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Carfizome 60Mg Inj is used to treat Multiple Myeloma. It contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells. Sometimes, Carfizome 60Mg Inj may cause side effects such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever).

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CARFILZOMIB-60MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Carfizome 60Mg Inj

Carfizome 60Mg Inj is a specialised prescription medicine used to treat adults with a type of blood cancer called multiple myeloma. It is typically prescribed when the cancer has returned after previous treatments or has stopped responding to other therapies. This medication plays a vital role in slowing down the progression of cancer cells in the bone marrow.

This medicine is given as an injection directly into your vein (intravenous infusion) by a healthcare professional in a clinic or hospital setting. It is usually given in treatment cycles, meaning you will receive the injection on specific days of the week followed by rest periods. To help your body handle this treatment, drinking plenty of water and staying well-hydrated is one of the most important lifestyle habits you must maintain during your therapy.

While undergoing treatment, you may experience some common side effects such as fatigue, mild nausea, headache, or temporary changes in your blood cell counts. However, you must contact your doctor immediately if you experience serious symptoms like sudden chest pain, shortness of breath, severe dizziness, or swelling in your legs. These can be signs of more serious complications that require prompt medical evaluation.

Do not take this medicine if you are pregnant, as it can cause serious harm to an unborn baby. Before starting your first treatment, you must tell your healthcare provider if you have a history of heart disease, kidney problems, liver conditions, or lung disorders. Your doctor will carefully evaluate your health history to decide if this treatment is safe for you.

This medicine can interact with other prescription drugs, over-the-counter medications, or herbal supplements, so keeping your healthcare team fully informed is essential. It is highly recommended to avoid drinking alcohol during your treatment cycle to prevent putting extra strain on your liver. If you are breastfeeding, elderly, or planning a family, talk to your doctor or pharmacist to understand the specific risks and precautions required.

Uses of Carfizome 60Mg Inj

Your doctor may prescribe Carfizome 60Mg Inj for the following condition:

  • Multiple Myeloma: Carfizome 60Mg Inj is used to treat adults with relapsed or refractory multiple myeloma, which is a cancer of the plasma cells in the bone marrow. It is often combined with other medications to help control the disease and prevent cancer cells from multiplying.

Key Benefits

This medicine provides meaningful clinical benefits by targeting cancer cells directly, which helps manage the disease more effectively. Key benefits include:

  • Slowing Cancer Growth: By stopping cancer cells from dividing, it helps keep the disease in check and delays the progression of multiple myeloma.
  • Promoting Remission: When used alongside other therapies, it can help reduce the amount of cancer in the body, leading to longer periods where the disease is inactive.
  • Symptom Control: By lowering the overall cancer cell count, it can help relieve associated symptoms such as bone pain, weakness, and extreme tiredness, helping you feel more comfortable.
Side effects of Carfizome 60Mg Inj
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Here's a comprehensive approach to managing medication-triggered high blood pressure (hypertension):
  • Inform your doctor if you experience high blood pressure symptoms after starting a new medication or changing your medication regimen.
  • To reduce high blood pressure symptoms, your doctor may change your medication regimen or dose.
  • Monitor your blood pressure regularly to track changes and potential side effects.
  • Make lifestyle changes, such as following a healthy diet, exercising regularly, and reducing sodium intake.
  • Consider incorporating stress-reducing activities, like meditation or deep breathing exercises, into your daily routine.
  • Create a personalized plan with your doctor to manage high blood pressure, which may include additional medications, therapies, or lifestyle modifications.
  • Follow up with your doctor on a frequent basis to assess progress, change treatment plans, and address any concerns or issues.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Carfizome 60Mg Inj will be administered by a doctor or nurse in a healthcare facility.
  • Do not self-administer.

How Carfizome 60Mg Inj Works

Carfizome 60Mg Inj contains carfilzomib, which belongs to a group of medicines called proteasome inhibitors. Proteasomes are tiny structures inside cells that act as the cell's waste disposal and recycling system, breaking down damaged or unnecessary proteins. Multiple myeloma cells produce large amounts of abnormal proteins and depend heavily on this recycling process to survive and grow. Carfilzomib works by blocking the action of proteasomes. As a result, damaged and unwanted proteins build up inside the myeloma cells, causing severe stress and disrupting their normal function. This protein overload eventually triggers the cancer cells to die. Because multiple myeloma cells rely more heavily on proteasomes than healthy cells, they are more sensitive to this effect, helping to control the disease while allowing normal cells to recover.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Carfizome 60Mg Inj.

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Pregnancy

Unsafe

Carfizome 60Mg Inj should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.

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Breast Feeding

Unsafe

Do not breastfeed while you are receiving Carfizome 60Mg Inj and for two weeks after your final dose.

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Driving

Caution

Carfizome 60Mg Inj may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.

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Liver

Caution

Extreme caution is exercised while using Carfizome 60Mg Inj in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.

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Kidney

Caution

Limited information is available. Please inform your doctor before prescribing Carfizome 60Mg Inj if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Carfizome 60Mg Inj.

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Children

Caution

The safety and effectiveness of Carfizome 60Mg Inj in pediatric patients have not been established.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Carfizome 60Mg Inj.

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Geriatrics

Caution

Carfizome 60Mg Inj can be used in the elderly when prescribed by a doctor. If you have any concerns about using Carfizome 60Mg Inj, please consult a doctor.

What if I have taken an overdose of Carfizome 60Mg Inj

Since this medication is prepared and given by qualified healthcare providers, an accidental overdose is highly unlikely. However, if you suspect an error has occurred or experience sudden, severe symptoms after an infusion, seek immediate emergency medical attention or contact your doctor right away.

Diet & Lifestyle Advise

  • Prioritize Hydration: Drink 6 to 8 glasses of water daily, especially in the 24 to 48 hours before and after each infusion. This helps flush your kidneys and prevents complications from cellular waste.
  • Eat Small, Frequent Meals: If you experience nausea or loss of appetite, eating five or six small, nutritious meals throughout the day can be easier to manage than three large ones.
  • Practice Infection Prevention: Since this medicine can lower your white blood cell count, wash your hands frequently with soap and water, avoid close contact with sick individuals, and stay away from crowded public spaces when possible.
  • Incorporate Gentle Movement: Engage in light activities like short daily walks if your energy levels allow. This can help combat cancer-related fatigue and support your cardiovascular health.
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How Soon It Starts Working

The time required for Carfizome 60Mg Inj to start to work: The time required for Carfizome 60Mg Inj to show its action is not clinically established. The time for which the effects of Carfizome 60Mg Inj last: The duration of action for Carfizome 60Mg Inj is not clinically established.

What if you forget to take Carfizome 60Mg Inj

Because this medicine is given at a clinic by healthcare professionals, a missed dose means missing an appointment. If you miss a scheduled session, call your cancer clinic or doctor's office immediately to reschedule. Do not attempt to catch up by receiving doses too close together; your clinical team will determine the safest schedule adjustment for you.

Storage

• Store unopened vials of Carfizome 60Mg Inj in a refrigerator between 2°C and 8°C (36°F and 46°F). Do not freeze the vials.•Keep the vials in their original carton to protect them from light.
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Keep Refrigerated. Do not freeze.

Drug Warnings

  • Check the Solution: Ensure your healthcare provider inspects the vial before use; the mixed solution should be clear and colourless to pale yellow, with no visible particles.
  • Monitor Your Weight: Weigh yourself daily at home. Inform your doctor immediately if you experience a sudden weight gain of more than 2 to 3 pounds in a single day, as this can indicate fluid retention or heart strain.
  • Keep Blood Pressure Records: Keep a regular log of your blood pressure readings, especially on infusion days, as this medicine can cause sudden blood pressure spikes.
  • Stay Consistent with Blood Tests: Attend all scheduled laboratory appointments; regular blood checks are vital to monitor your liver, kidneys, and blood cell counts.
  • Avoid Driving After Infusion: Do not drive, operate heavy machinery, or engage in hazardous activities if you feel dizzy, faint, or extremely fatigued immediately after your clinic session.
  • Use effective contraception: Women who can become pregnant and male patients with partners who can become pregnant should use effective contraception during treatment and for the recommended period after the last dose. Speak with your doctor about family planning before starting treatment.
  • Report infusion reactions immediately: Tell your healthcare team straight away if you develop fever, chills, flushing, chest tightness, shortness of breath, dizziness, or low blood pressure during or shortly after your infusion.
  • Watch for blood clots: Seek immediate medical attention if you experience sudden leg pain or swelling, chest pain, or unexplained shortness of breath, as these may be signs of a blood clot.

Drug-Drug Interactions

verifiedApollotooltip
  • Medicines that affect kidney function: Taking pain relievers like ibuprofen or naproxen (NSAIDs) alongside Carfizome 60Mg Inj can significantly increase the risk of kidney strain. Always consult your doctor before taking any pain medication.
  • Other chemotherapy drugs: Combining this medicine with certain other cancer therapies can increase your risk of low blood cell counts or nerve numbness.

Drug-Drug Interactions

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How does the drug interact with Carfizome 60Mg Inj:
The combined use of Testosterone and Carfizome 60Mg Inj can increase the risk of blood clots.

How to manage the interaction:
Co-administration of Testosterone and Carfizome 60Mg Inj can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Carfizome 60Mg Inj:
Combining Darbepoetin alfa with Carfizome 60Mg Inj can increase the risk of blood clots.

How to manage the interaction:
Although there is a possible interaction between Carfizome 60Mg Inj and Darbepoetin alfa, you can take these medicines together if prescribed by your doctor. However, if you experience chest pain; shortness of breath; difficulty breathing; coughing up blood; sudden loss of vision; pain, redness, or swelling in an arm or leg; and numbness or weakness on one side of the body, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Carfizome 60Mg Inj:
Taking Carfizome 60Mg Inj with Tofacitinib may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Tofacitinib with Carfizome 60Mg Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Carfizome 60Mg Inj:
Carfizome 60Mg Inj can occasionally cause dangerous blood clots and using it together with levonorgestrel may increase the risk.

How to manage the interaction:
Co-administration of Carfizome 60Mg Inj with Levonorgestrel can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: blood clots that can be harmful, high blood pressure or cholesterol, heart problems like heart attack or blockage in the lung, stroke, complications, chest pain, difficulty breathing, coughing up blood, sudden vision loss, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of your body. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Carfizome 60Mg Inj:
Combining Adalimumab with Carfizome 60Mg Inj can increase the risk of infections.

How to manage the interaction:
Co-administration of Carfizome 60Mg Inj with Adalimumab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Carfizome 60Mg Inj:
Combining Carfizome 60Mg Inj with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Clozapine with Carfizome 60Mg Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of the following symptoms, contact your doctor immediately: severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain or burning when urinating. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Carfizome 60Mg Inj:
Coadministration of Carfizome 60Mg Inj and sulfasalazine can increase the risk or severity of developing blood clots.

How to manage the interaction:
Although taking Carfizome 60Mg Inj and sulfasalazine together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, and numbness or weakness on one side of the body, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Carfizome 60Mg Inj:
Carfizome 60Mg Inj can cause serious blood clots and taking it with ethinyl estradiol may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Carfizome 60Mg Inj and Ethinylestradiol, but it can be taken if prescribed by a doctor. However, if you experience chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness, or swelling in an arm or leg, or numbness or weakness on one side of the body, you should consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Carfizome 60Mg Inj:
Taking Carfizome 60Mg Inj with tamoxifen may increase the risk of blood clots. The risk is also increased with age, cigarette smoking, high blood pressure, or high cholesterol.

How to manage the interaction:
Although taking tamoxifen and Carfizome 60Mg Inj together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not stop using any medications without consulting doctor.
CarfilzomibConjugated Estrogens
Severe
How does the drug interact with Carfizome 60Mg Inj:
Combining Carfizome 60Mg Inj with Conjugated Estrogens can increase the risk of developing blood clots.

How to manage the interaction:
Although taking Conjugated estrogen and Carfizome 60Mg Inj together can result in an interaction, it can be taken if prescribed by a doctor. However, if you experience chest discomfort, shortness of breath, weakness, or blurred vision, consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid consuming alcohol during your treatment, as it can worsen liver strain, dehydration, and nausea.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Carfizome 60Mg Inj is used to treat Multiple Myeloma.
Carfizome 60Mg Inj contains Carfilzomib, which inhibits proteasomes and thereby prevents protein breakdown in MM (multiple myeloma) cells. When the proteasome action within the MM cell is disturbed, a protein accumulation occurs, destroying the cancerous cells.
No, it is unsafe to father a child while taking Carfizome 60Mg Inj. It is recommended for sexually active men to use condoms while on treatment and for at least several months after their last dose of Carfizome 60Mg Inj.
Based on the medical condition, Carfizome 60Mg Inj may be given alone or together with other medicines used to treat multiple myeloma.
Tell your healthcare professional immediately if you get any signs of an infusion-related reaction during or after the infusion. Your doctor may give other medicines, or the infusion may need to be slowed down or stopped.
Carfizome 60Mg Inj can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment. Tell your healthcare provider if you develop a fever or have signs of bruising or bleeding.
Carfizome 60Mg Inj treats multiple myeloma that has returned or no longer responds to treatment. It's often used with other medications. If you have questions or concerns, talk to your doctor. They will help you understand if Carfizome 60Mg Inj is right for you.
Carfizome 60Mg Inj is to be administered by intravenous infusion in a hospital setting under the supervision of a physician qualified to administer cancer chemotherapeutic agents.
Carfizome 60Mg Inj is given on two consecutive days each week for three weeks followed by a 12-day rest period or it may be given once a week for 3 weeks followed by a 13-day rest period. However, the pattern and duration of treatment may vary. Please consult the doctor if you have any concerns.
You may experience nausea and extreme tiredness from Carfizome 60Mg Inj. To cope with nausea, try eating small meals, avoiding strong smells, and staying hydrated. For tiredness, prioritize rest, break tasks into smaller chunks, and take regular breaks. Practice relaxation techniques like deep breathing, meditation, or yoga, and stay hydrated and energized with nutritious food. However, if these are bothering you consult your doctor immediately.
Carfizome 60Mg Inj can lower your blood cell and platelet counts, increasing the risk of infections, anemia, and bleeding. To keep an eye on this, your doctor will likely order regular blood tests before and during treatment. Consult your doctor if you suspect any symptoms of low immunity like delayed healing or frequent infections.
If you experience any of the following, seek a doctor's advice right away: fever, infection signs, unusual bleeding, shortness of breath, chest pain, severe nausea, weakness, confusion, or severe headache. Also, consult your doctor if you have concerns or questions about your treatment, notice any health changes or side effects, miss a dose, or need to change your treatment schedule.
Carfizome 60Mg Inj should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are pregnant or think you may be pregnant while on therapy.
Do not breastfeed while you are receiving Carfizome 60Mg Inj and for two weeks after your final dose as it may pass into the breastmilk. Consult your doctor if you have any concerns regarding it.
Drinking plenty of water is crucial because Carfizome 60Mg Inj can put significant strain on your kidneys as it helps break down cancer cells. Proper hydration helps flush these waste products out of your body safely. Talk to your doctor or pharmacist about how much water you should drink daily.
Warning signs of potential heart complications include sudden chest pain, shortness of breath, rapid weight gain, or swelling in your ankles and feet. If you notice any of these symptoms, seek emergency medical care immediately. Talk to your doctor if you have a history of heart problems.
Carfizome 60Mg Inj is not considered a permanent cure for multiple myeloma, but it is highly effective at controlling the disease, slowing cancer growth, and keeping you in remission for longer periods. Talk to your doctor to understand the realistic goals of your cancer therapy.
You should avoid receiving live vaccines while undergoing treatment with Carfizome 60Mg Inj, as your immune system may be too weak to handle them safely. Non-live vaccines may be safe but could be less effective during chemotherapy. Talk to your doctor or pharmacist before scheduling any vaccinations.
Your doctor will schedule regular blood tests, often before each treatment cycle or even before every dose. These tests check your kidney function, liver health, and blood cell counts to ensure it is safe to proceed with the injection. Talk to your doctor for more details on your monitoring schedule.
It is highly recommended to avoid alcohol while receiving Carfizome 60Mg Inj, as alcohol can worsen treatment-related dehydration, put extra strain on your liver, and increase nausea. Talk to your doctor or pharmacist if you need help managing lifestyle changes during your treatment.

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Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - CAR1481
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