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compositionComposition:AMITRIPTYLINE-10MG
prescription
Prescription Medicine
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Medtrip-10 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, it is used to treat bedwetting in children aged 6 years and above. It contains Amitriptyline, which works by affecting certain chemical messengers (serotonin and norepinephrine) in the brain, which communicate between brain cells, thereby helping to regulate mood and prevent depression. Additionally, it reduces the transmission of pain signals, thereby providing relief from neuropathic pain. In some cases, you may experience certain common side effects such as sleepiness, drowsiness, headache, irregular heartbeat, dry mouth, constipation, nausea, weight gain, slurred or slow speech, and a congested nose. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMITRIPTYLINE-10MG

Manufacturer/Marketer :

Medsmile Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Medtrip-10 Tablet

Medtrip-10 Tablet is an oral prescription medication primarily used to treat depression and help elevate mood. Doctors also prescribe this medicine to help prevent migraine headaches and manage certain types of long-term nerve pain. It belongs to a class of medicines known as tricyclic antidepressants, which work by balancing natural chemicals in the brain.

For the best results, you should take Medtrip-10 Tablet consistently every day, exactly as prescribed by your doctor, even if you begin to feel better. You can take this medication with or without food, though taking it with food may help prevent an upset stomach. Combining this treatment with regular sleep patterns, gentle exercise, and stress-reduction techniques can significantly support your overall recovery.

Some people may experience mild side effects when starting Medtrip-10 Tablet , such as drowsiness, dry mouth, or mild constipation. While these issues often improve as your body adjusts, you must contact your healthcare provider immediately if you experience serious symptoms like a fast or irregular heartbeat, severe dizziness, or unusual changes in your mood.

Do not take this if you have recently had a heart attack or are currently taking certain medications for depression known as monoamine oxidase inhibitors (MAOIs). Talk to your doctor before starting Medtrip-10 Tablet if you have a history of heart disease, liver damage, glaucoma, seizures, or difficulty urinating.

Drinking alcohol while taking Medtrip-10 Tablet can cause extreme drowsiness and increase the risk of dangerous breathing difficulties, so it should be avoided. You should also talk to your doctor or pharmacist if you are pregnant, breastfeeding, or are an elderly individual, as you may be more sensitive to the effects of this medicine.

Uses of Medtrip-10 Tablet

Medtrip-10 Tablet is used to treat depression. The detailed uses of Medtrip-10 Tablet are as follows:

  • Depression: Medtrip-10 Tablet helps elevate mood, reduce anxiety, and improve daily energy levels by balancing chemical messengers in the brain.
  • Neuropathic pain: It relieves chronic nerve pain, such as burning or tingling sensations caused by nerve damage, by altering how your body processes pain signals.
  • Migraine prevention: Taken daily, it reduces the frequency and severity of migraine attacks, though it is not used to treat a migraine headache that has already started.
  • Fibromyalgia: It can help improve sleep quality and reduce widespread muscle pain and tenderness associated with this condition.
     

Key Benefits

Medtrip-10 Tablet helps manage multiple conditions by influencing certain chemical messengers in the brain. By improving mood, reducing nerve-related pain, and helping prevent migraine attacks, it supports overall well-being and enhances day-to-day functioning. This medicine offers several key benefits:

  • Supports Improved Mood and Emotional Well-Being: Medtrip-10 Tablet helps restore the balance of important brain chemicals involved in mood regulation. This can lead to gradual improvements in feelings of sadness, anxiety, and emotional distress, while also supporting better sleep quality, energy levels, and overall mental well-being.
  • Provides Relief from Nerve Pain: By reducing abnormal pain signals sent by damaged or irritated nerves, Medtrip-10 Tablet helps relieve persistent nerve-related pain. This can make everyday activities more comfortable, improve mobility, and support a better quality of life.
  • Helps Prevent Migraine Attacks: Medtrip-10 Tablet can help reduce the frequency and severity of migraine episodes when taken regularly as prescribed. By preventing migraine attacks before they occur, it helps minimise disruptions to daily activities and allows for a more active and productive lifestyle.
     
Side effects of Medtrip-10 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Maintain a gentle oral hygiene routine by brushing your teeth twice daily with a soft-bristled toothbrush and fluoride toothpaste, and flossing once a day to remove trapped food particles.
  • Modify your diet to limit sugary and acidic foods and beverages, and opt for soft, easy-to-chew foods to reduce discomfort and promote healing.
  • Manage pain and discomfort with over-the-counter medication, cold compresses, and warm salt water rinses as needed.
  • Adopt healthy lifestyle habits, including quitting smoking and tobacco use, staying hydrated, and stimulating saliva production with sugar-free gum to support overall health and well-being.
  • Avoid extreme temperatures and irritants, such as extremely hot or cold foods and drinks, to prevent further discomfort and promote a smooth recovery.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

Directions for Use

To get the full benefit of Medtrip-10 Tablet and minimise side effects, follow these simple guidelines:

  • Take Medtrip-10 Tablet oral tablets by mouth, typically once daily, often at bedtime to help manage drowsiness.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet, as this can affect how the medicine is released into your body.
  • You can take this medicine with or without food, but keeping your choice consistent each day is recommended.
  • Always follow your doctor's exact instructions regarding how and when to take Medtrip-10 Tablet , and do not stop taking it suddenly without consulting them first.

 

How Medtrip-10 Tablet Works

Medtrip-10 Tablet works by increasing the levels of certain natural chemical messengers in the brain, specifically serotonin and norepinephrine. These chemicals are responsible for regulating your mood and blocking pain signals sent along your nerves. By preventing the brain from reabsorbing these chemicals too quickly, Medtrip-10 Tablet prolongs their active presence. This helps stabilise your emotional state and reduces the transmission of chronic pain signals to the brain, providing comfort over time.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Medtrip-10 Tablet as it may cause an increased sedative effect.

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Pregnancy

Consult your doctor

Avoid taking Medtrip-10 Tablet if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Medtrip-10 Tablet ; your doctor will decide whether breastfeeding mothers can take Medtrip-10 Tablet or not.

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Driving

Unsafe

Medtrip-10 Tablet causes sleepiness, dizziness and drowsiness. Do not drive or operate machinery if you experience these symptoms.

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Liver

Consult your doctor

Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Medtrip-10 Tablet can be given to children above 6 years if prescribed by the doctor for treating bedwetting. Medtrip-10 Tablet should not be given to children for treating depression or neuropathic pain.

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Heart

Caution

Extreme caution should be exercised in cardiac patients while taking Medtrip-10 Tablet . The patient should be closely monitored for any changes.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Medtrip-10 Tablet to geriatric patients. Your doctor will prescribe Medtrip-10 Tablet if the benefits outweigh the risks.

What if I have taken an overdose of Medtrip-10 Tablet

Do not take more than the prescribed dose of Medtrip-10 Tablet as it may cause an overdose. The symptoms of overdose include irregular heartbeat, seizures (fits), confusion, coma, hallucinations, drowsiness, or fever. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Sip water frequently, chew sugar-free gum, or suck on hard sugar-free candies to relieve dry mouth caused by this medication.
  • Increase your daily intake of dietary fiber and drink plenty of water to help prevent or manage constipation, which is a common side effect.
  • Stand up slowly from sitting or lying positions to minimize the risk of dizziness or fainting due to sudden drops in blood pressure.
  • Protect your skin from the sun by wearing sunscreen and protective clothing, as Medtrip-10 Tablet can make your skin more sensitive to sunlight.
  • Avoid driving or operating machinery until you know how Medtrip-10 Tablet affects your alertness, especially during the first few weeks of treatment.

 

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How Soon It Starts Working

  • The time required for Medtrip-10 Tablet to start to work: Medtrip-10 Tablet ideally shows its action within 4 to 6 weeks after administration.
  • The time for which the effects of Medtrip-10 Tablet last: The effect of Medtrip-10 Tablet lasts for 5 days.

What if you forget to take Medtrip-10 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not take a double dose.

Storage

•Store Medtrip-10 Tablet oral tablets at room temperature, ideally between 20°C to 25°C (68°F to 77°F). • Keep the tablets in their original container, tightly closed, to protect them from direct light and moisture.

Drug Warnings

  • Never stop taking Medtrip-10 Tablet suddenly, as doing so can trigger withdrawal symptoms like nausea, headache, and general weakness; always consult your doctor for a plan to gradually reduce your dose.
  • It may take several weeks of consistent daily use before you notice the full benefits of this medicine on your mood or pain levels.
  • Closely monitor your mood and behaviour, especially when first starting this medication, and report any sudden feelings of sadness, anxiety, or suicidal thoughts to a healthcare professional immediately.
  • Inform any surgeon, dentist, or doctor treating you that you are taking Medtrip-10 Tablet before undergoing any medical procedures or tests, as it can interact with anaesthetics.

 

Drug-Drug Interactions

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Drug-Drug Interactions

  • Taking Medtrip-10 Tablet alongside monoamine oxidase inhibitors (MAOIs) can cause dangerously high blood pressure and severe brain chemistry imbalances; avoid using them within 14 days of each other.
  • Combining this medication with other drugs that cause drowsiness, such as sleep medicines, muscle relaxants, or opioid pain relievers, can lead to severe sleepiness and slow breathing.
  • Using Medtrip-10 Tablet with drugs that affect your heart rhythm, such as certain antiarrhythmics or antipsychotics, can increase the risk of serious irregular heartbeats.

Drug-Food Interactions

  • Avoiding alcohol is highly recommended, as it can dangerously intensify the drowsy and sedative effects of this medication.
  • Grapefruit juice may interfere with how your body processes Medtrip-10 Tablet , potentially increasing the level of the drug in your bloodstream and raising the risk of side effects.

Drug-Disease Interactions

  • Heart conditions: May worsen arrhythmias, prolong the QT interval, or cause complications in individuals with a history of recent heart attacks.
  • Glaucoma: May increase pressure inside the eye, which can worsen narrow-angle glaucoma.
  • Seizure disorders: Can lower the seizure threshold, making seizures more likely to occur in individuals with epilepsy.
  • Urinary retention: Can worsen difficulties with urination, particularly in men with an enlarged prostate gland.
     
MontelukastRifapentine
Severe
MontelukastMiconazole
Severe

Drug-Drug Interactions

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MontelukastRifapentine
Severe
How does the drug interact with Medtrip-10 Tablet:
Coadministration of Rifapentine with Medtrip-10 Tablet may reduce the blood levels and effects of Medtrip-10 Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Rifapentine with Medtrip-10 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. If you experience increased side effects such as headache, fever, sore throat, cough, abdominal pain, diarrhea, earaches, runny nose, or behavior and mood changes consult a doctor. Do not discontinue any medications without consulting a doctor.
MontelukastMiconazole
Severe
How does the drug interact with Medtrip-10 Tablet:
Coadministration of Miconazole with Medtrip-10 Tablet may increase the blood levels and effects of Medtrip-10 Tablet. This increases the risk or severity of side effects.

How to manage the interaction:
Although there is a possible interaction between miconazole and Medtrip-10 Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as fever, sore throat, cough, stomach pain, diarrhea, earache, runny nose, or uncommon, depression, confusion, difficulty concentrating, anxiety, hallucinations, irritability. memory impairment, restlessness, sleep walking, Consult a doctor immediately. Do not stop using medications without a doctor's advice.
MontelukastPhenytoin
Severe
How does the drug interact with Medtrip-10 Tablet:
Coadministration of Medtrip-10 Tablet and Phenytoin may reduce the blood levels and effects of Medtrip-10 Tablet. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Medtrip-10 Tablet and Phenytoin may interact with one another, but they can be taken together if your doctor has prescribed them. However, if you experience signs such as headache, fever, sore throat, cough, abdominal pain, diarrhoea, earache, runny nose, or behaviour and mood changes, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MontelukastRifabutin
Severe
How does the drug interact with Medtrip-10 Tablet:
Coadministration of Medtrip-10 Tablet and rifabutin can reduce the levels and effects of Rifabutin. This can lead to low treatment outcomes.

How to manage the interaction:
Taking Medtrip-10 Tablet and rifabutin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience increased side effects such as headache, fever, sore throat, cough, abdominal pain, diarrhea, earache, runny nose, or behavior and mood changes consult a doctor. Do not discontinue any medications without consulting a doctor.
MontelukastPrimidone
Severe
How does the drug interact with Medtrip-10 Tablet:
Coadministration of Medtrip-10 Tablet and primidone can reduce the levels and effects of Medtrip-10 Tablet.

How to manage the interaction:
Taking Medtrip-10 Tablet and Primidone together can possibly result in an interaction, it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Medtrip-10 Tablet is used to treat depression, neuropathic pain, chronic tension-type headaches, and migraine in adults. Additionally, it is also used to treat bedwetting in children aged 6 years and above at night.
Medtrip-10 Tablet works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treating depression.
Medtrip-10 Tablet prevents the transmission of pain signals, thereby providing relief from neuropathic pain.
Medtrip-10 Tablet causes sleepiness, drowsiness, and dizziness. Do not drive or operate machinery if you are experiencing these symptoms.
Medtrip-10 Tablet causes weight gain due to increased appetite. Eat a healthy diet and exercise regularly to maintain a healthy weight.
Medtrip-10 Tablet may cause decreased sex drive, problems with erection and orgasm. Consult your doctor if you have any concerns regarding this.
You might notice improvement within a few weeks. Still, it typically takes 4 to 6 weeks for the full effects of amitriptyline to be experienced. Avoid stopping the medication after 1 or 2 weeks, even if you don't feel immediate benefits. Allow at least 6 weeks for the medication to take full effect.
Medtrip-10 Tablet is used to treat bedwetting in children aged 6 years and older. It should be given to children only if prescribed by the doctor.
Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.
Medtrip-10 Tablet is one of many medications used to treat depression. Incorporating lifestyle changes can maximise its benefits and speed up recovery. Maintaining an active lifestyle and adhering to a healthy diet can significantly impact the rate of recovery from depression.
Always take Medtrip-10 Tablet exactly as prescribed. Do not exceed the recommended dose or stop treatment without consulting your doctor. Inform your doctor about your medical history and all medicines or supplements you are taking to avoid interactions and minimise side effects. Be aware of possible side effects and seek medical advice if you have concerns.
It's necessary to understand that suicidal thoughts can be a side effect of a few antidepressants, including amitriptyline, especially when starting the medicine. However, it is equally crucial to understand that depression can lead to suicidal thoughts. If you are considering self-harm, please seek treatment right now.
Yes, Medtrip-10 Tablet may cause difficulty peeing in certain cases. If it happens, try to relax when you pee. Do not try to force the flow of urine. If you still cannot go, try again later. Talk to your doctor urgently if you cannot pee at all.
Taking more than the recommended dosage does not provide additional pain relief and can increase the risk of adverse effects.
You may notice some improvement within 1 to 2 weeks of starting Medtrip-10 Tablet . However, the full benefits for depression, neuropathic pain, headaches, or migraine prevention may take 4 to 6 weeks of regular use. Do not stop taking the medicine if you do not feel better immediately. Continue taking it as prescribed and consult your doctor if your symptoms do not improve.
Medtrip-10 Tablet is occasionally used to help individuals sleep better. It can make you feel very sleepy, especially when you first start taking it. For the first few days of therapy, it is advised to avoid driving, cycling, and using machinery or tools until you understand how this medicine affects you.
You should avoid alcohol while taking Medtrip-10 Tablet , as it can significantly increase drowsiness, impair your coordination, and increase the risk of serious side effects like breathing difficulties. Talk to your doctor.
Yes, Medtrip-10 Tablet can cause an increase in appetite and weight gain in some individuals. Maintaining a balanced diet and exercising regularly can help manage this side effect. Talk to your doctor.
Medtrip-10 Tablet should only be used during pregnancy if your doctor determines that the benefits outweigh the potential risks. Use during late pregnancy may occasionally affect the newborn or cause temporary withdrawal symptoms after birth. Discuss the risks and benefits with your doctor before taking this medicine during pregnancy.
Because Medtrip-10 Tablet commonly causes drowsiness and sleepiness, taking your daily dose at night can help you sleep better and prevent you from feeling overly tired during daytime hours. Talk to your doctor.
Do not stop taking Medtrip-10 Tablet without consulting your doctor, even if you feel better. Stopping suddenly may cause withdrawal symptoms such as headache, nausea, irritability, or sleep disturbances, and your symptoms may return. Your doctor will advise you on how to reduce the dose gradually and safely.
Yes, dry mouth is a common side effect of Medtrip-10 Tablet . You can help manage it by drinking water regularly, chewing sugar-free gum, sucking on sugar-free candies or ice chips, limiting caffeine intake, avoiding smoking, and avoiding alcohol-containing mouthwashes. Consult your doctor if the symptom becomes troublesome.
Yes, Medtrip-10 Tablet can affect blood pressure and may cause orthostatic hypotension, a sudden drop in blood pressure when standing up. This can make you feel dizzy or lightheaded. Rise slowly from sitting or lying positions and consult your doctor if symptoms persist or worsen.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.10849 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A682388 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Amitriptyline Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Amitriptyline For Pain - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Amitriptyline Amitriptyline. 2014. [Accessed on 19 Mar. 2019]Check here
  6. Drugs and Lactation Database (LactMed) [Internet]. 2006. [Accessed on 19 Feb. 2020]Check here
  7. Amitriptyline Hydrochloride [Drug Label]. 2016. [Accessed on 25 Jul. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

new no. 11, old no. 20 tatabad 1st street sivananda colony opp to satya medical centre coimbatore, tamil nadu, 641012 india
Other Info - MED1037
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