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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Medcarmib 60 mg Injection 1's is used to treat Multiple Myeloma. It contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells. Sometimes, Medcarmib 60 mg Injection 1's may cause side effects such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever).

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Composition :

CARFILZOMIB-60MG

Manufacturer/Marketer :

Medion Biotech Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Medcarmib 60 mg Injection 1's

Medcarmib 60 mg Injection 1's belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.

Medcarmib 60 mg Injection 1's contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Medcarmib 60 mg Injection 1's is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Before taking the Medcarmib 60 mg Injection 1's, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Medcarmib 60 mg Injection 1's can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.

Uses of Medcarmib 60 mg Injection 1's

Medcarmib 60 mg Injection 1's is used in the treatment of Multiple Myeloma. The detailed uses of Medcarmib 60 mg Injection 1's are as follows:

  • Relapsed or refractory multiple myeloma: Medcarmib 60 mg Injection 1's is used for the treatment of multiple myeloma in adult patients whose cancer has relapsed or is refractory to one or more lines of therapy. It is specifically indicated when the disease becomes resistant to previous treatments, helping to slow disease progression and extend survival. By targeting cancer cells that have adapted to earlier therapies, Medcarmib 60 mg Injection 1's provides a critical second-line or later treatment option.
  • Combination therapy support: Medcarmib 60 mg Injection 1's is used in combination with other agents such as dexamethasone or lenalidomide to enhance overall treatment efficacy in patients with relapsed or refractory multiple myeloma. These combinations have shown improved response rates and longer progression-free survival compared to monotherapy. The synergy between Medcarmib 60 mg Injection 1's and these medications helps increase cancer cell death while maintaining manageable toxicity profiles.
  • Proteasome inhibition in cancer therapy: Medcarmib 60 mg Injection 1's is used as a selective proteasome inhibitor that blocks the activity of proteasomes, which are cellular structures responsible for breaking down unneeded or damaged proteins. In cancer cells, this inhibition disrupts protein homeostasis and causes toxic proteins to accumulate, leading to cellular stress and programmed cell death (apoptosis). By targeting the increased protein turnover demands of myeloma cells, Medcarmib 60 mg Injection 1's effectively eliminates cancer cells while leaving most normal cells relatively unaffected.

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Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Medcarmib 60 mg Injection 1's will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

Medicinal Benefits

Carfilzomib, a proteasome inhibitor, is present in Medcarmib 60 mg Injection 1's. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

How Medcarmib 60 mg Injection 1's Works

Medcarmib 60 mg Injection 1's contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep Medcarmib 60 mg Injection 1's out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Medcarmib 60 mg Injection
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here's a comprehensive approach to managing medication-triggered high blood pressure (hypertension):
  • Inform your doctor if you experience high blood pressure symptoms after starting a new medication or changing your medication regimen.
  • To reduce high blood pressure symptoms, your doctor may change your medication regimen or dose.
  • Monitor your blood pressure regularly to track changes and potential side effects.
  • Make lifestyle changes, such as following a healthy diet, exercising regularly, and reducing sodium intake.
  • Consider incorporating stress-reducing activities, like meditation or deep breathing exercises, into your daily routine.
  • Create a personalized plan with your doctor to manage high blood pressure, which may include additional medications, therapies, or lifestyle modifications.
  • Follow up with your doctor on a frequent basis to assess progress, change treatment plans, and address any concerns or issues.

What if I have taken an overdose of Medcarmib 60 mg Injection 1's

As Medcarmib 60 mg Injection 1's is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of Medcarmib 60 mg Injection 1's may cause chills, dizziness, and decreased urination.

Drug Warnings

Before taking Medcarmib 60 mg Injection 1's, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Medcarmib 60 mg Injection 1's if you are pregnant or breastfeeding or allergic to any component present in Medcarmib 60 mg Injection 1's. Both women and men using this Medcarmib 60 mg Injection 1's should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Medcarmib 60 mg Injection 1's. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Medcarmib 60 mg Injection:
Combining Infliximab with Medcarmib 60 mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
Although taking Medcarmib 60 mg Injection and Infliximab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, losing weight, or pain or burning when you pee, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Co-administration of Medcarmib 60 mg Injection with Tranexamic acid can increase the risk of blood clots.

How to manage the interaction:
Taking Medcarmib 60 mg Injection with tranexamic acid is not recommended due to its increased effects, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, and numbness or weakness on one side of the body contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Combining Adalimumab with Medcarmib 60 mg Injection can increase the risk of infections.

How to manage the interaction:
Co-administration of Medcarmib 60 mg Injection with Adalimumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Combining Medcarmib 60 mg Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Taking Medcarmib 60 mg Injection with Leflunomide together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include liver damage, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Coadministration of Medcarmib 60 mg Injection and sulfasalazine can increase the risk or severity of developing blood clots.

How to manage the interaction:
Although taking Medcarmib 60 mg Injection and sulfasalazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
CarfilzomibConjugated Estrogens
Severe
How does the drug interact with Medcarmib 60 mg Injection:
Combining Medcarmib 60 mg Injection with Conjugated Estrogens can increase the risk of developing blood clots.

How to manage the interaction:
Although taking Conjugated estrogen and Medcarmib 60 mg Injection together can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience chest discomfort, shortness of breath, weakness, or blurred vision, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Combining Medcarmib 60 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Clozapine with Medcarmib 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of the following symptoms, contact your doctor immediately: severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain or burning when urinating. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Medcarmib 60 mg Injection:
Medcarmib 60 mg Injection can occasionally cause dangerous blood clots and using it together with ethinyl estradiol may increase the risk.

How to manage the interaction:
Co-administration of Desogestrel with Medcarmib 60 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like rapid loss of eyesight, chest pain, shortness of breath, breathing difficulties, coughing up blood, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, contact a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Medcarmib 60 mg Injection:
Coadministration of Eltrombopag with Medcarmib 60 mg Injection can increase the risk or severity of blood clots that can lead to complications such as heart attack, pulmonary embolism (blockage of an artery in the lung), and stroke.

How to manage the interaction:
Although taking Eltrombopag and Medcarmib 60 mg Injection together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, swelling in an arm or leg, or weakness on one side of your body it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Medcarmib 60 mg Injection:
Medcarmib 60 mg Injection can cause serious blood clots and taking it alongside estradiol may enhance the risk.

How to manage the interaction:
Co-administration of Estradiol with Medcarmib 60 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

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Alcohol

Caution

Avoid alcohol consumption while on treatment with Medcarmib 60 mg Injection 1's.

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Pregnancy

Unsafe

Medcarmib 60 mg Injection 1's should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

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Breast Feeding

Unsafe

Do not breastfeed while you are receiving Medcarmib 60 mg Injection 1's and for two weeks after your final dose.

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Driving

Caution

Medcarmib 60 mg Injection 1's may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.

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Liver

Caution

Extreme caution is exercised while using Medcarmib 60 mg Injection 1's in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.

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Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Medcarmib 60 mg Injection 1's if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Medcarmib 60 mg Injection 1's.

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Children

Caution

The safety and effectiveness of Medcarmib 60 mg Injection 1's in pediatric patients have not been established.

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Heart

If you have a history of heart disease, please inform the doctor before receiving Medcarmib 60 mg Injection 1's.

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Geriatrics

Caution

Medcarmib 60 mg Injection 1's can be used in the elderly when prescribed by a doctor. If you have any concerns about using Medcarmib 60 mg Injection 1's, please consult a doctor.

FAQs

Medcarmib 60 mg Injection 1's is used to treat Multiple Myeloma.

Medcarmib 60 mg Injection 1's contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.

No, it is unsafe to father a child while taking Medcarmib 60 mg Injection 1's. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Medcarmib 60 mg Injection 1's.

Based on the medical condition, Medcarmib 60 mg Injection 1's may be given alone or together with other medicines used to treat multiple myeloma.

Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.

Country of origin

India

Manufacturer/Marketer address

409, 4Th Floor, Devika Tower, Chander Nagar, Surya Nagar, Ghaziabad-201011, Uttar Pradesh, India
Other Info - MED1472

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