Meprate Tablet 10's with estrogen should not be used to prevent heart disease, heart attacks, strokes, or dementia. Using Meprate Tablet 10's with estrogen may increase the chance of getting heart attacks, strokes, breast cancer, and blood clots. In some cases, using Meprate Tablet 10's with estrogen may produce dementia among women age 65 and older. Do not use Meprate Tablet 10's if you are allergic to peanuts, have unusual vaginal bleeding, have or had any type of cancer (breast or uterus cancer), or undergoing estrogen plus progestin treatment. Tell your doctor before using Meprate Tablet 10's if you have had a heart attack, stroke, blood clot, liver problems, kidney problems, pregnant, breastfeeding or planning to get pregnant, asthma (wheezing), epilepsy (seizures), diabetes, migraine, endometriosis, lupus, heart problems, thyroid, or have high calcium levels in your blood. Use caution while driving a motor vehicle as dizziness or drowsiness may occur. If you are using Meprate Tablet 10's before any lab tests or biopsies tell your doctor about this as it can affect the report values. Diagnostic tests of blood coagulation, thyroid, cholesterol, and glucose metabolism result might be affected in people using Meprate Tablet 10's.

Drug-Drug Interactions: This medicine may have an interaction with medicines including anticonvulsants such as acetazolamide, and carbamazepine; anti-infectives (metronidazole, clindamycin), herbal preparation (like Ginkgo Biloba and St. John’s wort plant).

Drug-Food Interactions: Meprate Tablet 10's may interact with grapefruit, Ginkgo biloba herbal supplements and St. John’s wort plant (used for anti-depression).

Drug-Disease Interactions: Meprate Tablet 10's should not be given in the condition of abnormal genital bleeding, low level of bone mineral, breast cancer, liver disease, and thromboembolism (blood clot problem).

• Do regular exercise and physical activity to minimize hot flushes and improve sleep. Besides this, weight-bearing exercises can help in making your bone strong. Aerobics, yoga, and activities like tai chi may help in relaxing the body and mind.
• Try to wear loose clothes before going to bed and sleep in a cool, well-ventilated room. Doing this can prevent symptoms of hot flushes and night sweats. Take minimum sleep of 8 hours. 
• Avoid or limit intake of caffeine-containing beverages, alcohol, and spicy food, as these are known triggering agents for hot flushes.
• Try to be stress-free to improve your mood swings due to hormonal fluctuations. 
• Quit smoking as it will help to reduce hot flushes and your risk of developing chronic conditions like heart disease, stroke, and cancer.
• Try to apply vaginal lubricant or moisturizer if you have vaginal dryness.

• Talk with your doctor regularly about whether you should continue taking Meprate Tablet 10's. The addition of a Meprate Tablet 10's is generally recommended for women who have a chance of getting uterus cancer.
• Tell your doctor if you get vaginal bleeding while taking Meprate Tablet 10's.
• Try to have a yearly pelvic exam, breast exam and mammogram (breast X-ray) unless your doctor tells you otherwise. If your any family members have had breast cancer or breast lumps or an abnormal mammogram. Your doctor may ask you to have breast exams more often.
• Before using Meprate Tablet 10's let your doctor know if you have high blood pressure (hypertension), high cholesterol (hyperlipidemia), diabetes, or obesity (BMI more than 25). If you use tobacco, you may have a higher chance of getting heart disease. Ask your doctor for ways to lower your chance of getting heart disease.