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Mefril P Syrup is used to treat fever and mild to moderate pain in children. The medicine provides effective pain relief and helps improve comfort in conditions involving inflammation and fever.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Micro Labs Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mefril P Syrup

Mefril P Syrup is a paediatric medicine that combines paracetamol and mefenamic acid (a non-steroidal anti-inflammatory drug or NSAID). It is used to relieve mild to moderate pain and reduce fever in children. Seeing your child unwell can be worrying, but giving Mefril P Syrup exactly as prescribed and ensuring your child gets enough rest and fluids can help support their recovery. Mefril P Syrup should only be given to children of the age recommended by your doctor or according to the approved product information and is generally not recommended for infants below 6 months of age unless specifically prescribed.

Give Mefril P Syrup to your child exactly as directed by your doctor or according to the product label. Giving each dose at the recommended time helps provide consistent pain and fever relief. Always give this oral liquid with food or milk to reduce the chance of stomach irritation. Encourage your child to drink plenty of fluids and get adequate rest while recovering.

Most children tolerate Mefril P Syrup well, although some may develop mild side effects such as nausea, vomiting, diarrhoea, drowsiness, or stomach discomfort. These effects usually improve as Mefril P Syrup leaves your child's system over the next few hours. Seek immediate medical attention if your child develops severe stomach pain, vomits blood, has black stools, develops a severe skin rash, swelling of the face or throat, difficulty breathing, or yellowing of the eyes or skin.

Before giving Mefril P Syrup, tell your doctor if your child has liver disease, kidney disease, asthma, stomach ulcers, bleeding disorders, G6PD deficiency (a genetic condition that affects red blood cells), or has ever had an allergic reaction to paracetamol, mefenamic acid, aspirin, or other NSAIDs. Do not give Mefril P Syrup to children with active stomach bleeding, severe liver or kidney disease, or a known allergy to any of its ingredients. It is generally not recommended for infants below 6 months of age unless specifically prescribed.

Some medicines may interact with Mefril P Syrup and increase the risk of side effects or reduce how well it works. Inform your doctor about all prescription medicines, over-the-counter medicines, herbal products, vitamins, and supplements your child is taking before starting treatment. If you are unsure whether another medicine contains paracetamol or another pain reliever, ask your doctor or pharmacist before giving it to your child.

Uses of Mefril P Syrup

Mefril P Syrup is used in the treatment of pain and fever in children. The detailed uses of Mefril P Syrup are as follows:

  • Fever reduction: Mefril P Syrup helps lower high body temperature quickly, bringing comfort to a child suffering from a fever due to infections or post-vaccination reactions.
  • Mild to moderate pain: It provides effective relief from common childhood pains, including headaches, earaches, toothaches, teething pain, and sore throats.
  • Pain associated with inflammation: It helps relieve pain and inflammation when prescribed by a doctor for appropriate childhood conditions. Mefril P Syrup should not be used for sprains, strains, or joint pain without medical advice. 

Key Benefits

Mefril P Syrup helps relieve pain, reduce fever, and improve comfort in children during common illnesses. By combining two pain-relieving medicines with complementary actions, it provides effective symptom relief when used as directed by a healthcare professional.

Benefits may include:

  •  Helps reduce fever and improve your child's comfort.
  • Relieves mild to moderate pain associated with common childhood illnesses.
  • Helps reduce pain and inflammation when prescribed by a doctor.
  • Supports comfortable eating, sleeping, and daily activities during recovery.
  • Provides effective symptom relief in an easy-to-administer paediatric liquid formulation.
  • Improves your child's overall comfort and well-being when used as prescribed.

Directions for Use

  • Mefril P Syrup can be given to your child with food to prevent stomach upset.
  • Typically, it is given 2-3 times a day. However, follow the doctor's instructions regarding the required dosage and timing of this medication for optimal effectiveness.
  • Shake the bottle well before each use.
  • Give your child the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided with the pack.
  • Avoid using regular household spoons, as they may not measure the dose correctly.

How Mefril P Syrup Works

Mefril P Syrup contains Mefenamic Acid and Paracetamol. Mefenamic Acid: It is a non-steroidal anti-inflammatory drug (NSAID) that helps relieve pain and reduce inflammation by blocking the production of prostaglandins, the natural chemicals responsible for pain, swelling, and soreness. This helps reduce discomfort associated with conditions such as fever, toothache, earache, or musculoskeletal pain. Paracetamol: It is a pain reliever and fever-reducing medicine that works mainly in the brain to reduce the perception of pain and lower body temperature. This helps relieve pain and brings down fever, making your child feel more comfortable.
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Alcohol

Not applicable

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Pregnancy

Not applicable

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Breast Feeding

Not applicable

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Driving

Not applicable

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Liver

Consult your doctor

Please consult your doctor if your child has a liver impairment or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if your child has a kidney impairment or if you have any concerns regarding this.

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Children

Safe if prescribed

Mefril P Syrup is safe for children over 6 months of age when prescribed by a doctor. Your paediatrician will decide the dose of the medicine. Do not give your child more than the recommended dose.

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Heart

Caution

If your child has a heart condition, Mefril P Syrup should only be given under a doctor’s supervision.

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Geriatrics

Not applicable

Mefril P Syrup is specifically for children's use and is not meant for geriatric patients.

What if I have taken an overdose of Mefril P Syrup

If you suspect your child has taken more than the prescribed amount of Mefril P Syrup, seek immediate medical emergency care or contact a poison control center right away. Even if your child shows no immediate symptoms, prompt medical evaluation is critical to prevent serious liver damage or other complications.

Diet & Lifestyle Advise

  • Keep your child well hydrated: Encourage your child to drink plenty of water, oral rehydration solution (if recommended), clear soups, or other age-appropriate fluids to help prevent dehydration during a fever.
  • Offer nutritious, easy-to-digest meals: Give your child small, frequent meals if they have a mild stomach upset to help them eat comfortably.
  • Dress your child comfortably: Dress your child in light, comfortable clothing and keep the room at a comfortable temperature. Avoid overdressing, as it may make them feel hotter.
  • Use a lukewarm sponge bath: Give your child a lukewarm sponge bath only if recommended by your doctor. Do not use cold water, ice baths, or rubbing alcohol to reduce fever.
  • Encourage adequate rest: Ensure your child gets plenty of rest and avoids strenuous physical activities until they have fully recovered.
  • Avoid foods that may upset the stomach: If your child has stomach discomfort while taking Mefril P Syrup, avoid giving acidic or spicy foods until they feel better.
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How Soon It Starts Working

  • The time required for Mefril P Syrup to start to work: Mefril P Syrup ideally shows its action within 30 to 60 minutes after administration.
  • The time for which the effects of Mefril P Syrup last: The effect of Mefril P Syrup lasts for 12 hours.

What if you forget to take Mefril P Syrup

If you forget to give a dose, give it as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with the regular dosing schedule. Do not give two doses at the same time or an extra dose to make up for a missed dose.

Storage

• Store this paediatric liquid at room temperature, ideally between 15°C and 30°C. • Do not freeze Mefril P Syrup, as freezing can alter the formulation and make it unsafe or ineffective.

Drug Warnings

  • Shake the bottle before use: Shake the bottle well before every dose to ensure Mefril P Syrup is evenly mixed.
  • Measure the dose accurately: Always use the supplied oral syringe, dropper, or measuring cup to measure each dose. Never use a household spoon, as it may result in incorrect dosing.
  • Give with food or milk: Administer Mefril P Syrup with food or milk to help reduce the risk of stomach irritation.
  • Keep a dosing record: If more than one caregiver is looking after your child, record the time of each dose to help prevent accidental double dosing.
  • Avoid duplicate paracetamol-containing medicines: Check the labels of cough, cold, and fever medicines carefully before giving them, as many products already contain paracetamol. Giving them together may increase the risk of an accidental overdose.
  • Consult your doctor if: Your child's fever lasts for more than 3 days, pain persists for more than 5 days, or if your child develops repeated vomiting, worsening pain, poor fluid intake, or signs of dehydration. These symptoms may require further medical evaluation.
  • Seek immediate medical attention if: Your child develops difficulty breathing, a severe allergic reaction, black stools, vomiting blood, yellowing of the skin or eyes, seizures, becomes unusually sleepy, or is difficult to wake.

Drug-Drug Interactions

verifiedApollotooltip
  • Other paracetamol-containing medicines: Taking these medicines alongside Mefril P Syrup may increase the risk of accidental overdose and serious liver damage.
  • Other NSAIDs (e.g., ibuprofen, naproxen, aspirin): Using these medicines with Mefril P Syrup may increase the risk of stomach irritation, ulcers, or gastrointestinal bleeding.
  • Blood thinners (e.g., warfarin): Taking these medicines alongside Mefril P Syrup may increase the risk of bleeding.
  • Immunosuppressants (e.g., methotrexate): Mefril P Syrup may increase methotrexate levels and raise the risk of side effects. Your child's doctor may monitor treatment more closely.
  • Blood pressure medicines and diuretics (e.g., enalapril, furosemide): The mefenamic acid component may reduce the effectiveness of these medicines and increase the risk of kidney problems, especially in dehydrated children.

Drug-Drug Interactions

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How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of Mefril P Syrup 60 ml with Ketorolac can increase the risk or severity of bleeding and ulcers.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and ketorolac, it can be taken if a doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Co-administration of Mefril P Syrup 60 ml with prasugrel can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and prasugrel, it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of Mefril P Syrup 60 ml with piroxicam can increase the risk of side effects such as inflammation(swelling with redness and pain), bleeding, and ulceration.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and piroxicam, it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of cidofovir with Mefril P Syrup 60 ml can increase the risk of kidney problems.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and cidofovir, it can be taken if your doctor has suggested it. However, if you experience nausea, vomiting, less desire to eat, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, weakness, or dizziness, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of Mefril P Syrup 60 ml with lomitapide can cause liver problems.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and lomitapide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, nausea, vomiting, abdominal pain, or, fainting, Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Taking danaparoid with Mefril P Syrup 60 ml can increase the risk of bleeding complications.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and danaparoid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Co-administration of teriflunomide with Mefril P Syrup 60 ml may increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml with teriflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, fatigue, nausea, vomiting, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of Mefril P Syrup 60 ml with dabigatran can increase the risk or severity of bleeding.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and dabigatran etexilate, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Taking edoxaban together with Mefril P Syrup 60 ml may increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Mefril P Syrup 60 ml and edoxaban, it can be taken if your doctor has suggested it. If you experience dizziness, black or tarry stools, severe headache, weakness, or vomiting, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mefril P Syrup 60 ml:
Coadministration of mefenamic acid with celecoxib can increase the risk or severity of bleeding and ulcers of the stomach.

How to manage the interaction:
Although there is an interaction between mefenamic acid and celecoxib, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, loose stools, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Food or milk: Give Mefril P Syrup with food or milk to help reduce stomach irritation. This may slightly delay the onset of action but does not reduce its effectiveness.
  • Adequate fluids: Encourage your child to drink plenty of fluids during treatment, especially if they have fever, vomiting, or diarrhoea, to help reduce the risk of kidney problems.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANALGESIC AND ANTIPYRETIC AGENT]

FAQs

Mefril P Syrup is used to treat Pain and Fever.
Mefenamic acid (NSAID) and Paracetamol (antipyretic). Mefenamic acid works by blocking the effect of a chemical known as prostaglandin, which is responsible for inducing pain and inflammation in our body. Paracetamol lowers elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating).
The side effects of Mefril P Syrup include nausea, indigestion, stomach pain and diarrhoea. If these side effects persist or worsen, please consult your doctor.
Yes, Mefril P Syrup is safe to use in the prescribed dose and duration. The patient should follow the doctor’s recommendations.
Mefril P Syrup is generally used for short term and can be stopped when the pain is relieved. However, it should be continued for as long as it is advised by your doctor.
Mefril P Syrup is contraindicated in patients with known allergy to painkillers (NSAIDS) or any of the components or excipients of this medicine. Also, let the doctor know if the patient has kidney or liver disease.
You are recommended to consult your doctor before giving Mefril P Syrup to your child with vitamin B-complex or other supplements.
Yes, the long-term use of Mefril P Syrup can cause damage to the kidneys. Normal kidneys produce prostaglandins, a chemical that protects them from damage. Long-term use of painkillers lowers the prostaglandin levels in the body, leading to kidney damage. Therefore, painkillers are not recommended for patients with underlying kidney disease.
No, taking higher than the recommended dose of Mefril P Syrup may increase the risk of side effects such as nausea, vomiting, indigestion, heartburn, diarrhoea and can also harm the kidneys when used for an extended period of time. If your child's pain is not relieved by the recommended doses or if your child experiences increased severity of pain, please consult your doctor.
Store Mefril P Syrup below 25°C. Protect from light. Keep it out of reach and sight of children.
It is best to give Mefril P Syrup with food or milk, as it helps reduce the chance of stomach irritation. If your child refuses to eat or is unable to keep food down, speak to your doctor or pharmacist for advice before giving the next dose.
If your child vomits shortly after taking a dose, do not automatically give another dose. Contact your doctor or pharmacist for advice, as the need to repeat the dose depends on how long after taking Mefril P Syrup your child vomited. Seek medical advice if vomiting continues or your child cannot keep fluids down.
Check the ingredient list carefully before giving any cough, cold, or fever medicine. Many of these products already contain paracetamol, and using them together may lead to an accidental overdose. If you are unsure, ask your doctor or pharmacist before combining medicines.
The safe period after opening depends on the specific product and manufacturer. Always check the package insert or bottle label for the recommended shelf life after opening. If this information is unclear, ask your pharmacist before continuing to use Mefril P Syrup.
It is generally not recommended to give fever-reducing medicines before vaccination unless your doctor advises it. If your child develops fever or pain after vaccination, use Mefril P Syrup only as directed by your healthcare provider.
Some children with asthma may be sensitive to NSAIDs such as mefenamic acid, which can occasionally worsen breathing symptoms. Tell your doctor if your child has asthma before starting Mefril P Syrup so they can decide whether it is appropriate.
If your child's fever lasts for more than 3 days, pain lasts for more than 5 days, or symptoms become worse or are accompanied by difficulty breathing, repeated vomiting, severe drowsiness, dehydration, seizures, or a persistent high fever, seek medical evaluation promptly. These symptoms may indicate an underlying illness that requires further assessment and treatment.
Do not give Mefril P Syrup with other medicines containing paracetamol or another NSAID (such as ibuprofen or naproxen) unless your doctor specifically advises it. Using similar medicines together increases the risk of side effects, including liver damage, stomach irritation, or bleeding.

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Country of origin

India

Manufacturer/Marketer address

No. 28 Sundar Industrial Estate,N.T.Y Layout Mysore Road , Bangalore - 560026, India
Other Info - MEF0142
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