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Carfizome 60Mg Inj belongs to the group of proteasome inhibitors (anti-cancer medicines). It is used alone and in combination with other medications to treat people with multiple myeloma (a type of cancer of the bone marrow) who have already been treated with other medicines. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.
Carfizome 60Mg Inj contains Carfilzomib, which suppresses proteasomes that prevent protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.
Carfizome 60Mg Inj is administered in a hospital setting by a physician qualified by training and experience to administer cancer chemotherapeutic agents. Sometimes, you may experience common side effects, such as fatigue (feeling overtired), anaemia, nausea, thrombocytopenia (low platelet level), dyspnea (feeling short of breath), diarrhoea, and pyrexia (fever). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.
Before taking the Carfizome 60Mg Inj, inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Carfizome 60Mg Inj can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant while undergoing therapy and for several months afterwards. Before beginning treatment, discuss effective contraception with your healthcare professional. Inform them immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment since it is unknown whether this medication passes into breast milk. Do not skip any laboratory checks because Thrombocytopenia, Hepatic Toxicity and Hepatic Failure may occur. If it happens, reduce or interrupt dosing as clinically indicated.
Carfizome 60Mg Inj is used in the treatment of Multiple Myeloma. The detailed uses of Carfizome 60Mg Inj are as follows:
Carfilzomib, a proteasome inhibitor, is present in Carfizome 60Mg Inj. It suppresses proteasomes, preventing protein breakdown in MM (multiple myeloma) cells. When proteasome function is stopped within the MM cell, a protein build-up occurs within the MM cell, which destroys the malignant cells.
Caution
Avoid alcohol consumption while on treatment with Carfizome 60Mg Inj.
Unsafe
Carfizome 60Mg Inj should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.
Unsafe
Do not breastfeed while you are receiving Carfizome 60Mg Inj and for two weeks after your final dose.
Caution
Carfizome 60Mg Inj may cause fatigue, dizziness, fainting, and/or a drop in blood pressure. So, if you have any of these symptoms while in therapy, you should not operate machinery or drive a car.
Caution
Extreme caution is exercised while using Carfizome 60Mg Inj in patients with liver impairment. Inform your doctor if you have liver impairment. Your doctor monitors liver enzymes and withholds dosing if suspected.
Caution
Limited information is available. Please inform your doctor before prescribing Carfizome 60Mg Inj if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Carfizome 60Mg Inj.
Caution
The safety and effectiveness of Carfizome 60Mg Inj in pediatric patients have not been established.
Caution
If you have a history of heart disease, please inform the doctor before receiving Carfizome 60Mg Inj.
Caution
Carfizome 60Mg Inj can be used in the elderly when prescribed by a doctor. If you have any concerns about using Carfizome 60Mg Inj, please consult a doctor.
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Keep Refrigerated. Do not freeze.
Before taking Carfizome 60Mg Inj, inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Avoid taking Carfizome 60Mg Inj if you are pregnant or breastfeeding or allergic to any component present in Carfizome 60Mg Inj. Both women and men using this Carfizome 60Mg Inj should use birth control to avoid pregnancy. Inform your doctor right away if you or your partner become pregnant during treatment with Carfizome 60Mg Inj. Inform your doctor if you have a history of heart failure and ischemia, Pulmonary Hypertension, Thrombocytopenia, low blood pressure or hepatic toxicity; your doctor will closely monitor and manage it. Carfilzomib injection may induce serious or life-threatening responses for up to 24 hours following administration. Before each dose of carfilzomib, you will be given specific drugs to assist in preventing a reaction. If you develop any of the following symptoms after your treatment, contact your doctor right away: fever, chills, joint or muscle pain, flushing or swelling of the face, swelling or tightening of the throat, vomiting, weakness, shortness of breath, disorientation or fainting, or chest tightness or pain.
Drug-Drug Interactions: Carfizome 60Mg Inj may interact with monoclonal antibodies (e.g. adalimumab), immunomodulatory medication (e.g. baricitinib, fingolimod), vaccines (e.g. BCG Vaccine, Denue vaccine), and antipsychotic medication (e.g. clozapine), and anabolic steroid hormone (methyltestosterone).
Drug-Food Interactions: Avoid the consumption of alcoholic beverages.
Drug-Disease Interactions: Carfizome 60Mg Inj may interact with various disease conditions, including tumour lysis syndrome (a condition that occurs when a large number of cancer cells die within a short period, releasing their contents into the blood), heart disease, pulmonary impairment, bleeding disorders, low or high blood pressure, renal or hepatic impairment and infections (bacterial/fungal/protozoal/viral).
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