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compositionComposition:AZACITIDINE-200MG
prescription
Prescription Medicine
info
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MDS-O 200mg Tablet is used in treating Myelodysplastic syndrome, chronic myelomonocytic leukaemia, and acute myeloid leukaemia. It contains Azacitidine, a nucleoside metabolic inhibitor which works by preventing cancer cells from growing. It incorporates into the genetic material of the cells and interferes with the production of new DNA and RNA. This helps correct problems with the maturation and growth of young blood cells in the bone marrow, which causes myelodysplastic disorders.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZACITIDINE-200MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About MDS-O 200mg Tablet

MDS-O 200mg Tablet is a prescription medicine used to continue treatment for adults with acute myeloid leukaemia (AML). It is specifically prescribed for patients who have achieved complete remission after their initial chemotherapy but are not able to undergo a curative stem cell transplant.

This medicine is taken daily for a specific period during each treatment cycle, at the same time every day. You can take it with or without food, but your doctor may suggest taking medicine to prevent nausea about 30 minutes before each dose. Maintaining a healthy, clean living environment and practising safe food preparation are important lifestyle habits that can support your body during this treatment.

While taking MDS-O 200mg Tablet, you may experience some common side effects, including nausea, vomiting, diarrhoea, and fatigue. It is crucial to monitor your health closely and contact your healthcare provider immediately if you experience signs of infection, such as a high fever, or unexpected bruising or bleeding.

Talk to your doctor before starting this medicine if you have a history of liver damage or kidney disease. Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as it can cause serious harm to a developing baby.

Inform your doctor about all other medicines you take, as certain combinations can increase your risk of side effects. Avoid alcohol and smoking while taking MDS-O 200mg Tablet to prevent worsening stomach irritation and dehydration. Pregnant women, breastfeeding mothers, and elderly patients should consult their healthcare provider for specific safety guidance before starting therapy.

Uses of MDS-O 200mg Tablet

MDS-O 200mg Tablet is used to help maintain remission in adults with acute myeloid leukaemia (AML). The detailed uses of MDS-O 200mg Tablet are as follows:

  • Acute Myeloid Leukaemia (AML) Maintenance: MDS-O 200mg Tablet is used as a continued treatment for adults with AML who achieved their first complete remission following chemotherapy but cannot undergo a stem cell transplant. It helps delay the return of the leukaemia and prolongs survival.

Key Benefits

MDS-O 200mg Tablet helps maintain remission and supports long-term disease management in adults with acute myeloid leukaemia (AML). The key benefits of MDS-O 200mg Tablet are as follows:

  • Helps Maintain Remission: By targeting residual cancer cells that may remain in the body after chemotherapy, MDS-O 200mg Tablet reduces the likelihood of the leukaemia returning, helping patients experience longer periods of disease-free survival.
  • Convenient Oral Treatment: As an oral tablet, MDS-O 200mg Tablet allows continued cancer therapy to be managed at home, reducing the need for frequent hospital visits for intravenous infusions and making treatment more convenient.
Side effects of MDS-O 200mg Tablet
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in white blood cells which may lead to impaired immunity.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Eat a well-balanced diet, and avoid highly processed foods.
  • Regular exercise can help prevent ascites.
  • Maintain a healthy weight, as obesity is a risk factor for ascites.
  • Limit salt intake; try to consume no more than 2,000–4,000 milligrams of salt per day.
  • Avoid alcohol, as it can damage your liver and increase the risk of cirrhosis.
  • Practice safe sex, unprotected sex can lead to hepatitis, which can damage the liver and cause cirrhosis.
  • Get vaccinated for diseases like hepatitis, influenza, and pneumococcal.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.

Directions for Use

  • MDS-O 200mg Tablet can be taken with or without food, as food does not affect its absorption or effectiveness.
  • MDS-O 200mg Tablet is usually taken once daily; however, follow your doctor's advice regarding the dosage and duration.
  • Swallow the tablet as a whole with a glass of water.
  • Do not break, crush or chew MDS-O 200mg Tablet.

How MDS-O 200mg Tablet Works

MDS-O 200mg Tablet contains azacitidine, an antimetabolite (a type of medicine that mimics the natural building blocks cells need to grow, tricking cancer cells into taking it in). After entering rapidly dividing cancer cells, it blocks specific enzymes (DNA methyltransferases, which control how genes are turned on and off). This helps restore normal gene control over cell growth and division, allowing abnormal blood cells to mature and function more normally. Additionally, it interferes with the production of new DNA and RNA, preventing cancer cells from multiplying and ultimately causing them to die. This helps maintain remission and delays the return of acute myeloid leukaemia (AML).
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Alcohol

Consult your doctor

It is not known if alcohol affects MDS-O 200mg Tablet. Please consult your doctor.

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Pregnancy

Unsafe

MDS-O 200mg Tablet can harm the unborn baby. Avoid becoming pregnant during treatment with MDS-O 200mg Tablet. Consult the doctor immediately if you become pregnant during treatment with MDS-O 200mg Tablet.

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment with MDS-O 200mg Tablet and for one week after the last dose.

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Driving

Consult your doctor

It is unknown if MDS-O 200mg Tablet affects your ability to drive. Drive only if you are alert.

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Liver

Caution

If you have a history of liver disease, inform your doctor before taking MDS-O 200mg Tablet.

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Kidney

Caution

If you have a history of kidney disease, inform your doctor before taking MDS-O 200mg Tablet.

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Children

Unsafe

MDS-O 200mg Tablet is not recommended for children below 18 years as safety and effectiveness have not been established.

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Heart

Caution

MDS-O 200mg Tablet should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using MDS-O 200mg Tablet.

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Geriatrics

Safe if prescribed

MDS-O 200mg Tablet is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of MDS-O 200mg Tablet

If you accidentally take more than your prescribed dose, seek immediate medical attention or call emergency services. An overdose can lead to severe side effects, especially a dangerous drop in your blood cell counts.

Diet & Lifestyle Advise

  • Follow a neutropenic-friendly diet (a safe eating plan for people with low white blood cell counts): Since this medicine can temporarily lower your infection-fighting white blood cells, focus on eating fully cooked meals. Avoid raw meats, unpasteurized dairy, and unwashed raw fruits or vegetables to lower your risk of foodborne infections.
  • Stay well-hydrated: Drink plenty of fluids, such as water or clear broths, especially if you experience nausea, vomiting, or diarrhoea. This helps prevent dehydration and supports kidney function.
  • Practice strict hand hygiene: Wash your hands frequently with soap and warm water, especially before eating and after using the restroom. Ask family members and visitors to do the same to protect you from common germs.
  • Avoid crowds and sick individuals: Try to steer clear of crowded places and anyone showing signs of a cold, flu, or other contagious illnesses, as your immune system may be weakened during treatment.
  • Use a soft toothbrush: Protect your gums from bleeding by using a soft-bristled toothbrush and avoiding vigorous flossing while your platelet counts may be low.
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How Soon It Starts Working

The time required for MDS-O 200mg Tablet to start to work: MDS-O 200mg Tablet ideally shows its action within 30 minutes after administration. The time for which the effects of MDS-O 200mg Tablet last: The effect of MDS-O 200mg Tablet lasts for 24 hours.

What if you forget to take MDS-O 200mg Tablet

If you miss a dose, or if you vomit after taking your dose, do not take an extra tablet to make up for it. Instead, take your next regular dose at your scheduled time the following day. Inform your doctor or pharmacist about the missed or vomited dose.

Storage

• Store MDS-O 200mg Tablet tablets at room temperature, between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Monitor your blood counts regularly: You will need frequent blood tests to check your blood cell levels (white cells, red cells, and platelets) before and during each treatment cycle.
  • Inspect the tablets before taking them: Check each tablet before swallowing. Do not take any tablet that is broken, chipped, or leaking powder.
  • Avoid direct contact with broken tablets: If a tablet breaks, do not touch the powder. If it touches your skin, wash the area immediately with soap and water.
  • Use reliable birth control: Both men and women should use highly effective birth control during treatment and for a specified time after the last dose to prevent pregnancy.
  • Do not substitute forms: Do not switch between oral tablets and injectable forms of this medicine, as they are absorbed differently and are not interchangeable.

Drug-Drug Interactions

verifiedApollotooltip

  • Other Chemotherapy Medicines or Immunosuppressants: Taking MDS-O 200mg Tablet with other medicines that weaken your immune system or lower blood cell counts, such as other chemotherapy agents or immunosuppressants, can increase your risk of severe infections and bleeding.

AzacitidineYellow fever vaccine
Critical
AzacitidineFilgrastim
Severe

Drug-Drug Interactions

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AzacitidineYellow fever vaccine
Critical
How does the drug interact with MDS-O 200mg Tablet:
Taking Yellow fever vaccine with MDS-O 200mg Tablet can increase the risk of infection.

How to manage the interaction:
Although there is a possible interaction between MDS-O 200mg Tablet and the Yellow fever vaccine, you can take these medicines together if prescribed by a doctor. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.
AzacitidineFilgrastim
Severe
How does the drug interact with MDS-O 200mg Tablet:
Coadministration of Filgrastim with MDS-O 200mg Tablet can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is an interaction between filgrastim and MDS-O 200mg Tablet, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
AzacitidineGolimumab
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking MDS-O 200mg Tablet with Golimumab can raise the risk of severe infections.

How to manage the interaction:
Co-administration of MDS-O 200mg Tablet with Golimumab can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineTofacitinib
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking MDS-O 200mg Tablet with tofacitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between MDS-O 200mg Tablet and Tofacitinib, you can take these medicines together if prescribed by a doctor. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineEfalizumab
Severe
How does the drug interact with MDS-O 200mg Tablet:
Using efalizumab together with MDS-O 200mg Tablet may increase the risk of serious infections.

How to manage the interaction:
Taking MDS-O 200mg Tablet with Efalizumab together can result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - complications, infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, pain or burning during urination - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineLeflunomide
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking MDS-O 200mg Tablet and leflunomide together may increase the chances of developing severe infections.

How to manage the interaction:
Although there is an interaction between leflunomide and MDS-O 200mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineFingolimod
Severe
How does the drug interact with MDS-O 200mg Tablet:
The use of fingolimod in conjunction with MDS-O 200mg Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of MDS-O 200mg Tablet with Fingolimod can possibly result in an interaction, but it can be taken if your doctor has advised it. However, Consult a doctor immediately if you have a fever, chills, diarrhoea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. Do not discontinue any medications without consulting a doctor.
AzacitidineAdalimumab
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking Adalimumab with MDS-O 200mg Tablet may raise the risk of severe infections.

How to manage the interaction:
Taking MDS-O 200mg Tablet with Adalimumab together can result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of these symptom's fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain or burning while peeing - make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.
AzacitidineBaricitinib
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking baricitinib and MDS-O 200mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with MDS-O 200mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
AzacitidineBCG vaccine
Severe
How does the drug interact with MDS-O 200mg Tablet:
Taking BCG vaccine with MDS-O 200mg Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of MDS-O 200mg Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with MDS-O 200mg Tablet when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

MDS-O 200mg Tablet is used to treat Acute myeloid leukaemia.
MDS-O 200mg Tablet works by helping bone marrow in the production of normal blood cells and killing abnormal cells in the bone marrow.
MDS-O 200mg Tablet may affect fertility in men and women. Consult the doctor if you have any concerns.
The doctor will prescribe anti-nausea medicine to help prevent nausea and vomiting during treatment with MDS-O 200mg Tablet. Take the anti-nausea medicine 30 minutes before each dose of MDS-O 200mg Tablet or as the doctor advises.
If you vomit after taking a dose MDS-O 200mg Tablet, avoid taking another dose on the same day. Take the next dose at the regular time the next day. Talk to the doctor if you have any concerns.
Yes, you can take MDS-O 200mg Tablet with or without food. Try to take it at the same time each day to maintain a steady level of the medicine in your body. Talk to your doctor if you experience stomach upset.
MDS-O 200mg Tablet can lower your white blood cells, red blood cells, and platelets. Regular blood tests help your doctor monitor these levels to ensure it is safe for you to continue treatment.
No, you must swallow the tablet whole. Do not crush, split, or chew the tablet, as doing so can change how the drug is absorbed and may be harmful. Talk to your doctor if you cannot swallow tablets.
No, the oral tablets and the injectable forms are not interchangeable because they are absorbed by the body differently. Never substitute one for the other. Talk to your doctor for details.
You should avoid live vaccines during treatment because your immune system may be weakened. Always consult your doctor before getting any vaccination.
This medicine is typically taken as continued maintenance therapy. Your doctor will determine how many treatment cycles you need based on your progress and blood tests.
A fever can be a sign of a serious infection due to low white blood cell counts. Call your doctor or seek emergency medical care immediately if your temperature rises.

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Reference

  1. U.S. Food and Drug Administration (FDA). 214120S000Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A620060 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Azacitidine Oral Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Azacitidine Azacitidine. 2008. [Accessed on 26 Mar. 2019]Check here
  5. Zentiva Pharma UK Limited. Azacitidine 25 mg/ml powder for suspension for injection azacitidine. European Medicines Compendium. [Revised in September 2022]. [Accessed on 10th October 2024]Check here
  6. American Society of Health-System Pharmacists. Azacitidine Injection. Medlineplus.gov. [Accessed on 10th October 2024]Check here

Country of origin

India
Other Info - MD26652
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