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  3. Mefalgin 250mg Tablet

Mefalgin 250mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mefalgin 250mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, it is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods. It contains Mefenamic acid, which works by blocking the effect of chemical messengers that cause pain and inflammation. In some cases, you may experience certain common side effects such as abdominal pain, nausea, vomiting, diarrhoea, heartburn and indigestion. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

MEFENAMIC ACID-250MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Mefalgin 250mg Tablet

Mefalgin 250mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, Mefalgin 250mg Tablet is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods.

Mefalgin 250mg Tablet contains 'mefenamic acid', which works by blocking the effect of chemical messengers that cause pain and inflammation. Thereby relieving pain and inflammation.

In some cases, you may experience certain common side effects such as abdominal pain, nausea, vomiting, diarrhoea, heartburn and indigestion. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Consult your doctor if you are pregnant or breastfeeding. Mefalgin 250mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol with Mefalgin 250mg Tablet as it could lead to increased drowsiness and dizziness; it might also increase the risk of stomach bleeding. Keep your doctor informed about your health condition and any medications you are taking to help rule out any potential side effects.

Uses of Mefalgin 250mg Tablet

Mefalgin 250mg Tablet is used to relieve pain and inflammation in various conditions. The detailed uses of Mefalgin 250mg Tablet are as follows: <br/>• Treatment of menstrual pain (dysmenorrhea): Provides effective relief from lower abdominal cramps and discomfort during menstruation.<br/>• Management of mild to moderate pain: Used to treat headaches, joint pain, and muscular aches.<br/>• Relief from arthritis-related pain: Mefalgin 250mg Tablet helps manage pain and inflammation in conditions like osteoarthritis and rheumatoid arthritis.<br/>• Fever reduction: Reduces body temperature in mild to moderate fevers.<br/>• Post-operative pain management: Reduces pain and inflammation after surgical operations or childbirth.<br/>• Support in inflammatory conditions: Reduces swelling, redness, and discomfort in various musculoskeletal disorders.<br/>

Directions for Use

  • Mefalgin 250mg Tablet can be taken with food or as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Tablet/capsule: Swallow it as a whole with a glass of water.
  • Dispersible tablet: Dissolve the tablet in a glass of water and consume it immediately.
  • Do not break, chew, or crush it.

Medicinal Benefits

Mefalgin 250mg Tablet belongs to a group of medicines called NSAIDs (Non-Steroidal Anti-Inflammatory Drugs) used to provide relief from mild to moderate pain and inflammation associated with musculoskeletal, rheumatic, arthritic disorders, headaches, trauma, dental pain, and pain after surgery or childbirth. Additionally, Mefalgin 250mg Tablet is used to relieve period pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Mefalgin 250mg Tablet works by blocking the effect of a chemical messenger in your body, known as cyclo-oxygenase (COX) enzymes, which make another chemical, prostaglandins. These prostaglandins are produced at injury sites and cause pain and swelling. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which reduces mild to moderate pain and inflammation at the injured or damaged site.

How Mefalgin 250mg Tablet Works

Mefalgin 250mg Tablet contains 'mefenamic acid', which works by blocking the effect of chemical messengers that cause pain and inflammation. Thereby relieving pain and inflammation.

Storage

Keep Mefalgin 250mg Tablet out of reach and sight of children.
Side effects of Mefalgin 250mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Mefalgin 250mg Tablet

Do not take more than the prescribed dose of Mefalgin 250mg Tablet as it may cause an overdose. The symptoms of overdose include nausea, vomiting, extreme tiredness, stomach pain, vomit that is bloody or looks like coffee grounds, black/tarry/bloody stools, slowed breathing or coma. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Mefalgin 250mg Tablet if you are allergic to any of its components, if you have severe heart, kidney or liver failure, have suffered bleeding problems such as bleeding from the stomach or bowels while taking any pain killers or have peptic ulcers or inflammatory bowel disease. Inform your doctor if you have high blood pressure, heart problems, high cholesterol, dehydration, asthma, liver and kidney problems. Consult your doctor if you are pregnant or breastfeeding. Mefalgin 250mg Tablet may cause drowsiness and dizziness, so drive only if you are alert. Stop taking Mefalgin 250mg Tablet and consult your doctor immediately if you experience stomach pain or any signs of intestinal or stomach bleeding, such as blood in your stools.

Drug-Drug Interactions

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Mefenamic acidMeloxicam
Critical
Mefenamic acidKetorolac
Critical

Drug-Drug Interactions

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Mefenamic acidMeloxicam
Critical
How does the drug interact with Mefalgin 250mg Tablet:
Co-administration of Mefalgin 250mg Tablet with Meloxicam together can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Meloxicam together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking a doctor.
Mefenamic acidKetorolac
Critical
How does the drug interact with Mefalgin 250mg Tablet:
Coadministration of Mefalgin 250mg Tablet with Ketorolac can increase the risk or severity of gastric bleeding and ulcers.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Ketorolac together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidCabozantinib
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Using cabozantinib together with Mefalgin 250mg Tablet may increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Mefalgin 250mg Tablet and Cabozantinib, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms like blood clotting problems, excessive bleeding, or severe headaches, it's best to contact a doctor right away. They can help address any complications and provide the necessary support. Do not stop using any medications without talking to a doctor.
Mefenamic acidApixaban
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Mefalgin 250mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Mefalgin 250mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without first consulting your doctor, never stop taking any medications.
Mefenamic acidBaricitinib
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Using Mefalgin 250mg Tablet and baricitinib together may increase the risk of gastrointestinal perforation (a serious health condition where a hole develops through the stomach or intestine).

How to manage the interaction:
Co-administration of Mefalgin 250mg Tablet with Baricitinib can result in an interaction, but it can be taken if your doctor has advised it. If you notice any signs like severe stomach pain, fever, or vomiting, consult a doctor. Do not stop using any medications without talking to a doctor.
Mefenamic acidNaproxen
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Coadministration of Mefalgin 250mg Tablet with Naproxen can increase the risk or severity of stomach bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Naproxen together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidDanaparoid
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Using danaparoid together with Mefalgin 250mg Tablet can increase the risk of bleeding complications.

How to manage the interaction:
There may be a possibility of interaction between Mefalgin 250mg Tablet and Danaparoid, but it can be taken if prescribed by a doctor. If you notice any of these signs - bruising, swelling, vomiting, headache, dizziness, weakness, bleeding, or blood in your urine or stools, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
Mefenamic acidDeferasirox
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Coadministration of Mefalgin 250mg Tablet with Deferasirox can increase the risk or severity of gastric bleeding.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Deferasirox together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of increased or decreased urination, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidRivaroxaban
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Coadministration of Mefalgin 250mg Tablet with Rivaroxaban can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Rivaroxaban together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Mefenamic acidDasatinib
Severe
How does the drug interact with Mefalgin 250mg Tablet:
Co-administration of Mefalgin 250mg Tablet with Dasatinib can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Mefalgin 250mg Tablet with Dasatinib together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness, lightheadedness, red or black tarry stools, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MEFENAMIC ACID-250MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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MEFENAMIC ACID-250MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking Mefalgin 250mg Tablet with caffeine-containing foods or drinks can show an interaction. Taking Mefalgin 250mg Tablet with caffeine-containing foods or drinks can reduce the effectiveness of Mefalgin 250mg Tablet. Avoid or limit your caffeine consumption while taking Mefalgin 250mg Tablet dose. Do not stop using any medications without talking to a doctor.

Diet & Lifestyle Advise

  • Mild exercises such as jogging and walking are helpful for muscle stretching.
  • Massages can also be helpful.
  • Avoid freezing and hot temperatures.
  • Avoid wearing tight-fitting clothes, instead, wear loose garments.
  • Rest well, get plenty of sleep.
  • To avoid developing pressure sores, change your position at least every two hours.
  • Hot or cold therapy can help treat pain. Apply an ice pack or hot pack on the muscle for 15-20 minutes.
  • Stay hydrated by drinking plenty of water.

Habit Forming

No

Therapeutic Class

ANALGESICS

Mefalgin 250mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Mefalgin 250mg Tablet as it may increase drowsiness. It can also increase the risk of stomach bleeding.

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Pregnancy

Caution

Mefalgin 250mg Tablet belongs to pregnancy category C. Please consult your doctor if you are pregnant or planning to become pregnant. Your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Mefalgin 250mg Tablet may pass into breastmilk. Consult your doctor if you are breastfeeding.

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Driving

Caution

Mefalgin 250mg Tablet may cause dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Please consult your doctor. Your doctor will recommend it based on your child's condition.

Have a query?

FAQs

Mefalgin 250mg Tablet is used to provide relief from mild to moderate pain and inflammation associated with muscular, rheumatic, and arthritic disorders, headache, trauma, dental pain, and pain after surgery or childbirth. Additionally, it is used to relieve period pain and premenstrual syndrome symptoms (PMS) and manage excessively heavy periods.

Mefalgin 250mg Tablet works by blocking the chemical messengers that are responsible for pain and inflammation. Thereby, Mefalgin 250mg Tablet provides relief from pain and inflammation.

Mefalgin 250mg Tablet is generally prescribed for short-term use. Do not take Mefalgin 250mg Tablet for longer durations as it might increase the risk of heart problems and stomach bleeding.

Mefalgin 250mg Tablet is used to relieve menstrual (period) pain, symptoms of premenstrual syndrome (PMS), and management of excessively heavy periods. Take only as prescribed by the doctor.

Avoid taking Mefalgin 250mg Tablet if you have stomach ulcers. Mefalgin 250mg Tablet might increase the risk of stomach ulcers, perforation of the stomach and intestinal bleeding with higher doses.

Diarrhoea might be a side-effect of Mefalgin 250mg Tablet. Drink plenty of fluids and eat food rich in fibre. Consult your doctor if you experience excessive diarrhoea or if you find blood in stools.

It is considered harmful for patients with severe kidney problems and those experiencing active intravascular clotting, which obstructs blood flow due to blood clots.

Store Mefalgin 250mg Tablet at room temperature, away from sunlight. Keep the Mefalgin 250mg Tablet out of reach of children.

No, Mefalgin 250mg Tablet doesn’t act as a contraceptive; it is used to relieve mild to moderate pain and inflammation.

Mefalgin 250mg Tablet should be taken only as it is prescribed by the doctor. Do not self-medicate and do not recommend Mefalgin 250mg Tablet to others with the same condition.

Mefalgin 250mg Tablet is not recommended during pregnancy unless advised by the doctor. Therefore, if you are pregnant or planning to become pregnant, please consult a doctor.

If the dose of Mefalgin 250mg Tablet is missed, take the missed dose as soon as you remember. If it is time for the next dose, skip the missed dose and continue taking the regular dose. Avoid taking a double dose to make up for the missed one.

Mefalgin 250mg Tablet is used for a short time, not more than 3-5 days of your menstrual cycle. However, the duration for your use will be advised by the doctor. Do not self-medicate.

Country of origin

India
Other Info - ME91471

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:41 AM IST

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Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/eec4b0f8-a82a-4ba9-8e04-d411ee4d7b95.pdf
  2. https://meftal.com/assets/MEFTAL-250-DT.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/015034s040lbl.pdf
  4. https://medlineplus.gov/druginfo/meds/a681028.html
  5. https://www.drugs.com/mtm/mefenamic-acid.html
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