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More about the Product

Composition :

AMOXYCILLIN-250MG+CLAVULANIC ACID-125MG

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Megamox CV 375 mg Tablet

Megamox CV 375 mg Tablet is an antibiotic medicine used to treat bacterial infections in children. It is used to treat infections of the skin, throat, ear, and lungs caused by bacteria.

Megamox CV 375 mg Tablet contains Amoxycillin and Clavulanic acid. Amoxycillin kills infection-causing bacteria by inhibiting the formation of the bacterial cell wall. Clavulanic acid inhibits the beta-lactamase enzyme, which prevents bacteria from destroying the efficacy of amoxycillin.

Megamox CV 375 mg Tablet may cause side effects such as indigestion, diarrhoea, nausea, and stomach pain. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your paediatrician.

Avoid giving Megamox CV 375 mg Tablet to your child if she/he is allergic to antibiotics. Keep your doctor informed about your child’s health condition, including his current medications and medical history, to rule out any side effects/interactions.

Uses of Megamox CV 375 mg Tablet

Megamox CV 375 mg Tablet is indicated in the treatment of bacterial infections. The detailed uses of Megamox CV 375 mg Tablet are as follows:

  • Treatment of bacterial infections: Megamox CV 375 mg Tablet is used to treat bacterial infections in children.
  • Respiratory infections: Megamox CV 375 mg Tablet is effective against pneumonia, bronchitis, and sinus infections.
  • Ear infections: Megamox CV 375 mg Tablet is used for acute otitis media (middle ear infection).
  • Throat infections: Megamox CV 375 mg Tablet treats strep throat and tonsillitis.
  • Skin and soft tissue infections: Megamox CV 375 mg Tablet helps manage bacterial skin conditions.
  • Urinary tract infections (UTIs): Megamox CV 375 mg Tablet is used for bacterial UTIs in children.

Key Benefits

  • Megamox CV 375 mg Tablet is used in children to treat respiratory tract infections, ear infections, urinary tract infections, skin infections, and dental infections.
  • It is effective against a wide range of bacterial infections, including both aerobic (oxygen-dependent) and anaerobic (non-oxygen-dependent) bacteria.
  • Amoxicillin weakens and damages the bacterial cell wall, leading to bacterial death and stopping the spread of infection.
  • Clavulanic acid blocks the beta-lactamase enzyme produced by certain bacteria, ensuring amoxicillin remains effective.
  • It helps in quicker resolution of symptoms by effectively targeting and eliminating infection-causing bacteria.
Side effects of Megamox Cv 375mg Tablet
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
Managing Medication-Triggered Moniliasis (a yeast infection): A Step-by-Step Guide:
  • If you experience symptoms like itching, burning, redness, or discharge after taking medication, consult your doctor immediately and share your symptoms, medication regimen, and medical history.
  • Your doctor will assess your medication regimen to determine if it's contributing to the moniliasis and identify the best course of action to manage your condition.
  • Your doctor may prescribe antifungal medications or recommend other treatments to help clear up the infection. They may also suggest self-care measures to help manage symptoms and prevent future infections.
  • If your condition doesn't improve or persists, consult your doctor and report it. Your doctor will assess your progress, adjust your treatment plan, and provide advice to ensure the best outcome.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Eat fiber-rich foods like broccoli, cauliflower, leafy greens, and Brussels sprouts.
  • Limit sugar and refined carbs like avoid sugary drinks, white bread, and processed foods.
  • Choose lean protein sources like chicken, fish, and tofu.
  • Choose low-sugar fruits like berries, citrus fruits, and apples in moderation.
  • Maintain good hygiene and keep affected areas clean and dry.
  • Wear breathable clothing to reduce moisture.
  • Consider natural antifungal agents like coconut oil, tea tree oil, and garlic (consult a healthcare professional before use).

Directions for Use

  • Megamox CV 375 mg Tablet can be given to your child with or without food. However, giving it with food may help reduce stomach upset.
  • Follow your doctor's instructions regarding the dosage and duration.
  • Dissolve Megamox CV 375 mg Tablet in the prescribed amount of water and have your child consume it immediately.
  • Do not crush, chew, or let your child swallow the medicine whole.
  • Do not handle Megamox CV 375 mg Tablet with wet hands.

How Megamox CV 375 mg Tablet Works

Megamox CV 375 mg Tablet contains Amoxycillin and Clavulanic acid. Amoxycillin works by inhibiting the formation of the bacterial cell wall (a protective covering) and causing damage to the bacterial cell wall. This eventually leads to the death of the bacterial cell and thus prevents the growth of bacterial infections. Clavulanic acid inhibits the beta-lactamase enzyme, which prevents bacteria from destroying the efficacy of amoxycillin. Together, Megamox CV 375 mg Tablet helps treat bacterial infections.
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Alcohol

Not applicable

-

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Pregnancy

Not applicable

-

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Breast Feeding

Not applicable

-

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Driving

Not applicable

-

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Liver

Consult your doctor

Please consult your doctor if your child has a liver impairment or if you have any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if your child has kidney impairment or if you have any concerns regarding this.

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Children

Safe if prescribed

Megamox CV 375 mg Tablet is safe for children if prescribed by the doctor. Your paediatrician will decide the dose of the medicine. Do not give your child more than the recommended dose.

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Heart

Caution

Avoid giving Megamox CV 375 mg Tablet to a child with heart problems without a doctor’s approval. Though generally safe, underlying cardiac conditions may require adjusted dosing or alternative antibiotics.

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Geriatrics

Not applicable

Megamox CV 375 mg Tablet is specifically for children use and is not meant for geriatric patients.

What if I have taken an overdose of Megamox CV 375 mg Tablet

An overdose of Megamox CV 375 mg Tablet may cause unpleasant side effects. Consult your doctor if you suspect an overdose.

Diet & Lifestyle Advise

  • Increase your child's intake of foods high in fibre. Your gut bacteria can readily break down fibre, which promotes growth.
  • Foods high in fibre may aid in the restoration of good gut flora following an antibiotic course.
  • Avoid foods high in iron or excessive calcium, as these may interfere with Megamox CV 375 mg Tablet 's functionality.
  • Encourage your kid to consume more liquids to prevent dehydration.

Health Queries

What should I do if the amoxylin and paracetamol my dentist recommended are not working after three days of treatment?

Vikas Singh

Vikas Singh

M Pharmacy

It can be frustrating when treatment doesn't bring quick relief, but please don't worry. If your amoxicillin and paracetamol haven't improved your symptoms after three days, it is important to contact your dentist right away. The infection might require a different antibiotic, or there may be a localized issue, like a dental abscess, that needs physical treatment to heal. Your dentist might also suggest a different pain reliever. Please continue taking your amoxicillin as prescribed until you speak with them, and do not increase your paracetamol dose. A quick follow-up will help get you comfortable and on track safely!

I was prescribed augmentin for 5 days, 3 times in a day. But because of my irregular meals and times cuz of exams, I only had it twice for 4 days, and last day I had it for 3 times. Do I continue rest of the medications now? Or let it be?

Bayyarapu Mahesh Kumar

Bayyarapu Mahesh Kumar

M Pharmacy

Since your Augmentin course was not taken exactly as prescribed, it’s best not to continue or extend the remaining tablets on your own. Antibiotics should be taken at the prescribed intervals, and missed doses should not be replaced by taking extra doses. The decision on whether you should repeat, adjust, or stop the course depends on the infection being treated and how you are currently responding. Please contact your doctor in person, explain how you took the medicine, and ask for guidance. If your symptoms are persisting or worsening, seek medical review promptly.

Is it safe to take Augmentin while breastfeeding?

Vikas Singh

Vikas Singh

M Pharmacy

Augmentin (amoxicillin/clavulanic acid) is generally considered safe to take while breastfeeding. Only tiny amounts of the medication pass into breast milk, and it is actually an antibiotic frequently prescribed directly to infants. While you are taking it, simply monitor your baby for any mild, temporary changes like loose stools or diaper rash. Please rest assured that you can safely complete your treatment while continuing to nurse your baby.

What should I do if my fever and sore throat are not improving after taking Augmentin 375 and paracetamol, and I am now experiencing back pain, chest pressure, and coughing when I try to get up?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Since your fever and sore throat are not improving with Augmentin and paracetamol, and you are now experiencing chest pressure, coughing, and back pain, it is very important to be evaluated by a healthcare professional right away. Please visit an urgent care or emergency room today so a doctor can listen to your lungs and check your heart. This helps ensure you receive the correct treatment. Please rest, stay hydrated, and seek care promptly.

I completed a four-day course of Augmentin Duo 625, Pan 40, and Montek LC for throat pain, but the pain has returned two days after stopping the medication. What treatment or prescription is recommended now?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

It is common for throat pain to return if the underlying infection was not fully cleared, as a four-day course of amoxicillin-clavulanate is often shorter than the standard duration required for bacterial throat infections. It could also indicate a viral infection. Please do not restart any antibiotics, pantoprazole, or montelukast-levocetirizine without a doctor's guidance. I highly recommend consulting your healthcare provider for a throat examination to determine the exact cause and get the correct prescription. For temporary relief, you can gargle with warm salt water, drink warm fluids, and rest. This is a very common issue and easily manageable with the right evaluation.
health query

Have a query?

How Soon It Starts Working

The time required for Megamox CV 375 mg Tablet to start to work: Megamox CV 375 mg Tablet ideally shows its action within 1 to 2 hours after administration.

The time for which the effects of Megamox CV 375 mg Tablet last: The effect of Megamox CV 375 mg Tablet lasts for 6 to 8 hours.

What if you forget to take Megamox CV 375 mg Tablet

If you forgot to give a dose of Megamox CV 375 mg Tablet to your child, give it as soon as you remember. If it is almost time for the next dose, skip the missed dose and follow the regular schedule. Do not give a double dose to make up for the missed one.

Storage

• Store in a cool and dry place away from sunlight.• Keep Megamox CV 375 mg Tablet out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Avoid giving Megamox CV 375 mg Tablet to your child if she/he is allergic to any of its components.
  • Inform your doctor if your child has liver or kidney-related issues before administration.
  • Keep your paediatrician informed about your child’s health condition, including their previous medications and medical history, to rule out any side effects/interactions.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Inform the doctor if the child is taking antibiotics (cefaclor, cefadroxil, cefixime, cefpodoxime), typhoid or cholera vaccines.

Drug-Food Interactions: No interactions found/established.

Drug-Disease Interactions: Inform your doctor before administering Megamox CV 375 mg Tablet if your child has any history of kidney or liver disease.

Clavulanic acid + AmoxicillinDoxycycline
Severe
Clavulanic acid + AmoxicillinCholera, live attenuated
Severe

Drug-Drug Interactions

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Clavulanic acid + AmoxicillinDoxycycline
Severe
How does the drug interact with Megamox Cv 375mg Tablet:
Co-administration of Megamox Cv 375mg Tablet with doxycycline may reduce the effectiveness of amoxicillin.

How to manage the interaction:
Although there is a possible interaction between Megamox Cv 375mg Tablet and Doxycycline, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
Clavulanic acid + AmoxicillinCholera, live attenuated
Severe
How does the drug interact with Megamox Cv 375mg Tablet:
Co-administration of Megamox Cv 375mg Tablet and Cholera vaccine, live attenuated may reduce the activity of the vaccine.

How to manage the interaction:
Taking Megamox Cv 375mg Tablet and Cholera vaccine, live attenuated together can lead to an interaction, it can be taken if prescribed by the doctor. It is advised to take cholera vaccine, live at least 14 days after stopping Megamox Cv 375mg Tablet dose. Do not discontinue the medication without consulting a doctor.
Clavulanic acid + AmoxicillinMethotrexate
Severe
How does the drug interact with Megamox Cv 375mg Tablet:
Co-administration of methotrexate with Megamox Cv 375mg Tablet can increase the levels and side effects of methotrexate.

How to manage the interaction:
Although there is a possible interaction between methotrexate and Megamox Cv 375mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as nausea, vomiting, mouth ulcers, pale skin, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, Consult a doctor immediately. Do not stop using medications without a doctor's advice.
Clavulanic acid + AmoxicillinBCG vaccine
Severe
How does the drug interact with Megamox Cv 375mg Tablet:
Co-administration of BCG vaccine with Megamox Cv 375mg Tablet may reduce the action of BCG vaccine.

How to manage the interaction:
Taking BCG vaccine with Megamox Cv 375mg Tablet can lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Megamox CV 375 mg Tablet is used to treat bacterial infections in children.
Megamox CV 375 mg Tablet contains amoxycillin and clavulanic acid. Amoxycillin works by inhibiting the formation of the bacterial cell wall (a protective covering) and causing damage to the bacterial cell wall. This eventually leads to the death of the bacterial cell and thus prevents the growth of bacterial infections. Clavulanic acid inhibits the beta-lactamase enzyme, which prevents bacteria from destroying the efficacy of amoxycillin.
No, Megamox CV 375 mg Tablet is not used to treat viral infections. It is an antibiotic used only to treat bacterial infections.
No. As an antibiotic, it is advised to complete your child's entire treatment course as prescribed. If the treatment is stopped abruptly, drug resistance may develop.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Amoxicillin/clavulanate potassium. [Accessed on 25 Jan. 2019]Check here
  2. Amoxicillin and clavulanic acid. 2017. [Accessed on 01 Feb. 2019]Check here
  3. Amoxicillin trihydrate and potassium clavulanate [EMC SmPC]. 2025. [Accessed on 02 Jul. 2025]Check here
  4. Augmentin 625 mg Capsules - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 7 July 2025]Check here
  5. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 23665637, Amoxicillin-Potassium Clavulanate Combination. [Accessed on 7 July 2025]Check here
  6. Drugbank.Amoxicillin.Drugbank [Accessed on 7 July 2025]Check here
  7. Akhavan BJ, Khanna NR, Vijhani P. Amoxicillin. [Updated 2023 Nov 17]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 7 July 2025]Check here

Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi Dl 110034 INDIA

Therapeutic Class

[ANTIBIOTICS]

Habit Forming

No
Other Info - MEG0182
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