores and seek medical advice if you notice any changes.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Inform your doctor if you are taking any of the following medicines, as they may interact with Mclazide Plus M Tablet : 

  • Beta-blockers: May hide the warning signs of low blood sugar (such as a fast heartbeat or palpitations).
  • Steroid medicines (corticosteroids): Can increase blood sugar levels, reducing the effectiveness of Mclazide Plus M Tablet .
  • Diuretics (water pills): May raise blood sugar levels and require your dose to be adjusted.
  • Other diabetes medications: Combined use may increase the risk of low blood sugar (hypoglycemia).

Drug-Food Interactions

  • Alcohol: Can interact with Mclazide Plus M Tablet to increase the risk of severe low blood sugar and a rare, serious condition called lactic acidosis.

Drug-Disease Interactions

Inform your doctor if you have a history of the following conditions before taking Mclazide Plus M Tablet , as it may worsen your condition or require closer monitoring: 

  • Severe Kidney Disease: Do not take this medicine if you have severe kidney impairment, as it can cause the medication to build up in your body. Your doctor may monitor your kidney function regularly and adjust treatment as needed, particularly if you are older or have declining kidney function.
  • Liver Damage: May increase the risk of lactic acidosis and make it harder for your body to regulate blood sugar.
  • Severe Infections or Dehydration: Can increase the risk of lactic acidosis; your doctor may advise you to temporarily stop taking the medicine.
     
Gliclazide + MetforminMetrizamide
Critical
Gliclazide + MetforminIopamidol
Critical

Drug-Drug Interactions

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Gliclazide + MetforminMetrizamide
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin and Metrizamide together can cause the risk of lactic acidosis (when the body produces too much lactic acid ).

How to manage the interaction:
Taking Metformin with Metrizamide is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience headaches, nausea, vomiting, diarrhea, muscle cramps or pain, body weakness, extreme fatigue, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Gliclazide + MetforminIopamidol
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Iopamidol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iopamidol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Gliclazide + MetforminGatifloxacin
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin with Gatifloxacin can cause both hypoglycemia (low blood glucose) and hyperglycemia (high blood glucose).

How to manage the interaction:
There is a possibility of interaction between Metformin and Gatifloxacin but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms like headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, sweating, palpitation, and tachycardia (fast heart rate). Do not discontinue without consulting a doctor.
Gliclazide + MetforminIopromide
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Iopromide with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Iopromide with Metformin is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Gliclazide + MetforminIodixanol
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Iodixanol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iodixanol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Gliclazide + MetforminIodamide
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin and Iodamide can increase the risk of lactic acidosis (when the body produces too much lactic acid).

How to manage the interaction:
Taking Metformin with Iodamide is generally avoided as it can result in an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Gliclazide + MetforminIomeprol
Critical
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Iomeprol with Metformin can increase the risk of lactic acidosis (a medical condition characterized by a build-up of lactate in the body).

How to manage the interaction:
Taking Metformin with Iomeprol is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
Gliclazide + MetforminAcetazolamide
Severe
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin with Acetazolamide may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is a possible interaction between Metformin and Acetazolamide, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, difficulty breathing, dizziness, chest pain or discomfort, fatigue, or loss of appetite, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Gliclazide + MetforminMethazolamide
Severe
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin with Methazolamide may increase the risk of Lactic acidosis (excessive lactic acid production in the blood).

How to manage the interaction:
Although there is a possible interaction between Metformin and Methazolamide, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, respiratory distress, fatigue, loss of appetite, slow or irregular heartbeat, breathing difficulty, or chills, contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
Gliclazide + MetforminEthanol
Severe
How does the drug interact with Mclazide Plus M Tablet:
Co-administration of Metformin with Ethanol may increase the risk of Lactic acidosis (excessive lactic acid production in blood).

How to manage the interaction:
Although there is a possible interaction between Metformin and Ethanol, you can take these medicines together if prescribed by a doctor. However, if you have symptoms such as weakness, muscle pain, increased drowsiness, dizziness, stomach pain or discomfort, slow or irregular heartbeat difficulty in breathing, or loss of appetite, contact a doctor immediately. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

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Therapeutic Class

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FAQs

Mclazide Plus M Tablet is used to treat Type 2 diabetes.
Mclazide Plus M Tablet is a combination of two anti-diabetic drugs: Gliclazide and‚ Metformin. Gliclazide works by increasing the amount of insulin released by the pancreas. On the other hand, Metformin works by lowering the glucose production in the liver, delaying glucose absorption from the intestines and increasing the body's response to insulin. In a nutshell, the two medicines prevent blood glucose levels from rising to very high levels, thus keeping your diabetes under control.
Hypoglycemia refers to low blood sugar levels and it is one of the side effects of Mclazide Plus M Tablet . Hypoglycemia can occur if you miss or delay your food, drink alcohol, over-exercise or take other antidiabetic medicine along with this medicine. It is important to regularly monitor blood sugar levels.
No, Mclazide Plus M Tablet should not be used with other anti-diabetic medications as it may cause hypoglycemia (lowering of blood sugar level).
If you feel thirsty after taking Mclazide Plus M Tablet , it may be because of dehydration as Mclazide Plus M Tablet can lead to loss of fluids. Increase intake of fluids, if even then you feel thirsty please consult your doctor.
Yes, long-term usage of Mclazide Plus M Tablet can cause vitamin B12 deficiency as it interferes with the absorption of vitamin B12 in the stomach. The symptoms of vitamin B12 deficiency include fatigue, nerve problems, tingling sensation and numbness in hands and feet, weakness, urinary problems, affect mental status, and difficulty in maintaining balance. These symptoms can be managed by taking Vitamin B12 supplements as advised by your doctor.
If you have symptoms like increased hunger, increased thirst, frequent urination (usually at night), unexplained weight loss, fatigue, blurred vision, slow wound/sores healing, and frequent infections, contact doctor as it can be a condition of type 2 diabetes.
If you experience symptoms of low blood sugar, such as sweating, shaking, dizziness, weakness, hunger, or confusion, immediately consume a fast-acting source of sugar such as glucose tablets, fruit juice, non-diet soft drinks, sugar candies, or sugar dissolved in water. Monitor your symptoms and seek medical attention if they do not improve or worsen.
Type-2 diabetes generally does not affect healthy children and teens, but it may affect children who are obese, which is also known as Childhood Obesity.
Include a diet rich in fruits, vegetables and whole grains like brown rice, whole wheat, oats, barley, and quinoa. Non-fat or low-fat dairy and proteins like chicken, lean meats, nuts, beans, tofu, lentils, eggs, fish, and turkey can also be included.
Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.
Hypoglycaemia (low blood sugar) may occur because you inject too much insulin, miss or delay meals, do not eat enough, eat food containing less carbohydrate than normal, drink alcohol, lose carbohydrates due to vomiting or diarrhoea, do more exercise than usual or a different type of physical activity, are recovering from an injury, illness, operation or stress, or are taking/have stopped taking other medicines.
Mclazide Plus M Tablet is an anti-diabetic medicine used to treat type-2 diabetes.
Possible side effects of Mclazide Plus M Tablet are low blood sugar, taste change, nausea, diarrhoea, stomach pain, headache, and upper respiratory symptoms. Consult the doctor if the side effects persist or worsen.
Yes, Mclazide Plus M Tablet can rarely cause lactic acidosis, a serious medical emergency caused by a buildup of lactic acid in the blood. The risk is higher in people with kidney disease, liver disease, severe dehydration, or excessive alcohol consumption. Seek immediate medical attention if you experience symptoms such as muscle pain, abdominal pain, rapid breathing, severe fatigue, vomiting, or reduced body temperature.
Mclazide Plus M Tablet should not be taken by people who are allergic to any of its components, people having severe kidney disease or diabetic ketoacidosis.
No, you should avoid drinking alcohol while taking Mclazide Plus M Tablet . Alcohol can increase the risk of hypoglycaemia (low blood sugar) and may also increase the risk of lactic acidosis, a rare but serious medical condition associated with metformin. Consult your doctor for personalised advice regarding alcohol consumption.
Mclazide Plus M Tablet may not be recommended for children as the safety and efficacy have not been established. Please consult the doctor.
Overdose may cause hypoglycaemia (low blood sugar). Seek medical attention if you have overdosed on Mclazide Plus M Tablet .
Mclazide Plus M Tablet contains two medicines that can affect body weight differently. Metformin may help with weight maintenance or modest weight loss in some people, while gliclazide may cause mild weight gain. Maintaining a balanced diet and regular physical activity can help support healthy weight management during treatment. Discuss weight management goals and dietary tips with your doctor.
Yes, it is highly recommended to take Mclazide Plus M Tablet with meals. Taking this medicine with food helps reduce common digestive side effects, such as nausea, stomach upset, or diarrhoea. Talk to your doctor or pharmacist about the best timing for your doses.
Mclazide Plus M Tablet is generally not recommended during pregnancy or breastfeeding. Managing blood sugar during these times is critical, and alternative treatments are usually prescribed. Talk to your doctor as soon as possible if you are pregnant, planning a pregnancy, or breastfeeding.
This medicine starts working to lower your blood sugar within a few hours of taking it, but it may take several weeks of consistent use, alongside diet and exercise changes, to see the full clinical effect on your long-term blood sugar levels. Talk to your doctor for regular monitoring.
No, you should not stop taking Mclazide Plus M Tablet without consulting your doctor, even if your blood sugar levels have normalised. This medicine controls your diabetes but does not cure it, and stopping it abruptly can cause your blood sugar to rise sharply again. Talk to your doctor before making any changes.

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Reference

  1. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Pil.5883 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Metformin hydrochloride. [Accessed on 08 Apr. 2019] Check here
  4. Glucophage 850 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2021 [Accessed on 13 December 2021] Check here
  5. Corcoran C, Jacobs TF. Metformin. NIH National Library of Medicine, National center for biotechnology information. Stat Pearls. January 2023. [Accessed on 3rd July 2025] Check here
  6. Brown & Burk UK Ltd. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 3rd July 2025] Check here
  7. Drug bank. Gliclazide. [Accessed on 3rd July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

F19, F20, F21, Kohinoor Mall, Opp. Don Bosco Engineering College, Kirol Road, Kurla (W), Mumbai - 400 070
Other Info - MCL0013

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